Updated on 2022/06/22

写真a

 
SHIMOTAI Yoshitaka
 
Title
Assistant Professor
Date of Birth
1978

Research Areas

  • Life Science / Virology

  • Life Science / Cell biology

  • Life Science / Molecular biology

Graduating School

  • Aomori University, Faculty of Engineering

    2001.03, Graduated

Graduate School

  • Iwate University, Graduate School, Division of Agricltural Sciences

    Doctor's Course, 2006.03, Completed

  • Iwate University, Graduate School, Division of Agriculture

    Master's Course, 2003.03, Completed

Degree

  • Doctor (Agriculture), Iwate University, 2006.03

External Career

  • , Part-time Lecturer, 2022.05 -

 

Papers

  • TMPRSS2 activates hemagglutinin-esterase glycoprotein of influenza C virus., Journal of virology, 95(21) e0129621, 2021.11

    Ko Sato, Hideki Hayashi, Yoshitaka Shimotai, Mutsuo Yamaya, Seiji Hongo, Kazuyoshi Kawakami, Yoko Matsuzaki, Hidekazu Nishimura

    Single Author

  • The proton ATPase inhibitor bafilomycin A1 reduces the release of rhinovirus C and cytokines from primary cultures of human nasal epithelial cells, Virus Research, 304 198548, 2021.10

    Mutsuo Yamaya, Xue Deng, Akiko Kikuchi, Mitsuru Sugawara, Natsumi Saito, Toru Kubo, Haruki Momma, Tetsuaki Kawase, Kazuyuki Nakagome, Yoshitaka Shimotai, Hidekazu Nishimura

    Single Author

  • Longitudinal epidemiology of human coronavirus OC43 in Yamagata, Japan, 2010-2017: Two groups based on spike gene appear one after another., Journal of medical virology, 93(2) 945-951, 2021.02

    Kenichi Komabayashi, Yohei Matoba, Shizuka Tanaka, Junji Seto, Yoko Aoki, Tatsuya Ikeda, Yoshitaka Shimotai, Yoko Matsuzaki, Tsutomu Itagaki, Katsumi Mizuta

    Single Author

  • The clinically used serine protease inhibitor nafamostat reduces influenza virus replication and cytokine production in human airway epithelial cells and viral replication in mice., Journal of medical virology, 93(6) 3484-3495, 2020.12

    Mutsuo Yamaya, Yoshitaka Shimotai, Ayako Ohkawara, Enkhbold Bazarragchaa, Masatoshi Okamatsu, Yoshihiro Sakoda, Hiroshi Kida, Hidekazu Nishimura

    Single Author

  • Antigenic changes among the predominantly circulating C/Sao Paulo lineage strains of influenza C virus in Yamagata, Japan, between 2015 and 2018., Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 81 104269, 2020.07

    Yoko Matsuzaki, Yoshitaka Shimotai, Yoko Kadowaki, Kanetsu Sugawara, Seiji Hongo, Katsumi Mizuta, Hidekazu Nishimura

    Single Author

  • Inhibitory effects of glycopyrronium, formoterol, and budesonide on coronavirus HCoV-229E replication and cytokine production by primary cultures of human nasal and tracheal epithelial cells., Respiratory investigation, 2020.05

    Mutsuo Yamaya, Hidekazu Nishimura, Xue Deng, Mitsuru Sugawara, Oshi Watanabe, Kazuhiro Nomura, Yoshitaka Shimotai, Haruki Momma, Masakazu Ichinose, Tetsuaki Kawase

    Multiple Authorship (Only Japanese)

  • Polyclonal spread of multiple genotypes of Mycoplasma pneumoniae in semi-closed settings in Yamagata, Japan., Journal of medical microbiology, 68(5) 785-790, 2019.05

    Suzuki Y, Seto J, Shimotai Y, Itagaki T, Katsushima Y, Katsushima F, Ikeda T, Mizuta K, Hongo S, Matsuzaki Y

    Multiple Authorship (Only Japanese)

  • Effects of high temperature on pandemic and seasonal human influenza viral replication and infection-induced damage in primary human tracheal epithelial cell cultures., Heliyon, 5(2) e01149, 2019.02

    Yamaya M, Nishimura H, Lusamba Kalonji N, Deng X, Momma H, Shimotai Y, Nagatomi R

    Multiple Authorship (Including Foreigners)

  • Neutralizing Epitopes and Residues Mediating the Potential Antigenic Drift of the Hemagglutinin-Esterase Protein of Influenza C Virus., Viruses, 167(169) E417, 2018.08

    Matsuzaki Y, Sugawara K, Furuse Y, Shimotai Y, Hongo S, Mizuta K, Nishimura H

    Multiple Authorship (Including Foreigners)

  • Trends of Human Coronaviruses in Yamagata, Japan in 2015-2016 Focusing on the OC43 Outbreak of June 2016., Japanese Journal of Infectious Diseases, 71(2) 167-169, 2018.03

    Matoba Y, Aoki Y, Tanaka S, Unno M, Komabayashi K, Ikeda T, Shimotai Y, Matsuzaki Y, Itagaki T, Mizuta K.

    Multiple Authorship (Including Foreigners)

  • Multiple-Locus Variable-Number Tandem-Repeat Analysis of Mycoplasma pneumoniae Isolates between 2004 and 2014 in Yamagata, Japan: Change in Molecular Characteristics during an 11-year Period., Japanese Journal of Infectious Diseases, 70(6) 642-646, 2017.11

    Suzuki Y, Seto J, Shimotai Y, Itagaki T, Katsushima Y, Katsushima F, Ikeda T, Mizuta K, Hongo S, Matsuzaki Y.

    Multiple Authorship (Including Foreigners)

  • Development of macrolide resistance-associated mutations after macrolide treatment in children infected with Mycoplasma pneumoniae., Journal of Medical Microbiology, 66(11) 1531-1538, 2017.11

    Suzuki Y, Shimotai Y, Itagaki T, Seto J, Ikeda T, Yahagi K, Mizuta K, Hongo S, Matsuzaki Y.

    Multiple Authorship (Including Foreigners)

  • Effect of the phosphorylation of the CM2 protein on influenza C virus replication., Journal of Virology, 2017.09

    Takanari Goto, Yoshitaka Shimotai, Yoko Matsuzaki, Yasushi Muraki, Ri Sho, Kanetsu Sugawara, Seiji Hongo

    Multiple Authorship (Including Foreigners)

  • Development of an endpoint genotyping assay to detect the Mycoplasma pneumoniae 23S rRNA gene and distinguish the existence of macrolide resistance-associated mutations at position 2063., Journal of Microbiological Methods, 131 130-134, 2016.10

    Yu Suzuki, Junji Seto, Yoshitaka Shimotai, Tatsuya Ikeda, Kazue Yahagi, Katsumi Mizuta, Yoko Matsuzaki, Seiji Hongo

    Multiple Authorship (Including Foreigners)

  • Genetic Lineage and Reassortment of Influenza C Viruses Circulating between 1947 and 2014., Journal of virology, 90(18) 8251-8265, 2016.09

    Matsuzaki Y, Sugawara K, Furuse Y, Shimotai Y, Hongo S, Oshitani H, Mizuta K, Nishimura H

    Multiple Authorship (Including Foreigners)

  • The serine protease inhibitor camostat inhibits influenza virus replication and cytokine production in primary cultures of human tracheal epithelial cells., Pulmonary Pharmacology and Therapeutics, 33 66-74, 2015.07

    Yamaya M, Shimotai Y, Hatachi Y, Kalonji NL, Tando Y, Kitajima Y, Matsuo K, Kubo H, Nagatomi R, Hongo S, Homma M, Nishimura H

    Multiple Authorship (Including Foreigners)

  • The effect of the cytoplasmic tail of influenza C virus CM2 protein on its biochemical properties and intracellular processing, Biochemistry and Biophysics Reports, 3 1-6, 2015.07

    Shimotai Y, Goto T, Matsuzaki Y, Muraki Y, Sugawara K, Hongo S

    Multiple Authorship (Including Foreigners)

  • An Outbreak of Human Coronavirus OC43 during the 2014-2015 Influenza Season in Yamagata, Japan., Japanese Journal of Infectious Diseases, 68(5) 442-445, 2015.07

    Matoba Y, Aoki Y, Tanaka S, Yahagi K, Shimotai Y, Matsuzaki Y, Itagaki T, Mizuta K.

    Multiple Authorship (Including Foreigners)

  • Epstein-Barr Virus in the Enlarged Salivary Tissues of Patients With IgG4-Related Disease, The Laryngoscope, 2015

    Takatoshi Furukawa, Yoshitaka Shimotai, Nobuo Ohta, Akihiro Ishida, Kazuya Kurakami, Hitoshi Suzuki, Mitsunori Yamakawa, Seiji Hongo, Seiji Kakehata

    Multiple Authorship (Including Foreigners)

  • Epitope Mapping of the Hemagglutinin Molecule of A/(H1N1)pdm09 Virus by Using Monoclonal Antibody Escape Mutants., Journal of Virology, 2014

    Matsuzaki Y, Sugawara K, Nakauchi M, Takahashi Y, Onodera T, Tsunetsugu-Yokota Y, Matsumura T, Ato M, Kobayashi K, Shimotai Y, Mizuta K, Hongo S, Tashiro M, Nobusawa E

    Multiple Authorship (Including Foreigners)

  • Epidemiological information regarding the periodic epidemics of influenza C virus in Japan (1996-2013) and the seroprevalence of antibodies to different antigenic groups., Journal of Clinical Virology, 61(1) 87-93, 2014

    Matsuzaki Y, Sugawara K, Abiko C, Ikeda T, Aoki Y, Mizuta K, Katsushima N, Katsushima F, Katsushima Y, Itagaki T, Shimotai Y, Hongo S, Muraki Y, Nishimura H

    Multiple Authorship (Including Foreigners)

  • Detection and quantification of influenza C virus in pediatric respiratory specimens by real-time PCR and comparison with infectious viral counts. , Journal of Clinical Virology, 54(2) 130-134, 2012.06

    Matsuzaki Y, Ikeda T, Abiko C, Aoki Y, Mizuta K, Shimotai Y, Sugawara K, Hongo S

    Multiple Authorship (Including Foreigners)

  • The roles of M- and NS-gene translational products in influenza C virus replication, Current Topics in Virology, 9 , 2011.12

    Seiji Hongo, Yasushi Muraki, and Yoshitaka Shimotai

    Multiple Authorship (Including Foreigners)

  • The Role of the CM2 Protein in the Influenza C Virus Replication Cycle, Journal of Virology, 85(3) 1322-1329, 2011.02

    Furukawa T, Muraki Y, Noda T, Takashita E, Sho R, Sugawara K, Matsuzaki Y, Shimotai Y, Hongo S.

    Multiple Authorship (Including Foreigners)

  • Anti-influenza virus principles from Muehlenbeckia hastulata. (共著), Journal of Natural Medicines, 64(2) 206-211, 2010.04

    Takaaki Yasuda, Mitsuo Yamaki, Akiko Iimura, Yoshitaka Shimotai, Kazufumi Shimizu, Toshiro Noshita and Shinji Funayama

    Multiple Authorship (Including Foreigners)

  • Structure and allele-specific expression variation of novel alpha/beta hydrolase fold proteins in gentian plants. (共著), Molecular Genetics and Genomics, 278(1) 95-104, 2007.04

    Hikage T, Saitoh Y, Tanaka-Saito C, Hagami H, Satou F, Shimotai Y, Nakano Y, Takahashi M, Takahata Y, Tsutsumi K.

    Multiple Authorship (Including Foreigners)

  • A binding site for Purα and Purβ is structurally unstable and is required for replication in vivo from the rat aldolase B origin., Biochemical and Biophysical Research Communications, 340(2) 517-525, 2006.02

    Shimotai Y, Minami H, Saitoh Y, Onodera Y, Mishima Y, Kelm RJ Jr, Tsutsumi K.

    Multiple Authorship (Including Foreigners)

  • Antiproliferative activity of root extract from gentian plant (Gentiana triflora) on cultured and implanted tumor cells., Bioscience, Biotechnology, and Biochemistry, 70(4) 1046-1048, 2006.02

    Matsukawa K, Ogata M, Hikage T, Minami H, Shimotai Y, Saitoh Y, Yamashita T, Ouchi A, Tsutsumi R, Fujioka T, Tsutsumi K.

    Multiple Authorship (Including Foreigners)

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Review Papers

  • Serine Proteases and their Inhibitors in Human Airway Epithelial Cells: Effects on Influenza Virus Replication and Airway Inflammation, Clinical Microbiology, 5(2) , 2016.03

    Yamaya M, Shimotai Y, Hatachi Y, Homma M, Nishimura H

  • Activation of influenza virus by airway epithelial proteases: a potential treatment for influenza, Annals of the Japanese Respiratory Society, 2016

    Mutsuo Yamaya, Yoshitaka Shimotai, Yukimasa Hatachi, Morio Homma, Hidekazu Nishimura

Grant-in-Aid for Scientific Research

  • Grant-in-Aid for Young Scientists(B)，2016.04 - 2019.03

  • Grant-in-Aid for Scientific Research(C)，2014.04 - 2017.03

  • Grant-in-Aid for Scientific Research(C)，2011.04 - 2014.03

  • Grant-in-Aid for Young Scientists(B)，2011.04 - 2013.03

Other external funds procured

  • Investigation of genome packaging mechanism of influenza C virus.，2021，Investigation of genome packaging mechanism of influenza C virus.

    Takeda Science Fandation

Presentations

  • The 62th Annual Meeting of the Japanese Society for Virology, Domestic presentation, 2014.11, Oral presentation (general)

  • International Union of Microbiological Societies 2011 Congress , International presentation, 2011.09, Symposium, workshop panel (public)

  • Options for the Control of Influenza VII, International presentation, 2010.09, Overexpression of UBE2L6 gene inhibits the propagation of influenza virus, Poster presentation

  • American Society of Pharmacognosy 50th Anniversary Meeting, International presentation, 2009.06 - 2009.07, ANTI-INFLUENZA VIRUS COMPOUNDS FROM MUEHLENBECKIA HASTULATA. , Oral presentation (general)

  • 20th IUBMB International Congress of Biochemistry and Molecular Biology, International presentation, 2006.06, Involvement of Purα and β in replication initiation in vivo at the rat aldolase B origin., Poster presentation