研究経歴
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リン酸化酵素阻害剤CEP-1347による網膜芽細胞増殖抑制機序の解明,2019年04月 ~ 2022年03月
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ぶどう膜悪性黒色腫に対するp53活性化誘導を基軸とした新規治療薬の開発,2021年04月 ~ 継続中
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ぶどう膜悪性黒色腫の急所MDM4, PKCを同時に標的とする新規治療薬の開発,2023年04月 ~ 継続中
2023/06/17 更新
リン酸化酵素阻害剤CEP-1347による網膜芽細胞増殖抑制機序の解明,2019年04月 ~ 2022年03月
ぶどう膜悪性黒色腫に対するp53活性化誘導を基軸とした新規治療薬の開発,2021年04月 ~ 継続中
ぶどう膜悪性黒色腫の急所MDM4, PKCを同時に標的とする新規治療薬の開発,2023年04月 ~ 継続中
Givinostat Inhibition of Sp1-dependent MGMT Expression Sensitizes Glioma Stem Cells to Temozolomide,ANTICANCER RESEARCH,43(3) 1131-1138,2023年03月
Nakagawa-Saito Yurika, Mitobe Yuta, Togashi Keita, Suzuki Shuhei, Sugai Asuka, Kitanaka Chifumi, Okada Masashi
単著
CEP-1347 Targets MDM4 Protein Expression to Activate p53 and Inhibit the Growth of Glioma Cells,ANTICANCER RESEARCH,42(10) 4727-4733,2022年10月
Mitobe Yuta, Nakagawa-saito Yurika, Togashi Keita, Suzuki Shuhei, Sugai Asuka, Matsuda Ken-ichiro, Sonoda Yukihiko, Kitanaka Chifumi, Okada Masashi
単著
Inhibition of the Phospholipase C epsilon-c-Jun N-Terminal Kinase Axis Suppresses Glioma Stem Cell Properties,INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,23(15) ,2022年08月
Okada Masashi, Nakagawa-Saito Yurika, Mitobe Yuta, Sugai Asuka, Togashi Keita, Suzuki Shuhei, Kitanaka Chifumi
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HDAC Class I Inhibitor Domatinostat Preferentially Targets Glioma Stem Cells over Their Differentiated Progeny,INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,23(15) ,2022年08月
Nakagawa-Saito Yurika, Saitoh Shinichi, Mitobe Yuta, Sugai Asuka, Togashi Keita, Suzuki Shuhei, Kitanaka Chifumi, Okada Masashi
単著
Gemcitabine Cooperates with Everolimus to Inhibit the Growth of and Sensitize Malignant Meningioma Cells to Apoptosis Induced by Navitoclax, an Inhibitor of Anti-Apoptotic BCL-2 Family Proteins,CANCERS,14(7) ,2022年04月
Yamamoto Masahiro, Suzuki Shuhei, Togashi Keita, Sugai Asuka, Okada Masashi, Kitanaka Chifumi
単著
Targeting Folate Metabolism Is Selectively Cytotoxic to Glioma Stem Cells and Effectively Cooperates with Differentiation Therapy to Eliminate Tumor-Initiating Cells in Glioma Xenografts,INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,22(21) ,2021年11月
Okada Masashi, Suzuki Shuhei, Togashi Keita, Sugai Asuka, Yamamoto Masahiro, Kitanaka Chifumi
単著
Dexamethasone Sensitizes Cancer Stem Cells to Gemcitabine and 5-Fluorouracil by Increasing Reactive Oxygen Species Production through NRF2 Reduction,LIFE-BASEL,11(9) ,2021年09月
Suzuki Shuhei, Yamamoto Masahiro, Sanomachi Tomomi, Togashi Keita, Sugai Asuka, Seino Shizuka, Yoshioka Takashi, Okada Masashi, Kitanaka Chifumi
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Lurasidone Sensitizes Cancer Cells to Osimertinib by Inducing Autophagy and Reduction of Survivin,ANTICANCER RESEARCH,41(9) 4321-4331,2021年09月
Suzuki Shuhei, Yamamoto Masahiro, Sanomachi Tomomi, Togashi Keita, Seino Shizuka, Sugai Asuka, Yoshioka Takashi, Okada Masashi, Kitanaka Chifumi
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Roles for hENT1 and dCK in gemcitabine sensitivity and malignancy of meningioma,NEURO-ONCOLOGY,23(6) 945-954,2021年06月
Yamamoto Masahiro, Sanomachi Tomomi, Suzuki Shuhei, Uchida Hiroyuki, Yonezawa Hajime, Higa Nayuta, Takajo Tomoko, Yamada Yuki, Sugai Asuka, Togashi Keita, Seino Shizuka, Okada Masashi, Sonoda Yukihiko...
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Metastatic Orbital Tumor From Breast Ductal Carcinoma With Neuroendocrine Differentiation Initially Presenting as Ocular Symptoms: A Case Report and Literature Review,FRONTIERS IN ENDOCRINOLOGY,12 625663,2021年02月
Togashi Keita, Nishitsuka Koichi, Hayashi Shion, Namba Hiroyuki, Goto Sakiko, Takeda Yusuke, Suzuki Shuhei, Kato Tomoya, Yamada Yuki, Konno Eriko, Yoshioka Takashi, Yamakawa Mitsunori, Sonoda Yukihiko...
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Inhibition of the Lipid Droplet-Peroxisome Proliferator-Activated Receptor alpha Axis Suppresses Cancer Stem Cell Properties,GENES,12(1) ,2021年01月
Kuramoto Kenta, Yamamoto Masahiro, Suzuki Shuhei, Togashi Keita, Sanomachi Tomomi, Kitanaka Chifumi, Okada Masashi
単著
Gemcitabine radiosensitization primes irradiated malignant meningioma cells for senolytic elimination by navitoclax,NEURO-ONCOLOGY ADVANCES,3(1) vdab148,2021年
Yamamoto Masahiro, Sanomachi Tomomi, Suzuki Shuhei, Togashi Keita, Sugai Asuka, Seino Shizuka, Sato Atsushi, Okada Masashi, Kitanaka Chifumi
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Therapeutic targeting of pancreatic cancer stem cells by dexamethasone modulation of the MKP-1-JNK axis,JOURNAL OF BIOLOGICAL CHEMISTRY,295(52) 18328-18342,2020年12月
Suzuki Shuhei, Okada Masashi, Sanomachi Tomomi, Togashi Keita, Seino Shizuka, Sato Atsushi, Yamamoto Masahiro, Kitanaka Chifumi
単著
Inhibition of Retinoblastoma Cell Growth by CEP1347 Through Activation of the P53 Pathway,ANTICANCER RESEARCH,40(9) 4961-4968,2020年09月
Togashi Keita, Okada Masashi, Suzuki Shuhei, Sanomachi Tomomi, Seino Shizuka, Yamamoto Masahiro, Yamashita Hidetoshi, Kitanaka Chifumi
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Doxazosin, a Classic Alpha 1-Adrenoceptor Antagonist, Overcomes Osimertinib Resistance in Cancer Cells via the Upregulation of Autophagy as Drug Repurposing,BIOMEDICINES,8(8) ,2020年08月
Suzuki Shuhei, Yamamoto Masahiro, Sanomachi Tomomi, Togashi Keita, Sugai Asuka, Seino Shizuka, Okada Masashi, Yoshioka Takashi, Kitanaka Chifumi
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Verteporfin inhibits oxidative phosphorylation and induces cell death specifically in glioma stem cells,FEBS JOURNAL,287(10) 2023-2036,2020年05月
Kuramoto Kenta, Yamamoto Masahiro, Suzuki Shuhei, Sanomachi Tomomi, Togashi Keita, Seino Shizuka, Kitanaka Chifumi, Okada Masashi
単著
Spironolactone, a Classic Potassium-Sparing Diuretic, Reduces Survivin Expression and Chemosensitizes Cancer Cells to Non-DNA-Damaging Anticancer Drugs,CANCERS,11(10) ,2019年10月
Sanomachi Tomomi, Suzuki Shuhei, Togashi Keita, Sugai Asuka, Seino Shizuka, Okada Masashi, Yoshioka Takashi, Kitanaka Chifumi, Yamamoto Masahiro
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Brexpiprazole Reduces Survivin and Reverses EGFR Tyrosine Kinase Inhibitor Resistance in Lung and Pancreatic Cancer,ANTICANCER RESEARCH,39(9) 4817-4828,2019年09月
Sanomachi Tomomi, Suzuki Shuhei, Togashi Keita, Seino Shizuka, Yoshioka Takashi, Kitanaka Chifumi, Okada Masashi, Yamamoto Masahiro
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Brexpiprazole, a Serotonin-Dopamine Activity Modulator, Can Sensitize Glioma Stem Cells to Osimertinib, a Third-Generation EGFR-TKI, via Survivin Reduction,CANCERS,11(7) ,2019年06月
Suzuki Shuhei, Yamamoto Masahiro, Sanomachi Tomomi, Togashi Keita, Sugai Asuka, Seino Shizuka, Yoshioka Takashi, Kitanaka Chifumi, Okada Masashi
単著
In vitro and in vivo anti-tumor effects of brexpiprazole, a newly-developed serotonin-dopamine activity modulator with an improved safety profile.,Oncotarget,10(37) 3547-3558,2019年05月
Suzuki S, Yamamoto M, Togashi K, Sanomachi T, Sugai A, Seino S, Yoshioka T, Kitanaka C, Okada M
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AS602801 Sensitizes Ovarian Cancer Stem Cells to Paclitaxel by Down-regulating MDR1,ANTICANCER RESEARCH,39(2) 609-617,2019年02月
Yamamoto Masahiro, Suzuki Shuhei, Togashi Keita, Sanomachi Tomomi, Seino Shizuka, Kitanaka Chifumi, Okada Masashi
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AS602801, an Anticancer Stem Cell Candidate Drug, Reduces Survivin Expression and Sensitizes A2780 Ovarian Cancer Stem Cells to Carboplatin and Paclitaxel,ANTICANCER RESEARCH,38(12) 6699-6706,2018年12月
Yamamoto Masahiro, Suzuki Shuhei, Togashi Keita, Sanomachi Tomomi, Seino Shizuka, Kitanaka Chifumi, Okada Masashi
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AS602801, an Anti-Cancer Stem Cell Drug Candidate, Suppresses Gap-junction Communication Between Lung Cancer Stem Cells and Astrocytes,ANTICANCER RESEARCH,38(9) 5093-5099,2018年09月
Kuramoto Kenta, Yamamoto Masahiro, Suzuki Shuhei, Sanomachi Tomomi, Togashi Keita, Seino Shizuka, Kitanaka Chifumi, Okada Masashi
単著
Involvement of GLUT1-mediated glucose transport and metabolism in gefitinib resistance of non-small-cell lung cancer cells.,Oncotarget,9(66) 32667-32679,2018年08月
Suzuki S, Okada M, Takeda H, Kuramoto K, Sanomachi T, Togashi K, Seino S, Yamamoto M, Yoshioka T, Kitanaka C
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A Small-molecule Kinase Inhibitor, CEP-1347, Inhibits Survivin Expression and Sensitizes Ovarian Cancer Stem Cells to Paclitaxel,ANTICANCER RESEARCH,38(8) 4535-4542,2018年08月
Togashi Keita, Okada Masashi, Yamamoto Masahiro, Suzuki Shuhei, Sanomachi Tomomi, Seino Shizuka, Yamashita Hidetoshi, Kitanaka Chifumi
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