Updated on 2023/02/08

写真a

 
KITANAKA Chihumi
 
Title
Professor

Research Areas

  • Life Science / Cell biology

  • Life Science / Neurosurgery

  • Life Science / Pathological biochemistry

Graduating School

  • The University of Tokyo, Faculty of Medicine

    1987.03, Graduated

 

Papers

  • Spironolactone, a Classic Potassium-Sparing Diuretic, Reduces Survivin Expression and Chemosensitizes Cancer Cells to Non-DNA-Damaging Anticancer Drugs., Cancers, 11(10) , 2019.10

    Sanomachi T, Suzuki S, Togashi K, Sugai A, Seino S, Okada M, Yoshioka T, Kitanaka C, Yamamoto M

    Single Author

  • Brexpiprazole Reduces Survivin and Reverses EGFR Tyrosine Kinase Inhibitor Resistance in Lung and Pancreatic Cancer., Anticancer research, 39(9) 4817-4828, 2019.09

    Sanomachi T, Suzuki S, Togashi K, Seino S, Yoshioka T, Kitanaka C, Okada M, Yamamoto M

    Single Author

  • Brexpiprazole, a Serotonin-Dopamine Activity Modulator, Can Sensitize Glioma Stem Cells to Osimertinib, a Third-Generation EGFR-TKI, via Survivin Reduction., Cancers, 11(7) , 2019.07

    Suzuki S, Yamamoto M, Sanomachi T, Togashi K, Sugai A, Seino S, Yoshioka T, Kitanaka C, Okada M

    Single Author

  • <i>In vitro</i> and <i>in vivo</i> anti-tumor effects of brexpiprazole, a newly-developed serotonin-dopamine activity modulator with an improved safety profile., Oncotarget, 10(37) 3547-3558, 2019.05

    Suzuki S, Yamamoto M, Togashi K, Sanomachi T, Sugai A, Seino S, Yoshioka T, Kitanaka C, Okada M

    Single Author

  • AS602801, an Anti-Cancer Stem Cell Drug Candidate, Suppresses Gap-junction Communication Between Lung Cancer Stem Cells and Astrocytes., Anticancer Res, 2018.09

    Kuramoto Kenta, Yamamoto Masahiro, Suzuki Shuhei, Sanomachi Tomomi, Togashi Keita, Seino Shizuka, Kitanaka Chifumi, Okada Masashi

    Single Author

  • Involvement of GLUT1-mediated glucose transport and metabolism in gefitinib resistance of non-small-cell lung cancer cells., Oncotarget, 9(66) 32667-32679, 2018.08

    Suzuki Shuhei, Okada Masashi, Takeda Hiroyuki, Kuramoto Kenta, Sanomachi Tomomi, Togashi Keita, Seino Shizuka, Yamamoto Masahiro, Yoshioka Takashi, Kitanaka Chifumi

    Multiple Authorship (Only Japanese)

  • Olanzapine, an Atypical Antipsychotic, Inhibits Survivin Expression and Sensitizes Cancer Cells to Chemotherapeutic Agents., Anticancer Res, 37(11) 6177-6188, 2017.11

    Sanomachi Tomomi, Suzuki Shuhei, Kuramoto Kenta, Takeda Hiroyuki, Sakaki Hirotsugu, Togashi Keita, Seino Shizuka, Yoshioka Takashi, Okada Masashi, Kitanaka Chifumi

    Multiple Authorship (Only Japanese)

  • Antitumor activity of gemcitabine against high-grade meningioma in vitro and in vivo., Oncotarget, 8(53) 90996-91008, 2017.10

    Takeda Hiroyuki, Okada Masashi, Kuramoto Kenta, Suzuki Shuhei, Sakaki Hirotsugu, Sanomachi Tomomi, Seino Shizuka, Yoshioka Takashi, Hirano Hirofumi, Arita Kazunori, Kitanaka Chifumi

    Multiple Authorship (Only Japanese)

  • Repositioning CEP-1347, a chemical agent originally developed for the treatment of Parkinson's disease, as an anti-cancer stem cell drug., Oncotarget, 8(55) 94872-94882, 2017.10

    Okada Masashi, Takeda Hiroyuki, Sakaki Hirotsugu, Kuramoto Kenta, Suzuki Shuhei, Sanomachi Tomomi, Togashi Keita, Seino Shizuka, Kitanaka Chifumi

    Multiple Authorship (Only Japanese)

  • Licochalcone A specifically induces cell death in glioma stem cells via mitochondrial dysfunction., FEBS Open Bio, 7(6) 835-844, 2017.06

    Kuramoto Kenta, Suzuki Shuhei, Sakaki Hirotsugu, Takeda Hiroyuki, Sanomachi Tomomi, Seino Shizuka, Narita Yoshitaka, Kayama Takamasa, Kitanaka Chifumi, Okada Masashi

    Multiple Authorship (Including Foreigners)

  • Rho-Associated Protein Kinase (ROCK) Inhibitors Inhibit Survivin Expression and Sensitize Pancreatic Cancer Stem Cells to Gemcitabine., Anticancer Res, 36(12) 6311-6318, 2016.12

    Takeda Hiroyuki, Okada Masashi, Suzuki Shuhei, Kuramoto Kenta, Sakaki Hirotsugu, Watarai Hikaru, Sanomachi Tomomi, Seino Shizuka, Yoshioka Takashi, Kitanaka Chifumi

    Multiple Authorship (Only Japanese)

  • Impact of H3K27 Demethylase Inhibitor GSKJ4 on NSCLC Cells Alone and in Combination with Metformin., Anticancer Res, 36(11) 6083-6092, 2016.11

    Watarai Hikaru, Okada Masashi, Kuramoto Kenta, Takeda Hiroyuki, Sakaki Hirotsugu, Suzuki Shuhei, Seino Shizuka, Oizumi Hiroyuki, Sadahiro Mitsuaki, Kitanaka Chifumi

    Multiple Authorship (Only Japanese)

  • Aripiprazole, an Antipsychotic and Partial Dopamine Agonist, Inhibits Cancer Stem Cells and Reverses Chemoresistance., Anticancer Res, 36(10) 5153-5161, 2016.10

    Suzuki Shuhei, Okada Masashi, Kuramoto Kenta, Takeda Hiroyuki, Sakaki Hirotsugu, Watarai Hikaru, Sanomachi Tomomi, Seino Shizuka, Yoshioka Takashi, Kitanaka Chifumi

    Multiple Authorship (Only Japanese)

  • The novel JNK inhibitor AS602801 inhibits cancer stem cells in vitro and in vivo., Oncotarget, 7(19) 27021-27032, 2016.05

    Okada Masashi, Kuramoto Kenta, Takeda Hiroyuki, Watarai Hikaru, Sakaki Hirotsugu, Seino Shizuka, Seino Manabu, Suzuki Shuhei, Kitanaka Chifumi

    Multiple Authorship (Only Japanese)

  • Time-staggered inhibition of JNK effectively sensitizes chemoresistant ovarian cancer cells to cisplatin and paclitaxel., Oncol Rep, 35(1) 593-601, 2016.01

    Seino Manabu, Okada Masashi, Sakaki Hirotsugu, Takeda Hiroyuki, Watarai Hikaru, Suzuki Shuhei, Seino Shizuka, Kuramoto Kenta, Ohta Tsuyoshi, Nagase Satoru, Kurachi Hirohisa, Kitanaka Chifumi

    Multiple Authorship (Only Japanese)

  • GSKJ4, A Selective Jumonji H3K27 Demethylase Inhibitor, Effectively Targets Ovarian Cancer Stem Cells., Anticancer Res, 35(12) 6607-6614, 2015.12

    Sakaki Hirotsugu, Okada Masashi, Kuramoto Kenta, Takeda Hiroyuki, Watarai Hikaru, Suzuki Shuhei, Seino Shizuka, Seino Manabu, Ohta Tsuyoshi, Nagase Satoru, Kurachi Hirohisa, Kitanaka Chifumi

    Multiple Authorship (Only Japanese)

  • Targeting the facilitative glucose transporter GLUT1 inhibits the self-renewal and tumor-initiating capacity of cancer stem cells., Oncotarget, 6(2) 651-661, 2015.01

    Shibuya Keita, Okada Masashi, Suzuki Shuhei, Seino Manabu, Seino Shizuka, Takeda Hiroyuki, Kitanaka Chifumi

    Multiple Authorship (Only Japanese)

  • JNK suppression of chemotherapeutic agents-induced ROS confers chemoresistance on pancreatic cancer stem cells., Oncotarget, 2015.01

    Suzuki S, Okada M, Shibuya K, Seino M, Sato A, Takeda H, Seino S, Yoshioka T, Kitanaka C.

    Single Author

  • Differential contribution of ROS to resveratrol-induced cell death and loss of self-renewal capacity of ovarian cancer stem cells., Anticancer Res, 2015.01

    Seino M, Okada M, Shibuya K, Seino S, Suzuki S, Takeda H, Ohta T, Kurachi H, Kitanaka C.

    Single Author

  • Requirement of JNK signaling for self-renewal and tumor-initiating capacity of ovarian cancer stem cells., Anticancer Res, 2014.09

    Seino M, Okada M, Shibuya K, Seino S, Suzuki S, Ohta T, Kurachi H, Kitanaka C.

    Single Author

  • Targeting the K-Ras--JNK axis eliminates cancer stem-like cells and prevents pancreatic tumor formation., Oncotarget, 2014.07

    Okada M, Shibuya K, Sato A, Seino S, Suzuki S, Seino M, Kitanaka C.

    Single Author

  • Flotillin-1 regulates oncogenic signaling in neuroblastoma cells by regulating ALK membrane association., Cancer Res, 2014.07

    Tomiyama A, Uekita T, Kamata R, Sasaki K, Takita J, Ohira M, Nakagawara A, Kitanaka C, Mori K, Yamaguchi H, Sakai R.

    Single Author

  • JNK contributes to temozolomide resistance of stem-like glioblastoma cells via regulation of MGMT expression., Int J Oncol, 2014.02

    Okada M, Sato A, Shibuya K, Watanabe E, Seino S, Suzuki S, Seino M, Narita Y, Shibui S, Kayama T, Kitanaka C.

    Single Author

  • Treatment outcomes in glioblastoma patients aged 76 years or older: a multicenter retrospective cohort study., J Neurooncol, 2014.01

    Uzuka T, Asano K, Sasajima T, Sakurada K, Kumabe T, Beppu T, Ichikawa M, Kitanaka C, Aoki H, Saito K, Ogasawara K, Tominaga T, Mizoi K, Ohkuma H, Fujii Y, Kayama T; Tohoku Brain Tumor Study Group.

    Single Author

  • Pivotal role for ROS activation of p38 MAPK in the control of differentiation and tumor-initiating capacity of glioma-initiating cells., Stem Cell Res, 2014.01

    Sato A, Okada M, Shibuya K, Watanabe E, Seino S, Narita Y, Shibui S, Kayama T, Kitanaka C.

    Single Author

  • Specific role of JNK in the maintenance of the tumor-initiating capacity of A549 human non-small cell lung cancer cells., Oncol Rep, 30(4) 1957-1964, 2013.10

    Okada Masashi, Shibuya Keita, Sato Atsushi, Seino Shizuka, Watanabe Eriko, Suzuki Shuhei, Seino Manabu, Kitanaka Chifumi

    Multiple Authorship (Only Japanese)

  • JNK Signaling in the Control of the Tumor-Initiating Capacity Associated with Cancer Stem Cells., Genes Cancer, 4(9-10) 388-396, 2013.09

    Kitanaka Chifumi, Sato Atsushi, Okada Masashi

    Multiple Authorship (Only Japanese)

  • New developments in medical education for the realization of next-generation personalized medicine: concept and design of a medical education and training program through the genomic cohort study., J Hum Genet, 58(9) 639-640, 2013.09

    Narimatsu Hiroto, Kitanaka Chifumi, Kubota Isao, Sato Shinya, Ueno Yoshiyuki, Kato Takeo, Fukao Akira, Yamashita Hidetoshi, Kayama Takamasa, Yamagata University Medical Education and Training Program ...

    Multiple Authorship (Only Japanese)

  • Cytoplasmic localization of DGKzeta exerts a protective effect against p53-mediated cytotoxicity., J Cell Sci, 126(Pt 13) 2785-2797, 2013.07

    Tanaka Toshiaki, Okada Masashi, Hozumi Yasukazu, Tachibana Ken, Kitanaka Chifumi, Hamamoto Yoshioki, Martelli Alberto M, Topham Matthew K, Iino Mitsuyoshi, Goto Kaoru

    Multiple Authorship (Only Japanese)

  • Serum prolactin levels and prolactin mRNA expression in peripheral blood mononuclear cells in hepatitis C virus infection., J Med Virol, 2013.07

    Ishii R, Saito T, Shao L, Okumoto K, Nishise Y, Watanabe H, Makino N, Fukao A, Kitanaka C, Kayama T, Ueno Y, Kawata S.

    Single Author

  • Resveratrol promotes proteasome-dependent degradation of Nanog via p53 activation and induces differentiation of glioma stem cells., Stem Cell Res, 11(1) 601-610, 2013.07

    Sato Atsushi, Okada Masashi, Shibuya Keita, Watanabe Eriko, Seino Shizuka, Suzuki Kaori, Narita Yoshitaka, Shibui Soichiro, Kayama Takamasa, Kitanaka Chifumi

    Multiple Authorship (Only Japanese)

  • Symptomatic recurrence of intracranial arterial dissections: follow-up study of 143 consecutive cases and pathological investigation., Stroke, 44(1) 126-131, 2013.01

    Ono Hideaki, Nakatomi Hirofumi, Tsutsumi Kazuo, Inoue Tomohiro, Teraoka Akira, Yoshimoto Yuhei, Ide Takafumi, Kitanaka Chifumi, Ueki Keisuke, Imai Hideaki, Saito Nobuhito

    Multiple Authorship (Only Japanese)

  • Constructing a contemporary gene-environmental cohort: study design of the Yamagata Molecular Epidemiological Cohort Study., J Hum Genet, 58(1) 54-56, 2013.01

    Narimatsu Hiroto, Yamagata University Genomic Cohort Consortium

    Multiple Authorship (Only Japanese)

  • Glioma-initiating cell elimination by metformin activation of FOXO3 via AMPK., Stem Cells Transl Med, 1(11) 811-824, 2012.11

    Sato Atsushi, Sunayama Jun, Okada Masashi, Watanabe Eriko, Seino Shizuka, Shibuya Keita, Suzuki Kaori, Narita Yoshitaka, Shibui Soichiro, Kayama Takamasa, Kitanaka Chifumi

    Multiple Authorship (Only Japanese)

  • Targeting JNK for therapeutic depletion of stem-like glioblastoma cells., Sci Rep, 2 516, 2012

    Matsuda Ken-ichiro, Sato Atsushi, Okada Masashi, Shibuya Keita, Seino Shizuka, Suzuki Kaori, Watanabe Eriko, Narita Yoshitaka, Shibui Soichiro, Kayama Takamasa, Kitanaka Chifumi

    Multiple Authorship (Only Japanese)

  • MEK-ERK signaling dictates DNA-repair gene MGMT expression and temozolomide resistance of stem-like glioblastoma cells via the MDM2-p53 axis., Stem Cells, 29(12) 1942-1951, 2011.12

    Sato Atsushi, Sunayama Jun, Matsuda Ken-ichiro, Seino Shizuka, Suzuki Kaori, Watanabe Eriko, Tachibana Ken, Tomiyama Arata, Kayama Takamasa, Kitanaka Chifumi

    Multiple Authorship (Only Japanese)

  • FoxO3a functions as a key integrator of cellular signals that control glioblastoma stem-like cell differentiation and tumorigenicity., Stem Cells, 29(9) 1327-1337, 2011.09

    Sunayama Jun, Sato Atsushi, Matsuda Ken-Ichiro, Tachibana Ken, Watanabe Eriko, Seino Shizuka, Suzuki Kaori, Narita Yoshitaka, Shibui Soichiro, Sakurada Kaori, Kayama Takamasa, Tomiyama Arata, Kitanaka...

    Multiple Authorship (Only Japanese)

  • Establishment of a novel monoclonal antibody SMab-1 specific for IDH1-R132S mutation., Biochem Biophys Res Commun, 406(4) 608-613, 2011.03

    Kaneko Mika Kato, Tian Wei, Takano Shingo, Suzuki Hiroyuki, Sawa Yoshihiko, Hozumi Yasukazu, Goto Kaoru, Yamazaki Kentaro, Kitanaka Chifumi, Kato Yukinari

    Multiple Authorship (Only Japanese)

  • Dual blocking of mTor and PI3K elicits a prodifferentiation effect on glioblastoma stem-like cells., Neuro Oncol, 12(12) 1205-1219, 2010.12

    Sunayama Jun, Sato Atsushi, Matsuda Ken-ichiro, Tachibana Ken, Suzuki Kaori, Narita Yoshitaka, Shibui Soichiro, Sakurada Kaori, Kayama Takamasa, Tomiyama Arata, Kitanaka Chifumi

    Multiple Authorship (Only Japanese)

  • Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells., Stem Cells, 28(11) 1930-1939, 2010.11

    Sunayama Jun, Matsuda Ken-Ichiro, Sato Atsushi, Tachibana Ken, Suzuki Kaori, Narita Yoshitaka, Shibui Soichiro, Sakurada Kaori, Kayama Takamasa, Tomiyama Arata, Kitanaka Chifumi

    Multiple Authorship (Only Japanese)

  • MEK-ERK-dependent multiple caspase activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation-induced glioma cell death., Cell Death Dis, 1 e60, 2010.07

    Tomiyama A, Tachibana K, Suzuki K, Seino S, Sunayama J, Matsuda K-i, Sato A, Matsumoto Y, Nomiya T, Nemoto K, Yamashita H, Kayama T, Ando K, Kitanaka C

    Multiple Authorship (Only Japanese)

  • Association of stem cell marker CD133 expression with dissemination of glioblastomas., Neurosurg Rev, 33(2) 175-83; discussion 183, 2010.04

    Sato Atsushi, Sakurada Kaori, Kumabe Toshihiro, Sasajima Toshio, Beppu Takaaki, Asano Kenichiro, Ohkuma Hiroki, Ogawa Akira, Mizoi Kazuo, Tominaga Teiji, Kitanaka Chifumi, Kayama Takamasa, Tohoku Brai...

    Multiple Authorship (Only Japanese)

  • Regulation of neural stem/progenitor cell maintenance by PI3K and mTOR., Neurosci Lett, 470(2) 115-120, 2010.02

    Sato Atsushi, Sunayama Jun, Matsuda Ken-ichiro, Tachibana Ken, Sakurada Kaori, Tomiyama Arata, Kayama Takamasa, Kitanaka Chifumi

    Multiple Authorship (Only Japanese)

  • Activin inhibits cell growth and induces differentiation in human retinoblastoma y79 cells., Curr Eye Res, 34(8) 652-659, 2009.08

    Kanno Chikako, Kashiwagi Yoshiko, Horie Kuniko, Inomata Motoko, Yamamoto Teiko, Kitanaka Chifumi, Yamashita Hidetoshi

    Multiple Authorship (Only Japanese)

  • Downregulation of Ras C-terminal processing by JNK inhibition., Biochem Biophys Res Commun, 371(2) 273-277, 2008.06

    Mouri Wataru, Tachibana Ken, Tomiyama Arata, Sunayama Jun, Sato Atsushi, Sakurada Kaori, Kayama Takamasa, Kitanaka Chifumi

    Multiple Authorship (Only Japanese)

  • Nestin expression in central nervous system germ cell tumors., Neurosurg Rev, 31(2) 173-6; discussion 176, 2008.04

    Sakurada K, Saino M, Mouri W, Sato A, Kitanaka C, Kayama T

    Multiple Authorship (Only Japanese)

  • Ras protein expression and autophagic tumor cell death in neuroblastoma., Am J Surg Pathol, 31(1) 153-5; author reply 155, 2007.01

    Kitanaka Chifumi, Kato Keisuke, Tanaka Yukichi

    Multiple Authorship (Only Japanese)

  • Critical role for mitochondrial oxidative phosphorylation in the activation of tumor suppressors Bax and Bak., J Natl Cancer Inst, 98(20) 1462-1473, 2006.10

    Tomiyama Arata, Serizawa Shinobu, Tachibana Ken, Sakurada Kaori, Samejima Hirotsugu, Kuchino Yoshiyuki, Kitanaka Chifumi

    Multiple Authorship (Only Japanese)

  • The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson's disease., J Neurosci, 26(36) 9227-9238, 2006.09

    Arawaka Shigeki, Wada Manabu, Goto Saori, Karube Hiroki, Sakamoto Masahiro, Ren Chang-Hong, Koyama Shingo, Nagasawa Hikaru, Kimura Hideki, Kawanami Toru, Kurita Keiji, Tajima Katsushi, Daimon Makoto, ...

    Multiple Authorship (Only Japanese)

  • Physical and functional interaction between BH3-only protein Hrk and mitochondrial pore-forming protein p32., Cell Death Differ, 11(7) 771-781, 2004.07

    Sunayama J, Ando Y, Itoh N, Tomiyama A, Sakurada K, Sugiyama A, Kang D, Tashiro F, Gotoh Y, Kuchino Y, Kitanaka C

    Multiple Authorship (Only Japanese)

  • Forced expression of antisense 14-3-3beta RNA suppresses tumor cell growth in vitro and in vivo., Carcinogenesis, 24(9) 1549-1559, 2003.09

    Sugiyama Akinori, Miyagi Yohei, Komiya Yuko, Kurabe Nobuya, Kitanaka Chifumi, Kato Naoko, Nagashima Yoji, Kuchino Yoshiyuki, Tashiro Fumio

    Multiple Authorship (Only Japanese)

  • Guanine nucleotide exchange factor, Tiam1, directly binds to c-Myc and interferes with c-Myc-mediated apoptosis in rat-1 fibroblasts., J Biol Chem, 278(7) 5132-5140, 2003.02

    Otsuki Yoshiro, Tanaka Masamitsu, Kamo Takaharu, Kitanaka Chifumi, Kuchino Yoshiyuki, Sugimura Haruhiko

    Multiple Authorship (Only Japanese)

  • A cellular mechanism that reversibly inactivates pancaspase inhibitor zAsp-CH(2)-DCB: a potential pitfall causing discrepancy between in vitro and in vivo caspase assays., Biochem Biophys Res Commun, 291(4) 1022-1030, 2002.03

    Sakurada Kaori, Kitanaka Chifumi, Kokubu Akiko, Tomiyama Arata, Sunayama Jun, Kayama Takamasa, Kuchino Yoshiyuki

    Multiple Authorship (Only Japanese)

  • Increased Ras expression and caspase-independent neuroblastoma cell death: possible mechanism of spontaneous neuroblastoma regression., J Natl Cancer Inst, 94(5) 358-368, 2002.03

    Kitanaka Chifumi, Kato Keisuke, Ijiri Rieko, Sakurada Kaori, Tomiyama Arata, Noguchi Kohji, Nagashima Yohji, Nakagawara Akira, Momoi Takashi, Toyoda Yasunori, Kigasawa Hisato, Nishi Toshiji, Shirouzu ...

    Multiple Authorship (Only Japanese)

  • Akt protein kinase inhibits non-apoptotic programmed cell death induced by ceramide., J Biol Chem, 277(4) 2790-2797, 2002.01

    Mochizuki Toshihiro, Asai Akio, Saito Nobuhito, Tanaka Sakae, Katagiri Hideki, Asano Tomoichiro, Nakane Makoto, Tamura Akira, Kuchino Yoshiyuki, Kitanaka Chifumi, Kirino Takaaki

    Multiple Authorship (Only Japanese)

  • Rat neuronal leucine-rich repeat protein-3: cloning and regulation of the gene expression., Biochem Biophys Res Commun, 287(1) 257-263, 2001.09

    Fukamachi K, Matsuoka Y, Kitanaka C, Kuchino Y, Tsuda H

    Multiple Authorship (Only Japanese)

  • ASK1-signaling promotes c-Myc protein stability during apoptosis., Biochem Biophys Res Commun, 281(5) 1313-1320, 2001.03

    Noguchi K, Kokubu A, Kitanaka C, Ichijo H, Kuchino Y

    Multiple Authorship (Only Japanese)

  • Molecular mechanism of stop codon recognition by eRF1: a wobble hypothesis for peptide anticodons., FEBS Lett, 488(3) 105-109, 2001.01

    Muramatsu T, Heckmann K, Kitanaka C, Kuchino Y

    Multiple Authorship (Only Japanese)

  • Differential role of the JNK and p38 MAPK pathway in c-Myc- and s-Myc-mediated apoptosis., Biochem Biophys Res Commun, 267(1) 221-227, 2000.01

    Noguchi K, Yamana H, Kitanaka C, Mochizuki T, Kokubu A, Kuchino Y

    Multiple Authorship (Only Japanese)

  • Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase., J Biol Chem, 274(46) 32580-32587, 1999.11

    Noguchi K, Kitanaka C, Yamana H, Kokubu A, Mochizuki T, Kuchino Y

    Multiple Authorship (Only Japanese)

  • Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway., J Biol Chem, 274(26) 18659-18666, 1999.06

    Mochizuki T, Kitanaka C, Noguchi K, Muramatsu T, Asai A, Kuchino Y

    Multiple Authorship (Only Japanese)

  • Caspase-independent programmed cell death with necrotic morphology., Cell Death Differ, 6(6) 508-515, 1999.06

    Kitanaka C, Kuchino Y

    Multiple Authorship (Only Japanese)

  • Oncogenic Ras triggers cell suicide through the activation of a caspase-independent cell death program in human cancer cells., Oncogene, 18(13) 2281-2290, 1999.04

    Chi S, Kitanaka C, Noguchi K, Mochizuki T, Nagashima Y, Shirouzu M, Fujita H, Yoshida M, Chen W, Asai A, Himeno M, Yokoyama S, Kuchino Y

    Multiple Authorship (Only Japanese)

  • Molecular cloning and chromosomal mapping of mouse intronless myc gene acting as a potent apoptosis inducer., Gene, 226(2) 273-283, 1999.01

    Sugiyama A, Noguchi K, Kitanaka C, Katou N, Tashiro F, Ono T, Yoshida M C, Kuchino Y

    Multiple Authorship (Only Japanese)

  • Heparin-binding epidermal growth factor-like growth factor stimulates mitogenic signaling and is highly expressed in human malignant gliomas., Acta Neuropathol, 96(4) 322-328, 1998.10

    Mishima K, Higashiyama S, Asai A, Yamaoka K, Nagashima Y, Taniguchi N, Kitanaka C, Kirino T, Kuchino Y

    Multiple Authorship (Only Japanese)

  • A functional role for death proteases in s-Myc- and c-Myc-mediated apoptosis., Mol Cell Biol, 17(11) 6736-6745, 1997.11

    Kagaya S, Kitanaka C, Noguchi K, Mochizuki T, Sugiyama A, Asai A, Yasuhara N, Eguchi Y, Tsujimoto Y, Kuchino Y

    Multiple Authorship (Only Japanese)

  • Caspase-dependent apoptosis of COS-7 cells induced by Bax overexpression: differential effects of Bcl-2 and Bcl-xL on Bax-induced caspase activation and apoptosis., Oncogene, 15(15) 1763-1772, 1997.10

    Kitanaka C, Namiki T, Noguchi K, Mochizuki T, Kagaya S, Chi S, Hayashi A, Asai A, Tsujimoto Y, Kuchino Y

    Multiple Authorship (Only Japanese)

  • Pim-1 kinase stimulates c-Myc-mediated death signaling upstream of caspase-3 (CPP32)-like protease activation., Oncogene, 15(12) 1471-1480, 1997.09

    Mochizuki T, Kitanaka C, Noguchi K, Sugiyama A, Kagaya S, Chi S, Asai A, Kuchino Y

    Multiple Authorship (Only Japanese)

  • Proliferative activity of central neurocytoma: measurement of tumor volume doubling time, MIB-1 staining index and bromodeoxyuridine labeling index., J Neurooncol, 32(2) 103-109, 1997.04

    Fujimaki T, Matsuno A, Sasaki T, Toyoda T, Matsuura R, Ogai M, Kitanaka C, Asai A, Matsutani M, Kirino T

    Multiple Authorship (Only Japanese)

  • Apoptosis in cancer., Hum Cell, 9(3) 223-228, 1996.09

    Kuchino Y, Kitanaka C

    Multiple Authorship (Only Japanese)

  • Increased expression of schwannoma-derived growth factor (SDGF) mRNA in rat tumor cells: involvement of SDGF in the growth promotion of rat gliomas., Int J Cancer, 66(3) 352-357, 1996.05

    Mishima K, Asai A, Sugiyama A, Miyagi Y, Kitanaka C, Kagaya S, Kirino T, Kuchino Y

    Multiple Authorship (Only Japanese)

  • Chronic encapsulated expanding hematoma in association with gamma knife stereotactic radiosurgery for a cerebral arteriovenous malformation. Case report., J Neurosurg, 84(5) 874-878, 1996.05

    Kurita H, Sasaki T, Kawamoto S, Taniguchi M, Kitanaka C, Nakaguchi H, Kirino T

    Multiple Authorship (Only Japanese)

  • Myc-mediated apoptosis., Prog Mol Subcell Biol, 16 104-129, 1996

    Kuchino Y, Asai A, Kitanaka C

    Multiple Authorship (Only Japanese)

  • Clinical features of progressive lacunar infarction--retrospective analysis of patients with motor syndromes., Neurol Med Chir (Tokyo), 35(9) 663-666, 1995.09

    Kitanaka C, Teraoka A

    Multiple Authorship (Only Japanese)

  • Functional prognosis after treatment of spinal radiculomeningeal arteriovenous malformations., Surg Neurol, 43(5) 453-7; discussion 458, 1995.05

    Kohno M, Takahashi H, Kitanaka C, Sasaki T, Ishijima B

    Multiple Authorship (Only Japanese)

  • s-Myc acts as a transcriptional activator and its sequence-specific DNA binding is required for induction of programmed cell death in glioma cells., Cell Death Differ, 2(2) 123-131, 1995.04

    Kitanaka C, Sugiyama A, Kanazu S, Miyagi Y, Mishima K, Asai A, Kuchino Y

    Multiple Authorship (Only Japanese)

  • Precocious puberty in a girl with an hCG-secreting suprasellar immature teratoma. Case report., J Neurosurg, 81(4) 601-604, 1994.10

    Kitanaka C, Matsutani M, Sora S, Kitanaka S, Tanae A, Hibi I

    Multiple Authorship (Only Japanese)

  • Nonsurgical treatment of unruptured intracranial vertebral artery dissection with serial follow-up angiography., J Neurosurg, 80(4) 667-674, 1994.04

    Kitanaka C, Tanaka J, Kuwahara M, Teraoka A, Sasaki T, Takakura K, Tanaki J [corrected to Tanaka J ]

    Multiple Authorship (Only Japanese)

  • Intracranial vertebral artery dissections: clinical, radiological features, and surgical considerations., Neurosurgery, 34(4) 620-6; discussion 626, 1994.04

    Kitanaka C, Sasaki T, Eguchi T, Teraoka A, Nakane M, Hoya K

    Multiple Authorship (Only Japanese)

  • Magnetic resonance imaging study of intracranial vertebrobasilar artery dissections., Stroke, 25(3) 571-575, 1994.03

    Kitanaka C, Tanaka J, Kuwahara M, Teraoka A

    Multiple Authorship (Only Japanese)

  • Malignant brain stem hyperthermia caused by brain stem hemorrhage., Stroke, 25(2) 518-520, 1994.02

    Kitanaka C, Inoh Y, Toyoda T, Sasaki T, Eguchi T

    Multiple Authorship (Only Japanese)

  • Spontaneous cervical internal carotid dissection presenting with intracerebral hematoma., Stroke, 24(9) 1420-1421, 1993.09

    Kitanaka C, Teraoka A

    Multiple Authorship (Only Japanese)

  • Intradural, purely extramedullary hemangioblastoma of the spinal cord--case report., Neurol Med Chir (Tokyo), 33(6) 377-380, 1993.06

    Kitanaka C, Kuwahara M, Teraoka A

    Multiple Authorship (Only Japanese)

  • Rebleeding from vertebral artery dissection after proximal clipping. Case report., J Neurosurg, 77(3) 466-468, 1992.09

    Kitanaka C, Morimoto T, Sasaki T, Takakura K

    Multiple Authorship (Only Japanese)

  • Retroflexion of holoprosencephaly: report of two cases., Childs Nerv Syst, 8(6) 317-321, 1992.09

    Kitanaka C, Iwasaki Y, Yamada H

    Multiple Authorship (Only Japanese)

  • Secondary malignant lymphoma of the central nervous system with delayed high uptake on 123I-IMP single-photon emission computerized tomography. Case report., J Neurosurg, 76(5) 871-873, 1992.05

    Kitanaka C, Eguchi T, Kokubo T

    Multiple Authorship (Only Japanese)

  • Avellis syndrome after minor head trauma: report of two cases., Surg Neurol, 37(3) 236-239, 1992.03

    Kitanaka C, Sugaya M, Yamada H

    Multiple Authorship (Only Japanese)

  • Postradiation astrocytoma. Report of two cases., J Neurosurg, 70(3) 469-474, 1989.03

    Kitanaka C, Shitara N, Nakagomi T, Nakamura H, Genka S, Nakagawa K, Akanuma A, Aoyama H, Takakura K

    Multiple Authorship (Only Japanese)

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Grant-in-Aid for Scientific Research

  • Grant-in-Aid for Scientific Research(B),2021.04 - 2024.03

  • Grant-in-Aid for Scientific Research(B),2018.04 - 2021.03

  • Grant-in-Aid for Scientific Research(B),2015.04 - 2018.03