Updated on 2023/11/30

写真a

 
OSAKI Tsukasa
 
Title
Assistant Professor

Research Areas

  • Life Science / Functional biochemistry

  • Life Science / Medical biochemistry

  • Laboratory medicine

External Career

  • Faculty of Medicine, Yamagata University, Assistant Professor, 2017.10 - 2021.04

  • Faculty of Medicine, Yamagata University, Assistant Professor, 2021.05 -

Academic Society Affiliations

  • THE JAPANESE SOCIETY ON THROMBOSIS AND HEMOSTASIS

  • THE JAPANESE BIOCHEMICAL SOCIETY

  • THE JAPANESE SOCIETY OF HEMATOLOGY

  • Japanese Society of Hematology

 

Research Career

  • Mechanism of innate immunity in invertebrates, 1996.04 - 2005.03

  • Peptidome mining for novel bioactive peptides, 2005.04 - 2012.03

  • Biochemical analysis of blood coagulation and fibrinolytic factors, 2012.04 -

Papers

  • Consequences of a peroxiredoxin 4 (Prdx4) deficiency on learning and memory in mice., Biochemical and biophysical research communications, 621 32-38, 2022.09

    Homma T, Fujiwara H, Osaki T, Fujii S, Fujii J

    Single Author

  • Acquired von Willebrand Syndrome in a Patient with Multiple Comorbidities, Including MALT Lymphoma with IgA Monoclonal Gammopathy and Hyperviscosity Syndrome., Internal medicine (Tokyo, Japan), advpub(0) , 2022.07

    Owari M, Harada-Shirado K, Togawa R, Fukatsu M, Sato Y, Fukuchi K, Endo M, Takahashi H, Kimura S, Osaki T, Souri M, Ichinose A, Shibata Y, Hashimoto Y, Ikezoe T

    Single Author

  • Endothelial Natriuretic Peptide Receptor 1 Play Crucial Role for Acute and Chronic Blood Pressure Regulation by Atrial Natriuretic Peptide., Hypertension (Dallas, Tex. : 1979), 79(7) 1409-1422, 2022.07

    Takeshi Tokudome, Kentaro Otani, Yuanjie Mao, Lars Jørn Jensen, Yuji Arai, Takahiro Miyazaki, Takashi Sonobe, James T Pearson, Tsukasa Osaki, Naoto Minamino, Junji Ishida, Akiyoshi Fukamizu, Hayato Ka...

    Single Author

  • D-Cysteine supplementation partially protects against ferroptosis induced by xCT dysfunction via increasing the availability of glutathione(和訳中), Journal of Clinical Biochemistry and Nutrition, 71(1) 48-54, 2022.07

    Homma Takujiro, Osaki Tsukasa, Kobayashi Sho, Sato Hideyo, Fujii Junichi

    Single Author

  • D-Cysteine supplementation partially protects against ferroptosis induced by xCT dysfunction via increasing the availability of glutathione, Journal of Clinical Biochemistry and Nutrition, 71(1) 48-54, 2022.07

    Homma Takujiro, Osaki Tsukasa, Kobayashi Sho, Sato Hideyo, Fujii Junichi

    Single Author

  • Plasma proteomics associated with autoimmune coagulation factor deficiencies reveals the link between inflammation and autoantibody development(和訳中), International Journal of Hematology, 115(5) 672-685, 2022.05

    Osaki Tsukasa, Souri Masayoshi, Ichinose Akitada

    Single Author

  • Urinary and plasma proteomics to discover biomarkers for diagnosing between diabetic nephropathy and minimal change nephrotic syndrome or membranous nephropathy., Biochemistry and biophysics reports, 27 101102, 2021.09

    Akira Araumi, Tsukasa Osaki, Kazunobu Ichikawa, Kosuke Kudo, Natsuko Suzuki, Sayumi Watanabe, Masafumi Watanabe, Tsuneo Konta

    Single Author

  • Association between milk and yogurt intake and mortality: a community-based cohort study (Yamagata study)., BMC nutrition, 7(1) 33, 2021.07

    Akiko Nakanishi, Erika Homma, Tsukasa Osaki, Ri Sho, Masayoshi Souri, Hidenori Sato, Masafumi Watanabe, Kenichi Ishizawa, Yoshiyuki Ueno, Takamasa Kayama, Tsuneo Konta

    Single Author

  • Autoimmune Coagulation Factor X Deficiency as a Rare Acquired Hemorrhagic Disorder: A Literature Review., Thrombosis and haemostasis, 122(03) 320-328, 2021.04

    Akitada Ichinose, Tsukasa Osaki, Masayoshi Souri

    Single Author

  • Pathological coagulation parameters in as many as 54 patients with autoimmune acquired factor XIII deficiency due to anti-factor XIII autoantibodies., Haemophilia : the official journal of the World Federation of Hemophilia, 27(3) 454-462, 2021.04

    Akitada Ichinose, Tsukasa Osaki, Masayoshi Souri

    Single Author

  • Relationship between social support status and mortality in a community-based population: a prospective observational study (Yamagata study)., BMC public health, 20(1) 1630, 2020.10

    Tsutomu Uzuki, Tsuneo Konta, Ritsuko Saito, Ri Sho, Tsukasa Osaki, Masayoshi Souri, Masafumi Watanabe, Kenichi Ishizawa, Hidetoshi Yamashita, Yoshiyuki Ueno, Takamasa Kayama

    Single Author

  • Deficiency of Cardiac Natriuretic Peptide Signaling Promotes Peripartum Cardiomyopathy-Like Remodeling in the Mouse Heart., Circulation, 141(7) 571-588, 2020.02

    Otani K,Tokudome T,Kamiya CA,Mao Y,Nishimura H,Hasegawa T,Arai Y,Kaneko M,Shioi G,Ishida J,Fukamizu A,Osaki T,Nagai-Okatani C,Minamino N,Ensho T,Hino J,Murata S,Takegami M,Nishimura K,Kishimoto I,Miya...

    Multiple Authorship (Only Japanese)

  • Successful management of acquired factor V deficiency developing shortly after induction of hemodialysis, Rinsho Ketsueki, 61(5) 445-450, 2020

    MATSUMOTO Akira, SHIMIZU Hiroaki, INOUE Madoka, HAYAKAWA Masaki, MURAKAMI Masami, ICHINOSE Akitada, HANDA Hiroshi, OGAWA Yoshiyuki, OSAKI Tsukasa, SOURI Masayoshi, YANAGISAWA Kunio, ISHIZAKI Takuma, N...

    Single Author

  • Lipidomic signatures of aortic media from patients with atherosclerotic and nonatherosclerotic aneurysms., Scientific reports, 9(1) 15472, 2019.10

    Saito K,Yagi H,Maekawa K,Nishigori M,Ishikawa M,Muto S,Osaki T,Iba Y,Minatoya K,Ikeda Y,Ishibashi-Ueda H,Ogino H,Sasaki H,Matsuda H,Saito Y,Minamino N

    Multiple Authorship (Only Japanese)

  • Generation and Application of Rat Monoclonal Antibodies Specific for a Human Blood Coagulation Protein: von Willebrand Factor., Monoclonal antibodies in immunodiagnosis and immunotherapy, 38(3) 133-136, 2019.06

    Yokoyama C,Ikeda S,Osaki T,Souri M,Ichinose A

    Multiple Authorship (Only Japanese)

  • A high titer of acquired factor V inhibitor in a hemodialysis patient who developed arterial thrombosis, INTERNATIONAL JOURNAL OF HEMATOLOGY, 109(2) 214-220, 2019.02

    Ogawa Hina, Souri Masayoshi, Kanouchi Kazunori, Osaki Tsukasa, Ohkubo Rie, Kawanishi Tomoko, Wakai Sachiko, Morikane Keita, Ichinose Akitada

    Multiple Authorship (Only Japanese)

  • Isolation of Endogenous Peptides from Cultured Cell Conditioned Media for Mass Spectrometry., Methods in molecular biology (Clifton, N.J.), 1719 51-58, 2018

    Sasaki K, Tsuchiya T, Osaki T

    Multiple Authorship (Only Japanese)

  • 常位胎盤早期剥離を繰り返した妊娠性第XIII因子欠乏および家族性プロテインS欠乏症の1例(原著論文/症例報告), 日本周産期・新生児医学会雑誌, 54 178-183, 2018

    尾崎 司, 惣宇利 正善, 一瀬 白帝

    Single Author

  • Successful Management of a Patient with Autoimmune Hemorrhaphilia due to Anti-Factor XIII/13 Antibodies Complicated by Pulmonary Thromboembolism., Acta Haematol, 137(3) 141-147, 2017.04

    Ogawa Y, Yanagisawa K, Souri M, Mihara M, Naito C, Takizawa M, Ishizaki T, Mitsui T, Handa H, Osaki T, Nojima Y, Ichinose A.

    Multiple Authorship (Only Japanese)

  • Molecular pathogenesis of plasminogen Hakodate: the second Japanese family case of severe type I plasminogen deficiency manifested late-onset multi-organic chronic pseudomembranous mucositis., J Thromb Thrombolysis, 42(2) 218-224, 2016.08

    Osaki T, Souri M, Song YS, Izumi N, Law R, Ichinose A

    Multiple Authorship (Including Foreigners)

  • Spontaneous splenic rupture accompanied by hepatic arterial dissection in a patient with autoimmune haemorrhaphilia due to anti-factor XIII antibodies., Haemophilia, 22(4) e314-e317, 2016.07

    Tsuda M, Kiyasu J, Sugio K, Hidaka D, Ikeda M, Fujioka E, Souri M, Osaki T, Yufu Y, Ichinose A.

    Multiple Authorship (Only Japanese)

  • Non-autoimmune combined factor XIII A and B subunit deficiencies in rheumatoid arthritis patients treated with anti-interleukin-6 receptor monoclonal antibody (tocilizumab)., Thromb Res, 140 100-105, 2016.04

    Souri M, Mokuda S, Inanami H, Osaki T, Takasugi K, Ichinose A.

    Multiple Authorship (Only Japanese)

  • Successful bypass surgery for esophageal carcinoma under adequate factor XIII/13 replacement therapy in a case of intractable autoimmune hemorrhaphilia due to anti-Factor XIII/13 antibodies., Int J Hematol., 103(3) 341-347, 2016.03

    Kojima M, Ichinose A, Souri M, Osaki T, Kawai H, Amaki J, Numata H, Miyamoto M, Ogiya D, Tsuboi K, Ogawa Y, Ozawa S, Ando K

    Multiple Authorship (Only Japanese)

  • Peptidomics for Studying Limited Proteolysis., J Proteome Res, 14(11) 4921-4931, 2015.11

    Tsuchiya T, Osaki T, Minamino N, Sasaki K

    Multiple Authorship (Only Japanese)

  • The plasma levels of protein Z-dependent protease inhibitor increase after gynecological surgery independently of estrogen., Thromb Res., 136(5) 980-986, 2015.11

    Yoshida T, Souri M, Osaki T, Saito S, Meijers JC, Kurachi H, Ichinose A.

    Multiple Authorship (Only Japanese)

  • Autoimmune Hemorrhaphilia Resulting from Autoantibody against the A Subunit of Factor XIII., Intern Med., 54(18) 2383-2387, 2015.09

    Uchida E, Watanabe K, Arai R, Yamamoto M, Souri M, Osaki T, Ichinose A, Miura O, Koyama T

    Multiple Authorship (Only Japanese)

  • Clinical features of 32 new Japanese cases with autoimmune haemorrha-philia due to anti-factor XIII antibodies., Haemophilia, 21(5) 653-658, 2015.09

    Ichinose A, Osaki T, Souri M

    Multiple Authorship (Only Japanese)

  • The Non-catalytic B Subunit of Coagulation Factor XIII Accelerates Fibrin Cross-linking., J Biol Chem, 290(19) 12027-12039, 2015.03

    Souri M, Osaki T, Ichinose A

    Multiple Authorship (Only Japanese)

  • Rapid immunochromatographic test for detection of anti-factor XIII A subunit antibodies can diagnose 90 % of cases with autoimmune haemorrhaphilia XIII/13, Thromb Haemost, 113(6) 1347-1356, 2015.03

    Osaki T, Sugiyama D, Magari Y, Souri M, Ichinose A

    Multiple Authorship (Including Foreigners)

  • Anti-factor XIII A subunit (FXIII-A) autoantibodies block FXIII-A2 B2 assembly and steal FXIII-A from native FXIII-A2 B2., J Thromb Haemost, 113(6) 1347-1356, 2015.03

    Souri M, Osaki T, Ichinose A.

    Multiple Authorship (Including Foreigners)

  • Complete remission achieved by steroid pulse therapy following rituximab treatment in a case with autoimmune haemorrhaphilia due to anti-factor XIII antibodies., Thrombosis and Haemostasis, 112(4) 831-833, 2014.07

    Ogawa Y, Mihara M, Souri M, Yanagisawa K, Hayashi T, Kobayashi N, Shimizu H, Iriuchishima H, Ishizaki T, Handa H, Osaki T, Nojima Y, Ichinose A.

    Multiple Authorship (Including Foreigners)

  • C/EBPβ (CCAAT/enhancer-binding protein β) mediates progesterone production through transcriptional regulation in co-operation with SF-1 (steroidogenic factor-1)., Biochem J, 460(3) 459-471, 2014.06

    Mizutani T, Ju Y, Imamichi Y, Osaki T, Yazawa T, Kawabe S, Ishikane S, Matsumura T, Kanno M, Kamiki Y, Kimura K, Minamino N, Miyamoto K.

    Multiple Authorship (Only Japanese)

  • Proteomic analysis of proteins eliminated by low-density lipoprotein apheresis., Ther Apher Dial, 18(1) 93-102, 2014.02

    Yuasa Y, Osaki T, Makino H, Iwamoto N, Kishimoto I, Usami M, Minamino N, Harada-Shiba M.

    Multiple Authorship (Only Japanese)

  • Expression of apolipoprotein (a) gene is regulated by 5’-haplotype rather than TTTTA repeat., Yamagata Med J., 32 17-28, 2014

    Okumura T, Osaki T, Ichinose A

    Multiple Authorship (Only Japanese)

  • Identification and characterization of Porphyromonas gingivalis client proteins that bind to Streptococcus oralis glyceraldehyde-3-phosphate dehydrogenase., Infect Immun., 81(3) 753-763, 2013.03

    Maeda K, Nagata H, Kuboniwa M, Ojima M, Osaki T, Minamino N, Amano A

    Multiple Authorship (Only Japanese)

  • Large-scale identification of endogenous secretory peptides using electron transfer dissociation mass spectrometry., Mol Cell Proteomics., 12(3) 700-709, 2013.03

    Sasaki K, Osaki T, Minamino N.

    Multiple Authorship (Only Japanese)

  • Peptidomics-based discovery of an antimicrobial peptide derived from insulin-like growth factor-binding protein 5, Journal of Proteome Research, 2011.04

    T. Osaki, K. Sasaki, N. Minamino.

    Multiple Authorship (Including Foreigners)

  • Impaired recovery of blood flow after hind-limb ischemia in mice lacking guanylyl cyclase-A, a receptor for atrial and brain natriuretic peptides., Arteriosclerosis Thrombosis and Vascular Biology, 2009.10

    T. Tokudome, I. Kishimoto, K. Yamahara, T. Osaki, N. Minamino, T. Horio, K. Sawai, Y. Kawano, M. Miyazato, M. Sata, M. Kohno, K. Nakao, K. Kangawa.

    Multiple Authorship (Including Foreigners)

  • A novel beta-defensin structure: a potential strategy of big defensin for overcoming resistance by Gram-positive bacteria., Biochemistry, 2008.10

    T. Kouno, N. Fujitani, T. Osaki, S. Nishimura, S. Kawabata, T. Aizawa, M. Demura, K. Nitta, K. Kawano.

    Multiple Authorship (Including Foreigners)

  • Genomic and expression analysis of canine calcitonin receptor-stimulating peptides and calcitonin/calcitonin gene-related peptide., Journal of Biochemistry, 2008.10

    T. Osaki, T. Katafuchi, N. Minamino.

    Multiple Authorship (Including Foreigners)

  • Central and peripheral cardiovascular actions of adrenomedullin 5, a novel member of the calcitonin gene-related peptide family, in mammals., Journal of Endocrinology, 2008.05

    Y. Takei, H. Hashimoto, K. Inoue, T. Osaki, K. Yoshizawa-Kumagaye, M. Tsunemi, T. X. Watanabe, M. Ogoshi, N. Minamino, Y. Ueta.

    Multiple Authorship (Including Foreigners)

  • An arthropod cuticular chitin-binding protein endows injured sites with transglutaminase-dependent mesh., Journal of Biological Chemistry, 2007.12

    Y. Matsuda, T. Koshiba, T. Osaki, H. Suyama, F. Arisaka, Y. Toh, S. Kawabata.

    Multiple Authorship (Including Foreigners)

  • A cysteine-rich protein from an arthropod stabilizes clotting mesh and immobilizes bacteria at injury sites., Journal of Biological Chemistry, 2007.11

    Y. Matsuda#, T. Osaki#, T. Hashii#, T. Koshiba, S. Kawabata.

    Multiple Authorship (Including Foreigners)

  • The solution structure of horseshoe crab antimicrobial peptide tachystatin B with an inhibitory cystine-knot motif., Journal of Peptide Science, 2007.04

    N. Fujitani, T. Kouno, T. Nakahara, K. Takaya, T. Osaki, S. Kawabata, M. Mizuguchi, T. Aizawa, M. Demura, S. Nishimura, K. Kawano.

    Multiple Authorship (Including Foreigners)

  • Comprehensive sequence analysis of horseshoe crab cuticlar proteins and their involvement in transglutaminase-dependent cross-linking., FEBS Journal, 2005.09

    M. Iijima, T. Hashimoto, Y. Matsuda, T. Nagai, Y. Yamano, T. Ichi, T. Osaki, S. Kawabata.

    Multiple Authorship (Including Foreigners)

  • A novel 43-kDa protein as a negative regulatory component of phenoloxidase-induced melanin synthesis., Journal of Biological Chemistry, 2005.04

    M. Zhao, I. Söderhäll, J. -W. Park, Y. -G. Ma, T. Osaki, N.-C. Ha, C. F. Wu, K. Söderhäll, B.–L. Lee.

    Multiple Authorship (Including Foreigners)

  • Peptidoglycan recognition proteins involved in 1,3-b-D-glucan-dependent prophenoloxidase activation system of insect., Journal of Biological Chemistry, 2004.01

    M.-H. Lee#, T. Osaki#, J.-Y. Lee, M.-J. Baek, R. Zhang, J.-W. Park, S. Kawabata, K. Söderhäll, B.-L. Lee.

    Multiple Authorship (Including Foreigners)

  • A serine protease zymogen functions as a pattern-recognition receptor for lipopolysaccharides., Proceedings of the National Academy of Sciences of the United States of America, 2004.01

    S. Ariki, K. Koori, T. Osaki, K. Motoyama, K. Inamori, S. Kawabata.

    Multiple Authorship (Including Foreigners)

  • Characterization and properties of a 1,3-b-D-glucan pattern recognition protein of Tenebrio molitor larvae that is specifically degraded by serine protease during prophenoloxidase activation., Journal of Biological Chemistry, 2003.10

    R. Zhang, H.-Y. Cho, H.-S. Kim, Y.-G. Ma, T. Osaki, S. Kawabata, K. Söderhäll, B.-L. Lee.

    Multiple Authorship (Including Foreigners)

  • Proline-rich cell surface antigens of horseshoe crab hemocytes are substrates for protein cross-linking with a clotting protein coagulin., Journal of Biological Chemistry, 2002.10

    T. Osaki, N. Okino, F. Tokunaga, S. Iwanaga, S. Kawabata.

    Multiple Authorship (Including Foreigners)

  • An immune responsive serpin regulates the melanization cascade in Drosophila., Developmental Cell, 2002.10

    E. D. Gregorio, S.-J. Han, W.-J. Lee, M.-J. Baek, T. Osaki, S. Kawabata, B.-L. Lee, S. Iwanaga, B. Lemaitre, P. T. Brey

    Multiple Authorship (Including Foreigners)

  • Production and characterization of recombinant tachycitin, the chitin-binding protein., Protein Engineering, 2002.09

    T. Suetake, T. Aizawa, N. Koganesawa, T. Osaki, Y. Kobashigawa, T. Demura, S. Kawabata, K. Kawano, S. Tsuda, K. Nitta.

    Multiple Authorship (Including Foreigners)

  • Structure of the antimicrobial peptide tachystatin A., Journal of Biological Chemistry, 2002.06

    N. Fujitani, S. Kawabata, T. Osaki, Y. Kumaki, M. Demura, K. Nitta, K. Kawano.

    Multiple Authorship (Including Foreigners)

  • Nitric oxide-reductase homologue that contains a copper atom and has cytochrome c-oxidase activity from an aerobic phototrophic bacterium Roseobacter denitrificans., Journal of Biochemistry, 2002.06

    Y. Matsuda, K. Inamori, T. Osaki, A. Eguchi, A. Watanabe, S. Kawabata, K. Iba, H. Arata.

    Multiple Authorship (Including Foreigners)

  • Functional conversion of hemocyanin to phenoloxidase by horseshoe crab antimicrobial peptides., Journal of Biological Chemistry, 2001.07

    T. Nagai#, T. Osaki#, S. Kawabata

    Multiple Authorship (Including Foreigners)

  • Horseshoe crab hemocyte-derived antimicrobial polypeptides, tachystatins, with sequence similarity to spider neurotoxins., Journal of Biological Chemistry, 1999.09

    T. Osaki, M. Omotezako, R. Nagayama, M. Hirata, S. Iwanaga, J. Kasahara, J. Hattori, I. Ito, H. Sugiyama, S. Kawabata.

    Multiple Authorship (Including Foreigners)

  • Functional and structural diversities of C-reactive proteins present in horseshoe crab hemolymph plasma., European Journal of Biochemistry, 1999.09

    D. Iwaki, T. Osaki, Y. Mizunoe, S. N. Wai, S. Iwanaga, S. Kawabata.

    Multiple Authorship (Including Foreigners)

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Review Papers

  • ALA生合成不全マウスでの糖代謝異常の分子機構解析, 日本分子生物学会年会プログラム・要旨集(Web), 37(2) 76-77, 2019.08

    斉藤真一, 斉藤真一, 尾崎司, 木村朋寛, 岡野聡, 山本雅之, 浅尾裕信, 高橋究, 田中徹, 中島元夫, 中島修

  • 13因子欠乏によると思われる出血症状をきたした慢性好中球性白血病, (一社)日本血液学会-東京事務局, 臨床血液, 60(5) 521, 2019.05

    青木志門, 田中智之, 佐藤直子, 矢野敏雄, 黒羽高志, 森山雅人, 惣宇利正善, 尾崎司, 桐戸敬太, 一瀬白帝, 古川達雄

  • 13因子欠乏によると思われる出血症状をきたした慢性好中球性白血病, (一社)日本血液学会-東京事務局, 臨床血液, 60(5) 521, 2019.05

    青木 志門, 田中 智之, 佐藤 直子, 矢野 敏雄, 黒羽 高志, 森山 雅人, 惣宇利 正善, 尾崎 司, 桐戸 敬太, 一瀬 白帝, 古川 達雄

  • 難治性自己免疫性第XIII/13因子欠乏症の一例, 日本血栓止血学会誌, 30(2) 434, 2019.05

    野崎華加, 北原茉莉, 植木俊充, 中澤英之, 惣宇利正善, 尾崎司, 一瀬白帝, 小林光

  • 治療抵抗性の自己免疫性第13因子欠乏症の1症例, 日本血栓止血学会誌, 30(2) 435, 2019.05

    島崎裕正, 三宅隆明, 伊藤俊輔, 井上政弥, 井上政弥, 高橋勉, 鈴木律朗, 尾崎司, 惣宇利正善, 一瀬白帝, 鈴宮淳司

  • 凝固第XIII因子の非酵素サブユニット認識抗体によるフィブリン架橋阻害, 日本血栓止血学会誌, 30(2) 434, 2019.05

    惣宇利正善, 横山智哉子, 尾崎司, 和田秀穂, 一瀬白帝

  • 生体内のヘム欠乏は,ATP代謝障害によるグリコーゲン合成異常のため,耐糖能異常・インスリン抵抗性を発症させる, (一社)日本糖尿病学会, 糖尿病, 62(Suppl.1) S-316, 2019.04

    中島 修, 斉藤 真一, 尾崎 司, van Wijk Koen, 木村 朋寛, 浅尾 裕信, 山本 雅之, 高橋 究, 田中 徹, 中島 元夫

  • 生体内でのヘム欠乏は,グリコーゲン合成異常を伴うインスリン抵抗性を惹起する, (一社)日本糖尿病学会, 糖尿病, 62(3) 203, 2019.03

    中島 修, 斉藤 真一, 尾崎 司, 木村 朋寛, 岡野 聡, 山本 雅之, 高橋 究, 田中 徹, 中島 元夫

  • 橋渡し研究のシーズとなった止血血栓学領域の基礎研究 自己免疫性第XIII因子欠乏症例で生じた抗第XIII因子自己抗体のモノクローン化による機能解析, (公社)日本生化学会, 日本生化学会大会プログラム・講演要旨集, 91回 [3S07m-04], 2018.09

    惣宇利 正善, 尾崎 司, 小澤 龍彦, 村口 篤, 一瀬 白帝

  • 自己免疫性第XIII因子欠乏症例で生じた抗第XIII因子自己抗体のモノクローン化による機能解析, 日本生化学会大会(Web), 91回 [3S07m-04], 2018.09

    惣宇利正善, 惣宇利正善, 尾崎司, 尾崎司, 小澤龍彦, 村口篤, 一瀬白帝, 一瀬白帝

  • ヒト血液凝固関連von Willebrand因子特異的ラットモノクローナル抗体の樹立と性状解析, (公社)日本生化学会, 日本生化学会大会(Web), 91回 [3P-380], 2018.09

    横山智哉子, 尾崎司, 惣宇利正善, 一瀬白帝

  • ALA欠乏マウスにおける糖代謝異常の発症メカニズムの解析, (公社)日本生化学会, 日本生化学会大会(Web), 91回 [3T14a-295)], 2018.09

    斉藤真一, 岡野聡, 木村朋寛, 尾崎司, 山本雅之, ケリー ビンセントP, 高橋究, 田中徹, 中島元夫, 中島修

  • 地域住民の生命予後における慢性腎臓病の影響:山形県コホート研究, 東北公衆衛生学会, 東北公衆衛生学会講演集, 67th(67) 24, 2018.07

    今田恒夫, 邵力, 尾崎司, 惣宇利正善

  • 自己免疫性凝固第XIII/13因子欠乏症(AH13)と後天性血友病A(AHA)の自己抗体検出およびAHAのFVIII抗原量,活性,抗FVIII自己抗体量の経時変化の測定, 自己免疫性出血症治療の[均てん化]のための実態調査と[総合的]診療指針の作成 平成29年度 総括・分担研究報告書(Web), 20‐22 (WEB ONLY), 2018

    尾崎司

  • Calcitonin receptor-stimulating peptide: Its evolutionary and functional relationship with calcitonin/calcitonin gene-related peptide based on gene structure., Elsevier, Peptides, 2009.09

    T. Katafuchi, H. Yasue, T. Osaki, N. Minamino.

  • Structure and function of coagulogen, a clottable protein in horseshoe crabs., Birkhäuser Verlag, Switzerland, Cellular and Molecular Life Sciences, 2004.06

    T. Osaki, S. Kawabata.

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Grant-in-Aid for Scientific Research

  • Grant-in-Aid for Scientific Research(C),2023.04 - 2026.03

Other external funds procured

  • Health and Labour Sciences Research Grants,2018.04 - 2021.03

    Ministry of Health, Labour and Welfare

  • Molecular pathology of autoimmune hemorrhaphilia XIII/13; analysis of anti-factor XIII autoantibodies and elucidation of the mechanism of their generation,2016.04 - 2019.03,Molecular pathology of autoimmune hemorrhaphilia XIII/13; analysis of anti-factor XIII autoantibodies and elucidation of the mechanism of their generation

    By using plasma and serum of a number of Japanese patients with autoimmune Factor XIII/13 (F13) deficiency (AiF13D), their anti-F13A and anti-F13B antibodies were analyzed in detail. Epitopes of patients' antibodies were also roughly mapped. However, antibodies of each patient must be oligoclonal or polyclonal so that their exact functions and epitopes cannot be determined.
    Therefore, anti-human F13A monoclonal antibodies' clones were produced from a single case for the first time, and their biding pattern, inhibitory mechanisms as well as ectopic sites were identified. Rat anti-F13B monoclonal antibodies were generated and used for the structure-function relationship analyses of F13B.
    When whole exome analyses were carried out in 20 AiF13D cases, large numbers of nucleotide sequences which differ from the Japanese reference sequences were identified; These are included in the genes coding HLA-A, -B, -F and -DQA1, etc., which are closely related to the antigen-presenting function.

    Japan Society for the Promotion of Science

  • Molecular mechanism elucidation of alternative fibrin degradation pathway aiming for diagnosis and treatment of plasminogen deficiency,2015.04 - 2018.03,Molecular mechanism elucidation of alternative fibrin degradation pathway aiming for diagnosis and treatment of plasminogen deficiency

    We concentrated fibrin degradation products (FDP) by its specific antibodies and identified cleavage sites of FDP, followed by a estimation of candidate proteases which cleave the cleavage sites. As a result, plasmin (PLM), cathepsin G, granulocyte elastase and matrix metalloproteinase-3 were considered candidates. We investigated the fibrin degradation by these proteases. The fibrin degradations in patients were mainly due to residual PLM activity, corresponding to about 15% of the degradations in healthy controls, while the degradations were little affected by other proteases. On the other hand, we found that the specific complement system proteins were high levels in the patient by plasma proteome analysis. Therefore, we investigated the complement activity on a fibrin clot. We found that the complement system was activated on the fibrin clot. We postulated that the complement-opsonized fibrin clot might be removed by phagocytosis.

    Japan Society for the Promotion of Science