Research Areas
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Nanotechnology/Materials / Bio chemistry
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Life Science / Functional biochemistry
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Life Science / Pathological biochemistry
Papers
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Biochemical characterization of anti-factor XIII autoantibodies in patients with hemorrhagic acquired factor XIII deficiency, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 9 50, 2011.07
Souri, M; Iwata, H; Zhang, WG; Ichinose, A
Single Author
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Isolation and purification of vasorelaxing polyphenols in red wine, JOURNAL OF PHARMACOLOGICAL SCIENCES, 112 143P, 2010
Yamazaki, S; Iwata, H; Katano, Y; Ishihata, A
Single Author
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Distinct C-terminus of the B subunit of factor XIII in a population-associated major phenotype: the first case of complete allele-specific alternative splicing products in the coagulation and fibrinolytic systems, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 7(7) 1084-1091, 2009.07
Iwata, H; Kitano, T; Umetsu, K; Yuasa, I; Yamazaki, K; Kemkes-Matthes, B; Ichinose, A
Single Author
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Gamma-glutamyl carboxylase is a cargo receptor for vitamin K-dependent proteins, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 7 228, 2009.07
Souri, M; Iwata, H; Zhang, W; Nakagaki, T; Ichinose, A
Single Author
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The first two Japanese cases of severe type I congenital plasminogen deficiency with ligneous conjunctivitis: Successful treatment with direct thrombin inhibitor and fresh plasma, AMERICAN JOURNAL OF HEMATOLOGY, 84(6) 363-365, 2009.06
Suzuki, T; Ikewaki, J; Iwata, H; Ohashi, Y; Ichinose, A
Single Author
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Unique secretion mode of human protein Z: its Gla domain is responsible for inefficient, vitamin K-dependent and warfarin-sensitive secretion, BLOOD, 113(16) 3857-3864, 2009.04
Souri, M; Iwata, H; Zhang, WG; Ichinose, A
Single Author
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Distinct carboxy-terminus of the B subunit for factor XIII in a population -associated major phenotype: the first case of complete allele-specific alternative splicing products in the coagulation and fibrinolytic systems., J Thromb Haemost., 2009
Iwata H, Kitano T, Umetsu K, Yuasa I, Yamazaki K, Kemkes-Matthes B and Ichinose A
Multiple Authorship (Including Foreigners)
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Altered coagulation and fibrinolytic systems in severe plasminogen deficiency: significance of alternative fibrinolytic pathway(s) in thrombolysis (hypothesis), Shinzo, 41(2) 190-194, 2009
Ichinose Akitada, Iwata Hiroki, Suzuki Takashi, Ikewaki Junko, Matsumoto Masanori, Fujimura Yoshihiro
Single Author
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Regulation of human protein Z gene expression by liver-enriched transcription factor HNF-4α and ubiquitous factor Sp1, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 5(11) 2250-2258, 2007.11
Sugawara, H; Iwata, H; Souri, M; Ichinose, A
Single Author
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An additional Glu30Lys substitution in the Gla domain of the protein Z gene is not a common polymorphism but a rare mutation, which would cause its deficiency, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 3(10) 2360-2361, 2005.10
Iwata, H; Souri, M; Kemkes-Matthes, B; Ichinose, A
Single Author
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A naturally occurring E30Q mutation in the Gla domain of protein Z causes its impaired secretion and subsequent deficiency, BLOOD, 105(8) 3149-3154, 2005.04
Souri, M; Koseki-Kuno, S; Iwata, H; Kemkes-Matthes, B; Ichinose, A
Single Author
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A naturally occurring E30Q mutation in the Gla domain of protein Z causes its impaired secretion and subsequent deficiency., Bood, 2005
Souri M, Koseki-Kuno S, Iwata H, Kemkes-Matthes B and Ichinose
Multiple Authorship (Only Japanese)
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An additional Glu30Lys substitution in the Gla domain of the protein Z gene is not a common polymorphism but a rare mutation, which would cause its deficiency., J Thromb Haemost., 2005
Iwata H, Souri M, Kemkes-Matthes B and Ichinose A
Multiple Authorship (Including Foreigners)
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Purification, identification, and characterization of elastase on erythrocyte membrane as factor IX-activating enzyme, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 316(1) 65-70, 2004.03
Iwata, H; Kaibara, M; Dohmae, N; Takio, K; Himeno, R; Kawakami, S
Single Author
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Purification, identification, and characterization of elastase on erythrocyte membrane as factor IX-activating enzyme., Biochem Biophys Res Commun., 2004
Iwata H, Kaibara M, Dohmae N, Takio K, Himeno R and Kawakami S
Multiple Authorship (Only Japanese)
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Activation of factor IX by erythrocyte membranes causes intrinsic coagulation., Blood Coagul Fibriol., 2002
Iwata H and Kaibara M
Multiple Authorship (Only Japanese)
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Antithrombogenicity of cultured endothelial cell detached surface., Colloids Surfaces B: Biointerfaces, 2000
Iwata H, Kaibara M, Suzuki Y and Nakajima H
Single Author
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As many as 12 cases with haemorrhagic acquired factor XIII deficiency due to its inhibitors were recently found in Japan., Thromb Haemost., 2011
14. Ichinose A, Souri M, Iwata H, Sakata Y, Yatomi Y, et al.
Multiple Authorship (Only Japanese)
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The first two Japanese cases of severe type I congenital plasminogen deficiency with ligneous conjunctivitis: successful treatment with direct thrombin inhibitor and fresh plasma., Am J Haematol, 2009
Suzuki T, Ikewaki J, Iwata H, Ohashi Y and Ichinose A
Multiple Authorship (Only Japanese)
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Regulation of human protein Z gene expression by liver-enriched transcription factor HNF-4alpha and ubiquitous factor Sp1, J Thromb Haemost., 2007
10. Sugawara H, Iwata H, Souri M and Ichinose A
Multiple Authorship (Only Japanese)
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Analysis of coagulation of blood in different animal species with special reference to procoagulant activity of red blood cell., J Jpn Soc Biorheol., 2006
Kaibara M, Shinozaki T, Kita R, Iwata H, Ujiie H, Sasaki K, Li J, Sawasaki T and Ogawa H
Single Author
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Rheological analyses of coagulation of blood from different individuals with special reference to procoagulant activity of erythrocytes., Blood Coagul Fibrinolysis., 2005
Kaibara M, Iwata H, Ujiie H, Himeno R and Kaibara M
Multiple Authorship (Only Japanese)
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Ion implantation into collagen for the substrate of small diameter artificial grafts. , Nucl Instr and Meth B, 1997
2. Suzuki Y, Iwata H, Nakao A, Iwaki M, Kaibara M, Sasabe H, Kaneko S, Nakajima H and Kusakabe M
Multiple Authorship (Only Japanese)
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Promotion and control of selective adhesion and proliferation of endothelial cells on polymer surface by carbon deposition., J Biomed Mater Res, 1996
Kaibara M, Iwata H, Wada H, Kawamoto Y, Iwaki M, and Suzuki Y
Multiple Authorship (Only Japanese)
Books
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Ischemic Blood Flow in the Brain, Springer, 2001
Kaibara M and Iwata H
Review Papers
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A Triggering Mechanism of Thrombus Formation under Stagnant Flow Conditions ~Activation of Factor IX by erythrocyte membranes~., Jpn. J. Thromb Haemost, 2002
Iwata H and Kaibara M
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Rheological and biochemical analyses on blood coagulation. ~ Discovery of a new pathway under stagnant flow conditions ~., Computional Biomechanics, 2001
Iwata H, Kaibara M, Dohmae N and Takio K
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Changes in rheological property and fibrin network during coagulation and fibrinolysis., Repts Prog PolymPhys Japan, 1997
Iwata H, Kasuga H, Nakayama M, Kaibara M and Sasabe H
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Proliferation of endothelial cells on carbon-deposited polymer surface., Repts Prog PolymPhys Japan, 1994
Kaibara M, Iwata H, Wada H, Suzuki Y and Iwaki M
Media Coverage
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血流停滞による血栓形成のメカニズムを解明 "エコノミークラス症候群"予防につながる新知見,2001.10