Updated on 2022/01/14


IWATA Hiroki
Assistant Professor
Laboratory Phone number
Laboratory Fax number

Research Areas

  • Nanotechnology/Materials / Bio chemistry

  • Life Science / Functional biochemistry

  • Life Science / Pathological biochemistry



  • Unique secretion mode of human protein Z: its Gla domain is responsible for inefficient, vitamin K-dependent and warfarin-sensitive secretion., Bood, 2009

    Souri M, Iwata H, Zhang WG and Ichinose A

    Multiple Authorship (Only Japanese)

  • Distinct carboxy-terminus of the B subunit for factor XIII in a population -associated major phenotype: the first case of complete allele-specific alternative splicing products in the coagulation and fibrinolytic systems., J Thromb Haemost., 2009

    Iwata H, Kitano T, Umetsu K, Yuasa I, Yamazaki K, Kemkes-Matthes B and Ichinose A

    Multiple Authorship (Including Foreigners)

  • A naturally occurring E30Q mutation in the Gla domain of protein Z causes its impaired secretion and subsequent deficiency., Bood, 2005

    Souri M, Koseki-Kuno S, Iwata H, Kemkes-Matthes B and Ichinose

    Multiple Authorship (Only Japanese)

  • An additional Glu30Lys substitution in the Gla domain of the protein Z gene is not a common polymorphism but a rare mutation, which would cause its deficiency., J Thromb Haemost., 2005

    Iwata H, Souri M, Kemkes-Matthes B and Ichinose A

    Multiple Authorship (Including Foreigners)

  • Purification, identification, and characterization of elastase on erythrocyte membrane as factor IX-activating enzyme., Biochem Biophys Res Commun., 2004

    Iwata H, Kaibara M, Dohmae N, Takio K, Himeno R and Kawakami S

    Multiple Authorship (Only Japanese)

  • Activation of factor IX by erythrocyte membranes causes intrinsic coagulation., Blood Coagul Fibriol., 2002

    Iwata H and Kaibara M

    Multiple Authorship (Only Japanese)

  • Antithrombogenicity of cultured endothelial cell detached surface., Colloids Surfaces B: Biointerfaces, 2000

    Iwata H, Kaibara M, Suzuki Y and Nakajima H

    Single Author

  • As many as 12 cases with haemorrhagic acquired factor XIII deficiency due to its inhibitors were recently found in Japan., Thromb Haemost., 2011

    14. Ichinose A, Souri M, Iwata H, Sakata Y, Yatomi Y, et al.

    Multiple Authorship (Only Japanese)

  • The first two Japanese cases of severe type I congenital plasminogen deficiency with ligneous conjunctivitis: successful treatment with direct thrombin inhibitor and fresh plasma., Am J Haematol, 2009

    Suzuki T, Ikewaki J, Iwata H, Ohashi Y and Ichinose A

    Multiple Authorship (Only Japanese)

  • Regulation of human protein Z gene expression by liver-enriched transcription factor HNF-4alpha and ubiquitous factor Sp1, J Thromb Haemost., 2007

    10. Sugawara H, Iwata H, Souri M and Ichinose A

    Multiple Authorship (Only Japanese)

  • Analysis of coagulation of blood in different animal species with special reference to procoagulant activity of red blood cell., J Jpn Soc Biorheol., 2006

    Kaibara M, Shinozaki T, Kita R, Iwata H, Ujiie H, Sasaki K, Li J, Sawasaki T and Ogawa H

    Single Author

  • Rheological analyses of coagulation of blood from different individuals with special reference to procoagulant activity of erythrocytes., Blood Coagul Fibrinolysis., 2005

    Kaibara M, Iwata H, Ujiie H, Himeno R and Kaibara M

    Multiple Authorship (Only Japanese)

  • Ion implantation into collagen for the substrate of small diameter artificial grafts. , Nucl Instr and Meth B, 1997

    2. Suzuki Y, Iwata H, Nakao A, Iwaki M, Kaibara M, Sasabe H, Kaneko S, Nakajima H and Kusakabe M

    Multiple Authorship (Only Japanese)

  • Promotion and control of selective adhesion and proliferation of endothelial cells on polymer surface by carbon deposition., J Biomed Mater Res, 1996

    Kaibara M, Iwata H, Wada H, Kawamoto Y, Iwaki M, and Suzuki Y

    Multiple Authorship (Only Japanese)

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  • Ischemic Blood Flow in the Brain, Springer, 2001

    Kaibara M and Iwata H

Review Papers

  • A Triggering Mechanism of Thrombus Formation under Stagnant Flow Conditions ~Activation of Factor IX by erythrocyte membranes~., Jpn. J. Thromb Haemost, 2002

    Iwata H and Kaibara M

  • Rheological and biochemical analyses on blood coagulation. ~ Discovery of a new pathway under stagnant flow conditions ~., Computional Biomechanics, 2001

    Iwata H, Kaibara M, Dohmae N and Takio K

  • Changes in rheological property and fibrin network during coagulation and fibrinolysis., Repts Prog PolymPhys Japan, 1997

    Iwata H, Kasuga H, Nakayama M, Kaibara M and Sasabe H

  • Proliferation of endothelial cells on carbon-deposited polymer surface., Repts Prog PolymPhys Japan, 1994

    Kaibara M, Iwata H, Wada H, Suzuki Y and Iwaki M


Media Coverage

  • 血流停滞による血栓形成のメカニズムを解明 "エコノミークラス症候群"予防につながる新知見,2001.10