Testis-specific peroxiredoxin 4 variant is not absolutely required for spermatogenesis and fertility in mice.，Scientific reports，10(1) 17934，2020年10月

Homma T, Kurahashi T, Ishii N, Shirasawa N, Fujii J

共著（国内のみ）

Cysteine preservation confers resistance to glutathione-depleted cells against ferroptosis via CDGSH iron sulphur domain-containing proteins (CISDs).，Free Radic Res.，2020年06月

Homma T, Kobayashi S, Fujii J.

共著（国内のみ）

Heterozygous SOD1 deficiency in mice with an NZW background causes male infertility and an aberrant immune phenotype.，Free Radic Res，2019年12月

Homma T, Takeda Y, Sakahara S, Ishii N, Kobayashi S, Abe H, Asao H, Fujii J

共著（国内のみ）

Edaravone, a free radical scavenger, protects against ferroptotic cell death in vitro.，Experimental cell research，384(1) 111592，2019年11月

Homma T, Kobayashi S, Sato H, Fujii J

共著（国内のみ）

Induction of ferroptosis by singlet oxygen generated from naphthalene endoperoxide.，Biochemical and biophysical research communications，518(3) 519-525，2019年10月

Homma T, Kobayashi S, Fujii J

共著（国内のみ）

An SOD1 deficiency aggravates proteasome inhibitor bortezomib-induced testicular damage in mice.，Biochim Biophys Acta Gen Subj，1863(6) 1108-1115，2019年06月

Homma Takujiro, Fujii Junichi

共著（国内のみ）

Mice deficient in aldo-keto reductase 1a (Akr1a) are resistant to thioacetamide-induced liver injury.，Toxicol Lett，294 37-43，2018年09月

Homma Takujiro, Shirato Takaya, Akihara Ryusuke, Kobayashi Sho, Lee Jaeyong, Yamada Ken-Ichi, Miyata Satoshi, Takahashi Motoko, Fujii Junichi

共著（国内のみ）

Double Knockout of Peroxiredoxin 4 (Prdx4) and Superoxide Dismutase 1 (Sod1) in Mice Results in Severe Liver Failure.，Oxid Med Cell Longev，2018 2812904，2018年

Homma Takujiro, Kurahashi Toshihiro, Lee Jaeyong, Nabeshima Atsunori, Yamada Sohsuke, Fujii Junichi

共著（国内のみ）

Heightened aggressive behavior in mice deficient in aldo-keto reductase 1a (Akr1a).，Behav Brain Res，319 219-224，2017年02月

Homma Takujiro, Akihara Ryusuke, Okano Satoshi, Shichiri Mototada, Yoshida Yasukazu, Yamada Ken-Ichi, Miyata Satoshi, Nakajima Osamu, Fujii Junichi

共著（国内のみ）

Heat stress promotes the down-regulation of IRE1alpha in cells: An atypical modulation of the UPR pathway.，Exp Cell Res，349(1) 128-138，2016年11月

Homma Takujiro, Fujii Junichi

共著（国内のみ）

SOD1 deficiency decreases proteasomal function, leading to the accumulation of ubiquitinated proteins in erythrocytes.，Arch Biochem Biophys，583 65-72，2015年10月

Homma Takujiro, Kurahashi Toshihiro, Lee Jaeyong, Kang Eun Sil, Fujii Junichi

共著（国内のみ）

SOD1 deficiency induces the systemic hyperoxidation of peroxiredoxin in the mouse.，Biochem Biophys Res Commun，463(4) 1040-1046，2015年08月

Homma Takujiro, Okano Satoshi, Lee Jaeyong, Ito Junitsu, Otsuki Noriyuki, Kurahashi Toshihiro, Kang Eun Sil, Nakajima Osamu, Fujii Junichi

共著（国内のみ）

Ubiquitin-specific protease 14 modulates degradation of cellular prion protein.，Sci Rep，5 11028，2015年06月

Homma Takujiro, Ishibashi Daisuke, Nakagaki Takehiro, Fuse Takayuki, Mori Tsuyoshi, Satoh Katsuya, Atarashi Ryuichiro, Nishida Noriyuki

共著（国内のみ）

Application of Glutathione as Anti-Oxidative and Anti-Aging Drugs.，Curr Drug Metab，16(7) 560-571，2015年

Homma Takujiro, Fujii Junichi

共著（国内のみ）

Persistent prion infection disturbs the function of Oct-1, resulting in the down-regulation of murine interferon regulatory factor-3.，Sci Rep，4 6006，2014年08月

Homma Takujiro, Ishibashi Daisuke, Nakagaki Takehiro, Fuse Takayuki, Sano Kazunori, Satoh Katsuya, Atarashi Ryuichiro, Nishida Noriyuki

共著（国内のみ）

Increased expression of p62/SQSTM1 in prion diseases and its association with pathogenic prion protein.，Sci Rep，4 4504，2014年03月

Homma Takujiro, Ishibashi Daisuke, Nakagaki Takehiro, Satoh Katsuya, Sano Kazunori, Atarashi Ryuichiro, Nishida Noriyuki

共著（国内のみ）

Dextran sulphate inhibits an association of prions with plasma membrane at the early phase of infection.，Neuroscience research，171 34-40，2021年10月

Fuse T, Nakagaki T, Homma T, Tange H, Yamaguchi N, Atarashi R, Ishibashi D, Nishida N

単著

Carnosine dipeptidase II (CNDP2) protects cells under cysteine insufficiency by hydrolyzing glutathione-related peptides.，Free radical biology & medicine，174 12-27，2021年10月

Kobayashi S, Homma T, Okumura N, Han J, Nagaoka K, Sato H, Konno H, Yamada S, Takao T, Fujii J

単著

Nitric oxide produced by NOS2 copes with the cytotoxic effects of superoxide in macrophages.，Biochemistry and biophysics reports，26 100942，2021年07月

Kobayashi S, Homma T, Fujii J

単著

Pleiotropic Actions of Aldehyde Reductase (AKR1A).，Metabolites，11(6) ，2021年05月

Fujii J, Homma T, Miyata S, Takahashi M

単著

Erythrocytes as a preferential target of oxidative stress in blood.，Free radical research，55(5) 562-580，2021年05月

Fujii J, Homma T, Kobayashi S, Warang P, Madkaikar M, Mukherjee MB

単著

Developmental retardation in neonates of aldehyde reductase (AKR1A)-deficient mice is associated with low ascorbic acid and high corticosterone levels.，The Journal of nutritional biochemistry，91 108604，2021年05月

Ishii N, Homma T, Takeda Y, Aung NY, Yamada KI, Miyata S, Asao H, Yamakawa M, Fujii J

単著

Characterization of a rat monoclonal antibody raised against ferroptotic cells.，J Immunol Methods.，2021年02月

Kobayashi S, Harada Y, Homma T, Yokoyama C, Fujii J.

共著（国内のみ）

Ferroptosis caused by cysteine insufficiency and oxidative insult.，Free radical research，54(11-12) 969-980，2020年12月

Fujii J, Homma T, Kobayashi S

単著

Ascorbic acid prevents N-nitrosodiethylamine-induced hepatic injury and hepatocarcinogenesis in Akr1a-knockout mice.，Toxicology letters，333 192-201，2020年10月

Ishii N, Homma T, Guo X, Yamada KI, Yamada S, Fujii J

単著

Genetic ablation of aldehyde reductase (Akr1a) augments exercise endurance in mice via activation of the PGC-1α-involved pathway.，Life sciences，249 117501，2020年05月

Takahashi M, Homma T, Yamada KI, Miyata S, Nakajima O, Fujii J

単著

Prion protein interacts with the metabotropic glutamate receptor 1 and regulates the organization of Ca²⁺ signaling.，Biochemical and biophysical research communications，525(2) 447-454，2020年04月

Matsubara T, Satoh K, Homma T, Nakagaki T, Yamaguchi N, Atarashi R, Sudo Y, Uezono Y, Ishibashi D, Nishida N

単著

Ascorbic acid and CoQ10 ameliorate the reproductive ability of superoxide dismutase 1-deficient female mice.，Biology of reproduction，102(1) 102-115，2020年02月

Ishii N, Homma T, Lee J, Mitsuhashi H, Yamada KI, Kimura N, Yamamoto Y, Fujii AJ

単著

Ascorbic acid insufficiency impairs spatial memory formation in juvenile AKR1A-knockout mice.，J Clin Biochem Nutr.，2019年11月

Kurihara K, Homma T, Kobayashi S, Shichiri M, Fujiwara H, Fujii S, Yamada KI, Nakane M, Kawamae K, Fujii J

共著（国内のみ）

A heterozygous deficiency in protein phosphatase Ppm1b results in an altered ovulation number in mice.，Mol Med Rep，19(6) 5353-5360，2019年06月

Ishii Naoki, Homma Takujiro, Watanabe Ren, Kimura Naoko, Ohnishi Motoko, Kobayashi Takayasu, Fujii Junichi

共著（国内のみ）

The Association of Peroxiredoxin 4 with the Initiation and Progression of Hepatocellular Carcinoma.，Antioxid Redox Signal，30(10) 1271-1284，2019年04月

Guo Xin, Noguchi Hirotsugu, Ishii Naoki, Homma Takujiro, Hamada Taiji, Hiraki Tsubasa, Zhang Jing, Matsuo Kei, Yokoyama Seiya, Ishibashi Hiroaki, Fukushige Tomoko, Kanekura Takuro, Fujii Junichi, Uram...

共著（国内のみ）

Type I interferon protects neurons from prions in in vivo models.，Brain，142(4) 1035-1050，2019年04月

Ishibashi Daisuke, Homma Takujiro, Nakagaki Takehiro, Fuse Takayuki, Sano Kazunori, Satoh Katsuya, Mori Tsuyoshi, Atarashi Ryuichiro, Nishida Noriyuki

共著（国内のみ）

Elevated ER stress exacerbates dextran sulfate sodium-induced colitis in PRDX4-knockout mice.，Free Radic Biol Med，134 153-164，2018年12月

Takagi Tomohisa, Homma Takujiro, Fujii Junichi, Shirasawa Nobuyuki, Yoriki Hiroyuki, Hotta Yuma, Higashimura Yasuki, Mizushima Katsura, Hirai Yasuko, Katada Kazuhiro, Uchiyama Kazuhiko, Naito Yuji, It...

共著（国内のみ）

Mutual interaction between oxidative stress and endoplasmic reticulum stress in the pathogenesis of diseases specifically focusing on non-alcoholic fatty liver disease.，World J Biol Chem，9(1) 1-15，2018年10月

Fujii Junichi, Homma Takujiro, Kobayashi Sho, Seo Han Geuk

共著（海外含む）

Unveiling systemic organ disorders associated with impaired lipid catabolism in fasted SOD1-deficient mice.，Arch Biochem Biophys，654 163-171，2018年09月

Lee Jaeyong, Homma Takujiro, Kobayashi Sho, Ishii Naoki, Fujii Junichi

共著（国内のみ）

Cystine/glutamate transporter, system xc(-), is involved in nitric oxide production in mouse peritoneal macrophages.，Nitric Oxide，78 32-40，2018年08月

Kobayashi Sho, Hamashima Shinji, Homma Takujiro, Sato Mami, Kusumi Ryosuke, Bannai Shiro, Fujii Junichi, Sato Hideyo

共著（国内のみ）

Potential involvement of ubiquitin-proteasome system dysfunction associated with oxidative stress in the pathogenesis of sickle cell disease.，Br J Haematol，182(4) 559-566，2018年08月

Warang Prashant, Homma Takujiro, Pandya Riddhi, Sawant Anuja, Shinde Nikhil, Pandey Debjeet, Fujii Junichi, Madkaikar Manisha, Mukherjee Malay B

共著（海外含む）

The viability of primary hepatocytes is maintained under a low cysteine-glutathione redox state with a marked elevation in ophthalmic acid production.，Exp Cell Res，361(1) 178-191，2017年12月

Lee Jaeyong, Kang Eun Sil, Kobayashi Sho, Homma Takujiro, Sato Hideyo, Seo Han Geuk, Fujii Junichi

共著（国内のみ）

Decreased reproductive performance in xCT-knockout male mice.，Free Radic Res，51(9-10) 851-860，2017年10月

Hamashima Shinji, Homma Takujiro, Kobayashi Sho, Ishii Naoki, Kurahashi Toshihiro, Watanabe Ren, Kimura Naoko, Sato Hideyo, Fujii Junichi

共著（国内のみ）

Mice in the early stage of liver steatosis caused by a high fat diet are resistant to thioacetamide-induced hepatotoxicity and oxidative stress.，Toxicol Lett，277 92-103，2017年08月

Lee Jaeyong, Homma Takujiro, Fujii Junichi

共著（国内のみ）

Oxidative stress caused by a SOD1 deficiency ameliorates thioacetamide-triggered cell death via CYP2E1 inhibition but stimulates liver steatosis.，Arch Toxicol，91(3) 1319-1333，2017年03月

Shirato Takaya, Homma Takujiro, Lee Jaeyong, Kurahashi Toshihiro, Fujii Junichi

共著（国内のみ）

A high-fat diet temporarily renders Sod1-deficient mice resistant to an oxidative insult.，J Nutr Biochem，40 44-52，2017年02月

Ito Junitsu, Ishii Naoki, Akihara Ryusuke, Lee Jaeyong, Kurahashi Toshihiro, Homma Takujiro, Kawasaki Ryo, Fujii Junichi

共著（国内のみ）

xCT deficiency aggravates acetaminophen-induced hepatotoxicity under inhibition of the transsulfuration pathway.，Free Radic Res，51(1) 80-90，2017年01月

Kang Eun Sil, Lee Jaeyong, Homma Takujiro, Kurahashi Toshihiro, Kobayashi Sho, Nabeshima Atsunori, Yamada Sohsuke, Seo Han Geuk, Miyata Satoshi, Sato Hideyo, Fujii Junichi

共著（海外含む）

Ablation of aldehyde reductase aggravates carbon tetrachloride-induced acute hepatic injury involving oxidative stress and endoplasmic reticulum stress.，Biochem Biophys Res Commun，478(2) 765-771，2016年09月

Akihara Ryusuke, Homma Takujiro, Lee Jaeyong, Yamada Ken-Ichi, Miyata Satoshi, Fujii Junichi

共著（国内のみ）

Ascorbic acid prevents acetaminophen-induced hepatotoxicity in mice by ameliorating glutathione recovery and autophagy.，Arch Biochem Biophys，604 36-46，2016年08月

Kurahashi Toshihiro, Lee Jaeyong, Nabeshima Atsunori, Homma Takujiro, Kang Eun Sil, Saito Yuka, Yamada Sohsuke, Nakayama Toshiyuki, Yamada Ken-Ichi, Miyata Satoshi, Fujii Junichi

共著（国内のみ）

Trichloroethylene exposure aggravates behavioral abnormalities in mice that are deficient in superoxide dismutase.，Regul Toxicol Pharmacol，79 83-90，2016年08月

Otsuki Noriyuki, Homma Takujiro, Fujiwara Hiroki, Kaneko Kenya, Hozumi Yasukazu, Shichiri Mototada, Takashima Mizuki, Ito Junitsu, Konno Tasuku, Kurahashi Toshihiro, Yoshida Yasukazu, Goto Kaoru, Fuji...

共著（海外含む）

The SOD1 transgene expressed in erythroid cells alleviates fatal phenotype in congenic NZB/NZW-F1 mice.，Free Radic Res，50(7) 793-800，2016年07月

Otsuki Noriyuki, Konno Tasuku, Kurahashi Toshihiro, Suzuki Saori, Lee Jaeyong, Okada Futoshi, Iuchi Yoshihito, Homma Takujiro, Fujii Junichi

共著（海外含む）

An SOD1 deficiency enhances lipid droplet accumulation in the fasted mouse liver by aborting lipophagy.，Biochem Biophys Res Commun，467(4) 866-871，2015年11月

Kurahashi Toshihiro, Hamashima Shinji, Shirato Takaya, Lee Jaeyong, Homma Takujiro, Kang Eun Sil, Fujii Junichi

共著（海外含む）

Oxidative stress triggers lipid droplet accumulation in primary cultured hepatocytes by activating fatty acid synthesis.，Biochem Biophys Res Commun，464(1) 229-235，2015年08月

Lee Jaeyong, Homma Takujiro, Kurahashi Toshihiro, Kang Eun Sil, Fujii Junichi

共著（国内のみ）

Physiological and pathological views of peroxiredoxin 4.，Free Radic Biol Med，83 373-379，2015年06月

Fujii Junichi, Ikeda Yoshitaka, Kurahashi Toshihiro, Homma Takujiro

共著（国内のみ）

Oxidative stress as a potential causal factor for autoimmune hemolytic anemia and systemic lupus erythematosus.，World J Nephrol，4(2) 213-222，2015年05月

Fujii Junichi, Kurahashi Toshihiro, Konno Tasuku, Homma Takujiro, Iuchi Yoshihito

共著（国内のみ）

Cystathionine is a novel substrate of cystine/glutamate transporter: implications for immune function.，J Biol Chem，290(14) 8778-8788，2015年04月

Kobayashi Sho, Sato Mami, Kasakoshi Takayuki, Tsutsui Takumi, Sugimoto Masahiro, Osaki Mitsuhiko, Okada Futoshi, Igarashi Kiharu, Hiratake Jun, Homma Takujiro, Conrad Marcus, Fujii Junichi, Soga Tomoy...

共著（海外含む）

Strain-Dependent Effect of Macroautophagy on Abnormally Folded Prion Protein Degradation in Infected Neuronal Cells.，PLoS One，10(9) e0137958，2015年

Ishibashi Daisuke, Homma Takujiro, Nakagaki Takehiro, Fuse Takayuki, Sano Kazunori, Takatsuki Hanae, Atarashi Ryuichiro, Nishida Noriyuki

共著（国内のみ）

Reductive detoxification of acrolein as a potential role for aldehyde reductase (AKR1A) in mammals.，Biochem Biophys Res Commun，452(1) 136-141，2014年09月

Kurahashi Toshihiro, Kwon Myoungsu, Homma Takujiro, Saito Yuka, Lee Jaeyong, Takahashi Motoko, Yamada Ken-Ichi, Miyata Satoshi, Fujii Junichi

共著（国内のみ）

Involvement of purinergic signaling in cellular response to gamma radiation.，Radiat Res，173(3) 298-309，2010年03月

Tsukimoto Mitsutoshi, Homma Takujiro, Ohshima Yasuhiro, Kojima Shuji

共著（国内のみ）

Low-dose gamma-ray irradiation induces translocation of Nrf2 into nuclear in mouse macrophage RAW264.7 cells.，J Radiat Res，51(3) 349-353，2010年

Tsukimoto Mitsutoshi, Tamaishi Nana, Homma Takujiro, Kojima Shuji

共著（国内のみ）

0.5 Gy gamma radiation suppresses production of TNF-alpha through up-regulation of MKP-1 in mouse macrophage RAW264.7 cells.，Radiat Res，171(2) 219-224，2009年02月

Tsukimoto Mitsutoshi, Homma Takujiro, Mutou Yasuko, Kojima Shuji

共著（国内のみ）