Research Areas
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Life Science / Neurosurgery
Graduating School
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Yamagata University, Faculty of Medicine
2015.03, Graduated
Papers
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CEP-1347 Boosts Chk2-Mediated p53 Activation by Ionizing Radiation to Inhibit the Growth of Malignant Brain Tumor Cells, International Journal of Clinical Oncology, 2024.08
Mitobe Y, Kitanaka C,Okada M
Multiple Authorship (Only Japanese)
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Antagonizing MDM2 Overexpression Induced by MDM4 Inhibitor CEP-1347 Effectively Reactivates Wild-Type p53 in Malignant Brain Tumor Cells, Cancers, 2023.08
Mitobe Y, Kitanaka C,Okada M
Multiple Authorship (Only Japanese)
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The Novel MDM4 Inhibitor CEP-1347 Activates the p53 Pathway and Blocks Malignant Meningioma Growth In Vitro and In Vivo, Biomedicines, 2023.07
Mitobe Y, Kitanaka C,Okada M
Multiple Authorship (Only Japanese)
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Effective Targeting of Glioma Stem Cells by BSJ-04-122, a Novel Covalent MKK4/7 Dual Inhibitor, Anticancer Research, 45(7) 2917-2924, 2025.07
Kazuki Nakamura,Yasufumi Ito , Senri Takenouchi , Yurika Nakagawa-Saito , Shuhei Suzuki , Keita Togashi , Asuka Sugai , Yuta Mitobe , Yukihiko Sonoda , Chifumi Kitanaka , Masashi Okada
Multiple Authorship (Only Japanese)
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Efficacy and safety of carmustine wafers, followed by radiation, temozolomide, and bevacizumab therapy, for newly diagnosed glioblastoma with maximal resection, International Journal of Clinical Oncology, 2024.11
金森政之,柴原一陽,水戸部祐太、他
Multiple Authorship (Including Foreigners)
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Cost of medical care for malignant brain tumors at hospitals in the Japan Clinical Oncology Group brain-tumor study group, Jpn J Clin Oncol, 2024.10
Kazuya Motomura, Keita Sasaki,....,Mitobe Y,....他
Multiple Authorship (Only Japanese)
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Neuroradiological, genetic and clinical characteristics of histone H3 K27-mutant diffuse midline gliomas in the Kansai Molecular Diagnosis Network for CNS Tumors (Kansai Network): multicenter retrospective cohort, Acta Neuropathol Commun, 2024.07
Nobuhide Hayashi,.....,Mitobe Y,....
Multiple Authorship (Only Japanese)
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The MDM2-p53 Axis Represents a Therapeutic Vulnerability Unique to Glioma Stem Cells, International Journal of Clinical Oncology, 2024.04
Nakagawa-Saito Y,Mitobe Y,Kitanaka C,Okada M
Multiple Authorship (Only Japanese)
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Association of ADC of hyperintense lesions on FLAIR images with TERT promoter mutation status in glioblastoma IDH wild type, Surgical Neurology International, 2024.03
神村慈,水戸部祐太,園田順彦
Multiple Authorship (Only Japanese)
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CEP-1347 Dually Targets MDM4 and PKC to Activate p53 and Inhibit the Growth of Uveal Melanoma Cells, Cancers, 2023.12
Keita Togashi, Shuhei Suzuki, Yuta Mitobe,....,Chifumi Kitanaka, Masashi Okada
Multiple Authorship (Only Japanese)
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Domatinostat Targets the FOXM1-Survivin Axis to Reduce the Viability of Ovarian Cancer Cells Alone and in Combination with Chemotherapeutic Agents, International journal of molecular science, 2023.06
Nakagawa-Saito Y,Mitobe Y,Kitanaka C,Okada M
Multiple Authorship (Only Japanese)
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Usefulness of Serum Soluble Interleukin-2 Receptor Levels for Differentiating between PCNSL and SCNSL, Neurologia medico-chirurgica, 2023.03
水戸部祐太,松田憲一朗,園田順彦
Multiple Authorship (Only Japanese)
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CEP-1347 targets MDM4 protein expression to activate p53 and inhibit the growth of glioma cells., Anticancer research, 2022.10
Mitobe Y, Kitanaka C,Okada M
Multiple Authorship (Only Japanese)
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Changes in vascular supply pattern associated with growth of nonfunctioning pituitary adenomas, Surgical Neurology International, 2022.10
Miiko Ito, Yuta Mitobe, Toshitada Hiraka, Masafumi Kanoto, Yukihiko Sonoda
Multiple Authorship (Only Japanese)
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Givinostat inhibition of Sp1-dependent MGMT expression sensitizes glioma stem cells to temozolomide, Anticancer research, 2022.09
Nakagawa-Saito Y,Mitobe Y,Kitanaka C,Okada M
Multiple Authorship (Only Japanese)
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Inhibition of the Phospholipase Cε-c-Jun N-Terminal Kinase Axis Suppresses Glioma Stem Cell Properties, International Journal of Clinical Oncology, 2022.08
Okada M, Nakagawa-Saito Y, Mitobe Y, …, Kitanaka C
Multiple Authorship (Only Japanese)
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HDAC Class I Inhibitor Domatinostat Preferentially Targets Glioma Stem Cells over Their Differentiated Progeny., International Journal of Clinical Oncology, 2022.06
Okada M, Nakagawa-Saito Y, Mitobe Y, …, Kitanaka C
Multiple Authorship (Only Japanese)
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Delayed acute subdural hematoma treated with endoscopic procedure: A case report, Surgical Neurology International, 2020.10
Atsushi Kuge, Rei Kondo, Yuta Mitobe, Tetsu Yamaki, Shinji Sato, Shinjiro Saito, Yukihiko Sonoda
Multiple Authorship (Only Japanese)
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[Seven Patients with Pituitary Metastases Treated at Our Department:Case Reports]., No shinkei geka. Neurological surgery, 48(8) 711-716, 2020.08
Mitobe Y, Ito M, Matsuda K, Sonoda Y
Single Author
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Novel Burr Hole Dilator for Endoscopic Surgery for Intracranial Hemorrhagic Lesion: Technical Note, WORLD NEUROSURGERY, 128 295-298, 2019.08
Kuge Atsushi, Kondo Rei, Sato Shinji, Mitobe Yuta, Saito Shinjiro, Sonoda Yukihiko
Single Author
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急性期抗血小板薬2剤併用療法及びヘパリン静注による進行性脳卒中の頻度と転帰, 山形県対脳卒中治療研究会会誌, (41) 1-6, 2019.06
水戸部 祐太, 近藤 礼, 佐藤 慎治, 齊藤 元太, 齋藤 伸二郎, 久下 淳史, 園田 順彦
Single Author
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[Magnetic Resonance Vessel Wall Imaging Reveals a Ruptured Blood Blister-like Aneurysm:A Case Report]., No shinkei geka. Neurological surgery, 46(12) 1087-1091, 2018.12
Mitobe Y, Kondo R, Yamaki T, Saito G, Saito S, Sonoda Y
Single Author
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破裂内頸動脈血マメ状動脈瘤の診断に造影MR vessel wall imagingが有用であった1例, Neurological Surgery, 46(12) 1087-1091, 2018.12
水戸部 祐太, 近藤 礼, 山木 哲, 齊藤 元太, 齋藤 伸二郎, 園田 順彦
Single Author
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市中病院における出血AVMの治療戦略, 山形県対脳卒中治療研究会会誌, (40) 5-11, 2018.12
佐藤 慎治, 近藤 礼, 水戸部 祐太, 下川 友侑, 久下 淳史, 齊藤 元太, 齋藤 伸二郎, 園田 順彦
Single Author
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[A Surgical Case of Anaplastic Ependymoma Involving a Bridging Vein that Drained Directly into the Occipital Sinus]., No shinkei geka. Neurological surgery, 46(8) 707-711, 2018.08
Mitobe Y, Yaoita R, Itagaki H, Matsuda K, Sonoda Y
Single Author
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Occipital sinusに直接流入する後頭蓋窩静脈を伴った退形成性上衣腫の1手術例, Neurological Surgery, 46(8) 707-711, 2018.08
水戸部 祐太, 矢尾板 亮, 板垣 寛, 松田 憲一朗, 園田 順彦
Single Author
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複数回の脳卒中後にラクナ梗塞の再発を契機に発症したparoxysmal sympathetic hyperactivity にintrathecal baclofen が有効であった1 症例, 脳卒中, 40(3) 174-178, 2018
水戸部 祐太, 齋藤 佑規, 菊地 善彰, 竹村 直, 園田 順彦
Single Author
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HDAC Class I Inhibitor Domatinostat Induces Apoptosis Preferentially in Glioma Stem Cells Through p53-Dependent and -Independent Activation of BAX Expression, International Journal of Molecular Sciences, 26(16) 7803, 2025.08
Yurika Nakagawa-Saito , Yasufumi Ito , Kazuki Nakamura , Yuta Mitobe , Keita Togashi ,Shuhei Suzuki , Senri Takenouchi , Asuka Sugai , Yukihiko Sonoda , Chifumi Kitanaka , Masashi Okada
Multiple Authorship (Only Japanese)
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Targeting Bcl-xL with Navitoclax Effectively Eliminates Senescent Tumor Cells That Appear Following CEP-1347-Induced Differentiation of Glioma Stem Cells, International Journal of Molecular Sciences, 26(14) 6984, 2025.07
Senri Takenouchi , Yasufumi Ito , Kazuki Nakamura , Yurika Nakagawa-Saito , Yuta Mitobe , Keita Togashi , Shuhei Suzuki , Asuka Sugai , Yukihiko Sonoda , Chifumi Kitanaka , Masashi Okada
Multiple Authorship (Only Japanese)
Review Papers
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前大脳動脈解離による脳梗塞の臨床的特徴, サノフィ(株)仙台オフィス, 東北脳血管障害研究会学術集会記録集, 40回 0112-0121, 2018.12
山本 哲, 近藤 礼, 水戸部 祐太, 齊藤 元太, 齋藤 伸二郎, 園田 順彦