2025/04/30 更新

写真a

トガシ　ケイタ
冨樫　敬太
TOGASHI Keita
職名
助教
 

研究経歴

  • リン酸化酵素阻害剤CEP-1347による網膜芽細胞増殖抑制機序の解明，2019年04月 ～ 2022年03月

  • ぶどう膜悪性黒色腫に対するp53活性化誘導を基軸とした新規治療薬の開発，2021年04月 ～ 継続中

  • ぶどう膜悪性黒色腫の急所MDM4, PKCを同時に標的とする新規治療薬の開発，2023年04月 ～ 継続中

論文

  • Nationwide multicenter prospective study on the usefulness, safety, and acceptability of colon capsule endoscopy in Japan.，Gastrointestinal endoscopy，101(5) 1051-1063.e7，2025年05月

    Hotta N, Ohmiya N, Hiraga H, Nakaji K, Osawa S, Omori T, Mitsufuji S, Hosoe N, Nouda S, Kobayashi T, Nakamura M, Oka S, Nonogaki K, Baba Y, Mukai R, Matsumoto H, Ikebuchi Y, Shimada M, Togashi K, Kats...

    単著

  • NOVEL MDM4 INHIBITOR CEP-1347-BASED THERAPY FOR P53 WILD-TYPE MALIGNANT MENINGIOMA，NEURO-ONCOLOGY，26 ，2024年11月

    Mitobe, Y; Suzuki, S; Nakagawa-Saito, Y; Togashi, K; Sugai, A; Sonoda, Y; Kitanaka, C; Okada, M

    単著

  • CEP-1347 Boosts Chk2-Mediated p53 Activation by Ionizing Radiation to Inhibit the Growth of Malignant Brain Tumor Cells，INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES，25(17) ，2024年09月

    Mitobe, Y; Suzuki, S; Nakamura, K; Nakagawa-Saito, Y; Takenouchi, S; Togashi, K; Sugai, A; Sonoda, Y; Kitanaka, C; Okada, M

    単著

  • Novel Molecularly Targeted Therapy for Retinoblastoma Through Activation of MDM4-p53 Pathway，INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE，65(7) ，2024年06月

    Togashi, K; Yutaka, K; Yamashita, H; Sugimoto, M

    単著

  • The MDM2-p53 Axis Represents a Therapeutic Vulnerability Unique to Glioma Stem Cells，INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES，25(7) ，2024年04月

    Nakagawa-Saito, Y; Mitobe, Y; Togashi, K; Suzuki, S; Sugai, A; Takenouchi, S; Nakamura, K; Sonoda, Y; Kitanaka, C; Okada, M

    単著

  • CEP-1347 Dually Targets MDM4 and PKC to Activate p53 and Inhibit the Growth of Uveal Melanoma Cells，CANCERS，16(1) ，2024年01月

    Togashi, K; Suzuki, S; Mitobe, Y; Nakagawa-Saito, Y; Sugai, A; Takenouchi, S; Sugimoto, M; Kitanaka, C; Okada, M

    単著

  • Antagonizing MDM2 Overexpression Induced by MDM4 Inhibitor CEP-1347 Effectively Reactivates Wild-Type p53 in Malignant Brain Tumor Cells，CANCERS，15(17) ，2023年09月

    Mitobe, Y; Suzuki, S; Nakagawa-Saito, Y; Togashi, K; Sugai, A; Sonoda, Y; Kitanaka, C; Okada, M

    単著

  • Domatinostat Targets the FOXM1-Survivin Axis to Reduce the Viability of Ovarian Cancer Cells Alone and in Combination with Chemotherapeutic Agents，INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES，24(13) ，2023年07月

    Nakagawa-Saito, Y; Mitobe, Y; Suzuki, S; Togashi, K; Sugai, A; Kitanaka, C; Okada, M

    単著

  • The Novel MDM4 Inhibitor CEP-1347 Activates the p53 Pathway and Blocks Malignant Meningioma Growth In Vitro and In Vivo，BIOMEDICINES，11(7) ，2023年07月

    Mitobe, Y; Suzuki, S; Nakagawa-Saito, Y; Togashi, K; Sugai, A; Sonoda, Y; Kitanaka, C; Okada, M

    単著

  • Givinostat Inhibition of Sp1-dependent MGMT Expression Sensitizes Glioma Stem Cells to Temozolomide，ANTICANCER RESEARCH，43(3) 1131-1138，2023年03月

    Nakagawa-Saito Yurika, Mitobe Yuta, Togashi Keita, Suzuki Shuhei, Sugai Asuka, Kitanaka Chifumi, Okada Masashi

    単著

  • CEP-1347 Targets MDM4 Protein Expression to Activate p53 and Inhibit the Growth of Glioma Cells，ANTICANCER RESEARCH，42(10) 4727-4733，2022年10月

    Mitobe Yuta, Nakagawa-saito Yurika, Togashi Keita, Suzuki Shuhei, Sugai Asuka, Matsuda Ken-ichiro, Sonoda Yukihiko, Kitanaka Chifumi, Okada Masashi

    単著

  • HDAC Class I Inhibitor Domatinostat Preferentially Targets Glioma Stem Cells over Their Differentiated Progeny，INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES，23(15) ，2022年08月

    Nakagawa-Saito Yurika, Saitoh Shinichi, Mitobe Yuta, Sugai Asuka, Togashi Keita, Suzuki Shuhei, Kitanaka Chifumi, Okada Masashi

    単著

  • Inhibition of the Phospholipase C epsilon-c-Jun N-Terminal Kinase Axis Suppresses Glioma Stem Cell Properties，INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES，23(15) ，2022年08月

    Okada Masashi, Nakagawa-Saito Yurika, Mitobe Yuta, Sugai Asuka, Togashi Keita, Suzuki Shuhei, Kitanaka Chifumi

    単著

  • Gemcitabine Cooperates with Everolimus to Inhibit the Growth of and Sensitize Malignant Meningioma Cells to Apoptosis Induced by Navitoclax, an Inhibitor of Anti-Apoptotic BCL-2 Family Proteins，CANCERS，14(7) ，2022年04月

    Yamamoto Masahiro, Suzuki Shuhei, Togashi Keita, Sugai Asuka, Okada Masashi, Kitanaka Chifumi

    単著

  • Targeting Folate Metabolism Is Selectively Cytotoxic to Glioma Stem Cells and Effectively Cooperates with Differentiation Therapy to Eliminate Tumor-Initiating Cells in Glioma Xenografts，INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES，22(21) ，2021年11月

    Okada Masashi, Suzuki Shuhei, Togashi Keita, Sugai Asuka, Yamamoto Masahiro, Kitanaka Chifumi

    単著

  • Dexamethasone Sensitizes Cancer Stem Cells to Gemcitabine and 5-Fluorouracil by Increasing Reactive Oxygen Species Production through NRF2 Reduction，LIFE-BASEL，11(9) ，2021年09月

    Suzuki Shuhei, Yamamoto Masahiro, Sanomachi Tomomi, Togashi Keita, Sugai Asuka, Seino Shizuka, Yoshioka Takashi, Okada Masashi, Kitanaka Chifumi

    単著

  • Lurasidone Sensitizes Cancer Cells to Osimertinib by Inducing Autophagy and Reduction of Survivin，ANTICANCER RESEARCH，41(9) 4321-4331，2021年09月

    Suzuki Shuhei, Yamamoto Masahiro, Sanomachi Tomomi, Togashi Keita, Seino Shizuka, Sugai Asuka, Yoshioka Takashi, Okada Masashi, Kitanaka Chifumi

    単著

  • Roles for hENT1 and dCK in gemcitabine sensitivity and malignancy of meningioma，NEURO-ONCOLOGY，23(6) 945-954，2021年06月

    Yamamoto Masahiro, Sanomachi Tomomi, Suzuki Shuhei, Uchida Hiroyuki, Yonezawa Hajime, Higa Nayuta, Takajo Tomoko, Yamada Yuki, Sugai Asuka, Togashi Keita, Seino Shizuka, Okada Masashi, Sonoda Yukihiko...

    単著

  • Metastatic Orbital Tumor From Breast Ductal Carcinoma With Neuroendocrine Differentiation Initially Presenting as Ocular Symptoms: A Case Report and Literature Review，FRONTIERS IN ENDOCRINOLOGY，12 625663，2021年02月

    Togashi Keita, Nishitsuka Koichi, Hayashi Shion, Namba Hiroyuki, Goto Sakiko, Takeda Yusuke, Suzuki Shuhei, Kato Tomoya, Yamada Yuki, Konno Eriko, Yoshioka Takashi, Yamakawa Mitsunori, Sonoda Yukihiko...

    単著

  • Inhibition of the Lipid Droplet-Peroxisome Proliferator-Activated Receptor alpha Axis Suppresses Cancer Stem Cell Properties，GENES，12(1) ，2021年01月

    Kuramoto Kenta, Yamamoto Masahiro, Suzuki Shuhei, Togashi Keita, Sanomachi Tomomi, Kitanaka Chifumi, Okada Masashi

    単著

  • Gemcitabine radiosensitization primes irradiated malignant meningioma cells for senolytic elimination by navitoclax，NEURO-ONCOLOGY ADVANCES，3(1) vdab148，2021年

    Yamamoto Masahiro, Sanomachi Tomomi, Suzuki Shuhei, Togashi Keita, Sugai Asuka, Seino Shizuka, Sato Atsushi, Okada Masashi, Kitanaka Chifumi

    単著

  • Therapeutic targeting of pancreatic cancer stem cells by dexamethasone modulation of the MKP-1-JNK axis，JOURNAL OF BIOLOGICAL CHEMISTRY，295(52) 18328-18342，2020年12月

    Suzuki Shuhei, Okada Masashi, Sanomachi Tomomi, Togashi Keita, Seino Shizuka, Sato Atsushi, Yamamoto Masahiro, Kitanaka Chifumi

    単著

  • Inhibition of Retinoblastoma Cell Growth by CEP1347 Through Activation of the P53 Pathway，ANTICANCER RESEARCH，40(9) 4961-4968，2020年09月

    Togashi Keita, Okada Masashi, Suzuki Shuhei, Sanomachi Tomomi, Seino Shizuka, Yamamoto Masahiro, Yamashita Hidetoshi, Kitanaka Chifumi

    単著

  • Doxazosin, a Classic Alpha 1-Adrenoceptor Antagonist, Overcomes Osimertinib Resistance in Cancer Cells via the Upregulation of Autophagy as Drug Repurposing，BIOMEDICINES，8(8) ，2020年08月

    Suzuki Shuhei, Yamamoto Masahiro, Sanomachi Tomomi, Togashi Keita, Sugai Asuka, Seino Shizuka, Okada Masashi, Yoshioka Takashi, Kitanaka Chifumi

    単著

  • Verteporfin inhibits oxidative phosphorylation and induces cell death specifically in glioma stem cells，FEBS JOURNAL，287(10) 2023-2036，2020年05月

    Kuramoto Kenta, Yamamoto Masahiro, Suzuki Shuhei, Sanomachi Tomomi, Togashi Keita, Seino Shizuka, Kitanaka Chifumi, Okada Masashi

    単著

  • Spironolactone, a Classic Potassium-Sparing Diuretic, Reduces Survivin Expression and Chemosensitizes Cancer Cells to Non-DNA-Damaging Anticancer Drugs，CANCERS，11(10) ，2019年10月

    Sanomachi Tomomi, Suzuki Shuhei, Togashi Keita, Sugai Asuka, Seino Shizuka, Okada Masashi, Yoshioka Takashi, Kitanaka Chifumi, Yamamoto Masahiro

    単著

  • Brexpiprazole Reduces Survivin and Reverses EGFR Tyrosine Kinase Inhibitor Resistance in Lung and Pancreatic Cancer，ANTICANCER RESEARCH，39(9) 4817-4828，2019年09月

    Sanomachi Tomomi, Suzuki Shuhei, Togashi Keita, Seino Shizuka, Yoshioka Takashi, Kitanaka Chifumi, Okada Masashi, Yamamoto Masahiro

    単著

  • Brexpiprazole, a Serotonin-Dopamine Activity Modulator, Can Sensitize Glioma Stem Cells to Osimertinib, a Third-Generation EGFR-TKI, via Survivin Reduction，CANCERS，11(7) ，2019年06月

    Suzuki Shuhei, Yamamoto Masahiro, Sanomachi Tomomi, Togashi Keita, Sugai Asuka, Seino Shizuka, Yoshioka Takashi, Kitanaka Chifumi, Okada Masashi

    単著

  • In vitro and in vivo anti-tumor effects of brexpiprazole, a newly-developed serotonin-dopamine activity modulator with an improved safety profile.，Oncotarget，10(37) 3547-3558，2019年05月

    Suzuki S, Yamamoto M, Togashi K, Sanomachi T, Sugai A, Seino S, Yoshioka T, Kitanaka C, Okada M

    単著

  • AS602801 Sensitizes Ovarian Cancer Stem Cells to Paclitaxel by Down-regulating MDR1，ANTICANCER RESEARCH，39(2) 609-617，2019年02月

    Yamamoto Masahiro, Suzuki Shuhei, Togashi Keita, Sanomachi Tomomi, Seino Shizuka, Kitanaka Chifumi, Okada Masashi

    単著

  • AS602801, an Anticancer Stem Cell Candidate Drug, Reduces Survivin Expression and Sensitizes A2780 Ovarian Cancer Stem Cells to Carboplatin and Paclitaxel，ANTICANCER RESEARCH，38(12) 6699-6706，2018年12月

    Yamamoto Masahiro, Suzuki Shuhei, Togashi Keita, Sanomachi Tomomi, Seino Shizuka, Kitanaka Chifumi, Okada Masashi

    単著

  • AS602801, an Anti-Cancer Stem Cell Drug Candidate, Suppresses Gap-junction Communication Between Lung Cancer Stem Cells and Astrocytes，ANTICANCER RESEARCH，38(9) 5093-5099，2018年09月

    Kuramoto Kenta, Yamamoto Masahiro, Suzuki Shuhei, Sanomachi Tomomi, Togashi Keita, Seino Shizuka, Kitanaka Chifumi, Okada Masashi

    単著

  • Involvement of GLUT1-mediated glucose transport and metabolism in gefitinib resistance of non-small-cell lung cancer cells.，Oncotarget，9(66) 32667-32679，2018年08月

    Suzuki S, Okada M, Takeda H, Kuramoto K, Sanomachi T, Togashi K, Seino S, Yamamoto M, Yoshioka T, Kitanaka C

    単著

  • A Small-molecule Kinase Inhibitor, CEP-1347, Inhibits Survivin Expression and Sensitizes Ovarian Cancer Stem Cells to Paclitaxel，ANTICANCER RESEARCH，38(8) 4535-4542，2018年08月

    Togashi Keita, Okada Masashi, Yamamoto Masahiro, Suzuki Shuhei, Sanomachi Tomomi, Seino Shizuka, Yamashita Hidetoshi, Kitanaka Chifumi

    単著

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