Yamagata University Faculty of Medicine, Professor and Chair, 2024.02 -

JAPAN SOCIETY FOR PEDIATRIC OTORHINOLARYNGOLOGY

THE JAPAN SOCIETY OF LOGOPEDICS AND PHONIATRICS

Association for Research in Otolaryngology

Japan Society for Head and Neck Cancer

International Working Group on Endoscopic Ear Surgery

Challenges for effective delivery of stem cells to the organ of Corti, 2015.04 - 2017.03

Regeneration of cochlear hair cell by transplantation of Multilineage-differentiating Stress Enduring (Muse) cell, 2015.04 - 2017.03

Multifaceted analysis of inner ear regeneration using Muse cells, 2016.04 - 2019.03

Regeneration of vestibular hair cells using Muse cell, 2016.04 - 2019.03

原著 動眼神経麻痺および外転神経麻痺を呈した副鼻腔悪性リンパ腫の1例, 耳鼻咽喉科・頭頸部外科, 96(11) 970-975, 2024.10

中村 美代子, 鈴木 祐輔, 千葉 真人, 天野 真太郎, 後藤 崇成, 新川 智佳子, 伊藤 吏

Single Author

Open-type cholesteatoma is the predictive factor for residual disease in congenital cholesteatoma treated with TEES, AURIS NASUS LARYNX, 51(5) 898-904, 2024.10

Kubota, T; Ito, T; Furukawa, T; Matsui, H; Goto, T; Shinkawa, C; Kakehata, S

Single Author

Estimation of Hearing Thresholds with Auditory Steady-State Responses to Narrow-Band Chirps in Children, AUDIOLOGY AND NEUROTOLOGY, 30(1) 89-100, 2024.09

Chiba, H; Ito, T; Kubota, T; Matsui, H; Shinkawa, C; Kakehata, S

Single Author

Comparison of auditory steady-state response thresholds and test time using narrow-band chirps in normal hearing adults, AUDIOLOGY JAPAN, 67(4) 260-266, 2024.08

Chiba Hiroyuki, Ito Tsukasa, Matsui Hirooki, Shinkawa Chikako, Amano Akiko, Abe Nozomi, Kakehata Seiji

Single Author

Ergonomics of Various Modalities for Ear Surgery, OTO OPEN, 8(3) e162, 2024.07

Lin, ME; Zhou, S; Kakeheta, S; Ito, T; Shibata, SB

Single Author

Clinical course of five patients definitively diagnosed with idiopathic perilymphatic fistula treated with transcanal endoscopic ear surgery, FRONTIERS IN NEUROLOGY, 15 1376949, 2024.03

Kubota, T; Ito, T; Furukawa, T; Matsui, H; Goto, T; Shinkawa, C; Matsuda, H; Ikezono, T; Kakehata, S

Single Author

特集 耳科診療の論点-異なる立場の対話とディベート- さまざまな手術法の中から 耳科手術の3鏡について-外視鏡のメリット,デメリット-, JOHNS, 40(3) 315-318, 2024.03

伊藤 吏

Single Author

Establishment of a Novel RNA Therapeutic Approach for Oral Cancer Using miR-223, CANCER SCIENCE, 115 1076, 2024.03

Sho, R; Zhang, XH; Chida, K; Ito, T; Tachibana, H; Souri, M; Konta, T

Single Author

The use of basic fibroblast growth factor to treat intractable Bell's palsy administered via transcanal endoscopic ear surgery, AMERICAN JOURNAL OF OTOLARYNGOLOGY, 45(1) 104020, 2024.01

Furukawa, T; Goto, T; Abe, Y; Sugiyama, M; Ito, T; Kubota, T; Matsui, H; Futai, K; Kakehata, S

Single Author

A case of a submucosal transglottic solitary fibrous tumor, JOURNAL OF JAPAN SOCIETY FOR HEAD AND NECK SURGERY, 34(1) 57-63, 2024

Abiko Yuko, Kurakami Kazuya, Chida Kuniaki, Yakuwa Shuichi, Kamata Kyohei, Hirano Yusuke, Ito Tsukasa, Kakehata Seiji

Single Author

Features and effectiveness of the next-generation ASSR, AUDIOLOGY JAPAN, 66(3) 186-194, 2023.06

Ito Tsukasa

Single Author

特集 内視鏡所見カラーアトラス-見極めポイントはここだ! 《耳領域》 外耳道・鼓膜-正常解剖/外耳道真珠腫/外耳道骨腫/中耳炎(慢性穿孔性・癒着性・真珠腫性)/コレステリン肉芽腫/グロムス腫瘍, 耳鼻咽喉科・頭頸部外科, 95(3) 198-203, 2023.03

松井 祐興, 伊藤 吏

Single Author

Actual Condition and Effect of Cochlear Implantation in Elderly Patients, Practica Oto-Rhino-Laryngologica, 116(7) 635-646, 2023

Hirano Yusuke, Shinkawa Chikako, Ito Tsukasa, Kubota Toshinori, Matsui Hirooki, Goto Takanari, Kakehata Seiji

Single Author

【内視鏡所見カラーアトラス】「外耳道・鼓膜」(特集), 医学書院「耳鼻咽喉科・頭頸部外科」, 95(3) 198-203, 2023

松井 祐興, 伊藤 吏

Single Author

Benefits of High-Dose Corticosteroid and Antiviral Agent Combination Therapy in the Treatment of House-Brackman Grade VI Ramsay Hunt Syndrome., Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2022.08

Furukawa T, Abe Y, Ito T, Kubota T, Hull M, Goto T, Sugiyama M, Kakehata S

Single Author

The Feasibility and Treatment Results of Transcanal Endoscopic Myringoplasty., Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 43(6) 650-656, 2022.07

Takatoshi Furukawa, Tsukasa Ito, Toshinori Kubota, Kazunori Futai, Hirooki Matsui, Seiji Kakehata

Single Author

Negative rate of the AR and positivity rate of the Metz test in patients with acute sensorineural hearing loss, AUDIOLOGY JAPAN, 64(4) 296-300, 2021.08

Toshinori Kubota, Tsukasa Ito, Hirooki Matsui, Chikako Shinkawa, Hiroyuki Chiba, Seiji Kakehata

Single Author

８．内視鏡下耳科手術, 日本耳鼻咽喉科学会会報, 2021.04

Tsukasa Ito

Single Author

Multicenter Study of Congenital Middle Ear Anomalies. Report on 246 Ears, The Laryngoscope, 131(7) E2323-E2328, 2021.03

Tsukasa Ito, Takatoshi Furukawa, Shinsuke Ohshima, Kuniyuki Takahashi, Yusuke Takata, Masayuki Furukawa, Harukazu Hiraumi, Daisuke Yamauchi, Yu Yuasa, Shinichi Goto, Akira Sasaki, Koh Koizumi, Koshi O...

Single Author

他覚的聴覚検査の革新, AUDIOLOGY JAPAN, 63(3) 163-173, 2020.06

Tsukasa Ito

Single Author

A new government program to aid in the purchase of hearing aids for children with mild or moderate hearing loss, AUDIOLOGY JAPAN, 63(4) 242-249, 2020

Matsui Hirooki, Ito Tsukasa, Kubota Toshinori, Shinkawa Chikako, Chiba Hiroyuki, Yonezawa Yumi, Kakehata Seiji

Single Author

Examination of the relationship between examination data and age-related hearing loss, AUDIOLOGY JAPAN, 63(4) 234-241, 2020

Inamura Kazutoshi, Matsui Hirooki, Ito Tsukasa, Kubota Toshinori, Kakehata Seiji

Single Author

Transcanal Endoscopic Ear Surgery for Congenital Cholesteatomas, Practica Oto-Rhino-Laryngologica, 113(12) 766-767, 2020

Ito Tsukasa

Single Author

経外耳道的内視鏡下耳科手術(TEES)に関するアンケート調査 2018, Otology Japan, 29(3) 259-266, 2019.09

伊藤 吏, 欠畑 誠治, 小島 博己, 金丸 眞一, 内田 真哉, 神崎 晶, 小林 泰輔, 西池 季隆, 堀 龍介, 松本 有, 水足 邦雄, 蓑田 涼生, 山内 大輔

Single Author

OTOF mutation analysis with massively parallel DNA sequencing in 2,265 Japanese sensorineural hearing loss patients, PLOS ONE, 14(5) 1-10, 2019.05

Iwasa Yoh-ichiro AND Nishio Shin-ya AND Sugaya Akiko AND Kataoka Yuko AND Kanda Yukihiko AND Taniguchi Mirei AND Nagai Kyoko AND Naito Yasushi AND Ikezono Tetsuo AND Horie Rie AND Sakurai Yuika AND Ma...

Single Author

Expression and localization of diacylglycerol kinase ζ in guinea pig cochlea and its functional implication under noise-exposure stress conditions., Histochemistry and cell biology, 151(6) 461-474, 2019.04

Shinkawa C, Ito T, Hozumi Y, Chiba M, Matsui H, Goto K, Kakehata S

Single Author

The Role of Powered Surgical Instruments in Ear Surgery: An Acoustical Blessing or a Curse?, Applied Sciences, 9(4) 765, 2019.02

Tsukasa Ito, Toshinori Kubota, Takatoshi Furukawa, Hirooki Matsui, Kazunori Futai, Melinda Hull, Seiji Kakehata

Single Author

当科における経外耳道的内視鏡下アブミ骨手術の工夫と術後成績, Otology Japan, 29(1) 52-57, 2019.02

浅野 敬史, 伊藤 吏, 窪田 俊憲, 古川 孝俊, 二井 一則, 新川 智佳子, 欠畑 誠治

Single Author

Long-term follow-up in cases of Alport syndrome, AUDIOLOGY JAPAN, 62(4) 299-306, 2019

Matsui Hirooki, Ito Tsukasa, Kubota Toshinori, Shinkawa Chikako, Chiba Hiroyuki, Yonezawa Yumi, Kakehata Seiji

Single Author

A retrospective analysis of postoperative hearing and complications following transcanal endoscopic stapes surgery (Postoperative outcomes of endoscopic stapes surgery), Otology Japan, 29(1) 52-57, 2019

Asano Takashi, Ito Tsukasa, Kubota Toshinori, Furukawa Takatoshi, Futai Kazunori, Shinkawa Chikako, Kakehata Seiji

Single Author

Efficacy of transcanal endoscopic ear surgery for congenital middle ear anomalies, Otology Japan, 29(2) 162-167, 2019

Saito Akiko, Ito Tsukasa, Kubota Toshinori, Furukawa Takatoshi, Futai Kazunori, Kakehata Seiji

Single Author

A case of superior semicircular canal dehiscence syndrome with functional convergence spasms, Equilibrium Research, 78(3) 178-184, 2019

Watanabe Chihiro, Owada Satoko, Ito Tsukasa, Murakami Shingo, Kakehata Seiji

Single Author

Setup of transcanal endoscopic ear surgery, Otolaryngology - Head and Neck Surgery (Japan), 91(11) , 2019

Ito, T.

Single Author

Comparison of Postoperative Pain in Patients Following Transcanal Endoscopic Versus Microscopic Ear Surgery., Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 39(7) 847-853, 2018.08

Kakehata S, Furukawa T, Ito T, Kubota T, Futai K, Watanabe T

Single Author

Two cases of systemic amyloidosis with macroglossia or submandibular swelling, Practica Otologica, Supplement, 152 56-57, 2018

Yoshihiro Onoe, Tomoo Watanabe, Takao Igarashi, Yasuhiro Abe, Takayoshi Waki, Tsukasa Ito, Shuji Koike, Nobuo Ohta, Seiji Kakehata

Single Author

Benefits of High-dose Steroid plus Hespander plus Mannitol Administration in the Treatment of Bell's Palsy, Otology & Neurotology, 38(2) 272-277, 2017

Furukawa T, Abe Y, Ito T, Kubota T, Kakehata S.

Single Author

乳幼児の他覚的聴力検査におけるCE-Chirp音を用いたABRとASSRの関連について, Audiology Japan, 60(5) 468, 2017

伊藤, 吏, 千葉, 寛之, 窪田, 俊憲 a, 新川, 智佳子, 米澤, 裕美, 阿部, 靖弘, 欠畑, 誠治

Single Author

Two Cases of Systemic Amyloidosis with Macroglossia or Submandibular Swelling, Practica Oto-Rhino-Laryngologica, 110(12) 815-821, 2017

Onoe Yoshihiro, Watanabe Tomoo, Igarashi Takao, Abe Yasuhiro, Waki Takayoshi, Ito Tsukasa, Koike Shuji, Ohta Nobuo, Kakehata Seiji

Single Author

Transcanal Endoscopic Ear Surgery for Lateralized Tympanic Membrane Arising as a Complication of Treatment for Langerhans Cell Histiocytosis, Practica Oto-Rhino-Laryngologica, 110(6) 379-384, 2017

Nakajima Sayuri, Ito Tsukasa, Watanabe Tomoo, Futai Kazunori, Kubota Toshinori, Chiba Makoto, Kakehata Seiji

Single Author

Safety of heat generated by endoscope light sources in simulated transcanal endoscopic ear surgery, Auris Nasus Larynx, 43(5) 501-6, 2016

Ito T, Kubota T, Takagi A, Watanabe T, Futai K, Furukawa T, Kakehata S.

Single Author

Extracranial Meningioma in the Frontal Sinus, Nihon Bika Gakkai Kaishi (Japanese Journal of Rhinology), 55(2) 141-146, 2016

Furukawa Takatoshi, Abe Yasuhiro, Ito Tsukasa, Kurakami Kazuya, Ohe Rintaro, Yamakawa Mitsunori, Kakehata Seiji

Single Author

Detectability and anatomical correlation of middle ear cholesteatoma using fused thin slice non-echo planar imaging diffusion-weighted image and magnetic resonance cisternography (FTS-nEPID), Magnetic Resonance Imaging, 33(10) 1253, 2015.12

Masafumi Kanoto, Yukio Sugai, Takaaki Hosoya, Yuuki Toyoguchi, Yoshihiro Konno, Fumika Watarai, Tsukasa Ito, Tomoo Watanabe, Seiji Kakehata

Single Author

The efficacy of color mapped fusion images in the diagnosis and treatment of cholesteatoma using transcanal endoscopic ear surgery., Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 36(5) 763-8, 2015.06

Tomoo Watanabe, Tsukasa Ito, Takatoshi Furukawa, Kazunori Futai, Toshinori Kubota, Masafumi Kanoto, Yuuki Toyoguchi, Takaaki Hosoya, Seiji Kakehata

Single Author

Transcanal endoscopic ear surgery for pediatric population with a narrow external auditory canal, Int J Pediatr Otorhinolaryngol, 79(12) 2265-9, 2015

Ito T, Kubota T, Watanabe T, Futai K, Furukawa T, Kakehata S.

Single Author

Orotate phosphoribosyltransferase localizes to the Golgi complex and its expression levels affect the sensitivity to anti-cancer drug 5-fluorouracil, Biomedical Research-Tokyo, 36(6) 403-409, 2015

Hozumi Y, Tanaka T, Nakano T, Matsui H, Nasu T, Koike S, Kakehata S, Ito T, Goto K.

Single Author

The Efficacy of Color-Mapped Diffusion-Weighted Images Combined With CT in the Diagnosis and Treatment of Cholesteatoma Using Transcanal Endoscopic Ear Surgery, Otology & Neurotology, 36(10) 1663-1668, 2015

Watanabe T, Ito T, Furukawa T, Futai K, Kubota T, Kanoto M, Toyoguchi Y, Hosoya T, Kakehata S.

Single Author

A Case of Sphenoidal Sinus Mucocele with Orbital-apex Syndrome, Jibi inkoka rinsho, 144 34-35, 2015

Takatoshi Furukawa, Nobuo Ohta, Tomoo Watanabe, Tsukasa Ito, Yusuke Suzuki, Seiji Kakehata

Single Author

聴性定常反応検査(ASSR)とその活用について, 日本耳鼻咽喉科学会会報, 118(10) 1250-1251, 2015

伊藤 吏

Single Author

Safety of Ultrasonic Bone Curette in Ear Surgery by Measuring Skull Bone Vibrations, Otology & Neurotology, 35(4) e135, 2014.04

Tsukasa Ito, Hideyuki Mochizuki, Tomoo Watanabe, Toshinori Kubota, Takatoshi Furukawa, Takuji Koike, Seiji Kakehata

Single Author

Feasibility and Advantages of Transcanal Endoscopic Myringoplasty, Otology & Neurotology, 35(4) e140, 2014.04

Takatoshi Furukawa, Tomoo Watanabe, Tsukasa Ito, Toshinori Kubota, Seiji Kakehata

Single Author

Frequency of mitochondrial mutations in non-syndromic hearing loss as well as possibly responsible variants found by whole mitochondrial genome screening, Journal of Human Genetics, 59(2) 100-106, 2014.02

Takuya Yano, Shin-Ya Nishio, Shin-Ichi Usami, Norihito Takeichi, Satoshi Fukuda, Atsushi Namba, Hideichi Shinkawa, Yumiko Kobayashi, Hiroaki Sato, Tetsuaki Kawase, Toshimitsu Kobayashi, Tomoo Watanabe...

Single Author

Extension of Indications for Transcanal Endoscopic Ear Surgery Using an Ultrasonic Bone Curette for Cholesteatomas, Otology & Neurotology, 35(1) 101, 2014.01

Seiji Kakehata, Tomoo Watanabe, Tsukasa Ito, Toshinori Kubota, Takatoshi Furukawa

Single Author

Mutation spectrum and genotype-phenotype correlation of hearing loss patients caused by SLC26A4 mutations in the Japanese: A large cohort study, Journal of Human Genetics, 59(5) 262-268, 2014

Maiko Miyagawa, Shin-Ya Nishio, Shin-Ichi Usami, Norihito Takeichi, Satoshi Fukuda, Atsushi Namba, Hideichi Shinkawa, Yumiko Kobayashi, Hiroaki Sato, Tetsuaki Kawase, Toshimitsu Kobayashi, Tomoo Watan...

Single Author

A case of pediatric bilateral facial nerve palsy secondary to acute otitis media, Otology Japan, 24(3) 221-226, 2014

Furukawa Takatoshi, Watanabe Tomoo, Ito Tsukasa, Kubota Toshinori, Inanura Hiroo, Kakehata Seiji

Single Author

【側頭骨実習の基礎】 経外耳道的内視鏡による中耳解剖, Otology Japan, 24(2) 137-143, 2014

伊藤 吏, 渡辺 知緒, 欠畑 誠治

Single Author

Powered Endoscopic Ear Surgery, Pract.Otol. (Kyoto), 106(3) 187-199, 2013.03

KAKEHATA Seiji, WATANABE Tomoo, ITO Tsukasa

Single Author

Clinical and pathological characteristics of organized hematoma., International journal of otolaryngology, 2013 539642, 2013

Nobuo Ohta, Tomoo Watanabe, Tsukasa Ito, Toshinori Kubota, Yusuke Suzuki, Akihiro Ishida, Masaru Aoyagi, Atsushi Matsubara, Kenji Izuhara, Seiji Kakehata

Single Author

Simultaneous screening of multiple mutations by invader assay improves molecular diagnosis of hereditary hearing loss: a multicenter study., PloS one, 2012.02

Usami S, Nishio SY, Nagano M, Abe S, Yamaguchi T, Deafness Gene Study Consortium

Single Author

Treatment of thyroglossal duct cysts by OK-432., The Laryngoscope, 122(1) 131-3, 2012.01

Nobuo Ohta, Shigeru Fukase, Tomoo Watanabe, Tsukasa Ito, Toshinori Kubota, Yusuke Suzuki, Masaru Aoyagi

Single Author

A case of sublingual dermoid cyst: extending the limits of the oral approach., Case reports in otolaryngology, 2012 634949, 2012

Nobuo Ohta, Tomoo Watanabe, Tsukasa Ito, Toshinori Kubota, Yusuke Suzuki, Akihiro Ishida, Seiji Kakehata, Masaru Aoyagi

Single Author

Detecting the recruitment phenomenon using the auditory steady-state response, AUDIOLOGY, 54(3) 222-229, 2011.06

KUBOTA Toshinori, ITO Tsukasa, WATANABE Tomoo, ABE Yasuhiro, CHIBA Hiroyuki, IKAWA Nobuko, SUZUKI Yutaka, AOYAGI Masaru

Single Author

Vibratory Stimulation Transmission Pathways Measured by Subjective Threshold and DPOAE, Pract.Otol.(Kyoto), (130) 1-8, 2011.03

WATANABE Tomoo, ITO Tsukasa, ABE Yasuhiro, KUBOTA Toshinori, CHIBA Hiroyuki, AOYAGI Masaru

Single Author

Clinical Observation and Application of Auditory Steady-State Response in Infants, Pract.Otol.(Kyoto), (130) 31-34, 2011.03

CHIBA Hiroyuki, WATANABE Tomoo, ITO Tsukasa, KUBOTA Toshinori, AOYAGI Masaru

Single Author

Clinical Efficacy of Arytenoid Adduction in Unilateral Vocal Cord Paralysis, Pract.Otol.(Kyoto), (130) 137-139, 2011.03

OHTA Nobuo, SUZUKI Yutaka, OKAZAKI Shinichi, KAWAGUCHI Kazuhiro, FURUSE Hidekazu, WAKI Takayoshi, OKAZAKI Masashi, KUBOTA Toshinori, ITO Tsukasa, WATANABE Tomoo, ABE Yasuhiro, AOYAGI Masaru

Single Author

Stapedius Reflex in Functional Hearing Loss, Pract.Otol.(Kyoto), (130) 26-30, 2011.03

KUBOTA Toshinori, WATANABE Tomoo, ITO Tsukasa, CHIBA Hiroyuki, AOYAGI Masaru

Single Author

Two Cases of Maxillary Sinus Hematocele Mimicking Malignant Tumors, Pract.Otol.(Kyoto), (130) 49-55, 2011.03

OHTA Nobuo, WATANABE Tomoo, ITO Tsukasa, KUBOTA Toshinori, SUZUKI Yusuke, ISHIDA Akihiro, ABE Yasuhiro, INAMURA Hiroo, AOYAGI Masaru

Single Author

A Case of Retropharyngeal Abscess Secondary to Pyogenic Spondylitis, Pract.Otol.(Kyoto), (130) 131-136, 2011.03

SHINKAWA Chikako, OHTA Nobuo, ITO Tsukasa, WATANABE Tomoo, KUBOTA Toshinori, INAMURA Kazutoshi, AOYAGI Masaru

Single Author

Increase of Th2 and Tc1 cells in patients with Kimura's disease., Auris, nasus, larynx, 38(1) 77-82, 2011.02

Ohta N, Fukase S, Suzuki Y, Ito T, Yoshitake H, Aoyagi M

Single Author

Bone conduction thresholds and skull vibration measured on the teeth during stimulation at different sites on the human head, Audiol Neurootol, 16(1) 12-22, 2011

Ito T, Roosli C, Kim C. J, Sim J. H, Huber A. M, Probst R.

Single Author

Expression of glucocorticoid receptor spliced variants in lymphoma cell lines, Hematological Oncology, 29(3) 147-150, 2011

Ishida A, Hozumi Y, Goto K, Ito T, Aoyagi M, Yamakawa M.

Single Author

前庭水管拡大症に対する人工内耳埋込術, 耳鼻咽喉科臨床 補冊, (補冊130) 14-17, 2011

伊藤 吏, 渡辺 知緒, 千葉 寛之, 窪田 俊憲, 後藤 崇成, 新川 智佳子, 太田 伸男, 川合 正和, 青柳 優

Single Author

心因性難聴における聴性定常反応ASSRの有用性, 耳鼻咽喉科臨床 補冊, (補冊130) 9-13, 2011

伊藤 吏, 渡辺 知緒, 阿部 靖弘, 窪田 俊憲, 千葉 寛之, 青柳 優

Single Author

日本耳科学会用語委員会報告 中耳真珠腫進展度分類2010改訂案, Otology Japan, 20(5) 743-753, 2010.12

東野 哲也, 青柳 優, 伊藤 吏, 奥野 妙子, 小島 博己, 比野平 恭之, 松田 圭二, 三代 康雄, 山本 裕, 日本耳科学会用語委員会

Single Author

A large cohort study of GJB2 mutations in Japanese hearing loss patients., Clinical genetics, 2010.11

Tsukada K, Nishio S, Usami S, Deafness Gene Study Consortium

Single Author

Effects and mechanism of OK-432 therapy in various neck cystic lesions., Acta oto-laryngologica, 130(11) 1287-92, 2010.11

Nobuo Ohta, Shigeru Fukase, Tomoo Watanabe, Tsukasa Ito, Masaru Aoyagi

Single Author

Relationship between stimulus intensity and power, latency and component synchrony measure (CSM) of autitory steady-state response (ASSR) in normal hearing adults : Analyzing recruitment phenomenon with ASSR, AUDIOLOGY, 53(4) 266-273, 2010.08

KUBOTA Toshinori, ITO Tsukasa, WATANABE Tomoo, ABE Yasuhiro, CHIBA Hiroyuki, IKAWA Nobuko, SUZUKI Yutaka, AOYAGI Masaru

Single Author

Endoscopic treatment of intranasal glioma in an infant presenting with dyspnea, Auris Nasus Larynx, 37(3) 373-6, 2010.06

Nobuo Ohta, Tsukasa Ito, Ayako Sasaki, Masaru Aoyagi

Single Author

成人における聴性定常反応の反応閾値に影響を及ぼす測定条件について, AUDIOLOGY JAPAN, 52(2) 120-125, 2009

Yasuhiro Abe, Tsukasa Ito, Tomoo Watanabe, Toshinori Kubota, Hiroyuki Chiba, Yutaka Suzuki, Masaru Aoyagi

Single Author

聴性定常反応の閾値に対する加算回数と背景ノイズの影響, Audiology Japan, 52(2) 126-132, 2009

伊藤 吏, 渡辺 知緒, 阿部 靖弘, 窪田 俊憲, 千葉 寛之, 青柳 優

Single Author

聴性定常反応の閾値に対する背景ノイズの影響, AUDIOLOGY JAPAN, 51(5) 481-482, 2008

TSUKASA ITO

Single Author

Differential subcellular targeting and activity-dependent subcellular localization of diacylglycerol kinase isozymes in transfected cells., European journal of cell biology, 86(8) 433-44, 2007.08

Naoki Kobayashi, Yasukazu Hozumi, Tsukasa Ito, Takaaki Hosoya, Hisatake Kondo, Kaoru Goto

Single Author

Clinical Study of Threshold Change by Objective Audiometry in Infants, Audiol Jpn, 50(3) 174-179, 2007.06

CHIBA Hiroyuki, WATANABE Tomoo, ITO Tsukasa, ABE Yasuhiro, AOYAGI Masaru

Single Author

Further examination After Newborn hearing screening in Yamagata prefecture, Audiology Japan, 50(3) 218-224, 2007.06

CHIBA Hiroyuki, ITO Tsukasa, WATANABE Tomoo, ABE Yasuhiro, INAMURA Hiroo, AOYAGI Masaru

Single Author

当科における鼓室形成術の聴力成績 伝音再建材料による検討, Otology Japan, 17(1) 9-15, 2007

伊藤 吏, 稲村 博雄, 渡辺 知緒, 阿部 靖弘, 青柳 優

Single Author

Gene expression and localization of diacylglycerol kinase isozymes in the rat spinal cord and dorsal root ganglia., Cell and tissue research, 326(1) 35-42, 2006.10

Hayato Sasaki, Yasukazu Hozumi, Hiroshi Hasegawa, Tsukasa Ito, Michiaki Takagi, Toshihiko Ogino, Masahiko Watanabe, Kaoru Goto

Single Author

聴性定常反応閾値に対する加算回数の影響, AUDIOLOGY JAPAN, 49(5) 493-494, 2006

TSUKASA ITO

Single Author

Usefulness of MASTER^【○!R】 as an objective audiometry for waking adults, 48(4) 266-273, 2005.08

ABE Yasuhiro, AOYAGI Masaru, ITO Tsukasa, WATANABE Tomoo, CHIBA Hiroyuki, SUZUKI Yutaka

Single Author

First bite syndrome after parotid surgery : Report of three cases, 15(1) 81-85, 2005.06

NASU Takashi, KOIKE Syuji, KOSYU Hidehiro, ITO Tsukasa, ABE Yasuhiro, AOYAGI Masaru

Single Author

Expression and localization of diacylglycerol kinase isozymes and enzymatic features in rat lung., American journal of physiology. Lung cellular and molecular physiology, 288(6) L1171-8, 2005.06

Yuji Katagiri, Tsukasa Ito, Sachiko Saino-Saito, Yasukazu Hozumi, Akira Suwabe, Kazuhisa Otake, Makoto Sata, Hisatake Kondo, Fumio Sakane, Hideo Kanoh, Isao Kubota, Kaoru Goto

Single Author

Gene expression, cellular localization, and enzymatic activity of diacylglycerol kinase isozymes in rat ovary and placenta., Cell and tissue research, 320(3) 525-33, 2005.06

Mayumi Toya, Yasukazu Hozumi, Tsukasa Ito, Morihiko Takeda, Fumio Sakane, Hideo Kanoh, Hidekazu Saito, Masahiko Hiroi, Hirohisa Kurachi, Hisatake Kondo, Kaoru Goto

Single Author

Clinical observation and application of multiple auditory steady-state response: MASTER, ＡＵＤＩＯＬＯＧＹ ＪＡＰＡＮ, 2005

Tsukasa Ito

Single Author

急性感音難聴を呈した脳幹部悪性リンパ腫症例, AUDIOLOGY JAPAN, 48(5) 495-496, 2005

TSUKASA ITO

Single Author

聴性定常反応を用いた他覚的聴力検査システムMASTERの有用性について, Audiology Japan, 48(2) 128-134, 2005

伊藤 吏, 渡辺 知緒, 阿部 靖弘, 千葉 寛之, 鈴木 豊, 青柳 優

Single Author

検査結果から考えるdecision making 他覚的聴力検査から考えること, 小児耳鼻咽喉科, 26(2) 32-36, 2005

伊藤 吏

Single Author

Analyses on the Organizing Mechanism of Amplitude Modulation Following Response, Audiology Japan, 47(4) 214-221, 2004.08

AOYAGI Masaru, SUZUKI Yutaka, WATANABE Tomoo, ITO Tsukasa

Single Author

Clinical Study Of Nonorganic Hearing Loss, Audiol Jpn, 47(3) 157-162, 2004.06

WATANABE Tomoo, ITO Tsukasa, AOYAGI Masaru

Single Author

Cloning and characterization of diacylglycerol kinase iota splice variants in rat brain, J Biol Chem, 279(22) 23317-26, 2004

Ito T, Hozumi Y, Sakane F, Saino-Saito S, Kanoh H, Aoyagi M, Kondo H, Goto K.

Single Author

Adenoid cystic carcinoma of the head and neck-report of 24 cases, Toukeibu Gan, 30(4) 594-599, 2004

Akihiro Ishida, Syuji Koike, Takashi Nasu, Tukasa Ito, Hiroo Inamura, Masaru Aoyagi, Tadashi Nakamura

Single Author

Correlation between clinical pathophysiologic features and expression of dihydropyrimidine dehydrogenase (DPD), thymidylate synthase (TS), and orotate phosphoribosyl transferase (OPRT) in head and neck cancer, Toukeibu Gan, 30(4) 657-661, 2004

Tsukasa Ito, Shuji Koike, Hidehiro Koshu, Takashi Nasu, Yasuhiro Abe, Hiroo Inamura, Masaru Aoyagi

Single Author

聴性定常反応を用いた他覚的聴力検査装置ＭＡＳＴＥＲの有用性について, AUDIOLOGY JAPAN, 47(5) 305-306, 2004

TSUKASA ITO

Single Author

ステロイド体存性感音難聴を呈した非典型的Cogan症候群, AUDIOLOGY JAPAN, 47(3) 175-180, 2004

Tsukasa Ito, Tomoo Watanabe, Masaru Aoyagi

Single Author

Nuclear localization of diacylglycerol kinase zeta in neurons, European Journal of Neuroscience, 18(6) 1448-1457, 2003

Hozumi Y, Ito T, Nakano T, Nakagawa T, Aoyagi M, Kondo H, Goto K.

Single Author

A Clinical Study on Deep Neck Infections, Pract.Otol. (Kyoto), 96(10) 919-924, 2003

Nasu Takashi, Koike Syuji, Inamura Hiroo, Suzuki Yutaka, Akatsuka Naoko, Ito Tsukasa, Nakamura Tadashi, Aoyagi Masaru

Single Author

非典型的 Cogan 症候群の一症例, ＡＵＤＩＯＬＯＧＹ ＪＡＰＡＮ, 2003

Tsukasa Ito

Single Author

当科における両側性顔面神経麻痺症例の検討, Facial Nerve Research, 22 120-122, 2002.12

川口 和浩, 稲村 博雄, 多田 雄一郎, 高橋 伸明, 伊藤 吏, 甲州 秀浩, 青柳 優

Single Author

Sudden-onset tinnitus associated with arterial dissection of the vertebrobasilar system, Acta Oto-Laryngologica, 29-33, 2000

Yokota M, Ito T, Hosoya T, Suzuki Y, Aoyagi M.

Single Author

Sudden-onset tinnitus associated with arterial dissection of the vertebrobasilar system, Acta Oto-Laryngologica, Supplement, (542) 29-33, 2000

Masashi Yokota, Tukasa Ito, Takaaki Hosoya, Yutaka Suzuki, Masaru Aoyagi

Single Author

Reliability of 80-Hz amplitude-modulation-following response detected by phase coherence, Audiology and Neuro-Otology, 4(1) 28-37, 1999

Aoyagi M, Suzuki Y, Yokota M, Furuse H, Watanabe T, Ito T.

Single Author

Clinical Application of 80-Hz Amplitude Modulation Following Response., AUDIOLOGY, 41(3) 221-227, 1998

Aoyagi Masaru, Yokota Masashi, Suzuki Yutaka, Watanabe Tomoo, Ito Tsukasa

Single Author

松果体部髄膜腫に合併した耳鳴症例, AUDIOLOGY JAPAN, 41(4) 334-339, 1998

Tsukasa Ito, Masashi Yokota, Yutaka Suzuki, Satoshi Itoh, Masaru Aoyagi, Shinjiro Saito, Takamasa Kayama

Single Author

【"みみ・はな"私のday & short stay surgery-適応と限界-】中耳手術【各論】day & short stay 中耳手術の実際 入院期間短縮を目指した経外耳道的内視鏡下耳科手術, (株)全日本病院出版会, ENTONI, (235) 41-48, 2019.08

伊藤 吏, 欠畑 誠治

【目からウロコ 内視鏡時代の臨床解剖】 耳領域 鼓室形成術における中耳解剖, 耳鼻咽喉科・頭頸部外科, 90(6) 398-404, 2018

伊藤 吏, 欠畑 誠治

【目からウロコ 内視鏡時代の臨床解剖】 耳領域 鼓室形成術における中耳解剖, 耳鼻咽喉科・頭頸部外科, 90(6) 398-404, 2018

伊藤 吏, 欠畑 誠治

突発性難聴の治療に関するシステマティックレビュー, (一社)日本耳科学会, Otology Japan, 27(4) 441, 2017.10

神崎 晶, 西尾 信哉, 武田 英彦, 岡田 昌浩, 藤岡 正人, 寺西 正明, 伊藤 吏, 菅原 一真, 内田 育恵, 狩野 章太郎, 小川 洋, 鬼頭 良輔, 曾根 三千彦, 羽藤 直人, 小川 郁, 宇佐美 真一

【中耳・内耳疾患を見逃さない!】 中耳真珠腫, ENTONI, (208) 1-7, 2017.07

伊藤 吏

【臨床力UP! 耳鼻咽喉科検査マニュアル】聴覚検査 聴性定常反応検査, 耳鼻咽喉科・頭頸部外科, 89(5) 68-73, 2017.04

伊藤 吏

耳鼻咽喉科内視鏡手術における自動追従型手台[iArmS]の有用性について, 耳鼻咽喉科臨床学会, 耳鼻咽喉科臨床 補冊, (補冊139) 64, 2014.06

工 穣, 塚田 景大, 宇佐美 真一, 坂本 達則, 中川 隆之, 伊藤 壽一, 渡辺 知緒, 伊藤 吏, 欠畑 誠治, 鴻 信義, 小島 博己, 小林 正佳, 竹内 万彦

【内視鏡でどこまでわかるか-最新のトピックス】 鼓室内は何がどうみえるか?, JOHNS, 30(2) 171-175, 2014

伊藤 吏, 欠畑 誠治

【検査結果をどう読むか?】 聴覚領域の検査 聴性脳幹反応検査、聴性定常反応検査, JOHNS, 29(9) 1483-1488, 2013

伊藤 吏

【診療所の外来でできる手術】 鼓膜形成術、鼓室形成術, JOHNS, 29(7) 1113-1118, 2013

伊藤 吏, 欠畑 誠治

【最新の診療NAVI 日常診療必携】 外傷診療NAVI 側頭骨骨折, 耳鼻咽喉科・頭頸部外科, 84(5) 163-168, 2012

伊藤 吏, 欠畑 誠治

【耳鼻咽喉科専門研修をはじめる医師へ 疼痛への対応】 帯状疱疹,Hunt症候群, 耳鼻咽喉科・頭頸部外科, 83(3) 191-195, 2011.03

伊藤, 吏, 稲村, 博雄, 青柳, 優

知っておきたい生理・病態の基礎 顔面知覚, 耳鼻咽喉科・頭頸部外科, 82(4) 327-332, 2010.04

伊藤, 吏, 青柳, 優

【お母さんへの回答マニュアル耳鼻咽喉科Q&A 2010】 顔面・頸部編 ある日突然、子どもが顔面神経麻痺になりました。原因は何でしょうか?治りますか?, JOHNS, 26(9) 1524-1526, 2010

伊藤 吏, 青柳 優

【耳鼻咽喉科・頭頸部外科の検査マニュアル 方法・結果とその解釈】 聴覚検査 聴性定常反応検査, 耳鼻咽喉科・頭頸部外科, 82(5) 71-79, 2010

伊藤 吏, 青柳 優

Grant-in-Aid for Scientific Research(C)，2021.04 - 2023.03

Grant-in-Aid for Scientific Research(C)，2020.04 - 2023.03

Grant-in-Aid for Scientific Research(B)，2020.04 - 2021.03

Grant-in-Aid for Scientific Research(B)，2018.04 - 2019.03

Grant-in-Aid for Scientific Research(C)，2017.04 - 2020.03

Grant-in-Aid for Young Scientists(B)，2004.04 - 2007.03

Study for the curative treatment of middle ear cholesteatoma by regeneration of middle ear mucosa using autologous stem cell induction，2017.04 - 2021.03，Study for the curative treatment of middle ear cholesteatoma by regeneration of middle ear mucosa using autologous stem cell induction

A model of middle ear mucosal damage was established using guinea pigs. Via transcanal approach using a 1.9 mm rigid endoscope under general anesthesia, the middle ear mucosa in the ciliated epithelial region around the Eustachian tube was scraped after opening the anterior tympanic membrane. Histological evaluation of the mucosal damage site by HE staining at 2 weeks postoperatively showed that the ciliated epithelial cells had disappeared and the normal mucosa had not regenerated in the mucosal damage model.
We attempted to regenerate the mucosa of the middle ear by topically administering high-mobility group box 1 (HMGB1), a molecule that acts in tissue repair through induction of autologous bone marrow mesenchymal stromal cells, but found increased abnormal granulation tissue and submucosal bone thickening at the site of mucosal damage, suggesting that HMGB1 rather promotes an inflammatory response.

Japan Society for the Promotion of Science

Development of Novel Objective Audiometry Based on Auditory Steady State Response and Sleep Stage Analysis，2012.04 - 2015.03，Development of Novel Objective Audiometry Based on Auditory Steady State Response and Sleep Stage Analysis

Auditory steady-state response (ASSR) is a frequency-specific response. It is used to objectively evaluate the hearing level in sleeping young infants. To investigate the influence of sleep stage on ASSR, we measured the thresholds of ASSR and recorded electroencephalographic data to determine the sleep stage simultaneously. The thresholds of ASSR were especially lower in stage N3 (deep sleep) and REM (rapid eye movement sleep) Hence, sleep stage should be taken into account when estimating the hearing level from ASSR. Simultaneous measurements of ASSR and sleep stage are very difficult and complicated using commercially available equipment. Thus we are developing the new system to measure both of ASSR and sleep stage and to estimate the hearing level form ASSR thresholds with revision by sleep stage.

Japan Society for the Promotion of Science

The research and development of the new objective audiometry technique using an auditory steady-state response (ASSR) in sleeping subjects，2009 - 2010，The research and development of the new objective audiometry technique using an auditory steady-state response (ASSR) in sleeping subjects

We analyzed the ASSR signal in contrast to the background noise at different sleep stages. The noise level was especially low in stage N3 (deep sleep) and REM (rapid eye movement sleep), whereas there was no significant difference in the response signals among sleep stages. Consequently, the signal-to-noise ratio (SNR) was high in both stage N2, N3 and REM. Hence, sleep stage should be taken into account when estimating the hearing level fromASSR.

Japan Society for the Promotion of Science

Development of regenerative therapy targeting synapses between inner hair cells and cochlear nerves，2020.04 - 2023.03，Development of regenerative therapy targeting synapses between inner hair cells and cochlear nerves

Recent studies have focused on the pathogenesis of Cochlear Synaptopathy, a synaptic pathology between inner hair cells and the cochlear nerve, as an early lesion in noise-induced, drug-induced, and age-related hearing loss. In this study, we investigated the regenerative effects of ROCK inhibitors on cochlear synaptopathy in an in vivo experimental system and examined the effects of ROCK inhibitors on the Cochlear synaptopathy model by laser-induced shockwave (LISW). 10 mM local administration of ROCK inhibitor showed a reappearance of ABR I wave amplitude and an increase in the number of synapses.

Japan Society for the Promotion of Science

Development of regenerative therapy targeting synapses between inner hair cells and cochlear nerves，2020.04 - 2023.03，Development of regenerative therapy targeting synapses between inner hair cells and cochlear nerves

Recent studies have focused on the pathogenesis of Cochlear Synaptopathy, a synaptic pathology between inner hair cells and the cochlear nerve, as an early lesion in noise-induced, drug-induced, and age-related hearing loss. In this study, we investigated the regenerative effects of ROCK inhibitors on cochlear synaptopathy in an in vivo experimental system and examined the effects of ROCK inhibitors on the Cochlear synaptopathy model by laser-induced shockwave (LISW). 10 mM local administration of ROCK inhibitor showed a reappearance of ABR I wave amplitude and an increase in the number of synapses.

Japan Society for the Promotion of Science

Challenge to development of new regenerative therapy targeting synapses between hair cells and auditory nerve fibers，2017.06 - 2021.03，Challenge to development of new regenerative therapy targeting synapses between hair cells and auditory nerve fibers

Inner ear regeneration is one of the unsolved themes in therapeutic research for hearing impairment. In this study, we challenged the development of a new therapeutic method targeting auditory nerve-inner hair cell synapses based on the new pathological concepts of primary neural degeneration and cochlear synaptopathy.
Rho-associated coiled-coil containing protein kinase (ROCK) inhibitors has been reported to have neuroprotective and regenerative effects on synaptic pathways. Therefore, we analyzed the effect of ROCK inhibitions in a model of peripheral axonal damage in the spiral ganglion neurons induced by the glutamate agonists, N-methyl-D-aspartate (NMDA) and kainic acid in the explanted cochlea.
This study suggested that ROCK inhibitors would be a potentially therapeutic candidate for the regeneration of peripheral axons and synaptic reformation in the cochlea.

Japan Society for the Promotion of Science

Regeneration of vestibular hair cells using Muse cell，2016.04 - 2019.03，Regeneration of vestibular hair cells using Muse cell

We confirmed many advantages such as stable inner ear injury, sufficient weight gain, and no death after administration of gentamicin (40 mg / ml) to the guinea pig tympanic cavity. In addition, it was confirmed that the tissue damage was hair cells only, and the tissue morphology of the surrounding environment such as supporting cells was maintained. In these models, MUSE cells were administered, and at 2 weeks, it was confirmed that the transplanted cells were engrafted in vestibular tissue.

Japan Society for the Promotion of Science

Multifaceted analysis of inner ear regeneration using Muse cells，2016.04 - 2019.03，Multifaceted analysis of inner ear regeneration using Muse cells

We examined the possibility of functional regeneration by transplanting Muse cells,a type of the pluripotent stem cell, to the injured inner ear in this study. Inner ear regeneration mechanism of Muse cells engrafted in the cochlea differentiate into inner ear cell lineage by their specific microenvironment and self repair of inner ear hair cells and synapses by trophic factor of Muse cells were analyzed in multiple aspects functionally, morphologically and immunohistologically using a guinea pig inner ear injury model and mouse inner ear three-dimensional organ culture.From this study, possibility of improvement of hearing by Muse cells in the guinea pig inner ear injury model was shown and Muse cells themselves have the possibility of differentiating to nerves in inner ear three-dimensional organ culture.

Japan Society for the Promotion of Science

Regeneration of cochlear hair cell by transplantation of Multilineage-differentiating Stress Enduring (Muse) cell，2015.04 - 2017.03，Regeneration of cochlear hair cell by transplantation of Multilineage-differentiating Stress Enduring (Muse) cell

First I made a inner ear degeneration model by band noise exposure. Noise frequency was from 4 to 8 kHz and its sound presser was 130 dBSPL. This condition can make a permanent threshold shift of hearing. I transplanted 10,000 Muse cells into scala tympani of this model using micro catheter 1 day after noise exposure. the hearing threshold recovered significantly on Muse transplanted ear at the area of 4 and 8 kHz from 6 weeks after noise exposure to the end point.I counted the rest of outer hair cell at 12 weeks after noise exposure, this revealed that more outer hair cells were alive in Muse transplanted group than control at 8 kHz area with a statistically significant difference. Now we are investigating whether Muse cells can migrate and engraft to the damaged organ of Corti and differentiate into hair cells or hair cell progenitor cells.

Japan Society for the Promotion of Science

Challenges for effective delivery of stem cells to the organ of Corti，2015.04 - 2017.03，Challenges for effective delivery of stem cells to the organ of Corti

Approximately 250-350g, male Hartley strain guinea pigs were exposed to 4-8 kHz octave-band noise at 136 dB sound pressure level (SPL) for 2 hours in the sound proof box under general anesthesia. All the animals were measured their ABR threshold before and 24 hours, 1 week and 2 weeks after the noise exposure to confirm the permanent threshold shift. The ABR threshold of 2 weeks after the noise exposure showed profound deafness. Cochlear frequency mapping was performed with ImageJ plugin to identify the tonotopic area, demonstrating that outer hair cells were disappeared.
Multilineage-differentiating stress-enduring (Muse) cells were transplanted into the Scala tympani of the severely damaged animals of the number of 10,000 or 30,000 cells through a micro catheter. ABR of the transfected ears did not show evident hearing improvement compared to the control group. Immunohistochemistrical data show no GFP-positive cells alive in the cochlear.

Japan Society for the Promotion of Science

Effect of transplanting normal human dermal fibroblasts (NHDF) in the rat facial nerve palsy model，2013.04 - 2015.03，Effect of transplanting normal human dermal fibroblasts (NHDF) in the rat facial nerve palsy model

Objective: To determine the effect of transplanting normal human dermal fibroblasts (NHDF) in the rat facial nerve palsy model. Methods: Eight weeks old Wister male rats (250g) were used. Facial nerves were transected at buccal branch and marginal branch in 6 mm length under general anesthesia. Polimer tubes filled with NHDF plus matrigel were grafted between the cut nerves. Wisking amplitude was measured to determine the facial nerve function. Result: Wisking amplitude was gradually recovered in 8 week. However, the effect of NHDF was not significant.

Japan Society for the Promotion of Science

Immunohistochemical and molecular biological study on expression of diacylglycrol kinase in human origined malignant tumor cells from head and neck，2003 - 2004，Immunohistochemical and molecular biological study on expression of diacylglycrol kinase in human origined malignant tumor cells from head and neck

Diacylglycerol (DG) is one of the important second messengers, which serves as an activator of protein kinase C (PKC). DG kinase (DGK) phosphorylates DG to generate phosphatidic acid, thus DGK is considered to be a regulator of PKC activity through attenuation of DG. Recent studies have revealed molecular structures of several DGK isozymes from mammalian species, and showed that most of the isozymes are expressed ih the brain in various amounts. Five DGK isozyme cDNA have been cloned from rat brain library (DGKα, -β, -γ, -ζ, -ι) in Department of Anatomy and cell biology, Yamagata University School of medicine. mRNA expressions of DGK isozymes in rat brain have been studied by in situ hybridization histochemistry, but their mRNA expressions in human malignant tumor cells, especially epithelial cells, have not been examined. In this study, we examined the mRNA expression of DGK isozymes in human squamous cell carcinoma cell lines. To study the localization and functional role of DGKζ, we generated the specific antibody against rat DGKζ and examined the specificity of the antibody. Furthermore, human malignant tumor cell has been cultured with DGK inhibitors and it was revealed that DGK inhibitor might suppress cell growth. It shows that DGK may have some relations to the molecular mechanism of cell growth.

Japan Society for the Promotion of Science

Clinical Application of Auditory Steady-State Response evoked by multiple simultaneous amplitude-modulated stimuli (amplitude-modulation following response : AMFR) for Assessment of hearing in infants and young children，2001 - 2002，Clinical Application of Auditory Steady-State Response evoked by multiple simultaneous amplitude-modulated stimuli (amplitude-modulation following response : AMFR) for Assessment of hearing in infants and young children

In recent years newborn hearing screening has been widely implemented using automated ABR screener and EOAE test unit. However, hearing threshold prediction and follow-up evaluation using traditional ABR technique cannot provide sufficient information in a frequency-specific manner. Thus, it is necessary to develop new tests to obtain detailed information from specific cochlear regions. Our study is indicated about new detection algorithm to use multiple simultaneous amplitude-modulated stimuli and separate analysis for each MF with phase coherence. The responses for each MF are separated with software-triggering from the averaged waveforms to obtain using simultaneously multiple amplitude-modulated tones, from which the phase coherence value is calculated for each MF. Test reliability of SSR using simultaneously multiple amplitude-modulated stimuli (Four-CF combined stimulus in MFs around 40 HZ) with our detection algorithm was evaluated among normal-hearing adults and comparison with resulting in mono AM tone was performed. In addition examples of puretone audiograms and thresholds estimated from SSR using simultaneously multiple ampliude-modulated stimuli were demonstrated in adult subjects with hearing impairment. The new algorithm for response detection of SSR using simultaneously multiple amplitude-modulated stimuli at the optimal modulation rates is expected in clinical use for assessment of hearing in infants and young children.

Japan Society for the Promotion of Science

the 12th Asia Pacific Symposium on Cochlear Implants and Related Sciences, International presentation, 2019.11, Endoscope-assisted cochlear implantation in patients with middle ear disease., Other

the 12th Asia Pacific Symposium on Cochlear Implants and Related Sciences, International presentation, 2019.11, Endoscope-assisted cochlear implantation in patients with middle ear disease., Poster presentation

World Congress on Endoscopic Ear Surgery 3.0, International presentation, 2019.06, Current Status of Transcanal Endoscopic Ear Surgery (TEES) in Japan – Results Of A Questionnaire To Representatives of The Japan Otological Society In 2018, Other

World Congress on Endoscopic Ear Surgery 3.0, International presentation, 2019.06, Current Status of Transcanal Endoscopic Ear Surgery (TEES) in Japan – Results Of A Questionnaire To Representatives of The Japan Otological Society In 2018, Poster presentation

World Congress on Endoscopic Ear Surgery 3.0, International presentation, 2019.06, Clinical Outcome of The Endoscopic Ear Surgery for Pars Tensa Cholesteatoma, Other

World Congress on Endoscopic Ear Surgery 3.0, International presentation, 2019.06, Clinical Outcome of The Endoscopic Ear Surgery for Pars Tensa Cholesteatoma, Oral presentation (general)

Surgical seminar: Transcanal endoscopic ear surgery, International presentation, 2019.05, Surgical seminar: Transcanal endoscopic ear surgery, Other

International Congress of ORL-HNS 2019, International presentation, 2019.04, Transcanal Endoscopic Ear Surgery for Congenital Cholesteatoma, Other

International Congress of ORL-HNS 2019, International presentation, 2019.04, Transcanal Endoscopic Ear Surgery for Congenital Cholesteatoma, Symposium, workshop panel (nominated)

The 6th East Asian Symposium on Otology, International presentation, 2018.05, Feasibility and Safety of Transcanal Endoscopic Ear Surgery with Powered Instruments., Other

The 6th East Asian Symposium on Otology, International presentation, 2018.05, Feasibility and Safety of Transcanal Endoscopic Ear Surgery with Powered Instruments., Oral presentation (general)

The 17th Korea-Japan Joint Meeting of ​Otorhinolaryngology-Head and Neck Surgery, International presentation, 2018.04, Transcanal Endoscopic Ear Surgery for Children, Other

The 17th Korea-Japan Joint Meeting of ​Otorhinolaryngology-Head and Neck Surgery, International presentation, 2018.04, Transcanal Endoscopic Ear Surgery for Children, Symposium, workshop panel (nominated)

The 14th Taiwan-Japan Conference on Otolaryngology-Head and Neck Surgery, International presentation, 2017.12, Feasibility of Transcanal Endoscopic Ear Surgery for Pediatric Patients with a Narrow External Auditory Canal, Symposium, workshop panel (nominated)

100 Years Otorhinolaryngology, International presentation, 2017.08 - 2017.09, Symposium: Feasibility and safety of transcanal endoscopic ear surgery: TEES, Symposium, workshop panel (nominated)