2023/11/21 更新

写真a

フジイ ジユンイチ
藤井 順逸
FUJII Junichi
職名
教授

研究分野

  • ライフサイエンス / 病態医化学

  • ライフサイエンス / 医化学

出身大学

  • 静岡大学  理学部

    1982年03月,卒業

出身大学院

  • 静岡大学  生物科学研究科

    修士課程,1984年03月,修了

  • 大阪大学  医学研究科

    博士課程,1988年03月,修了

取得学位

  • 理学修士,静岡大学,1994年03月

  • 博士(医学),大阪大学,1988年03月

所属学会・委員会

  • 日本生化学会

  • 日本分子生物学会

  • 日本癌学会

  • 日本酸化ストレス学会

 

研究テーマ

  •  生活習慣病や老化に深くかかわる活性酸素による病気の発症と、それに対する防御機構に関して、分子レベルの基礎的研究を行っています。活性酸素は様々な環境要因で生じますが、酸素呼吸に伴い身体の中でも常に生じています。各種ストレス下ではその生成が増し、病気の原因もしくは増悪因子となっていると考えられています。こうした活性酸素から身を護り健康な生活を行えるように、とりわけシステイン-グルタチオン代謝系とフェロトーシス誘導の分子機構に着目して研究を行っています。

研究経歴

  • 筋小胞体カルシウム輸送の分子機構,1987年01月 ~ 1991年03月

論文

  • Nitric oxide produced by NOS2 copes with the cytotoxic effects of superoxide in macrophages.,Biochemistry and biophysics reports,26 100942,2021年07月

    Kobayashi S, Homma T, Fujii J

    単著

  • Superoxide produced by mitochondrial complex III plays a pivotal role in the execution of ferroptosis induced by cysteine starvation.,Archives of biochemistry and biophysics,700 108775,2021年03月

    Homma T, Kobayashi S, Sato H, Fujii J

    単著

  • Developmental retardation in neonates of aldehyde reductase (AKR1A)-deficient mice is associated with low ascorbic acid and high corticosterone levels.,The Journal of nutritional biochemistry,108604,2021年02月

    Ishii N, Homma T, Takeda Y, Naing YA, Yamada KI, Miyata S, Asao H, Yamakawa M, Fujii J

    単著

  • Characterization of a rat monoclonal antibody raised against ferroptotic cells,JOURNAL OF IMMUNOLOGICAL METHODS,489 112912,2021年02月

    Kobayashi Sho, Harada Yumi, Homma Takujiro, Yokoyama Chikako, Fujii Junichi

    単著

  • Defective biosynthesis of ascorbic acid in Sod1-deficient mice results in lethal damage to lung tissue.,Free radical biology & medicine,162 255-265,2021年01月

    Homma T, Takeda Y, Nakano T, Akatsuka S, Kinoshita D, Kurahashi T, Saitoh S, Yamada KI, Miyata S, Asao H, Goto K, Watanabe T, Watanabe M, Toyokuni S, Fujii J

    単著

  • Testis-specific peroxiredoxin 4 variant is not absolutely required for spermatogenesis and fertility in mice,SCIENTIFIC REPORTS,10(1) 17934,2020年10月

    Homma Takujiro, Kurahashi Toshihiro, Ishii Naoki, Shirasawa Nobuyuki, Fujii Junichi

    単著

  • Ascorbic acid prevents N-nitrosodiethylamine-induced hepatic injury and hepatocarcinogenesis in Akr1a-knockout mice,TOXICOLOGY LETTERS,333 192-201,2020年10月

    Ishii Naoki, Homma Takujiro, Guo Xin, Yamada Ken-ichi, Yamada Sohsuke, Fujii Junichi

    単著

  • Iron loading exerts synergistic action via a different mechanistic pathway from that of acetaminophen-induced hepatic injury in mice,FREE RADICAL RESEARCH,54(8-9) 606-619,2020年09月

    Moon Gyul, Kobayashi Sho, Naing Ye Aung, Yamada Ken-ichi, Yamakawa Mitsunori, Fujii Junichi

    単著

  • Cysteine preservation confers resistance to glutathione-depleted cells against ferroptosis via CDGSH iron sulphur domain-containing proteins (CISDs),FREE RADICAL RESEARCH,54(6) 397-407,2020年06月

    Homma Takujiro, Kobayashi Sho, Fujii Junichi

    単著

  • Genetic ablation of aldehyde reductase (Akr1a) augments exercise endurance in mice via activation of the PGC-1 alpha-involved pathway,LIFE SCIENCES,249 117501,2020年05月

    Takahashi Miku, Homma Takujiro, Yamada Ken-ichi, Miyata Satoshi, Nakajima Osamu, Fujii Junichi

    単著

  • gamma-Glutamylcysteine synthetase and gamma-glutamyl transferase as differential enzymatic sources of gamma-glutamylpeptides in mice,AMINO ACIDS,52(4) 555-566,2020年04月

    Kobayashi Sho, Ikeda Yoshitaka, Shigeno Yuhei, Konno Hiroyuki, Fujii Junichi

    単著

  • Ascorbic acid and CoQ(10) ameliorate the reproductive ability of superoxide dismutase 1-deficient female mice,BIOLOGY OF REPRODUCTION,102(1) 102-115,2020年01月

    Ishii Naoki, Homma Takujiro, Lee Jaeyong, Mitsuhashi Hikaru, Yamada Ken-ichi, Kimura Naoko, Yamamoto Yorihiro, Fujii Junichi

    単著

  • Heterozygous SOD1 deficiency in mice with an NZW background causes male infertility and an aberrant immune phenotype,FREE RADICAL RESEARCH,53(11-12) 1060-1072,2019年12月

    Homma Takujiro, Takeda Yuji, Sakahara Satoshi, Ishii Naoki, Kobayashi Sho, Abe Hiroyuki, Asao Hironobu, Fujii Junichi

    単著

  • Ascorbic acid insufficiency impairs spatial memory formation in juvenile AKR1A-knockout mice,JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION,65(3) 209-216,2019年11月

    Kurihara Kazuki, Homma Takujiro, Kobayashi Sho, Shichiri Mototada, Fujiwara Hiroki, Fujii Satoshi, Yamada Ken-ichi, Nakane Masaki, Kawamae Kaneyuki, Fujii Junichi

    単著

  • Edaravone, a free radical scavenger, protects against ferroptotic cell death in vitro,EXPERIMENTAL CELL RESEARCH,384(1) 111592,2019年11月

    Homma Takujiro, Kobayashi Sho, Sato Hideyo, Fujii Junichi

    単著

  • Induction of ferroptosis by singlet oxygen generated from naphthalene endoperoxide,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,518(3) 519-525,2019年10月

    Homma Takujiro, Kobayashi Sho, Fujii Junichi

    単著

  • Oxidative stress triggers systemic organ disorders associated with impaired lipid catabolism in mice during fasting,FREE RADICAL BIOLOGY AND MEDICINE,139 S29,2019年08月

    Homma Takujiro, Lee Jaeyong, Kobayashi Sho, Ishii Naoki, Fujii Junichi

    単著

  • A heterozygous deficiency in protein phosphatase Ppm1b results in an altered ovulation number in mice.,Molecular medicine reports,19(6) 5353-5360,2019年06月

    Ishii N, Homma T, Watanabe R, Kimura N, Ohnishi M, Kobayashi T, Fujii J

    共著(国内のみ)

  • An SOD1 deficiency aggravates proteasome inhibitor bortezomib-induced testicular damage in mice.,Biochimica et biophysica acta. General subjects,1863(6) 1108-1115,2019年06月

    Homma T, Fujii J

    共著(国内のみ)

  • Quantitative analysis of γ-glutamylpeptides by liquid chromatography-mass spectrometry and application for γ-glutamyltransferase assays.,Analytical biochemistry,578 13-22,2019年05月

    Kobayashi S, Tokairin Y, Miyakoshi T, Saito T, Nagaoka K, Ikeda Y, Fujii J, Konno H

    共著(国内のみ)

  • The Association of Peroxiredoxin 4 with the Initiation and Progression of Hepatocellular Carcinoma,ANTIOXIDANTS & REDOX SIGNALING,30(10) 1271-1284,2019年04月

    Guo Xin, Noguchi Hirotsugu, Ishii Naoki, Homma Takujiro, Hamada Taiji, Hiraki Tsubasa, Zhang Jing, Matsuo Kei, Yokoyama Seiya, Ishibashi Hiroaki, Fukushige Tomoko, Kanekura Takuro, Fujii Junichi, Uram...

    共著(国内のみ)

  • Elevated ER stress exacerbates dextran sulfate sodium-induced colitis in PRDX4-knockout mice.,Free radical biology & medicine,134 153-164,2018年12月

    Takagi T, Homma T, Fujii J, Shirasawa N, Yoriki H, Hotta Y, Higashimura Y, Mizushima K, Hirai Y, Katada K, Uchiyama K, Naito Y, Itoh Y

    共著(国内のみ)

  • Expression of TRPM8 in human reactive lymphoid tissues and mature B-cell neoplasms,ONCOLOGY LETTERS,16(5) 5930-5938,2018年11月

    Hirai Akinori, Aung Naing Ye, Ohe Rintaro, Nishida Akiko, Kato Tomoya, Meng Hongxue, Ishizawa Kenichi, Fujii Junichi, Yamakawa Mitsunori

    共著(国内のみ)

  • Mutual interaction between oxidative stress and endoplasmic reticulum stress in the pathogenesis of diseases specifically focusing on non-alcoholic fatty liver disease.,World journal of biological chemistry,9(1) 1-15,2018年10月

    Fujii J, Homma T, Kobayashi S, Seo HG

    共著(国内のみ)

  • Mice deficient in aldo-keto reductase 1a (Akr1a) are resistant to thioacetamide-induced liver injury,TOXICOLOGY LETTERS,294 37-43,2018年09月

    Homma Takujiro, Shirato Takaya, Akihara Ryusuke, Kobayashi Sho, Lee Jaeyong, Yamada Ken-ichi, Miyata Satoshi, Takahashi Motoko, Fujii Junichi

    共著(国内のみ)

  • Unveiling systemic organ disorders associated with impaired lipid catabolism in fasted SOD1-deficient mice,ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,654 163-171,2018年09月

    Lee Jaeyong, Homma Takujiro, Kobayashi Sho, Ishii Naoki, Fujii Junichi

    共著(国内のみ)

  • Cystine/glutamate transporter, system x(c)(-), is involved in nitric oxide production in mouse peritoneal macrophages,NITRIC OXIDE-BIOLOGY AND CHEMISTRY,78 32-40,2018年08月

    Kobayashi Sho, Hamashima Shinji, Homma Takujiro, Sato Mami, Kusumi Ryosuke, Bannai Shiro, Fujii Junichi, Sato Hideyo

    共著(国内のみ)

  • Potential involvement of ubiquitin-proteasome system dysfunction associated with oxidative stress in the pathogenesis of sickle cell disease,BRITISH JOURNAL OF HAEMATOLOGY,182(4) 559-566,2018年08月

    Warang Prashant, Homma Takujiro, Pandya Riddhi, Sawant Anuja, Shinde Nikhil, Pandey Debjeet, Fujii Junichi, Madkaikar Manisha, Mukherjee Malay B.

    共著(海外含む)

  • Double Knockout of Peroxiredoxin 4 (Prdx4) and Superoxide Dismutase 1 (Sod1) in Mice Results in Severe Liver Failure,OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2018 2812904,2018年

    Homma Takujiro, Kurahashi Toshihiro, Lee Jaeyong, Nabeshima Atsunori, Yamada Sohsuke, Fujii Junichi

    共著(国内のみ)

  • The viability of primary hepatocytes is maintained under a low cysteine-glutathione redox state with a marked elevation in ophthalmic acid production,EXPERIMENTAL CELL RESEARCH,361(1) 178-191,2017年12月

    Lee Jaeyong, Kang Eun Sil, Kobayashi Sho, Homma Takujiro, Sato Hideyo, Seo Han Geuk, Fujii Junichi

    共著(国内のみ)

  • Increased ophthalmic acid production is supported by amino acid catabolism under fasting conditions in mice,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,491(3) 649-655,2017年09月

    Kobayashi Sho, Lee Jaeyong, Takao Toshifumi, Fujii Junichi

    共著(国内のみ)

  • Mice in the early stage of liver steatosis caused by a high fat diet are resistant to thioacetamide-induced hepatotoxicity and oxidative stress,TOXICOLOGY LETTERS,277 92-103,2017年08月

    Lee Jaeyong, Homma Takujiro, Fujii Junichi

    共著(国内のみ)

  • Macrophages from xCT-deficient mice survive under low cysteine/glutathione redox conditions with high oxidative stress,FREE RADICAL BIOLOGY AND MEDICINE,108 S52,2017年07月

    Kobayashi Sho, Hamashima Shinji, Homma Takujiro, Fujii Junichi, Sato Hideyo

    共著(国内のみ)

  • Protective role of testis-specific peroxiredoxin 4 against cellular oxidative stress,JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION,60(3) 156-161,2017年05月

    Tasaki Eisuke, Matsumoto Shotaro, Tada Hisashi, Kurahashi Toshihiro, Zhang Xuhong, Fujii Junichi, Utsumi Toshihiko, Iuchi Yoshihito

    共著(国内のみ)

  • Oxidative stress caused by a SOD1 deficiency ameliorates thioacetamide-triggered cell death via CYP2E1 inhibition but stimulates liver steatosis,ARCHIVES OF TOXICOLOGY,91(3) 1319-1333,2017年03月

    Shirato Takaya, Homma Takujiro, Lee Jaeyong, Kurahashi Toshihiro, Fujii Junichi

    共著(国内のみ)

  • Heightened aggressive behavior in mice deficient in aldo-keto reductase 1a (Akr1a),BEHAVIOURAL BRAIN RESEARCH,319 219-224,2017年02月

    Homma Takujiro, Akihara Ryusuke, Okano Satoshi, Shichiri Mototada, Yoshida Yasukazu, Yamada Ken-ichi, Miyata Satoshi, Nakajima Osamu, Fujii Junichi

    共著(国内のみ)

  • [Oxidative damage on blood cells and blood-associated autoimmune diseases].,Seikagaku. The Journal of Japanese Biochemical Society,89(1) 81-5,2017年02月

    Konno T, Fujii J

    共著(国内のみ)

  • A high-fat diet temporarily renders Sod1-deficient mice resistant to an oxidative insult,JOURNAL OF NUTRITIONAL BIOCHEMISTRY,40 44-52,2017年02月

    Ito Junitsu, Ishii Naoki, Akihara Ryusuke, Lee Jaeyong, Kurahashi Toshihiro, Homma Takujiro, Kawasaki Ryo, Fujii Junichi

    共著(国内のみ)

  • A high fat diet temporarily renders Sod1-deficient mice resistant to an oxidative insult.,J Nutr Biochem,40 44-52,2017年

    Junitsu Ito, Naoki Ishii, Ryusuke Akihara, Jaeyong Lee, Toshihiro Kurahashi, Takujiro Homma, Ryo Kawasaki, Junichi Fujii

    共著(国内のみ)

  • Heightened aggressive behavior in mice deficient in aldo-keto reductase 1a (Akr1a),Behav Brain Res,319 219-224,2017年

    Takujiro Homma, Ryusuke Akihara, Satoshi Okano, Mototada Shichiri, Yasukazu Yoshida, Ken-ichi Yamada, Satoshi Miyata, Osamu Nakajima, Junichi Fujii

    共著(国内のみ)

  • Oxidative stress caused by a SOD1 deficiency ameliorates thioacetamide-triggered cell death via CYP2E1 inhibition but stimulates liver steatosis.,Arch Toxicol,91 1319-1333,2017年

    Takaya Shirato, Takujiro Homma, Jaeyong Lee, Toshihiro Kurahashi, Junichi Fujii.

    共著(海外含む)

  • Protective role of testis-specific peroxiredoxin 4 against cellular oxidative stress.,J Clin Biochem Nutr,60 156-161,2017年

    Eisuke Tasaka, Shotaro Matsumoto, Hisashi Tada, Toshihiro Kurahashi, Xuhong Zhang, Junichi Fujii, Toshihiko Utsumi, Yoshihito Iuchi

    共著(海外含む)

  • xCT deficiency aggravates acetaminophen-induced hepatotoxicity under inhibition of the transsulfuration pathway,Free Radic Res,51 80-90,2017年

    Eun Sil Kang, Jaeyong Lee, Takujiro Homma, Toshihiro Kurahashi, Sho Kobayashi, Atsunori Nabeshima, Sohsuke Yamada, Han Geuk Seo, Satoshi Miyata, Hideyo Sato, Junichi Fujii

    共著(海外含む)

  • Mice in the early stage of liver steatosis caused by a high fat diet are resistant to thioacetamide-induced hepatotoxicity and oxidative stress,Toxicol Lett,277 92-103,2017年

    Jaeyong Lee, Takujiro Homma, Junichi Fujii

    共著(海外含む)

  • Increased ophthalmic acid production is supported by amino acid catabolism under fasting conditions in mice,Biochem Biophys Res Commun,491 649-655,2017年

    Sho Kobayashi, Jaeyong Lee, Toshifumi Takao, Junichi Fujii

    共著(国内のみ)

  • Decreased reproductive performance in xCT-knockout male mice,Free Radic Res,51 851-860,2017年

    Shinji Hamashima, Takujiro Homma, Sho Kobayashi, Naoki Ishii, Toshihiro Kurahashi, Ren Watanabe, Naoko Kimura, Hideyo Sato, Junichi Fujii

    共著(海外含む)

  • The viability of primary hepatocytes is maintained under a low cysteine-glutathione redox state with a marked elevation in ophthalmic acid production,Exp Cell Res,361 178-191,2017年

    Jaeyong Lee, Eun Sil Kang, Sho Kobayashi, Takujiro Homma, Hideyo Sato, Han Geuk Seo, Junichi Fujii

    共著(海外含む)

  • Decreased reproductive performance in xCT-knockout male mice,FREE RADICAL RESEARCH,51(9-10) 851-860,2017年

    Hamashima Shinji, Homma Takujiro, Kobayashi Sho, Ishii Naoki, Kurahashi Toshihiro, Watanabe Ren, Kimura Naoko, Sato Hideyo, Fujii Junichi

    共著(国内のみ)

  • xCT deficiency aggravates acetaminophen-induced hepatotoxicity under inhibition of the transsulfuration pathway,FREE RADICAL RESEARCH,51(1) 80-90,2017年

    Kang Eun Sil, Lee Jaeyong, Homma Takujiro, Kurahashi Toshihiro, Kobayashi Sho, Nabeshima Atsunori, Yamada Sohsuke, Seo Han Geuk, Miyata Satoshi, Sato Hideyo, Fujii Junichi

    共著(海外含む)

  • Heat stress promotes the down-regulation of IREl alpha in cells: An atypical modulation of the UPR pathway,EXPERIMENTAL CELL RESEARCH,349(1) 128-138,2016年11月

    Homma Takujiro, Fujii Junichi

    共著(国内のみ)

  • SOD1-Knockout Mice Are Resistant to Lethal Effects of Thioacetamide-Induced Hepatotoxicity,FREE RADICAL BIOLOGY AND MEDICINE,100 S99,2016年11月

    Homma Takujiro, Shirato Takaya, Lee Jaeyong, Kurahashi Toshihiro, Fujii Junichi

    共著(国内のみ)

  • Ablation of aldehyde reductase aggravates carbon tetrachloride-induced acute hepatic injury involving oxidative stress and endoplasmic reticulum stress,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,478(2) 765-771,2016年09月

    Akihara Ryusuke, Homma Takujiro, Lee Jaeyong, Yamada Ken-ichi, Miyata Satoshi, Fujii Junichi

    共著(国内のみ)

  • Ascorbic acid prevents acetaminophen-induced hepatotoxicity in mice by ameliorating glutathione recovery and autophagy,ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,604 36-46,2016年08月

    Kurahashi Toshihiro, Lee Jaeyong, Nabeshima Atsunori, Homma Takujiro, Kang Eun Sil, Saito Yuka, Yamada Sohsuke, Nakayama Toshiyuki, Yamada Ken-ichi, Miyata Satoshi, Fujii Junichi

    共著(国内のみ)

  • Trichloroethylene exposure aggravates behavioral abnormalities in mice that are deficient in superoxide dismutase,REGULATORY TOXICOLOGY AND PHARMACOLOGY,79 83-90,2016年08月

    Otsuki Noriyuki, Homma Takujiro, Fujiwara Hiroki, Kaneko Kenya, Hozumi Yasukazu, Shichiri Mototada, Takashima Mizuki, Ito Junitsu, Konno Tasuku, Kurahashi Toshihiro, Yoshida Yasukazu, Goto Kaoru, Fuji...

    共著(国内のみ)

  • Overexpression of Peroxiredoxin 4 Affects Intestinal Function in a Dietary Mouse Model of Nonalcoholic Fatty Liver Disease,PLOS ONE,11(4) e0152549,2016年04月

    Nawata Aya, Noguchi Hirotsugu, Mazaki Yuichi, Kurahashi Toshihiro, Izumi Hiroto, Wang Ke-Yong, Guo Xin, Uramoto Hidetaka, Kohno Kimitoshi, Taniguchi Hatsumi, Tanaka Yoshiya, Fujii Junichi, Sasaguri Ya...

    共著(国内のみ)

  • Heat stress promotes the down-regulation of IRE1α in cells: An atypical modulation of the UPR pathway,Exp Cell Res,349 128-138 ,2016年

    Homma T, Fujii J

    共著(海外含む)

  • Ablation of aldehyde reductase aggravates carbon tetrachloride-induced acute hepatic injury involving oxidative stress and endoplasmic reticulum stress,Biochem Biophys Res Commun,478 765-771,2016年

    Akihara R, Homma T, Lee J, Yamada K, Miyata S, Fujii J

    共著(海外含む)

  • Ascorbic acid prevents acetaminophen-induced hepatotoxicity in mice by ameliorating glutathione recovery and autophagy,Arch Biochem Biophys,604 36-46,2016年

    Kurahashi T, Lee J, Nabeshima A, Homma T, Kang ES, Saito Y, Yamada S, Nakayama T, Yamada KI, Miyata S, Fujii J

    共著(海外含む)

  • The SOD1 transgene expressed in erythroid cells alleviates fatal phenotype in congenic NZB/NZW-F1 mice,Free Radic Res,50 793-800,2016年

    Otsuki N, Konno T, Kurahashi T, Suzuki S, Lee J, Okada F, Iuchi Y, Homma T,  Fujii J.

    共著(海外含む)

  • Characteristics of skeletal muscle fibers of SOD1 knockout mice.,Oxid Med Cell Longev,9345970,2016年

    Nagahisa H, Okabe K, Iuchi Y, Fujii J, Miyata H.

    共著(海外含む)

  • Trichloroethylene exposure aggravates behavioral abnormalities in mice that are deficient in superoxide dismutase.,Regul Toxicol Pharmacol.,79 83-90,2016年

    Otsuki N, Homma T, Fujiwara H, Kaneko K, Hozumi Y, Shichiri M, Takashima M, Ito J, Konno T, Kurahashi T, Yoshida Y, Goto K, Fujii S, Fujii J

    共著(海外含む)

  • Overexpression of Peroxiredoxin 4 Affects Intestinal Function in a Dietary Mouse Model of Nonalcoholic Fatty Liver Disease.,PLoS One,11 e0152549,2016年

    Nawata A, Noguchi H, Mazaki Y, Kurahashi T, Izumi H, Wang KY, Guo X, Uramoto H, Kohno K, Taniguchi H, Tanaka Y, Fujii J, Sasaguri Y, Tanimoto A, Nakayama T, Yamada S.

    共著(海外含む)

  • Characteristics of Skeletal Muscle Fibers of SOD1 Knockout Mice,OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2016 9345970,2016年

    Nagahisa Hiroshi, Okabe Kazuma, Iuchi Yoshihito, Fujii Junichi, Miyata Hirofumi

    共著(国内のみ)

  • The SOD1 transgene expressed in erythroid cells alleviates fatal phenotype in congenic NZB/NZW-F1 mice,FREE RADICAL RESEARCH,50(7) 793-800,2016年

    Otsuki Noriyuki, Konno Tasuku, Kurahashi Toshihiro, Suzuki Saori, Lee Jaeyong, Okada Futoshi, Iuchi Yoshihito, Homma Takujiro, Fujii Junichi

    共著(国内のみ)

  • An SOD1 deficiency enhances lipid droplet accumulation in the fasted mouse liver by aborting lipophagy,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,467(4) 866-871,2015年11月

    Kurahashi Toshihiro, Hamashima Shinji, Shirato Takaya, Lee Jaeyong, Homma Takujiro, Kang Eun Sil, Fujii Junichi

    共著(国内のみ)

  • SOD1 deficiency decreases proteasomal function, leading to the accumulation of ubiquitinated proteins in erythrocytes,ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,583 65-72,2015年10月

    Homma Takujiro, Kurahashi Toshihiro, Lee Jaeyong, Kang Eun Sil, Fujii Junichi

    共著(国内のみ)

  • Oxidative stress triggers lipid droplet accumulation in primary cultured hepatocytes by activating fatty acid synthesis,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,464(1) 229-235,2015年08月

    Lee Jaeyong, Homma Takujiro, Kurahashi Toshihiro, Kang Eun Sil, Fujii Junichi

    共著(国内のみ)

  • SOD1 deficiency induces the systemic hyperoxidation of peroxiredoxin in the mouse,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,463(4) 1040-1046,2015年08月

    Homma Takujiro, Okano Satoshi, Lee Jaeyong, Ito Junitsu, Otsuki Noriyuki, Kurahashi Toshihiro, Kang Eun Sil, Nakajima Osamu, Fujii Junichi

    共著(国内のみ)

  • Physiological and pathological views of peroxiredoxin 4,FREE RADICAL BIOLOGY AND MEDICINE,83 373-379,2015年06月

    Fujii Junichi, Ikeda Yoshitaka, Kurahashi Toshihiro, Homma Takujiro

    共著(国内のみ)

  • Roles of Antioxidative Enzymes in Wound Healing,JOURNAL OF DEVELOPMENTAL BIOLOGY,3(2) 57-70,2015年06月

    Kurahashi Toshihiro, Fujii Junichi

    共著(国内のみ)

  • Oxidative stress as a potential causal factor for autoimmune hemolytic anemia and systemic lupus erythematosus.,World journal of nephrology,4(2) 213-22,2015年05月

    Fujii J, Kurahashi T, Konno T, Homma T, Iuchi Y

    共著(国内のみ)

  • Prdx4 is a compartment-specific H2O2 sensor that regulates neurogenesis by controlling surface expression of GDE2,NATURE COMMUNICATIONS,6 7006,2015年05月

    Yan Ye, Wladyka Cynthia, Fujii Junichi, Sockanathan Shanthini

    共著(海外含む)

  • Cystathionine Is a Novel Substrate of Cystine/Glutamate Transporter IMPLICATIONS FOR IMMUNE FUNCTION,JOURNAL OF BIOLOGICAL CHEMISTRY,290(14) 8778-8788,2015年04月

    Kobayashi Sho, Sato Mami, Kasakoshi Takayuki, Tsutsui Takumi, Sugimoto Masahiro, Osaki Mitsuhiko, Okada Futoshi, Igarashi Kiharu, Hiratake Jun, Homma Takujiro, Conrad Marcus, Fujii Junichi, Soga Tomoy...

    共著(海外含む)

  • An SOD1 deficiency enhances lipid droplet accumulation in the fasted mouse liver by aborting lipophagy,Biochem Biophys Res Commun,,in press ,2015年

    Toshihiro Kurahashi, Shinji Hamashima, Takaya Shirato, Jaeyong Lee, Takujiro Homma, Eun Sil Kang, Junichi Fujii.

    共著(海外含む)

  • Cystathionine is a novel substrate ofcystine/glutamate transporter: implications forimmune function.,J Biol Chem,290 8778-8788,2015年

    Sho Kobayashi, Mami Sato, Takayuki Kasakoshi, Takumi Tsutsui, Masahiro Sugimoto, Mitsuhiko Osaki, Futoshi Okada, Kiharu Igarashi,Jun Hiratake, Takujiro Homma, Marcus Conrad, Junichi Fujii, Tomoyoshi S...

    共著(海外含む)

  • Prdx4 is a compartment-specific H2O2 sensor that regulates neurogenesis by controlling surface expression of GDE2.,Nat Commun,6 7006,2015年

    Ye Yan, Cynthia Wladyka, Junichi Fujii, Shanthini Sockanathan.

    共著(海外含む)

  • SOD1 deficiency induces the systemic hyperoxidation of peroxiredoxin in the mouse.,Biochem Biophys Res Commun,463 1040-1046,2015年

    Takujiro Homma, Satoshi Okano, Jaeyong Lee, Junitsu Ito, Noriyuki Otsuki, Toshihiro Kurahashi, Eun Sil Kang, Osamu Nakajima, Junichi Fujii.

    共著(海外含む)

  • Oxidative stress triggers lipid droplet accumulation in primary cultured hepatocytes by activating fatty acid synthesis.,Biochem Biophys Res Commun,464 229-235,2015年

    Jaeyong Lee, Takujiro Homma, Toshihiro Kurahashi, Eun Sil Kang, Junichi Fujii.

    共著(海外含む)

  • SOD1 deficiency decreases proteasomal function, leading to the accumulation of ubiquitinated proteins in erythrocytes. ,Arch Biochem Biophys,583 65-72,2015年

    Takujiro Homma, Toshihiro Kurahashi, Jaeyong Lee, Eun Sil Kang, Junichi Fujii

    共著(海外含む)

  • Application of Glutathione as Anti-Oxidative and Anti-Aging Drugs,CURRENT DRUG METABOLISM,16(7) 560-571,2015年

    Homma Takujiro, Fujii Junichi

    共著(国内のみ)

  • Reductive detoxification of acrolein as a potential role for aldehyde reductase (AKR1A) in mammals,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,452(1) 136-141,2014年09月

    Kurahashi Toshihiro, Kwon Myoungsu, Homma Takujiro, Saito Yuka, Lee Jaeyong, Takahashi Motoko, Yamada Ken-ichi, Miyata Satoshi, Fujii Junichi

    共著(国内のみ)

  • Redox reactions in mammalian spermatogenesis and the potential targets of reactive oxygen species under oxidative stress.,Spermatogenesis,4(2) e979108,2014年05月

    Fujii J, Imai H

    共著(国内のみ)

  • Oxidative stress and redox regulation of gametogenesis, fertilization, and embryonic development.,Reproductive medicine and biology,13(2) 71-79,2014年04月

    Tsunoda S, Kimura N, Fujii J

    共著(国内のみ)

  • Ascorbic acid reverses the prolonged anesthetic action of pentobarbital in Akr1a-knockout mice,LIFE SCIENCES,95(1) 1-8,2014年01月

    Ito Junitsu, Otsuki Noriyuki, Zhang Xuhong, Konno Tasuku, Kurahashi Toshihiro, Takahashi Motoko, Yamato Mayumi, Matsuoka Yuta, Yamada Ken-ichi, Miyata Satoshi, Fujii Junichi

    共著(国内のみ)

  • Ascorbic acid reverses the prolonged anesthetic action of pentobarbital in Akr1a-knockout mice.,Life Science,95 1-8,2014年

    unitsu Ito, Noriyuki Otsuki, Xuhong Zhang, Tasuku Konno, Toshihiro Kurahashi, Motoko Takahashi, Mayumi Yamato, Yuta Matsuoka, Ken-ichi Yamada, Satoshi Miyata, Junichi Fujii.

    共著(海外含む)

  • Kidney fibrosis is independent of the amount of ascorbic acid in mice with unilateral ureteral obstruction.,Free Radic Res,48 1115--1124,2014年

    Hayato Nishida, Toshihiro Kurahashi, Yuka Saito, Noriyuki Otsuki, Myoungsu Kwon, Hiroya Ohtake, Mitsunori Yamakawa, Ken-ichi Yamada, Satoshi Miyata, Yoshihiko Tomita, Junichi Fujii.

    共著(海外含む)

  • Reductive detoxification of acrolein as a potential role for aldehyde reductase (AKR1A) in mammals. ,Biochem Biophys Res Commun,452 136-141,2014年

    Toshihiro Kurahashi, Myoungsu Kwon, Takujiro Homma, Yuka Saito, Jaeyong Lee, Motoko Takahashi, Ken-ichi Yamada, Satoshi Miyata, Junichi Fujii.

    共著(海外含む)

  • Peroxiredoxin 4 Protects Against Nonalcoholic Steatohepatitis and Type 2 Diabetes in a Nongenetic Mouse Model,ANTIOXIDANTS & REDOX SIGNALING,19(17) 1983-1998,2013年12月

    Nabeshima Atsunori, Yamada Sohsuke, Guo Xin, Tanimoto Akihide, Wang Ke-Yong, Shimajiri Shohei, Kimura Satoshi, Tasaki Takashi, Noguchi Hirotsugu, Kitada Shohei, Watanabe Teruo, Fujii Junichi, Kohno Ki...

    共著(国内のみ)

  • Reactive oxygen species exacerbate autoimmune hemolytic anemia in New Zealand Black mice,FREE RADICAL BIOLOGY AND MEDICINE,65 1378-1384,2013年12月

    Konno Tasuku, Otsuki Noriyuki, Kurahashi Toshihiro, Kibe Noriko, Tsunoda Satoshi, Iuchi Yoshihito, Fujii Junichi

    共著(国内のみ)

  • Differential responses of SOD1-deficient mouse embryonic fibroblasts to oxygen concentrations,ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,537(1) 5-11,2013年09月

    Tsunoda Satoshi, Kibe Noriko, Kurahashi Toshihiro, Fujii Junichi

    共著(国内のみ)

  • Upregulation of fatty acid synthesis and the suppression of hepatic triglyceride lipase as a direct cause of hereditary postprandial hypertriglyceridemia in rabbits,JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION,53(2) 114-121,2013年09月

    Fukuda Naoki, Ito Tsunekata, Ohwada Kazuo, Fujii Junichi

    共著(国内のみ)

  • Peroxiredoxin 4 Protects Against Nonalcoholic Steatohepatitis and Type 2 Diabetes in a Nongenetic Mouse Model.,Antioxid. Redox Signal,19 1983-1998,2013年

    Atsunori Nabeshima, Sohsuke Yamada, Xin Guo, Akihide Tanimoto, Ke-Yong Wang, Shohei Shimajiri, Satoshi Kimura, Takashi Tasaki, Hirotsugu Noguchi, Shohei Kitada, Teruo Watanabe, Junichi Fujii, Kimito...

    共著(海外含む)

  • Differential responses of SOD1-deficient mouse embryonic fibroblasts to oxygen concentrations.,Arch. Biochem. Biophys,537 5-11,2013年

    Satoshi Tsunoda, Noriko Kibe, Toshihiro Kurahashi, Junichi Fujii.

    共著(海外含む)

  • Upregulation of fatty acid synthesis and the suppression of hepatic triglyceride lipase as a direct cause of hereditary postprandial hypertriglyceridemia in rabbits,J. Clin. Biochem. Nutr.,53 114-121,2013年

    Naoki Fukuda, Tsunekata Ito, Kazuo Ohwada, Junichi Fujii.

    共著(海外含む)

  • Reactive oxygen species exacerbate autoimmune hemolytic anemia in New Zealand black mice.,Free Radic. Biol. Med. ,65 1378-1384,2013年

    Tasuku Konno, Noriyuki Otsuki, Toshihiro Kurahashi, Noriko Kibe, Satoshi Tsunoda, Yoshihito Iuchi, Junichi Fujii.

    共著(海外含む)

  • Enhanced expression of cystine/glutamate transporter in the lung caused by the oxidative-stress-inducing agent paraquat,FREE RADICAL BIOLOGY AND MEDICINE,53(12) 2197-2203,2012年12月

    Kobayashi Sho, Kuwata Kazuho, Sugimoto Takayuki, Igarashi Kiharu, Osaki Mitsuhiko, Okada Futoshi, Fujii Junichi, Bannai Shiro, Sato Hideyo

    共著(国内のみ)

  • A malfunction in triglyceride transfer from the intracellular lipid pool to apoB in enterocytes of SOD1-deficient mice,FEBS LETTERS,586(24) 4289-4295,2012年12月

    Kurahashi Toshihiro, Konno Tasuku, Otsuki Noriyuki, Kwon Myoungsu, Tsunoda Satoshi, Ito Junitsu, Fujii Junichi

    共著(国内のみ)

  • Impaired Fertilizing Ability of Superoxide Dismutase 1-Deficient Mouse Sperm During In Vitro Fertilization,BIOLOGY OF REPRODUCTION,87(5) 121,2012年11月

    Tsunoda Satoshi, Kawano Natsuko, Miyado Kenji, Kimura Naoko, Fujii Junichi

    共著(国内のみ)

  • In vivo role of aldehyde reductase,BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS,1820(11) 1787-1796,2012年11月

    Takahashi Motoko, Miyata Satoshi, Fujii Junichi, Inai Yoko, Ueyama Shigemitsu, Araki Motoko, Soga Tomoyoshi, Fujinawa Reiko, Nishitani Chiaki, Ariki Shigeru, Shimizu Takeyuki, Abe Tomomi, Ihara Yoshit...

    共著(国内のみ)

  • Endoplasmic Reticulum Thiol Oxidase Deficiency Leads to Ascorbic Acid Depletion and Noncanonical Scurvy in Mice,MOLECULAR CELL,48(1) 39-51,2012年10月

    Zito Ester, Hansen Henning Gram, Yeo Giles S. H., Fujii Junichi, Ron David

    共著(海外含む)

  • Measurement of peroxiredoxin-4 serum levels in rat tissue and its use as a potential marker for hepatic disease,MOLECULAR MEDICINE REPORTS,6(2) 379-384,2012年08月

    Ito Ritsu, Takahashi Motoko, Ihara Hideyuki, Tsukamoto Hiroki, Fujii Junichi, Ikeda Yoshitaka

    共著(国内のみ)

  • In vivo role of aldehyde reductase.,Bichim Biophys Acta,1820 1787-1796,2012年

    Motoko Takahashi, Satoshi Miyata, Junichi Fujii, Yoko Inai, Shigemitsu Ueyama, Motoko Araki, Tomoyoshi Soga, Reiko Fujinawa, Chiaki Nishitani, Shigeru Ariki, Takeyuki Shimizu; Tomomi Abe, Yoshito Ihar...

    共著(海外含む)

  • Measurement of Peroxiredoxin-4 in Rat Tissues and Implication of Its Serum Levels as a Potential Marker for Hepatic Disease. ,Mol Med Report,6 379-384,2012年

    Ritsu Ito, Motoko Takahashi, Hideyuki Ihara, Hiroki Tsukamoto, Junichi Fujii, Yoshitaka Ikeda

    共著(海外含む)

  • Impaired fertilizing ability of Sod1-deficient mouse sperm during in-vitro fertilization. ,Biol Reprod,87 1-6 ,2012年

    Satoshi Tsunoda, Natsuko Kawano, Kenji Miyado, Naoko Kimura, Junichi Fujii.

    共著(海外含む)

  • Endoplasmic reticulum thiol oxidase deficiency leads to ascorbic acid depletion and noncanonical scurvy in mice. ,Mol Cell,48 39-51,2012年

    Ester Zito, Henning Gram Hansen, Giles S. H. Yeo, Junichi Fujii, David Ron.

    共著(海外含む)

  • A malfunction in the triglyceride transfer from the intracellular lipid pool to the apoB in the enterocytes of SOD1-deficient mice.,FEBS Lett,586 4289-4295,2012年

    Toshihiro Kurahashi, Tasuku Konno, Noriyuki Otsuki, Myoungsu Kwon, Satoshi Tsunoda, Junitsu Ito, Junichi Fujii.

    共著(海外含む)

  • Enhanced expression of cystine/glutamate transporter in the lung caused by the oxidative stress-inducing agent paraquat,Free Radic Biol Med,53 2197-2203,2012年

    Sho Kobayashi, Kazuho Kuwata, Takayuki Sugimoto, Kiharu Igarashi, Mitsuhiko Osaki, Futoshi Okada , Junichi Fujii, Shiro Bannai, Hideyo Sato.

    共著(海外含む)

  • Identification and Characterization of Alternatively Transcribed Form of Peroxiredoxin IV Gene That Is Specifically Expressed in Spermatids of Postpubertal Mouse Testis,JOURNAL OF BIOLOGICAL CHEMISTRY,286(45) 39002-39012,2011年11月

    Yim Sun Hee, Kim Yoo-Jin, Oh Sue Young, Fujii Junichi, Zhang Yan, Gladyshev Vadim N., Rhee Sue Goo

    共著(海外含む)

  • Peroxiredoxin-controlled G-CSF signalling at the endoplasmic reticulum-early endosome interface,JOURNAL OF CELL SCIENCE,124(21) 3695-3705,2011年11月

    Palande Karishma, Roovers Onno, Gits Judith, Verwijmeren Carola, Iuchi Yoshihito, Fujii Junichi, Neel Benjamin G., Karisch Robert, Tavernier Jan, Touw Ivo P.

    共著(海外含む)

  • Introduction to serial reviews: physiological relevance of antioxid/redox genes; learning from genetically modified animals Introduction,JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION,49(2) 69,2011年09月

    Fujii Junichi

    単著

  • Unveiling the roles of the glutathione redox system in vivo by analyzing genetically modified mice,JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION,49(2) 70-78,2011年09月

    Fujii Junichi, Ito Jun-itsu, Zhang Xuhong, Kurahashi Toshihiro

    共著(国内のみ)

  • Development of a quantitative bioassay to assess preventive compounds against inflammation-based carcinogenesis,NITRIC OXIDE-BIOLOGY AND CHEMISTRY,25(2) 183-194,2011年08月

    Onuma Kunishige, Suenaga Yuka, Sakaki Ryuta, Yoshitome Satoshi, Sato Yu, Ogawara Satomi, Suzuki Saori, Kuramitsu Yasuhiro, Yokoyama Hidekatsu, Murakami Akira, Hamada Junichi, Nicolson Garth L., Kobaya...

    共著(海外含む)

  • Redox regulation of fertilisation and the spermatogenic process,ASIAN JOURNAL OF ANDROLOGY,13(3) 420-423,2011年05月

    Fujii Junichi, Tsunoda Satoshi

    共著(国内のみ)

  • Identification and characterization of an alternatively transcribed form of peroxiredoxin IV that is specifically expressed in spermatids of the postpubertal mouse testis,J Biol Chem,286 39002-39012,2011年

    Sun Hee Yim, Yoo-Jin Kim, Sue Young Oh, Junichi Fujii, Yan Zhang, Vadim N. Gladyshev, Sue Goo Rhee

    共著(海外含む)

  • Peroxiredoxin-controlled G-CSF signalling at the endoplasmic reticulum-early endosome interface. ,J Cell Sci,124 3695-3705,2011年

    Karishma Palande, Onno Roovers, Judith Gits, Carola Verwijmeren, Yoshihito Iuchi, Junichi Fujii, Benjamin G Neel, Robert Karisch, Jan Tavernier, Ivo P Touw.

    共著(海外含む)

  • Development of a Quantitative Bioassay to Assess Preventive Compounds against Inflammation-based Carcinogenesis,Nitric Oxide,25 183-194,2011年

    unishige Onuma, Yuka Suenaga, Ryuta Sakaki, Satoshi Yoshitome, Yu Sato, Satomi Ogawara, Saori Suzuki, Mitsuhiro Kuramitsu, Hidekatsu Yokoyama, Akira Murakami, Junichi Hamada, Garth L Nicolson, Masanob...

    共著(海外含む)

  • Different consequences of the reactions with hydrogen peroxide and t-butyl hydroperoxide in the hyperoxidative inactivation of rat peroxiredoxin-4.,J. Biochem.,149 443-453,2011年

    Yoshitaka Ikeda, Miyako Nakano, Hideyuki Ihara, Ritsu Ito, Naoyuki Taniguchi, Junichi Fujii.

    共著(海外含む)

  • Different consequences of reactions with hydrogen peroxide and t-butyl hydroperoxide in the hyperoxidative inactivation of rat peroxiredoxin-4,JOURNAL OF BIOCHEMISTRY,149(4) 443-453,2011年

    Ikeda Yoshitaka, Nakano Miyako, Ihara Hideyuki, Ito Ritsu, Taniguchi Naoyuki, Fujii Junichi

    共著(国内のみ)

  • Identification of a Lipid Peroxidation Product as the Source of Oxidation-specific Epitopes Recognized by Anti-DNA Autoantibodies,JOURNAL OF BIOLOGICAL CHEMISTRY,285(44) 33834-33842,2010年10月

    Otaki Natsuki, Chikazawa Miho, Nagae Ritsuko, Shimozu Yuki, Shibata Takahiro, Ito Sohei, Takasaki Yoshinari, Fujii Junichi, Uchida Koji

    共著(国内のみ)

  • B- to Plasma-Cell Terminal Differentiation Entails Oxidative Stress and Profound Reshaping of the Antioxidant Responses,ANTIOXIDANTS & REDOX SIGNALING,13(8) 1133-1144,2010年10月

    Bertolotti Milena, Yim Sun Hee, Garcia-Manteiga Jose M., Masciarelli Silvia, Kim Yoo-Jin, Kang Min-Hee, Iuchi Yoshihito, Fujii Junichi, Vene Roberta, Rubartelli Anna, Rhee Sue Goo, Sitia Roberto

    共著(海外含む)

  • Spontaneous skin damage and delayed wound healing in SOD1-deficient mice,MOLECULAR AND CELLULAR BIOCHEMISTRY,341(1-2) 181-194,2010年08月

    Iuchi Yoshihito, Roy Dipa, Okada Futoshi, Kibe Noriko, Tsunoda Satoshi, Suzuki Saori, Takahashi Motoko, Yokoyama Hidekatsu, Yoshitake Jun, Kondo Seiji, Fujii Junichi

    共著(国内のみ)

  • Expression of N-terminally truncated forms of rat peroxiredoxin-4 in insect cells,PROTEIN EXPRESSION AND PURIFICATION,72(1) 1-7,2010年07月

    Ikeda Yoshitaka, Ito Ritsu, Ihara Hideyuki, Okada Takahiro, Fujii Junichi

    共著(国内のみ)

  • Intrinsic oxidative stress causes either 2-cell arrest or cell death depending on developmental stage of the embryos from SOD1-deficient mice,MOLECULAR HUMAN REPRODUCTION,16(7) 441-451,2010年07月

    Kimura Naoko, Tsunoda Satoshi, Iuchi Yoshihito, Abe Hiroyuki, Totsukawa Kiyoshi, Fujii Junichi

    共著(国内のみ)

  • Reactive Nitrogen Oxide Species in Red Blood Cells Are Possible Cause for Hemolytic Anemia and Autoimmunity in SOD1-Deficient Mice,NITRIC OXIDE-BIOLOGY AND CHEMISTRY,22 S60,2010年06月

    Fujii Junichi, luchi Yoshihito, Tsunoda Satoshi, Kibe Noriko, Suzuki Saori, Okada Futoshi

    共著(国内のみ)

  • Implication of oxidative stress as a cause of autoimmune hemolytic anemia in NZB mice,FREE RADICAL BIOLOGY AND MEDICINE,48(7) 935-944,2010年04月

    Iuchi Yoshihito, Kibe Noriko, Tsunoda Satoshi, Suzuki Saori, Mikami Takeshi, Okada Futoshi, Uchida Koji, Fujii Junichi

    共著(国内のみ)

  • Implication of oxidative stress as a cause of autoimmune hemolytic anemia in the NZB mice.,Free. Radic. Biol. Med.,48 935-944,2010年

    Yoshihito Iuchi, Noriko Kibe, Satoshi Tsunoda, Saori Suzuki, Takeshi Mikami, Futoshi Okada, Koji Uchida, Junichi Fujii.

    共著(海外含む)

  • Identification of a lipid peroxidation product as the source of oxidation-specific epitopes recognized by anti-DNA autoantibodies.,J Biol Chem.,285 33834-33842,2010年

    Natsuki Otaki, Miho Chikazawa, Ritsuko Nagae, Yuki Shimozu, Takahiro Shibata, Sohei Ito, Yoshinari Takasaki, Junichi Fujii, Koji Uchida.

    共著(海外含む)

  • B to plasma cell terminal differentiation entails oxidative stress and profound reshaping of the antioxidant responses.,Antioxid Redox Signal. ,13 1133-1144,2010年

    Milena Bertolotti, Sun Hee Yim, Jose M. Garcia-Manteiga, Silvia Masciarelli, Yoo-Jin Kim, Min-Hee Kang, Yoshihito Iuchi, Junichi Fujii, Roberta Vene, Anna Rubartelli, Sue Goo Rhee, Roberto Sitia.

    共著(海外含む)

  • Spontaneous skin damage and delayed wound healing in SOD1-deficient mice.,Mol. Cell. Biochem. ,341 181-194 ,2010年

    Yoshihito Iuchi, Dipa Roy, Futoshi Okada, Noriko Kibe, Satoshi Tsunoda, Saori Suzuki, Motoko Takahashi, Hidekatsu Yokoyama, Jun Yoshitake, Seiji Kondo, Junichi Fujii.

    共著(海外含む)

  • Expression of N-terminally truncated forms of rat peroxiredoxin-4 in insect cells.,Protein Expr. Purif.,72 1-7,2010年

    Yoshitaka Ikeda, Ritsu Ito, Hideyuki Ihara, Takahiro Okada, Junichi Fujii.

    共著(海外含む)

  • Intrinsic oxidativestress causes either two-cell arrest or cell death depending on developmental stage of the embryo from SOD1-deficient mice.,Mol. Hum. Reprod.,16 441-451,2010年

    Naoko Kimura, Satoshi Tsunoda, Yoshihito Iuchi, Hiroyuki Abe, Kiyoshi Totsukawa, and Junichi Fujii.

    共著(海外含む)

  • Nano-Scaled Particles of Titanium Dioxide Convert Benign Mouse Fibrosarcoma Cells into Aggressive Tumor Cells,AMERICAN JOURNAL OF PATHOLOGY,175(5) 2171-2183,2009年11月

    Onuma Kunishige, Sato Yu, Ogawara Satomi, Shirasawa Nobuyuki, Kobayashi Masanobu, Yoshitake Jun, Yoshimura Tetsuhiko, Iigo Masaaki, Fujii Junichi, Okada Futoshi

    共著(国内のみ)

  • Aggravation of ischemia-reperfusion-triggered acute renal failure in xCT-deficient mice,ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,490(1) 63-69,2009年10月

    Shibasaki Tomohiro, Iuchi Yoshihito, Okada Futoshi, Kuwata Kazuho, Yamanobe Takuya, Bannai Shiro, Tomita Yoshihiko, Sato Hideyo, Fujii Junichi

    共著(国内のみ)

  • Rescue of anaemia and autoimmune responses in SOD1-deficient mice by transgenic expression of human SOD1 in erythrocytes,BIOCHEMICAL JOURNAL,422(2) 313-320,2009年09月

    Iuchi Yoshihito, Okada Futoshi, Takamiya Rina, Kibe Noriko, Tsunoda Satoshi, Nakajima Osamu, Toyoda Kazuyo, Nagae Ritsuko, Suematsu Makoto, Soga Tomoyoshi, Uchida Koji, Fujii Junichi

    共著(国内のみ)

  • Peroxiredoxin 4 knockout results in elevated spermatogenic cell death via oxidative stress,BIOCHEMICAL JOURNAL,419(1) 149-158,2009年04月

    Iuchi Yoshihito, Okada Futoshi, Tsunoda Satoshi, Kibe Noriko, Shirasawa Nobuyuki, Ikawa Masahito, Okabe Masaru, Ikeda Yoshitaka, Fujii Junichi

    共著(国内のみ)

  • Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress.,Free. Radic. Biol. Med.,46 443-453,2009年

    Harvey CJ, Thimmulappa RK, Singh A, Blake DJ, Ling G, Wakabayashi N, Fujii J, Myers A, Biswal S.

    共著(海外含む)

  • Aggravation of ischemia-reperfusion-triggered acute renal failure in xCT-deficient mice.,Arch. Biochem. Biophys. ,490 63-69,2009年

    Tomohiro Shibasaki, Yoshihito Iuchi, Futoshi Okada, Kazuho Kuwata, Takuya Yamanobe, Shiro Bannai, Yoshihiko Tomita, Hideyo Sato, Junichi Fujii.

    共著(海外含む)

  • Nano-scaled Particles of Titanium Dioxide Convert Benign Mouse Fibrosarcoma Cells into Aggressive Tumor Cells.,Am. J. Pathol. ,175 2171-2183 ,2009年

    Kunishige Onuma, Yu Sato, Satomi Ogawara, Nobuyuki Shirasawa, Masanobu Kobayashi, Jun Yoshitake, Tetsuhiko Yoshimura, Masaaki Iigo, Junichi Fujii, Futoshi Okada.

    共著(海外含む)

  • Rescue of Anemia and Autoimmune Responses in SOD1-Deficient Mice by Transgenic Expression of Human SOD1 in Erythrocytes.,Biochem. J.,422 313-320,2009年

    Yoshihito IUCHI, Futoshi OKADA, Rina TAKAMIYA, Noriko KIBE, Satoshi TSUNODA, Osamu NAKAJIMA, Kazuyo TOYODA, Ritsuko NAGAE, Makoto SUEMATSU, Tomoyoshi SOGA, Koji UCHIDA, Junichi FUJII

    共著(海外含む)

  • Peroxiredoxin 4 knockout results in elevated spermatogenic cell death via oxidative stress. ,Biochem. J. ,419 149-158,2009年

    Yoshihito IUCHI, Futoshi OKADA, Satoshi TSUNODA, Noriko KIBE, Nobuyuki SHIRASAWA, Masahito IKAWA, Masaru OKABE, Yoshitaka IKEDA, Junichi FUJII.

    共著(海外含む)

  • Deficiency of the cystine-transporter gene, xCT, does not exacerbate the deleterious phenotypic consequences of SOD1 knockout in mice,MOLECULAR AND CELLULAR BIOCHEMISTRY,319(1-2) 125-132,2008年12月

    Iuchi Yoshihito, Kibe Noriko, Tsunoda Satoshi, Okada Futoshi, Bannai Shiro, Sato Hideyo, Fujii Junichi

    共著(国内のみ)

  • Deficiency of the cystine-transporter gene, xCT, does not exacerbate the deleterious phenotypic consequences of SOD1 knockout in mice. ,Mol. Cell. Biochem.,319 125-132,2008年

    Yoshihito Iuchi, Noriko Kibe, Satoshi Tsunoda, Futoshi Okada , Shiro Bannai, Hideyo Sato, Junichi Fujii

    共著(海外含む)

  • Inactivation of cysteine and serine proteases by singlet oxygen,ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,461(2) 151-158,2007年05月

    Suto Daisuke, Iuchi Yoshihito, Ikeda Yoshitaka, Sato Kazuaki, Ohba Yoshihiro, Fujii Junichi

    共著(国内のみ)

  • Elevated oxidative stress in erythrocytes due to a SOD1 deficiency causes anaemia and triggers autoantibody production,BIOCHEMICAL JOURNAL,402(2) 219-227,2007年03月

    Iuchi Yoshihito, Okada Futoshi, Onuma Kunishige, Onoda Tadashi, Asao Hironobu, Kobayashi Masanobu, Fujii Junichi

    共著(国内のみ)

  • Deterioration of ischemia/reperfusion-induced acute renal failure in SOD1-deficient mice,FREE RADICAL RESEARCH,41(2) 200-207,2007年02月

    Yamanobe Takuya, Okada Futoshi, Iuchi Yoshihito, Onuma Kunishige, Tomita Yoshihiko, Fujii Junichi

    共著(国内のみ)

  • Deterioration of Ischemia/Reperfusion-induced Acute Renal Failure in SOD1-deficient Mice.,Free Radic Res,41 200-207,2007年

    Takuya Yamanobe, Futoshi Okada, Yoshihito Iuchi, Kunishige Onuma, Yoshihiko Tomita, and Junichi Fujii.

    共著(海外含む)

  • Inactivation of cysteine and serine proteases by singlet oxygen.,Arch. Biochem. Biophys. ,461 151-158,2007年

    Daisuke Suto, Yoshihito Iuchi, Yoshitaka Ikeda, Kazuaki Sato, Yoshihiro Ohba, Junichi Fujii

    共著(海外含む)

  • Elevated oxidative stress in erythrocytes due to an SOD1 deficiency causes anemia and triggers autoantibody production. ,Biochem. J.,402 219-227,2007年

    Yoshihito Iuchi, Futoshi Okada, Kunishige Onuma, Tadashi Onoda, Hironobu Asao, Masanobu Kobayashi, Junichi Fujii.

    共著(海外含む)

  • Molecular mechanisms of inflammation-induced carcinogenesis,JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION,39(3) 103-111,2006年11月

    Okada Futoshi, Fujii Junichi

    共著(国内のみ)

  • Structural analysis of amino acids, oxidized by reactive oxygen species and an antibody against N-formylkynurenine,JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION,38(2) 107-111,2006年03月

    Suto Daisuke, Ikeda Yoshitaka, Fujii Junichi, Ohba Yoshihiro

    共著(国内のみ)

  • Daisuke Suto, Yoshitaka Ikeda, Junichi Fujii, and Yoshihiro Ohba Structural analysis of amino acids, oxidized by reactive oxygen species and an antibody against N-Formylkynurenine. ,J. Clin. Biochem. Nutr.,38 107-111 ,2006年

    Daisuke Suto, Yoshitaka Ikeda, Junichi Fujii, Yoshihiro Ohba

    共著(海外含む)

  • Impaired portal circulation resulting from L-arginine deficiency in patients with lysinuric protein intolerance.,Gut ,55 1526-1527,2006年

    Tadashi Takeda, Hisayoshi Watanabe, Takafumi Saito, Koji Saito, Hiroaki Takeda, Hitoshi Togashi, Junichi Fujii, Yuhei Takasago, Sumio Kawata.

    共著(海外含む)

  • Suppression of the pro-apoptotic function of cytochrome c by singlet oxygen via a haem redox state-independent mechanism.,The Biochemical journal,392(Pt 2) 399-406,2005年12月

    Suto D, Sato K, Ohba Y, Yoshimura T, Fujii J

    共著(国内のみ)

  • Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice.,Proceedings of the National Academy of Sciences of the United States of America,102(44) 15791-6,2005年11月

    Wang X, Inoue S, Gu J, Miyoshi E, Noda K, Li W, Mizuno-Horikawa Y, Nakano M, Asahi M, Takahashi M, Uozumi N, Ihara S, Lee SH, Ikeda Y, Yamaguchi Y, Aze Y, Tomiyama Y, Fujii J, Suzuki K, Kondo A, Shapi...

    共著(海外含む)

  • Fundamental roles of reactive oxygen species and protective mechanisms in the female reproductive system.,Reproductive biology and endocrinology : RB&E,3 43,2005年09月

    Fujii J, Iuchi Y, Okada F

    共著(国内のみ)

  • An abortive apoptotic pathway induced by singlet oxygen is due to the suppression of caspase activation.,The Biochemical journal,389(Pt 1) 197-206,2005年07月

    Otsu K, Sato K, Ikeda Y, Imai H, Nakagawa Y, Ohba Y, Fujii J

    共著(国内のみ)

  • Accelerated impairment of spermatogenic cells in SOD1-knockout mice under heat stress.,Free radical research,39(7) 697-705,2005年07月

    Ishii T, Matsuki S, Iuchi Y, Okada F, Toyosaki S, Tomita Y, Ikeda Y, Fujii J

    共著(国内のみ)

  • Specific inactivation of cysteine protease-type cathepsin by singlet oxygen generated from naphthalene endoperoxides.,Biochemical and biophysical research communications,331(1) 215-23,2005年05月

    Nagaoka Y, Otsu K, Okada F, Sato K, Ohba Y, Kotani N, Fujii J

    共著(国内のみ)

  • Cytoprotective effects of geranylgeranylacetone against retinal photooxidative damage.,The Journal of neuroscience : the official journal of the Society for Neuroscience,25(9) 2396-404,2005年03月

    Tanito M, Kwon YW, Kondo N, Bai J, Masutani H, Nakamura H, Fujii J, Ohira A, Yodoi J

    共著(国内のみ)

  • Detection of S-glutathionylated proteins by glutathione S-transferase overlay.,Archives of biochemistry and biophysics,435(1) 42-9,2005年03月

    Cheng G, Ikeda Y, Iuchi Y, Fujii J

    共著(国内のみ)

  • Cytoprotective Effects of Oral Geranylgeranylacetone, an Inducer of Thioredoxin and Heat Shock Protein 72, on Light-Induced Retinal Damage in Mice.,J. Neurosci. ,25 2396-2404,2005年

    Masaki Tanito, Yong-Won Kwon, Norihiko Kondo, Jie Bai, Hiroshi Masutani, Hajime Nakamura, Junichi Fujii, Akihiro Ohira, Junji Yodoi.

    共著(海外含む)

  • Dysregulation of TGF-β1 receptor activation leads to abnormal lung developmentand emphysema-like phenotype in core fucose-deficient mice.,Proc. Natl. Acad. Sci. USA,102 15791-15796,2005年

    Xiangchun Wang, Shinya Inoue, Jianguo Gu, Eiji Miyoshi, Katsuhisa Noda, Wenzhe Li,Yoko Mizuno-Horikawa, Miyako Nakano, Michio Asahi, Motoko Takahashi, Naofumi Uozumi, Shinji Ihara, Seung Ho Lee, Yoshi...

    共著(海外含む)

  • Accelerated impairment of spermatogenic cells in sod1-knockout mice under heat stress.,Free Radic. Res,39 697-705,2005年

    Tatsuya Ishii, Shingo Matsuki, Yoshihito Iuchi, Futoshi Okada, Shinjiro Toyosaki, Yoshihiko Tomita, Yoshitaka Ikeda, Junichi Fujii.

    共著(海外含む)

  • Suppression of the pro-apoptotic function of cytochrome c by singlet oxygen via a heme redox state-independent mechanism. ,Biochem. J. ,392 399-406,2005年

    Daisuke Suto, Kazuaki Sato, Yoshihiro Ohba, Tetsuhiko Yoshimura, Junichi Fujii.

    共著(海外含む)

  • Specific inactivation of cysteine protease-type cathepsin by singlet oxygen generated from naphthalene endoperoxides.,Biochem. Biophys. Res. Commun. ,331 215-223,2005年

    Yuki Nagaoka, Kaoru Otsu, Futoshi Okada, Kazuaki Sato, Yoshihiro Ohba, Naoki Kotani, Junichi Fujii.

    共著(海外含む)

  • An abortive apoptotic pathway induced by singelt oxygen is due to the suprression of caspase activation.,Biochem. J.,389 197-223,2005年

    Kaoru Otsu, Kazuaki Sato, Yoshitaka Ikeda, Hirotaka Imai, Yasuhito Nakagawa, Yoshihiro Ohba, Junichi Fujii.

    共著(海外含む)

  • Detection of S-glutathionylated proteins by glutathione S-transferase overlay. ,Arch. Biochem. Biophys. ,435 42-49,2005年

    Guang Cheng, Yoshitaka Ikeda, Yoshihito Iuchi, Junichi Fujii.

    共著(海外含む)

  • In vivo study on cross talk between inducible nitric-oxide synthase and cyclooxygenase in rat gastric mucosa: effect of cyclooxygenase activity on nitric oxide production.,The Journal of pharmacology and experimental therapeutics,309(3) 995-1002,2004年06月

    Uno K, Iuchi Y, Fujii J, Sugata H, Iijima K, Kato K, Shimosegawa T, Yoshimura T

    共著(国内のみ)

  • Carbonyl stress and detoxification ability in the male genital tract and testis of rats.,Histochemistry and cell biology,121(2) 123-30,2004年02月

    Iuchi Y, Kaneko T, Matsuki S, Ishii T, Ikeda Y, Uchida K, Fujii J

    共著(国内のみ)

  • Accumulation of manganese superoxide dismutase under metal-depleted conditions: proposed role for zinc ions in cellular redox balance.,The Biochemical journal,377(Pt 1) 241-8,2004年01月

    Otsu K, Ikeda Y, Fujii J

    共著(国内のみ)

  • In vivo study on cross-talk between inducible nitric oxide synthase and cyclooxygenase in rat gastric mucosa: Effect of COX activity on NO production.,J. Pharmacol. Exp. Ther. ,309 995-1002,2004年

    Kaname Uno, Yoshihito Iuchi, Junichi Fujii, Hideaki Sugata, Katsunori Iijima, Katuaki Kato, Tooru Shimosegawa, Testuhiko Yoshimura.

    共著(海外含む)

  • Glutathione reductase is expressed at high levels in pancreatic islet cells. ,Redox Rep. ,9 321-324,2004年

    Yuki Nagaoka, Yoshihito Iuchi, Yoshitaka Ikeda, Junichi Fujii.

    共著(海外含む)

  • The accumulation of Mn-superoxide dismutase under metal-depleted conditions: An implicated role of zinc ion for cellular redox balance. ,Biochem. J.,377 241-248,2004年

    Kaoru Otsu, Yoshitaka Ikeda, Junichi Fujii.

    共著(海外含む)

  • Carbonyl stress and detoxification ability in the male genital tract and testis of rats.,Histochem. Cell Biol.,121 123-130,2004年

    Yoshihito Iuchi, Tomoko Kaneko, Shingo Matsuki, Tatsuya Ishii, Yoshitaka Ikeda, Koji Uchida, Junichi Fujii.

    共著(海外含む)

  • Glutathione reductase is expressed at high levels in pancreatic islet cells.,Redox report : communications in free radical research,9(6) 321-4,2004年

    Nagaoka Y, Iuchi Y, Ikeda Y, Fujii J

    共著(国内のみ)

  • Suppression of cytochrome c release and apoptosis in testes with heat stress by minocycline.,Biochemical and biophysical research communications,312(3) 843-9,2003年12月

    Matsuki S, Iuchi Y, Ikeda Y, Sasagawa I, Tomita Y, Fujii J

    共著(国内のみ)

  • Cooperative function of antioxidant and redox systems against oxidative stress in male reproductive tissues.,Asian journal of andrology,5(3) 231-42,2003年09月

    Fujii J, Iuchi Y, Matsuki S, Ishii T

    共著(国内のみ)

  • Transient elevation of glutathione peroxidase 1 around the time of eyelid opening in the neonatal rat.,Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics,19(4) 361-9,2003年08月

    Fujii T, Ikeda Y, Yamashita H, Fujii J

    共著(国内のみ)

  • Glycation proceeds faster in mutated Cu, Zn-superoxide dismutases related to familial amyotrophic lateral sclerosis.,FASEB journal : official publication of the Federation of American Societies for Experimental Biology,17(8) 938-40,2003年05月

    Takamiya R, Takahashi M, Myint T, Park YS, Miyazawa N, Endo T, Fujiwara N, Sakiyama H, Misonou Y, Miyamoto Y, Fujii J, Taniguchi N

    共著(国内のみ)

  • Colocalization of polyol-metabolizing enzymes and immunological detection of fructated proteins in the female reproductive system of the rat.,Histochemistry and cell biology,119(4) 309-15,2003年04月

    Kaneko T, Iuchi Y, Takahashi M, Fujii J

    共著(国内のみ)

  • Concerted changes in the YB2/RYB-a protein and protamine 2 messenger RNA in the mouse testis under heat stress.,Biology of reproduction,68(1) 129-35,2003年01月

    Iuchi Y, Kaneko T, Matsuki S, Sasagawa I, Fujii J

    共著(国内のみ)

  • Suppression of cytochrome c release and apoptosis in testes with heat stress by minocycline. ,Biochem. Biophys. Res. Commun.,312 843-849,2003年

    Shingo Matsuki, Yoshihito Iuchi, Yoshitaka Ikeda, Isoji Sasagawa, Yoshihiko Tomita, Junichi Fujii

    共著(海外含む)

  • Concerted changes in the YB2/RYB-a protein and protamine 2 mRNA in the mouse testis under Heat Stress. ,Biol. Reprod.,68 129-135,2003年

    Yoshihito Iuchi, Tomoko Kaneko, Shingo Matsuki, Isoji Sasagawa, Junichi Fujii.

    共著(海外含む)

  • Glycation proceeds faster in mutated Cu, Zn-superoxide dismutases related to familial amyotrophic lateral sclerosis. ,FASEB J. ,17 938-940,2003年

    Rina Takamiya, Motoko Takahashi, Theingi Myint, Yong Seek Park, Nobuko Miyazawa, Takeshi Endo, Noriko Fujiwara, Haruhiko Sakiyama, Yoshiko Misonou, Yasuhide Miyamoto, Junichi Fujii, Naoyuki Taniguchi....

    共著(海外含む)

  • Transient elevation of glutathione peroxidase 1 around the time of eyelid opening in the neonatal rat. ,J. Ocul. Pharmacol. Ther. ,19 361-370 ,2003年

    Tsuneko Fujii, Yoshitaka Ikeda, Hidetoshi Yamashita, Junichi Fujii.

    共著(海外含む)

  • Colocalization of polyol-metabolizing enzymes and immunological detection of fructated proteins in the female reproductive system of the rat. ,Histochem. Cell Biol. ,119 309-315,2003年

    Tomoko Kaneko, Yoshihito Iuchi, Motoko Takahashi, and Junichi Fujii.

    共著(海外含む)

  • Differential expression of glutathione reductase and cytosolic glutathione peroxidase, GPX1, in developing rat lungs and kidneys.,Free radical research,36(10) 1041-9,2002年10月

    Fujii T, Endo T, Fujii J, Taniguchi N

    共著(国内のみ)

  • Localization and physiological implication of aldose reductase and sorbitol dehydrogenase in reproductive tracts and spermatozoa of male rats.,Journal of andrology,23(5) 674-83,2002年09月

    Kobayashi T, Kaneko T, Iuchi Y, Matsuki S, Takahashi M, Sasagawa I, Nakada T, Fujii J

    共著(国内のみ)

  • Apoptosis and expression of apoptosis-related genes in the mouse testis following heat exposure.,Fertility and sterility,77(4) 787-93,2002年04月

    Miura M, Sasagawa I, Suzuki Y, Nakada T, Fujii J

    共著(国内のみ)

  • The expression of glutathione reductase in the male reproductive system of rats supports the enzymatic basis of glutathione function in spermatogenesis.,European journal of biochemistry,269(5) 1570-8,2002年03月

    Kaneko T, Iuchi Y, Kobayashi T, Fujii T, Saito H, Kurachi H, Fujii J

    共著(国内のみ)

  • Localization and physiological implication of aldose reductase and sorbitol dehydrogenase in male reproductive systems, qccessory glands, and spermatozoa of rats.,J. Androl.,23 674-683,2002年

    Takashi Kobayashi, Tomoko Kaneko, Yoshihito Iuchi, Shingo Matsuki, Motoko Takahashi, Isoji Sasagawa, Teruhiro Nakada, Junichi Fujii

    共著(海外含む)

  • Differential epression of glutathione reductase and cytosolic glutathione peroxidase, GPX1, in developing rat lungs and kidneys.,Free Radic. Res.,36 1041-1049,2002年

    Tsuneko Fujii, Takeshi Endo, Junichi Fujii, Naoyuki Taniguchi.

    共著(海外含む)

  • Apoptosis and expression of apoptosis-related genes in mouse testis following heat exposure. ,Fertil. Steril.,77 787-793,2002年

    Michiharu Miura, Isoji Sasagawa, Yasuhiro Suzuki, Teruhiro Nakada, Junichi Fujii.

    共著(海外含む)

  • Impaired expression of peroxiredoxin 4 in damaged testes by artificial cryptorchidism.,Redox Rep.,7 276-278,2002年

    Shingo Matsuki, Isoji Sasagawa, Yoshihito Iuchi, Junichi Fujii.

    共著(海外含む)

  • Expression of glutathione reductase in the male reproductive system of rats supports the enzymatic basis of glutathione function in spermatogenesis.,Eur. J. Biochem.,269 1570-1578,2002年

    Tomoko Kaneko, Yoshihito Iuchi, Takashi Kobayashi, Tsuneko Fujii, Hidekazu Saito, Hirohisa Kurachi, Junichi Fujii.

    共著(海外含む)

  • Advances in our understanding of peroxiredoxin, a multifunctional, mammalian redox protein.,Redox report : communications in free radical research,7(3) 123-30,2002年

    Fujii J, Ikeda Y

    共著(国内のみ)

  • Impaired expression of peroxiredoxin 4 in damaged testes by artificial cryptorchidism.,Redox report : communications in free radical research,7(5) 276-8,2002年

    Matsuki S, Sasagawa I, Iuchi Y, Fujii J

    共著(国内のみ)

  • Active glycation in neurofibrillary pathology of Alzheimer disease: Ne-(carboxymethyl) lysine and hexitol-lysine.,Free Radic. Biol. Med.,31 175-180,2001年

    Rudy J. Castellani, Peggy L. Harris, Lawrence M. Sayre, Junichi Fujii, Naoyuki Taniguchi, Michael P. Vitek, Hank Founds, Craig S. Atwood, George Perry, Mark A. Smith.

    共著(海外含む)

  • Augmented expression of peroxiredoxinVI in rat lung and kidney after birth implies an antioxidative role.,Eur. J. Biochem. ,268 218-224,2001年

    Tsuneko Fujii, Junichi Fujii, Naoyuki Taniguchi.

    共著(海外含む)

  • Increased protein glycation in cerebrospinal fluid of Alzheimer's disease. ,Neurobiol. Aging ,22 397-402,2001年

    Vladimir V. Shuvaev, Isabelle Laffont, Jean-Marie Serot, Junichi Fujii, Naoyuki Taniguchi, Gerard Siest.

    共著(海外含む)

  • Roles of N-terminal active cysteines and C-terminal cysteine-selenocysteine in the catalytic mechanism of mammalian thioredoxin reductase. ,J. Biochem.,129 803-812,2001年

    Noriko Fujiwara, Tsuneko Fujii, Junichi Fujii, Naoyuki Taniguchi.

    共著(海外含む)

  • Possible involvement of the membrane-bound form of peroxiredoxin 4 in acrosome formation during spermiogenesis of rats.,Eur. J. Biochem.,268 3053-3061,2001年

    Isoji Sasagawa, Shingo Matsuki, Yasuhiro Suzuki, Yoshihito Iuchi, Kazuo Tohya, Michio Kimura, Teruhiro Nakada, Junichi Fujii

    共著(海外含む)

  • The expression of a Y-box protein, YB2/RYB-a, precedes protamine 2 during spermatogenesis in rodents.,Mol. Human Reprod. ,7 1023-1031,2001年

    Yoshihito Iuchi, Takashi Kobayashi, Tomoko Kaneko, Masatoshi Takahara, Toshihiko Ogino, Junichi Fujii

    共著(海外含む)

  • Alteration of glutathione reductase expression in the female reproductive organs during the estrous cycle. ,Biol. Reprod. ,65 1410-1416,2001年

    Tomoko Kaneko, Yoshihito Iuchi, Satoshi Kawachiya, Tsuneko Fujii, Hidekazu Saito, Hirohisa Kurachi, Junichi Fujii.

    共著(海外含む)

  • Multilocal expression and developmental changes in the levels of glutathione reductase in ocular tissues of rats.,Histochem. J.,33 267-272,2001年

    Tsuneko Fujii, Keiji Mori, Yoshinori Takahashi, Naoyuki Taniguchi, Akira Tonosaki, Hidetoshi Yamashita, Junichi Fujii.

    共著(海外含む)

  • Effect of cAMP on inducible nitric oxide synthase gene expression; Its dual and cell specific functions. ,Antioxid. Redox Signal. ,2 631-642,2000年

    Ayako Okado-Matsumoto, Akio Matsumoto, Junichi Fujii, Naoyuki Taniguchi.

    共著(海外含む)

  • Detection of an Amadori product, 1-hexitol-lysine, in the anterior horn of the amyotrophic lateral sclerosis and spinobulbar muscular atrophy spinal cord: Evidence for early involvement of glycation in motoneuron diseases. ,Acta Neuropathol.,99 63-66 ,2000年

    Seiji Kikuchi, Akihiko Ogata, Kazuyoshi Shinpo, Fumio Moriwaka, Junichi Fujii, Naoyuki Taniguchi, Kunio Tashiro

    共著(海外含む)

  • Gain in functions of mutant Cu,Zn-superoxide dismutases as a causative factor in familial amyotrophic lateral sclerosis: Less reactive oxidant formation but high spontaneous aggregation and precipitation.,Free Radic. Res.,33 65-73,2000年

    Ayako Okado-Matsumoto, Theingi Myint, Junichi Fujii, Naoyuki Taniguchi.

    共著(海外含む)

  • Pyruvate secreted by human lymphoid cell lines protects cells from hydrogen peroxide mediated apoptosis.,Free Radic. Res.,2000年

    Hideaki Miwa, Junichi Fujii, Hiroyuki Kanno, Naoyuki Taniguchi, Katsuyuki Aozasa

    共著(海外含む)

  • Peroxiredoxin IV is a secretable protein with heparin-binding properties under reduced conditions.,J. Biochem. ,127 493-501,2000年

    Ayako Okado-Matsumoto, Akio Matsumoto, Junichi Fujii, Naoyuki Taniguchi.

    共著(海外含む)

  • Genomic structure and promoter analysis of the human a1,6fucosyltransferase gene (FUT8).,Glycobiology,10 637-643,2000年

    Yukihiro Yamaguchi, Yoshitaka Ikeda, Tomoaki Takahashi, Hideyuki Ihara, Tatsuya Tanaka, Junichi Fujii, Naoyuki Taniguchi.

    共著(海外含む)

  • Redox capacity of cells affects inactivation of glutathione reductase by nitrosative stress.,Arch. Biochem. Biophys. ,378 123-130,2000年

    Tsuneko Fujii, Rieko Hamaoka, Junichi Fujii, Naoyuki Taniguchi.

    共著(海外含む)

  • A pivotal role of Zn-binding residues in the function of the copper chaperone for SOD1.,Biochem. Biphys. Res. Commun.,276 999-1004,2000年

    . Takeshi Endo, Tsuneko Fujii, Kenzo Sato, Naoyuki Taniguchi, Junichi Fujii.

    共著(海外含む)

  • Effect of cAMP on Inducible Nitric Oxide Synthase Gene Expression: Its Dual and Cell-Specific Functions,ANTIOXIDANTS & REDOX SIGNALING,2(4) 631-U20,2000年

    Okado-Matsumoto Ayako, Matsumoto Akio, Fujii Junichi, Taniguchi Naoyuki

    共著(国内のみ)

  • Glycation of apolipoprotein E impairs its binding to heparin. Identification of the major glycation Site.,Biochim. Biophys. Acta ,1454 296-308,1999年

    Vladimir V. Shuvaev, Junichi Fujii, Yoshimi Kawasaki, Hidehiko Itoh, Rieko Hamaoka, Anne Barbier, Olivier Ziegler, Gerard Siest, and Naoyuki Taniguchi

    共著(海外含む)

  • Cloning of Peroxiredoxin Gene Family in Rats and Characterization of the Fouth Member. ,FEBS Lett.,443 246-250,1999年

    Akio Matsumoto, Ayako Okado, Tsuneko Fujii, Junichi Fujii, Masayuki Egashira, Norio Niikawa, Naoyuki Taniguchi.

    共著(海外含む)

  • Mapping of the a1,6fucosyltransferase gene, FUT8, to human chromosome 14q24.3.,Cytogenet. Cell Genet.,84 58-60,1999年

    Yukihiro Yamaguchi, Junichi Fujii, Shinya Inoue, Naofumi Uozumi, Shusaku Yanagidani, Yoshitaka Ikeda, Masayuki Egashira, Osamu Miyoshi, Norio Niikawa, Naoyuki Taniguchi.

    共著(海外含む)

  • The structural organization of the human aldehyde reductase gene, AKR1A1, and mapping to chromosome 1p32-p33.,Cytogenet. Cell Genet.,84 230-232,1999年

    Junichi Fujii, Rieko Hamaoka, Akio Matsumoto, Tsuneko Fujii, Yukihiro Yamaguchi, Masayuki Egashira, Osamu Miyoshi, Norio Niikawa, Naoyuki Taniguchi.

    共著(海外含む)

  • Expression and characterization of the extracellular domain of guanylyl cyclase C from a baculovirus and Sf21 insect cells.,Protein Expr. Purif.,15 271-281,1999年

    Makoto Hasegawa, Yuki Kawano, Yoshiko Matsumoto, Yuji Hidaka, Junichi Fujii, Naouyuki Taniguchi, Akihiro Wada, Toshiya Hirayama, Yasutsugu Shimonishi.

    共著(海外含む)

  • Different expression patterns of nitric oxide synthase isozymes in various gynecological cancers.,J. Cancer Res. Clin. Oncol. ,125 321 -326,1999年

    Rieko Hamaoka, Yuji Yaginuma, Tomoaki Takahashi, Junichi Fujii, Masahiko Koizumi, Han Geuk Seo, Yutaka Hatanaka, Kaoru Hashizume, Kunio Ii, Toshiaki Hanafusa, Yuji Matsuzawa, Mutsuo Ishikawa, Naoyuki ...

    共著(海外含む)

  • Functional expression of rat thioredoxin reductase: Selenocysteine insertion sequence element is essential for the active enzyme.,Biochem. J. ,340 439-444,1999年

    Noriko Fujiwara, Tsuneko Fujii, Junichi Fujii, Naoyuki Taniguchi.

    共著(海外含む)

  • Overexpression of the aldose reductase gene induces apoptosis in pancreatic b-cells by causing redox imbalance.,J. Biochem. ,126 41,1999年

    Rieko Hamaoka, Junichi Fujii, Jun-ichiro Miyagawa, Motoko Takahashi, Michihiko Kishimoto, Makoto Moriwaki, Koji Yamamoto, Yoshitaka Kajimoto, Yoshimitsu Yamasaki, Toshiaki Hanafusa, Yuji Matsuzawa, Na...

    共著(海外含む)

  • Specific detection of the early process of the glycation reaction by fructose and glucose in diabetic rat lens.,FEBS Lett.,(441) 116-120,1998年

    Yoshimi Kawasaki, Junichi Fujii, Nobuko Miyazawa, Ayumu Hoshi, Ayako Okado, Yasuo Tano, Naoyuki Taniguchi

    共著(海外含む)

  • A high expression of heme oxygenase-1 in the liver of LEC rats at the stage of hepatitis; The possible implication of induction in uninvolved tissues. ,Free Radic. Res. ,28 383-391,1998年

    Akio Matsumoto, Rikinari Hanayama, Masahiro Nakamura, Keiichiro Suzuki, Junichi Fujii, Haruyuki Tatsumi, Naoyuki Taniguchi

    共著(海外含む)

  • A marked increase in free copper levels in the plasma and liver of LEC rats: An animal model of Wilson disease and liver cancer,Free Radic. Res.,28 441-450,1998年

    Masahiko Koizumi, Junichi Fujii, Keiichiro Suzuki, Takehiro Inoue, Toshihiko Inoue, John M. C. Gutteridge, Naoyuki Taniguchi

    共著(海外含む)

  • A defect in the mitochondrial import of mutant Mn-superoxide dismutase produced in Sf21 cells.,J. Biochem. ,124 340-346,1998年

    Junichi Fujii, Yoshitaka Ikeda, Toshiya Watanabe, Yoshimi Kawasaki, Keiichiro Suzuki, Chizuko Fujii, Motoko Takahashi, Naoyuki Taniguchi

    共著(海外含む)

  • Reactive oxygen species enhances the induction of inducible nitric oxide synthase by sphingomyelinase in RAW264.7 cells.,Biochim. Biophys. Acta,1393 203-210,1998年

    Yutaka Hatanaka, Junichi Fujii, Tatsushi Fukutomi, Toshiya Watanabe, Wenyi Che, Yasuhiro Sanada, Yasuyuki Igarashi, Naoyuki Taniguchi

    共著(海外含む)

  • Dysfunction of antioxidative enzymes in the trinitrobenzensulfonic acid-induced coliltis rat.,Pathophysiology, 5 191-198,1998年

    Toshiya Watanabe, Junichi Fujii, Keiichiro Suzuki, Tsuneko Fujii, Michio Asahi, Ken Matsuoka, Naoyuki Taniguchi

    共著(海外含む)

  • Immunological detection of fructated proteins in in vitro and in vivo.,Biochem. J. ,336 101-107,1998年

    Nobuko Miyazawa, Yoshimi Kawasaki, Junichi Fujii, Myint Theingi, Ayumu Hoshi, Rieko Hamaoka, Akio Matsumoto, Naofumi Uozumi, Tadashi Teshima, Naoyuki Taniguchi

    共著(海外含む)

  • The effect of nitric oxide synthase inhibitor on form deprivation myopia.,Curr. Eye Res.,16 992-996,1997年

    Takashi Fujikado, Yoshimi Kawasak, Junichi Fujii, Naoyuki Taniguchi, Masaki Okada, Atsushi Suzuki, Genjiro Ohmi, Yasuo Tano

    共著(海外含む)

  • TGF-beta triggers oxidative modification and enhances apoptosis in HIT-cells through accumulation of reactive oxygen species by suppression of catalase and glutathione peroxidase.,Free Radic. Biol. Med. ,22 1007-1017,1997年

    . Kazi Nazrul Islam, Yoshiro Kayanoki, Hideaki Kaneto, Keiichiro Suzuki, Michio Asahi, Junichi Fujii, Naoyuki Taniguchi.

    共著(海外含む)

  • Roles of purine nucleotides and adenosine in enhancing NOS II gene expression in interleukin-1b-stimulated rat vascular smooth muscle cells. ,Free Radic. Res.,26 409-418,1997年

    Han Geuk Seo, Junichi Fujii, Michio Asahi, Ayako Okado, Noriko Fujiwara, Naoyuki Taniguchi

    共著(海外含む)

  • The oxidation of selenocysteine is involved in the inactivation of glutathione peroxidase by nitric oxide donor.,J. Biol. Chem.,272 19152-19157 ,1997年

    Michio Asahi, Junichi Fujii, Toshifumi Takao, Tsunehiko Kuzuya, Masatsugu Hori, Yasutsugu Shimonishi, Naoyuki Taniguchi

    共著(海外含む)

  • Effect of a nitric oxide synthase inhibitor, S-ethylisothiourea, on cultured cells and cardiovascular functions of normal and lipopolysaccharide-treated rabbits. ,J. Biochem.,119 553-558,1996年

    Han Geuk Seo, Noriko Fujiwara, Hideaki Kaneto, Michio Asahi, Junichi Fujii, Naoyuki Taniguchi.

    共著(海外含む)

  • Reducing sugar triggers oxidative modification and apoptosis in pancreatic b-cells by provoking oxidative stress through glycation reaction.,Biochem. J. ,320 855-863,1996年

    Hideaki Kaneto, Junichi Fujii, Theingi Myint, Kazi Nazrul Islam, Nobuko Miyazawa, Keiichiro Suzuki, Yoshimi Kawasaki,Masahiro Nakamura, Haruyuki Tatsumi, Yoshimitsu Yamasaki, Naoyuki Taniguchi.

    共著(海外含む)

  • Quinazoline derivatives suppress nitric oxide production by macrophages through inhibition of NOS II gene expression,FEBS Lett,395 299-303,1996年

    Noriko Fujiwara, Ayako Okado, Han Geuk Seo, Junichi Fujii, Kigen Kondo, Naoyuki Taniguchi

    共著(海外含む)

  • The structural organization of the human skeletal muscle ryanodine receptor (RYR1) gene. ,Genomics,34 24-41,1996年

    Michael S. Phillips, Junichi Fujii, Vijay K. Khanna, Stella DeLeon, Kathy Yokobata, Pieter J. de Jong, David H. MacLennan

    共著(海外含む)

  • Induction of apoptotic cell death by methylglyoxal and 3-deoxyglucosone in macrophage-derived cell lines.,Biochem. Biophys. Res. Commun.,225 219-224,1996年

    Ayako Okado, Yoshimi Kawasaki, Yukiko Hasuike, Motoko Takahashi, Tadashi Teshima, Junichi Fujii, Naoyuki Taniguchi

    共著(海外含む)

  • Instability of mutant Cu/Zn superoxide disumutase (Ala4Thr) associated with familial amyotrophic lateral sclerosis. ,Neurosci. Lett. ,211 129-131,1996年

    Ryoichi Nakano, Takashi Inuzuka, Koki Kikugawa, Hitoshi Takahashi, Kenji Sakimura, Junichi Fujii, Naoyuki Taniguchi, Shoji Tsuji

    共著(海外含む)

  • Glycation and inactivation of sorbitol dehydrogenase in normal and diabetic rats. ,Biochem. J. ,318 119-123,1996年

    Ayumu Hoshi, Motoko Takahashi, Junichi Fujii, Theingi Myint, Hideaki Kaneto, Keiichiro Suzuki, Yoshimitu Yamasaki, Takenobu Kamada, Naoyuki Taniguchi.

    共著(海外含む)

  • Effect of substitutions of conserved histidine residues in human g-glutamyl transpeptidase.,J. Biochem. ,119 1166 -1170,1996年

    Yoshitaka Ikeda, Junichi Fujii, Naoyuki Taniguchi.

    共著(海外含む)

  • The protective role of glutathione peroxidase in apoptosis induced by reactive oxygen species.,J. Biochem.,119 817 -822,1996年

    Yoshiro Kayanoki, Junichi Fujii, Kazi Nazrul Islam, Keiichiro Suzuki, Sumio Kawata, Yuji Matsuzawa, Naoyuki Taniguchi.

    共著(海外含む)

  • Induction of aldose reductase gene expression in LEC rats during development of the hereditary hepatitis and hepatoma. ,Jpn. J. Cancer Res,87 337-341,1996年

    Motoko Takahashi, Ayumu Hoshi, Junichi Fujii, Eiji Miyoshi, Takehiro Kasahara, Keiichiro Suzuki, Katsuyuki Aozasa, Naoyuki Taniguchi.

    共著(海外含む)

  • Expression of an active glycosylated human g-glutamyl transpeptidase mutant that lacks a membrane anchor domain.,Proc. Natl. Acad. Sci. USA. ,92 126 -130,1995年

    Yoshitaka Ikeda, Junichi Fujii, Naoyuki Taniguchi, Alton Meister

    共著(海外含む)

  • Characterization of cDNA and genomic DNA encoding SERCA1, the Ca2+-ATPase of human fast-twitch skeletal muscle sarcoplasmic reticulum, and its elimination as a candidate gene for Brody disease,Genomics ,30 415-424,1995年

    Yilin Zhang, Junichi Fujii, Michael S. Phillips, Hai-Shiene Chen, George Karpati, Won-Chee Yee, Bertold Schrank, David R. Cornblath, Kevin B. Boylan, David H. MacLennan.

    共著(海外含む)

  • Induction of nitric oxide synthase and concomitant suppression of superoxide dismutases in experimental colitis in rats,Arch. Biochem. Biophys.,324 41-47,1995年

    Han Geuk Seo, Ikuya Takata, Masahiro Nakamura, Haruyuki Tatsumi, Keiichiro Suzuki, Junichi Fujii, Naoyuki Taniguchi

    共著(海外含む)

  • Organization of the human N-acetylglucosaminyltransferase V gene.,Eur. J. Biochem.,233 18-26,1995年

    Hiroyuki Saito, Jianguo Gu, Atsushi Nishikawa, Yoshito Ihara, Junichi Fujii, Yutaka Kohgo, Naoyuki Taniguchi.

    共著(海外含む)

  • Elevation of aldose reductase gene expression in rat primary hepatoma and hepatoma cell lines: Implication in detoxification of cytotoxic aldehydes.,Int. J. Cancer ,62 749-754,1995年

    Motoko Takahashi, Junichi Fujii, Eiji Miyoshi, Ayumu Hoshi, Naoyuki Taniguchi.

    共著(海外含む)

  • Involvement of Ser-451 and Ser-452 in the catalysis of human g-glutamyl transpeptidase.,J. Biol. Chem.,270 22223-22228 ,1995年

    Yoshitaka Ikeda, Junichi Fujii, Mary E. Anderson, Naoyuki Taniguchi, Alton Meister.

    共著(海外含む)

  • Inactivation of glutathione peroxidase by nitric oxide: Implication for cyototoxicity.,J. Biol. Chem. ,270 21035-21039,1995年

    Michio Asahi, Junichi Fujii, Keiichiro Suzuki, Han Geuk Seo, Tsunehiko Kuzuya, Masatsugu Hori, Michihiko Tada, Shigeru Fujii, Naoyuki Taniguchi

    共著(海外含む)

  • Apoptotic cell death triggered by nitric oxide in pancreatic b-cells.,Diabetes,44 733 -738,1995年

    Hideaki Kaneto, Junichi Fujii, Han Geuk Seo, Keiichiro Suzuki, Taka-aki Matsuoka, Masahiro Nakamura, Haruyuki Tatsumi, Yoshimitsu Yamasaki, Takenobu Kamada, Naoyuki Taniguchi.

    共著(海外含む)

  • Human gamma-glutamyl transpeptidase mutants involving conserved aspartate residues and the unique cysteine residues of the light subunit.,J. Biol. Chem. ,270 12471-12475,1995年

    Yoshitaka Ikeda, Junichi Fujii, Naoyuki Taniguchi, Alton Meister.

    共著(海外含む)

  • Different sites of acivicin binding and inactivation of gamma-glutamyl transpeptidase.,Proc. Natl. Acad. Sci. USA. ,92 2360-2364,1995年

    Terry K. Smith, Yoshitaka Ikeda, Junichi Fujii, Naoyuki Taniguchi, Alton Meister.

    共著(海外含む)

  • Heme requirement for production of active endothelial nitric oxide synthase in baculovirus-infected insect cells.,Biochem. Biophys. Res. Commun.,208 10-18,1995年

    Han Geuk Seo, Junichi Fujii, Hidenobu Soejima, Norio Niikawa, Naoyuki Taniguchi.

    共著(海外含む)

  • Characterization of wild-type and amyotrophic lateral sclerosis-related mutant Cu,Zn-superoxide dismutase overprodued in baculovirus-infected insect cells.,J. Neurochem.,64 1456-1461,1995年

    Junichi Fujii, Theingi Myint, Han Geuk Seo, Yoshiro Kayanoki, Yoshitaka Ikeda, Naoyuki Taniguchi.

    共著(海外含む)

  • In vivo glycation of aldehyde reductase, a major 3-deoxyglucosone reducing enzyme: Identification of glycation sites. ,Biochemistry,34 1433-1438,1995年

    Motoko Takahashi, Lu Ya-bin, Theingi Myint, Junichi Fujii, Yoshinao Wada, Naoyuki Taniguchi.

    共著(海外含む)

  • Nitric oxide synthase from rat colorectum: Purification, peptide sequencing, partial PCR, and immunohistochemistry,J. Biochem.,115 602-607,1994年

    Han Geuk Seo, Haruyuki Tatsumi, Junichi Fujii, Atsushi Nishikawa, Keiichiro Suzuki, Kenji Kangawa, Naoyuki Taniguchi.

    共著(海外含む)

  • A New Variant Cu/Zn Superoxide Dismutase (Val7→Glu) Deduced from Lymphocyte mRNA sequences from Japanese patients with familial amyotrophic lateral sclerosis. ,Biochem. Biophys. Res. Commun.,204 572-577,1994年

    Makito Hirano, Junichi Fujii, Yoshitaka Nagai, Masanobu Sonobe, Koichi Okamoto, Heihachi Araki, Naoyuki Taniguchi, Satoshi Ueno

    共著(海外含む)

  • DNA cleavage induced by glycation of Cu,Zn-superoxide dismutase.,Biochem. J.,304 219-225,1994年

    Hideaki Kaneto, Junichi Fujii, Keiichiro Suzuki, Hiroshi Kasai, Ryuzo Kawamori, Takenobu Kamada, Naoyuki Taniguchi.

    共著(海外含む)

  • Suppression of antioxidative enzyme expression by transforming growth factor-b1 in rat hepatocytes.,J. Biol. Chem.,269 15488-15492,1994年

    Yoshiro Kayanoki, Junichi Fujii, Keiichiro Suzuki, Sumio Kawata, Yuji Matsuzawa, Naoyuki Taniguchi.

    共著(海外含む)

  • A aovel mutation in Cu/Zn superoxide dismutase gene in a Japanese familial amyotrophic lateral sclerosis. ,Biochem. Biophys. Res. Commun.,200 695-703,1994年

    Ryoichi Nakano, Shuzo Sato, Takashi Inuzuka, Kenji Sakimura, Masayoshi Mishina, Hitoshi Takahashi, Fusahiro, Ikuta, Yoshiaki Honma, Junichi Fujii, Naoyuki Taniguchi, Shoji Tsuji

    共著(海外含む)

  • Induction of manganese superoxide dismutase mRNA by Okadaic acid and protein synthesis inhibitors.,Biochem. J.,301 31-34,1994年

    Junichi Fujii, Toshiyuki Nakata, Yoshitaka Ikeda, Eiji Miyoshi, Naoyuki Taniguchi

    共著(海外含む)

  • Significance of Arg-107 and Glu-108 in the catalytic mechanism of human gamma-glutamyl transpeptidase: Identification by site-directed mutagenesis.,J. Biol. Chem.,268 3980-3985,1993年

    Yoshitaka Ikeada, Junichi Fujii, Naoyuki Taniguchi

    共著(海外含む)

  • Manganese-superoxide dismutase in endothelial cells: Localization and mechanism of induction.,Am. J. Physiol.,(265) H1173-H1178,1993年

    Keiichiro Suzuki, Haruyuki Tatsumi, Shoji Satoh, Takao Senda, Toshiyuki Nakata, Junichi Fujii, Naoyuki Taniguchi

    共著(海外含む)

  • Chromosome mapping of five human cardiac and skeletal muscle sarcoplasmic reticulum protein genes,Genomics,17 507-509,1993年

    Kinya Otsu, Junichi Fujii, Muthu Periasamy, Michael Difilippantonio, Madhvi Uppender, David C. Ward, David H. MacLennan

    共著(海外含む)

  • Expression of DNA methyltransferase in LEC rats during hepatocarcinogenesis,Carcinogenesis,14 603-605,1993年

    Eiji Miyoshi, Suresh K. Jain, Toshihiro Sugiyama, Junichi Fujii, Norio Hayashi, Hideyuki Fusamoto, Takenobu Kamada, Naoyuki Taniguchi

    共著(海外含む)

  • Induction and release of manganese superoxide dismutase from mitochondria from human mmbilical vein endothelial cells tumor necrosis factor-a and interleukin-1a. ,Int. J. Cancer ,55 646 -650,1993年

    Toshiyuki Nakata, Keiichiro Suzuki, Junichi Fujii, Mutsuo Ishikawa, Naoyuki Taniguchi

    共著(海外含む)

  • Identity of a major 3-deoxyglucosone reducing enzyme with aldehyde Reductase in rat liver established by protein sequencing and cDNA expression.,Gene ,127 249-253,1993年

    Motoko Takahashi, Junichi Fujii, Tadashi Teshima, Keiichiro Suzuki, Tetsuo Shiba, Naoyuki Taniguchi

    共著(海外含む)

  • Polymorphisms and deduced amino acid substitutions in the coding sequence of the ryanodine receptor (RYR1) gene in individuals with malignant hyperthermia.,Genomics ,13 1247-1254,1992年

    Elizabeth F. Gillard, Kinya Otsu, Junichi Fujii, Catherine Duff, Stella de Leon,Vijay K. Khanna, Beverley A. Britt, Ronald G. Worton, David H. MacLennan

    共著(海外含む)

  • High expression of Mn-superoxide dismutase in 7,12-dimethylbenz(a) anthracene-induced ovarian cancer and increased serum levels in the tumor-bearing Rats. ,Carcinogenesis,13 1941-1943 ,1992年

    Toshiyuki Nakata, Keiichiro Suzuki, Junichi Fujii, Mutsuo Ishikawa, Haruyuki Tatsumi, Toru Sugiyama, Takashi Nishida, Tetsuya Shimizu, Michiaki Yakushiji, Naoyuki Taniguchi

    共著(海外含む)

  • Enhancement of hepatitis B surface antigen expression by 5-azacytidine in a hepatitis B virus-transfected cell line. ,Int. J. Cancer,52 137-140,1992年

    Eiji Miyoshi, Junichi Fujii, Norio Hayashi, Keiji Ueda, Takehiro Towata, Hideyuki Fusamoto, Takenobu Kamada, Naoyuki Taniguchi

    共著(海外含む)

  • Structure of the rabbit phospholamban gene, cloning of the human cDNA and assignment of the gene to human chromosome 6.,J. Biol. Chem,266 11669-11675,1991年

    Junichi Fujii, Angel Zarain-Herzberg, Huntington, F. Willard, Michihiko Tada, David H. MacLennan

    共著(海外含む)

  • Phorbol ester induces manganese-superoxide dismutase in tumor necrosis factor-resistant cells,J. Biol. Chem.,266 23142-23146 ,1991年

    Junichi Fujii, Naoyuki Taniguchi

    共著(海外含む)

  • A substitution of cysteine for arginine 614 in the ryanodine receptor is potentially causative of human malignant hyperthermia.,Genomics,11 751-755,1991年

    Elizabeth F. Gillard, Kinya Otsu, Junichi Fujii, Vijay K. Khanna, Stella de Leon, Jeanette Derdemezi, Beverley A. Britt, Catherine L. Duff, Ronald G. Worton, David H. MacLennan

    共著(海外含む)

  • Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia.,Science,253 448-451,1991年

    Junichi Fujii, Kinya Otsu, Francesco Zorzato, Stella de Leon, Vijay K. Khanna, Janice E. Weiler, Peter J. O'Brien, David H. MacLennan

    共著(海外含む)

  • Molecular cloning of cDNA encoding human and rabbit forms of the Ca2+ release channel (ryanodine receptor) of skeletal muscle sarcoplasmic reticulum.,J. Biol. Chem.,265 2244-2256 ,1990年

    Francesco Zorzato, Junichi Fujii, Kinya Otsu, Michael Phillips, N. Michael Green, F. Anthony Lai, Gerhard Meissner, David H. MacLennan.

    共著(海外含む)

  • Co-expression of cardiac/slow-twitch Ca2+-ATPase (SERCA2) and phospholamban. ,FEBS Lett.,273 232-234,1990年

    Junichi Fujii, Kei Maruyama, Michihiko Tada, David H. MacLennan

    共著(海外含む)

  • The human ryanodine receptor gene: Its mapping to 19q13.1, placement in a chromosome 19 linkage group and exclusion as the gene causing myotonic dystrophy.,Am. J. Hum. Genet.,46 1082-1089,1990年

    Alex E. MacKenzie, Robert G. Korneluk, Francesco Zorzato, Junichi Fujii, Michael Phillips, David Iles, Be Wieringa, Suzanne Leblond, Jane Bailly, Huntington F. Willard, Cathenine Duff, Ronald G. Worto...

    共著(海外含む)

  • Characterization and localization to human chromosome 1 of the human fast- twitch skeletal muscle calsequestrin gene.,Somat. Cell Mol. Genet,16 185-189,1990年

    Junichi Fujii, Huntington F. Willard, David H. MacLennan

    共著(海外含む)

  • The ryanodine receptor gene is a candidate gene for the predisposition to malignant hyperthermia.,Nature ,343 559-561,1990年

    David H. MacLennan, Chatherine Duff, Francesco Zorzato, Junichi Fujii, Michael Phillips, Robert G. Korneluk, Wanda Frodis, Beverley A. Britt, Ronald G. Worton.

    共著(海外含む)

  • Regulation of myocardial Ca-ATPase and phospholamban mRNA expression in response to pressure overload and thyroid hormone.,Proc. Natl. Acad. Sci. USA.,86 2966-2970 ,1989年

    Ryozo Nagai, Angel Zarain-Herzberg, Christopher J. Brandl, Junichi Fujii, Michihiko Tada, David H. MacLennan, Norman R. Alpert, Muthu Periasamy

    共著(海外含む)

  • Functional consequences of alterations to amino acids located in the catalytic (isolucine 348 to threonine 357) and nucleotide-binding domain of the Ca2+-ATPase of sarcoplasmic reticulum.,J. Biol. Chem.,264 13038-13042,1989年

    Kei Maruyama, David M. Clarke, Junichi Fujii, Giuseppe Inesi, Tip W. Loo, David H. MacLennan

    共著(海外含む)

  • Expression and site-specific mutagenesis of phospholamban: Studies of residues involved in phosphorylation and pentamer formation,J. Biol. Chem. ,264 12950-12955,1989年

    Junichi Fujii, Kei Maruyama, Michihiko Tada, David H. MacLennan

    共著(海外含む)

  • Slow/cardiac sarcoplasmic reticulum Ca2+-ATPase and phospholamban mRNAs are expressed in chronically stimulated rabbit fast-twitch muscle,Eur. J. Biochem.,185 51-54,1989年

    Ekkehard Leberer, Kar-Thomas Hartner, Christopher, J. Brandl, Junichi Fujii, Michihiko Tada, David H. MacLennan, Dirk Pette

    共著(海外含む)

  • Rabbit cardiac and slow-twitch muscle express the same phospholamban gene.,FEBS Lett.,227 51-55,1988年

    Junichi Fujii, Jonathan Lytton, Michihiko Tada, David H. MacLennan

    共著(海外含む)

  • The cDNA sequence of the major phospholamban mRNA in canine cardiac muscle,Nucleic Acids Res.,15 6738,1987年

    Atsuko Uyeda, Katsuhiko Kitano, Junichi Fujii, Masaaki Kadoma, Michihiko Tada, Shoji Tanaka

    共著(海外含む)

  • Characterizaion of structural unit of phospholamban by amino acid sequencing and electrophoretic analysis,Biochem. Biophys. Res. Commun.,138 1044-1050,1986年

    Junichi Fujii, Masaaki Kadoma, Michihiko Tada, Hiroko Toda, Fumio Sakiyama

    共著(海外含む)

  • Sarcoplasmic reticulum Ca-ATPase: Distinction of phosphoenzyme formed from Mg ATP and Ca ATP as substrates and interconversion of the phosphoenzymes by Mg2+ and Ca2+,J. Biochem.,100 1329-2342,1986年

    Shinpei Yamada, Junichi Fujii, Hajime Katayama

    共著(海外含む)

全件表示 >>

著書

  • Ferroptosis in Health and Disease,Springer Nature,2019年

    Junichi Fujii, Sho Kobayashi, Takujiro Homma

  • Glutathione and related compounds produced by the glutathione-synthesizing pathway,Nova Science Publisher Inc,2019年

    Junichi Fujii, Sho Kobayashi, Takujiro Homma.

  • Oxidative stress and dysfunction of the intracellular proteolytic machinery: a pathological hallmark of nonalcoholic fatty liver disease,Elsevier,2019年

    Takujiro Homma, Junichi Fujii

  • ベインズ・ドミニチャク生化学,エルゼビア・ジャパン,2018年

    Baynes John W., Dominiczak Marek H, 谷口 直之, 岩井 一宏, 藤井 順逸, 本家 孝一

  • Superoxide Dismutase (SOD): Sources, Therapeutic Uses and Health Benefits." (Nancy H. Phillips, ed.) ,Nova Science Publishers, Inc,2016年

    Takujiro Homma, Junichi Fujii

  • Ascorbic Acid: Properties, Synthesis and Applications,Nova Science Publishers, Inc,2016年

    Junichi Fujii, Takujiro Homma, Sho Kobayashi

  • Handbook of System Biology of Free Radicals and Anti-oxidants,Springer-Verlag,2014年

    Fujii J, Tsunoda S, Kimura N.

  • Medical Biochemistry 4th ed,Elsevier,2014年

    Junichi Fuji

  • Male and Female Infertility: Genetic Causes, Hormonal Treatments and Health Effects., Nova Science Publishers,2010年

    Fujii J, Iuchi Y

  • Male and Female Infertility: Genetic Causes, Hormonal Treatments and Health Effects.,Nova Science Publishers,2010年

    Kimura N, Fujii J

  • Medical Biochemistry 3rd ed,Elsevier,2009年

    Junichi Fujii

  • Medical Biochemistry 2nd ed,Mosby,2005年

    Junichi Fujii

  • The Maillard Reaction in Food Chemistry and Medical Science: Update for the Postgenomic Era, Elsevier,2002年

    Junichi Fujii, Tomoko Kaneko, Takashi Kobayashi, Yoshihito Iuchi, Motoko Takahashi.

  • Handbook of Oxidants and Antioxidants in Exercise,Elsevier,2000年

    K. Suzuki, H. Ohno, S. Oh-ishi, T. Kizaki, T. Ookawara, J. Fujii, Z. Radak, and N. Taniguchi.

  • Medical Biochemistry,Mosby,1999年

    Junichi Fujii

  • Redox Regulation of Cell Signaling and Its Clinical Applications,Marcel Dekker,1999年

    Junichi Fujii, Naoyuki Taniguchi

  • Pathophysiology of Lipid Peroxides and Related Free Radicals,Japan Scientific Societies Press,1998年

    Junichi Fujii, Michio Asahi, Ayako Okado, Naoyuki Taniguchi

  • Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases"(L. Montagnier, R. Olivier, and C. Pasquier eds,Marcel Dekker,1998年

    Naoyuki Taniguchi, Junichi Fujii, Hideaki Kaneto, Michio Asahi, Theingi Myint, Nobuko Miyazawa, Keiichiro Suzuki, Kazi Nazrul Islam

  • Bioinformatics: Information Transduction and Processing Systems from Cell to Whole Body,Elsevier,1988年

    Michihiko Tada, Masaaki Kadoma, Makoto Inui, Junichi Fujii, Yoshihiro Kimura, Yoshiyuki Kijima, Tatsuya Sasaki

  • Cell Calcium Metabolism: Physiology, Biochemistry, Pharmacology, and Clinical Applications, Plenum Press,1988年

    Michihiko Tada, Masaaki Kadoma, Junichi Fujii

  • Calcium Protein Signaling; Adavances in Experimental Medicine and Biology,Plenum Press,1988年

    Micihiko Tada, Masaaki Kadoma, Junihchi Fujii, Yoshihiro Kimura, Yoshiyuki Kijima

  • Ca Channel Blockers and the Heart,Interprint,1987年

    Michihiko Tada, Masaaki Kadoma, Junichi Fujii

  • Perspectives of Biological Energy Transduction,Academic Press,1987年

    Michihiko Tada, Masaaki Kadoma, Junichi Fujii

  • Heart Function and Metabolism,Martinus Nijhoff Publishin,1987年

    Michihiko Tada, Masaaki Kadoma, Junichi Fujii

  • Cardiac Function under Ischemic and Hypoxia,The University of Nagoya Press,1986年

    Michihiko Tada, Masaaki Kadoma, Junichi Fujii

全件表示 >>

総説・解説記事

  • Erythrocytes as a preferential target of oxidative stress in blood.,Free Radical Research,2021年01月

    Junichi Fujii, Takujiro Homma, Sho Kobayashi, Prashant Warang, Manisha Madkaikar, Malay B Mukherjee.

  • Ascorbate is a multifunctional micronutrient whose synthesis is lacking in primates.,Journal of Clinical Biochemistry and Nutrition,2021年

    Junichi Fujii

  • Emerging connections between oxidative stress, defective proteolysis, and metabolic diseases.,Free Radical Research,2020年04月

    Takujiro Homma, Junichi Fujii

  • Ferroptosis caused by cysteine insufficiency and oxidative insult.,Free Radical Research,2019年09月

    Junichi Fujii, Takujiro Homma, Sho Kobayashi

  • Physiological and Pathological Views of Prdx4. ,Free Radic. Biol. Med,83 373-379,2015年

    Junichi Fujii, Yoshitaka Ikeda, Toshihiro Kurahashi, Takujiro Homma

  • Application of glutathione as anti-oxidative and anti-aging drug.,Curr Drug Metab,in press ,2015年

    Takujiro Homma, Junichi Fujii.

  • Roles of Antioxidative Enzymes in Wound Healing,J Dev Biol,3 57-70,2015年

    Toshihiro Kurahashi, Junichi Fuji

  • Oxidative stress as a potential causal factor for autoimmune hemolytic anemia and systemic lupus erythematosus,World J Nephrol,4 213-222,2015年

    Junichi Fujii, Toshihiro Kurahashi, Tasuku Konno, Takujiro Homma, Yoshihito Iuchi.

  • Oxidative stress and redox regulation of gametogenesis, fertilization, and embryonic development. ,Reproductive Medicine and Biology,13 71-79,2014年

    Satoshi Tsunoda, Naoko Kimura, Junichi Fujii.

  • Redox reactions in mammalian spermatogenesis and the potential targets of reactive oxygen species under oxidative stress.,Spermatogenesis,4(2) e979108,2014年

    Junichi Fujii, Hirotaka Imai

  • Unveiling the Roles of the Glutathione Redox System In Vivo by Analyzing Genetically Modified Mice.,J. Clin. Biochem. Nutr.,49 70-78,2011年

    Junichi Fujii, Jun-itsu Ito, Xuhong Zhang, Toshihiro Kurahashi.

  • Redox regulation of spermatogenic process and fertilization,Asian J Androl,13 420-423,2011年

    Junichi Fujii, Satoshi Tsunoda

  • Molecular mechanisms of inflammation-induced carcinogenesis.,Clin Biochem Nutr,39 103-113,2006年

    Futoshi Okada, Junichi Fujii.

  • Prevention of tumor progression as the ultimate goal of cancer therapy,Cancer Therapy,3 219--226,2005年

    Futoshi Okada, Junichi Fujii.

  • Fundamental roles of reactive oxygen species and protective mechanisms in the female reproductive system. ,Reprod Biol Endocrinol, 3 43,2005年

    Junichi Fujii, Yoshihito Iuchi, Futoshi Okada.

  • Cooperative function of antioxidant and redox systems against oxidative stress in male reproductive tissues ,Asian J. Androl.,5 231-242,2003年

    Junichi Fujii, Yoshihito Iuchi, Shingo Matsuki, Tatsuya Ishii.

  • Down Regulation of Superoxide Dismutases and Glutathione Peroxidase by Reactive Oxygen and Nitrogen Species,Free Radic. Res,31 301-308,1999年

    Junichi Fujii, Naoyuki Taniguchi

  • LEC Rats: An Overview of Recent Findings.,J. Trace Elem. Exp. Med,1997年

    Eiji Miyoshi, Junichi Fujii, Norio Hayashi, Naoyuki Taniguchi

  • Involvement of Glycation and Oxidative Stress in Diabetic Macroangiopathy,Diabetes,45 S81-S83,1996年

    Naoyuki Taniguchi, Hideaki Kaneto, Michio Asahi, Motoko Takahashi, Shigeki Higashiyama, Junichi Fujii, Keiichiro Suzuki, Yoshiro Kayanoki

  • Oxidative Stress Caused by Glycation of Cu,Zn-Superoxide Dismutase and Its Effects on Intracellular Components.,Nephrol. Dial. Transpl.,11 34-40,1996年

    Junichi Fujii, Theingi Myint, Ayako Okado, Hideaki Kaneto, Naoyuki Taniguchi

  • Expression of Mn-superoxide Dismutase in Carcinogenesis,Tohoku J. Exp. Med,168: 105-111,1992年

    Naoyuki Taniguchi, Mutsuo Ishikawa, Tetsuo Kawaguchi, Junichi Fujii, Keiichiro Suzuki, Toshiyuki Nakata

  • The Role of the Skeletal Muscle Ryanodine Receptor Gene in Malignant Hyperthermia.,Symp. Soc. Exp. Biol.,46 189-201,1992年

    David H. MacLennan, Kinya Otsu, Junichi Fujii, Francesco Zorzato, Michael S. Phillips, Peter O'brien, Alan L. Archibald, Beverley A. Britt, Elizabeth F. Gillard, Ronald G. Worton

  • Expression and Mutation of Ca2+-ATPase of the Sarcoplasmic Reticulum.,Cell Motil. Cytoskel.,14 26-34,1989年

    Kei Maruyama, David M. Clarke, Junichi Fujii, Tip W. Loo, David H. MacLennan

  • Regulation of Ca Pump from Heart Sarcoplasmic Reticulum.,Methods Enz,157 107-154,1988年

    Michihiko Tada, Masaaki Kadoma, Makoto Inui, Junichi Fujii

全件表示 >>

その他研究活動

  • Scientific Report

    編集委員

  • World Journal of Biological Chemistry

    編集委員

  • Journal of Clinical Biochemistry and Nutrition

    編集委員

  • Journal of Biochemistry

    編集委員

  • Asian Journal of Andrology

    編集委員

  • Reproductive Biology and Endocrinology

    編集委員

全件表示 >>

学術関係受賞

  • 2020年日本酸化ストレス学会学会賞,2020年10月06日,日本国,日本酸化ストレス学会,藤井順逸

科研費(文科省・学振)獲得実績

  • 基盤研究(C),2018年04月 ~ 2021年03月,一酸化窒素(NO)合成酵素由来と外因性NOによるスーパーオキシドの毒性軽減の証明

    病態医化学関連

その他競争的資金獲得実績

  • 二国間交流事業共同研究,2019年04月 ~ 2021年03月,PPAR活性化による酸化ストレス・小胞体ストレス軽減による脂肪性肝疾患の改善

    文部科学省

  • 二国間交流事業共同研究,2018年06月 ~ 2020年03月,鎌状赤血球症の発症機構解明による疾患克服を目指す日印共同研究

    文部科学省

  • 二国間交流事業共同研究,2017年04月 ~ 2019年03月,リモデリングを司る細胞間基質の酸化障害と制御機構に関する日韓共同研究

    文部科学省

  • 二国間交流事業共同研究/セミナー,2016年06月 ~ 2018年03月,赤血球関連疾患の予防と診断を目指す日印共同研究

    文部科学省

  • 頭脳循環を加速する若手研究者戦略的海外派遣プログラム,2012年10月 ~ 2015年03月,蛋白質機能のレドックス制御機構を解明する若手研究者育成のための日欧共同研究

    文部科学省

共同研究実施実績

  • [大阪大学蛋白質研究所共同研究員]ジペプチダーゼCNDP2による酸化ストレスを起因とする新規細胞死・フェロトーシスからの保護機構の解明,2021年04月 ~ 2022年03月,国内共同研究

  • [大阪大学蛋白質研究所共同研究員]ジペプチダーゼCNDP2による酸化ストレスを起因とする新規細胞死・フェロトーシスからの保護機構の解明,2020年04月 ~ 2021年03月,国内共同研究

  • [大阪大学蛋白質研究所共同研究員]ジペプチダーゼCNDP2による酸化ストレスを起因とする新規細胞死・フェロトーシスからの 保護機構の解明,2019年04月 ~ 2020年03月,国内共同研究

  • [大阪大学蛋白質研究所共同研究員]酸化ストレスによる赤血球蛋白質の酸化的修飾の解明,2018年04月 ~ 2019年03月,国内共同研究

  • [東北大学加齢医学研究所 共同利用・共同研究]Nrf2により発現制御される抗酸化・レドックス遺伝子のアスコルビン酸欠乏下における役割の解明,2018年04月 ~ 2019年03月,国内共同研究

  • [大阪大学蛋白質研究所共同研究員]グルタチオン欠乏マクロファージの生存を可能とする因子のプロテオミクス解析による探索,2017年04月 ~ 2018年03月,国内共同研究

  • [大阪大学蛋白質研究所共同研究員]酸化ストレスによる赤血球蛋白質の酸化的修飾の解明,2016年04月 ~ 2017年03月,国内共同研究

  • [大阪大学蛋白質研究所共同研究員]レドックス分子Peroxiredoxin 4 (Prx4)のカルシウム制御と精巣における役割の解明,2015年04月 ~ 2016年03月,学内共同研究

  • [大阪大学蛋白質研究所共同研究員]タンパク質の酸化的折畳みにおけるレドックス分子Peroxiredoxin 4 (Prx4)の役割の解明,2014年03月 ~ 2015年03月,国内共同研究

  • [大阪大学蛋白質研究所共同研究員]タンパク質の酸化的折畳みにおけるレドックス分子 Peroxiredoxin 4 (Prx4)の役割の解明,2013年04月 ~ 2014年03月,国内共同研究

  • [大阪大学蛋白質研究所共同研究員]レドックス分子Peroxiredoxin 4 (Prx4)による活性酸素シグナルの制御機構の解明,2012年04月 ~ 2013年03月,国内共同研究

  • レドックス分子Perxoiredoxin 4(Prx4)による活性酸素シグナル制御機構の解明,2011年04月 ~ 2012年03月,国内共同研究

全件表示 >>

研究発表

  • 第73回日本酸化ストレス学会・第20回日本NO学会 合同学術集会,国内会議,2020年10月,グルタチオン合成阻害環境下における鉄硫黄クラスター形成反応のフェロトーシス感受性への関与,その他

  • 第73回日本酸化ストレス学会・第20回日本NO学会 合同学術集会,国際会議,2020年10月,マクロファージNOS2の生成するNOはスーパーオキシドの毒性消去に働く,その他

  • 第73回日本酸化ストレス学会・第20回日本NO学会 合同学術集会,国際会議,2020年10月,アスコルビン酸は遊離鉄の毒性を抑制することによりアセトアミノフェン肝障害を軽減する,その他

  • 第93回日本生化学会大会,国内会議,2020年09月,フェロトーシス細胞を認識するラットモノクローナル抗体の作製とその性質,ポスター発表

  • 8th International Translational Cancer Research Conference:Role of Inflammation and Immune System for Cancer Prevention and Treatment ,国際会議,2020年02月,Prevention of diethylnitrosamine-induced hepatic injury and carcinogenesis in mice by vitamin C,口頭発表(招待・特別)

  • The Society for Free Radical Research (SFRR)-INDIA-2020,国際会議,2020年02月,Oxidative stress as the causal factor for anemic diseases.,口頭発表(招待・特別)

  • 第92回日本生化学会大会,国内会議,2019年09月,LC-MSによるgグルタミルペプチド類の定量解析と生体内でのgグルタミルペプチド類の産生経路に関する研究,ポスター発表

  • 第92回日本生化学会大会,国内会議,2019年09月,Aldehyde reductase (Ak1a)ノックアウトマウスの発育障害ならびに発癌剤感受性に関する検討,ポスター発表

  • 第92回日本生化学会大会,国内会議,2019年09月,エダラボンをはじめとする各種フリーラジカル消去剤によるフェロトーシス抑制作用,ポスター発表

  • 第72回日本酸化ストレス学会,国内会議,2019年06月,フリーラジカル消去剤エダラボンによるフェロトーシス抑制作用,ポスター発表

  • 9th Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia),国際会議,2019年04月,Quantitative analysis of γ-glutamylpeptides by LC-MS and application for studying liver injury and γ-glutamyltransferase assay,ポスター発表

  • 9th Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia),国際会議,2019年04月,Amelioration of the reproductive ability of SOD1-deficient female mice by supplemented ascorbic acid and CoQ10,ポスター発表

  • 9th Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia),国際会議,2019年04月,Carnosine dipeptidase 2 (CNDP2) as a potential survival factor for xCT-deficient cells against ferroptosis.,ポスター発表

  • 9th Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia),国際会議,2019年04月,Oxidative stress aggravates proteasome inhibitor bortezomib-induced proteotoxicity in mice,シンポジウム・ワークショップ パネル(公募)

  • 9th Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia),国際会議,2019年04月,Cysteine-Glutathione Redox System Protective Against Ferroptosis,公開講演,セミナー,チュートリアル,講習,講義等

  • 第41回日本分子生物学会大会,国内会議,2018年11月,Oxidative stress triggers systemic organ disorders associated with impaired lipid catabolism in mice during fasting,ポスター発表

  • 第41回日本分子生物学会大会,国内会議,2018年11月,アスコルビン酸合成不全(Akr1a欠損)マウスは高い持久力を示す,ポスター発表

  • 第91回日本生化学会大会,国内会議,2018年09月,xCT遺伝子欠損マクロファージの生存を可能にする分子機構の解明,ポスター発表

  • 19th Biannual Meeting of the Society for Free Radical Research International (SFRRI 2018),国際会議,2018年06月,SOD1 haploinsufficiency exerts deleterious effects on the testis via activation of the autoimmune response in NZW mice.,ポスター発表

  • INTERNATIONAL CELL DEATH SOCIETY Meeting,国際会議,2018年05月 ~ 2018年06月,Hepatocytes are resistant to cysteine deficiency-induced ferroptosis due to recruitment of cysteine by the transsulfuration pathway.,ポスター発表

  • INTERNATIONAL CELL DEATH SOCIETY Meeting,国際会議,2018年05月 ~ 2018年06月,Oxidative stress causes male infertility by triggering autoimmune response in mice with the NZW background,ポスター発表

  • INTERNATIONAL CELL DEATH SOCIETY Meeting,国際会議,2018年05月 ~ 2018年06月,Macrophages from xCT-deficient mice survive under high oxidative stress caused by cysteine and glutathione insufficiency,ポスター発表

  • 第71回日本酸化ストレス学会,国内会議,2018年05月,Cys取込みによるグルタチオン合成の制御とgamma-グルタミル化ペプチドの生成機構,シンポジウム・ワークショップ パネル(指名)

  • 第71回日本酸化ストレス学会,国内会議,2018年05月,アスコルビン酸合成不全(Akr1a欠損)マウスは高い持久力を示す,ポスター発表

  • The 8th Joint Meeting of Society for Free Radical Research Australasia and Japan with International Symposium on Coenzyme Q10,国際会議,2017年12月,Heterozygous SOD1 deficiency causes male infertility by triggering autoimmune response in mice with the NZW background.,ポスター発表

  • The 8th Joint Meeting of Society for Free Radical Research Australasia and Japan with International Symposium on Coenzyme Q10,国際会議,2017年12月,CoQ10 and ascorbic acid ameliorate reproductive ability of SOD1-deficient female mice,口頭発表(一般)

  • The 8th Joint Meeting of Society for Free Radical Research Australasia and Japan with International Symposium on Coenzyme Q10,国際会議,2017年12月,Production of ophthalmic acid by the glutathione-synthesizing pathway in mouse hepatocytes under cysteine insufficiency,ポスター発表

  • 2017年度生命科学系学会合同年次大会(ConBio2017),国内会議,2017年12月,絶食によるアミノ酸代謝の亢進はオフタルミン酸合成を促進する,ポスター発表

  • 2017年度生命科学系学会合同年次大会(ConBio2017),国内会議,2017年12月,シスチントランスポーター・xCT欠損マウスは雄性生殖能が低下する,ポスター発表

  • 第70回日本酸化ストレス学会,国内会議,2017年06月,CoQ10およびアスコルビン酸はSOD1欠損雌マウスの生殖機能を改善する,ポスター発表

  • 第70回日本酸化ストレス学会,国内会議,2017年06月,シスチントランスポーター・xCTの男性生殖能における役割の検討,ポスター発表

  • OCC World Congress 2017 and Annual SFRR-E Conference; METABOLIC STRESS AND REDOX REGULATION,国際会議,2017年06月,Macrophages from xCT-deficient mice survive under low cysteine/glutathione redox conditions with high oxidative stress,ポスター発表

  • 第17回日本NO学会,国内会議,2017年05月,マクロファージの酸化ストレス防御とNO産生におけるシスチン・グルタミン酸トランスポーターの役割,口頭発表(一般)

  • The 23rd Annual Meeting, a joint meeting with the Society for Free Radical Research International (SfRBM/SFRRI 2016),国際会議,2016年11月,SOD1-knockout mice are resistant to lethal effects of thioacetamide-induced hepatotoxicity,ポスター発表

  • 第89回日本生化学会大会,国内会議,2016年09月,熱ストレス障害に対する小胞体ストレス応答の解析:酸化ストレスはIRE1発現を減少させる,ポスター発表

  • 第89回日本生化学会大会,国内会議,2016年09月,精子形成過程におけるシスチントランスポーター・xCTの生理的役割,ポスター発表

  • 第89回日本生化学会大会,国内会議,2016年09月,SOD1欠損マウスの絶食による腎障害機構,ポスター発表

  • 第89回日本生化学会大会,国内会議,2016年09月,薬剤性肝障害はSOD1欠損によりを軽減される,ポスター発表

  • 第69回日本酸化ストレス学会,国内会議,2016年08月,肝臓へのシステイン供給におけるxCTとTranssulfuration経路の役割,ポスター発表

  • 第69回日本酸化ストレス学会,国内会議,2016年08月,一過性の脂肪蓄積はSOD1欠損マウスの肝臓を酸化ストレスから保護する,ポスター発表

  • 第69回日本酸化ストレス学会,国内会議,2016年08月,アルデヒド還元酵素(AKR1a)欠損は四塩化炭素誘発脂肪肝を悪化させる,ポスター発表

  • 第69回日本酸化ストレス学会,国内会議,2016年08月,SOD1欠損による酸化ストレスはシトクロムP450活性を抑制することで薬剤誘発性肝障害を軽減する.,ポスター発表

  • The 9th International Conference on the Biology, Chemistry and Thrapeutic Applications of Nitric Oxide,国際会議,2016年05月,Differential contribution of xCT and the transsulfuration pathway as cysteine-supply systems in hepatocytes,ポスター発表

全件表示 >>

共同研究希望テーマ

  • グルタチオン代謝とフェロトーシスの機構解明,産学連携、民間を含む他機関等との共同研究等を希望する

 

学会・委員会等活動

  • 日本生化学会,評議員,2000年 ~ 継続中

  • 日本NO学会,評議員,2000年 ~ 継続中

  • 日本酸化ストレス学会,評議員,2001年 ~ 継続中

  • 日本酸化ストレス学会,理事,2008年 ~ 継続中

  • 日本酸化ストレス学会,第74回日本酸化ストレス学会学術集会 会長,2021年05月

相談に応じられる分野

  • 1)生化学・分子生物学

 
      

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