研究分野
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ライフサイエンス / 細胞生物学
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ライフサイエンス / 脳神経外科学
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ライフサイエンス / 病態医化学
出身大学
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東京大学 医学部 医学科
1987年03月,卒業
取得学位
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博士(医学),東京大学,2003年11月
所属学会・委員会
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日本癌学会
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日本脳神経外科学会
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日本脳腫瘍学会
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日本分子生物学会
研究テーマ
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抗ガン剤等によりガン細胞が選択的に細胞死をおこす仕組みを分子のレベルで明らかにし、その分子を標的とする新規薬剤(分子標的治療薬)を開発し治療に応用することにより、より効果的で安全な新規がん治療法を確立することを目指して研究を行っています。
また、近年はがん再発転移の重要な要因と考えられているがん幹細胞の特性解明とその知見を利用したがん幹細胞標的治療の開発を行っています。
論文
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Spironolactone, a Classic Potassium-Sparing Diuretic, Reduces Survivin Expression and Chemosensitizes Cancer Cells to Non-DNA-Damaging Anticancer Drugs.,Cancers,11(10) ,2019年10月
Sanomachi T, Suzuki S, Togashi K, Sugai A, Seino S, Okada M, Yoshioka T, Kitanaka C, Yamamoto M
単著
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Brexpiprazole Reduces Survivin and Reverses EGFR Tyrosine Kinase Inhibitor Resistance in Lung and Pancreatic Cancer.,Anticancer research,39(9) 4817-4828,2019年09月
Sanomachi T, Suzuki S, Togashi K, Seino S, Yoshioka T, Kitanaka C, Okada M, Yamamoto M
単著
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Brexpiprazole, a Serotonin-Dopamine Activity Modulator, Can Sensitize Glioma Stem Cells to Osimertinib, a Third-Generation EGFR-TKI, via Survivin Reduction.,Cancers,11(7) ,2019年07月
Suzuki S, Yamamoto M, Sanomachi T, Togashi K, Sugai A, Seino S, Yoshioka T, Kitanaka C, Okada M
単著
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<i>In vitro</i> and <i>in vivo</i> anti-tumor effects of brexpiprazole, a newly-developed serotonin-dopamine activity modulator with an improved safety profile.,Oncotarget,10(37) 3547-3558,2019年05月
Suzuki S, Yamamoto M, Togashi K, Sanomachi T, Sugai A, Seino S, Yoshioka T, Kitanaka C, Okada M
単著
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AS602801 Sensitizes Ovarian Cancer Stem Cells to Paclitaxel by Down-regulating MDR1,ANTICANCER RESEARCH,39(2) 609-617,2019年02月
Yamamoto Masahiro, Suzuki Shuhei, Togashi Keita, Sanomachi Tomomi, Seino Shizuka, Kitanaka Chifumi, Okada Masashi
単著
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AS602801, an Anticancer Stem Cell Candidate Drug, Reduces Survivin Expression and Sensitizes A2780 Ovarian Cancer Stem Cells to Carboplatin and Paclitaxel,ANTICANCER RESEARCH,38(12) 6699-6706,2018年12月
Yamamoto Masahiro, Suzuki Shuhei, Togashi Keita, Sanomachi Tomomi, Seino Shizuka, Kitanaka Chifumi, Okada Masashi
単著
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AS602801, an Anti-Cancer Stem Cell Drug Candidate, Suppresses Gap-junction Communication Between Lung Cancer Stem Cells and Astrocytes.,Anticancer Res,2018年09月
Kuramoto Kenta, Yamamoto Masahiro, Suzuki Shuhei, Sanomachi Tomomi, Togashi Keita, Seino Shizuka, Kitanaka Chifumi, Okada Masashi
単著
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Involvement of GLUT1-mediated glucose transport and metabolism in gefitinib resistance of non-small-cell lung cancer cells.,Oncotarget,9(66) 32667-32679,2018年08月
Suzuki Shuhei, Okada Masashi, Takeda Hiroyuki, Kuramoto Kenta, Sanomachi Tomomi, Togashi Keita, Seino Shizuka, Yamamoto Masahiro, Yoshioka Takashi, Kitanaka Chifumi
共著(国内のみ)
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A Small-molecule Kinase Inhibitor, CEP-1347, Inhibits Survivin Expression and Sensitizes Ovarian Cancer Stem Cells to Paclitaxel,ANTICANCER RESEARCH,38(8) 4535-4542,2018年08月
Togashi Keita, Okada Masashi, Yamamoto Masahiro, Suzuki Shuhei, Sanomachi Tomomi, Seino Shizuka, Yamashita Hidetoshi, Kitanaka Chifumi
単著
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Olanzapine, an Atypical Antipsychotic, Inhibits Survivin Expression and Sensitizes Cancer Cells to Chemotherapeutic Agents.,Anticancer Res,37(11) 6177-6188,2017年11月
Sanomachi Tomomi, Suzuki Shuhei, Kuramoto Kenta, Takeda Hiroyuki, Sakaki Hirotsugu, Togashi Keita, Seino Shizuka, Yoshioka Takashi, Okada Masashi, Kitanaka Chifumi
共著(国内のみ)
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Antitumor activity of gemcitabine against high-grade meningioma in vitro and in vivo.,Oncotarget,8(53) 90996-91008,2017年10月
Takeda Hiroyuki, Okada Masashi, Kuramoto Kenta, Suzuki Shuhei, Sakaki Hirotsugu, Sanomachi Tomomi, Seino Shizuka, Yoshioka Takashi, Hirano Hirofumi, Arita Kazunori, Kitanaka Chifumi
共著(国内のみ)
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Repositioning CEP-1347, a chemical agent originally developed for the treatment of Parkinson's disease, as an anti-cancer stem cell drug.,Oncotarget,8(55) 94872-94882,2017年10月
Okada Masashi, Takeda Hiroyuki, Sakaki Hirotsugu, Kuramoto Kenta, Suzuki Shuhei, Sanomachi Tomomi, Togashi Keita, Seino Shizuka, Kitanaka Chifumi
共著(国内のみ)
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Licochalcone A specifically induces cell death in glioma stem cells via mitochondrial dysfunction.,FEBS Open Bio,7(6) 835-844,2017年06月
Kuramoto Kenta, Suzuki Shuhei, Sakaki Hirotsugu, Takeda Hiroyuki, Sanomachi Tomomi, Seino Shizuka, Narita Yoshitaka, Kayama Takamasa, Kitanaka Chifumi, Okada Masashi
共著(海外含む)
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Rho-Associated Protein Kinase (ROCK) Inhibitors Inhibit Survivin Expression and Sensitize Pancreatic Cancer Stem Cells to Gemcitabine.,Anticancer Res,36(12) 6311-6318,2016年12月
Takeda Hiroyuki, Okada Masashi, Suzuki Shuhei, Kuramoto Kenta, Sakaki Hirotsugu, Watarai Hikaru, Sanomachi Tomomi, Seino Shizuka, Yoshioka Takashi, Kitanaka Chifumi
共著(国内のみ)
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Impact of H3K27 Demethylase Inhibitor GSKJ4 on NSCLC Cells Alone and in Combination with Metformin.,Anticancer Res,36(11) 6083-6092,2016年11月
Watarai Hikaru, Okada Masashi, Kuramoto Kenta, Takeda Hiroyuki, Sakaki Hirotsugu, Suzuki Shuhei, Seino Shizuka, Oizumi Hiroyuki, Sadahiro Mitsuaki, Kitanaka Chifumi
共著(国内のみ)
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Aripiprazole, an Antipsychotic and Partial Dopamine Agonist, Inhibits Cancer Stem Cells and Reverses Chemoresistance.,Anticancer Res,36(10) 5153-5161,2016年10月
Suzuki Shuhei, Okada Masashi, Kuramoto Kenta, Takeda Hiroyuki, Sakaki Hirotsugu, Watarai Hikaru, Sanomachi Tomomi, Seino Shizuka, Yoshioka Takashi, Kitanaka Chifumi
共著(国内のみ)
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The novel JNK inhibitor AS602801 inhibits cancer stem cells in vitro and in vivo.,Oncotarget,7(19) 27021-27032,2016年05月
Okada Masashi, Kuramoto Kenta, Takeda Hiroyuki, Watarai Hikaru, Sakaki Hirotsugu, Seino Shizuka, Seino Manabu, Suzuki Shuhei, Kitanaka Chifumi
共著(国内のみ)
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Time-staggered inhibition of JNK effectively sensitizes chemoresistant ovarian cancer cells to cisplatin and paclitaxel.,Oncol Rep,35(1) 593-601,2016年01月
Seino Manabu, Okada Masashi, Sakaki Hirotsugu, Takeda Hiroyuki, Watarai Hikaru, Suzuki Shuhei, Seino Shizuka, Kuramoto Kenta, Ohta Tsuyoshi, Nagase Satoru, Kurachi Hirohisa, Kitanaka Chifumi
共著(国内のみ)
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GSKJ4, A Selective Jumonji H3K27 Demethylase Inhibitor, Effectively Targets Ovarian Cancer Stem Cells.,Anticancer Res,35(12) 6607-6614,2015年12月
Sakaki Hirotsugu, Okada Masashi, Kuramoto Kenta, Takeda Hiroyuki, Watarai Hikaru, Suzuki Shuhei, Seino Shizuka, Seino Manabu, Ohta Tsuyoshi, Nagase Satoru, Kurachi Hirohisa, Kitanaka Chifumi
共著(国内のみ)
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Targeting the facilitative glucose transporter GLUT1 inhibits the self-renewal and tumor-initiating capacity of cancer stem cells.,Oncotarget,6(2) 651-661,2015年01月
Shibuya Keita, Okada Masashi, Suzuki Shuhei, Seino Manabu, Seino Shizuka, Takeda Hiroyuki, Kitanaka Chifumi
共著(国内のみ)
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JNK suppression of chemotherapeutic agents-induced ROS confers chemoresistance on pancreatic cancer stem cells.,Oncotarget,2015年01月
Suzuki S, Okada M, Shibuya K, Seino M, Sato A, Takeda H, Seino S, Yoshioka T, Kitanaka C.
単著
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Differential contribution of ROS to resveratrol-induced cell death and loss of self-renewal capacity of ovarian cancer stem cells.,Anticancer Res,2015年01月
Seino M, Okada M, Shibuya K, Seino S, Suzuki S, Takeda H, Ohta T, Kurachi H, Kitanaka C.
単著
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Requirement of JNK signaling for self-renewal and tumor-initiating capacity of ovarian cancer stem cells.,Anticancer Res,2014年09月
Seino M, Okada M, Shibuya K, Seino S, Suzuki S, Ohta T, Kurachi H, Kitanaka C.
単著
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Targeting the K-Ras--JNK axis eliminates cancer stem-like cells and prevents pancreatic tumor formation.,Oncotarget,2014年07月
Okada M, Shibuya K, Sato A, Seino S, Suzuki S, Seino M, Kitanaka C.
単著
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Flotillin-1 regulates oncogenic signaling in neuroblastoma cells by regulating ALK membrane association.,Cancer Res,2014年07月
Tomiyama A, Uekita T, Kamata R, Sasaki K, Takita J, Ohira M, Nakagawara A, Kitanaka C, Mori K, Yamaguchi H, Sakai R.
単著
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JNK contributes to temozolomide resistance of stem-like glioblastoma cells via regulation of MGMT expression.,Int J Oncol,2014年02月
Okada M, Sato A, Shibuya K, Watanabe E, Seino S, Suzuki S, Seino M, Narita Y, Shibui S, Kayama T, Kitanaka C.
単著
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Pivotal role for ROS activation of p38 MAPK in the control of differentiation and tumor-initiating capacity of glioma-initiating cells.,Stem Cell Res,2014年01月
Sato A, Okada M, Shibuya K, Watanabe E, Seino S, Narita Y, Shibui S, Kayama T, Kitanaka C.
単著
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Treatment outcomes in glioblastoma patients aged 76 years or older: a multicenter retrospective cohort study.,J Neurooncol,2014年01月
Uzuka T, Asano K, Sasajima T, Sakurada K, Kumabe T, Beppu T, Ichikawa M, Kitanaka C, Aoki H, Saito K, Ogasawara K, Tominaga T, Mizoi K, Ohkuma H, Fujii Y, Kayama T; Tohoku Brain Tumor Study Group.
単著
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Specific role of JNK in the maintenance of the tumor-initiating capacity of A549 human non-small cell lung cancer cells.,Oncol Rep,30(4) 1957-1964,2013年10月
Okada Masashi, Shibuya Keita, Sato Atsushi, Seino Shizuka, Watanabe Eriko, Suzuki Shuhei, Seino Manabu, Kitanaka Chifumi
共著(国内のみ)
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JNK Signaling in the Control of the Tumor-Initiating Capacity Associated with Cancer Stem Cells.,Genes Cancer,4(9-10) 388-396,2013年09月
Kitanaka Chifumi, Sato Atsushi, Okada Masashi
共著(国内のみ)
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New developments in medical education for the realization of next-generation personalized medicine: concept and design of a medical education and training program through the genomic cohort study.,J Hum Genet,58(9) 639-640,2013年09月
Narimatsu Hiroto, Kitanaka Chifumi, Kubota Isao, Sato Shinya, Ueno Yoshiyuki, Kato Takeo, Fukao Akira, Yamashita Hidetoshi, Kayama Takamasa, Yamagata University Medical Education and Training Program ...
共著(国内のみ)
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Cytoplasmic localization of DGKzeta exerts a protective effect against p53-mediated cytotoxicity.,J Cell Sci,126(Pt 13) 2785-2797,2013年07月
Tanaka Toshiaki, Okada Masashi, Hozumi Yasukazu, Tachibana Ken, Kitanaka Chifumi, Hamamoto Yoshioki, Martelli Alberto M, Topham Matthew K, Iino Mitsuyoshi, Goto Kaoru
共著(国内のみ)
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Serum prolactin levels and prolactin mRNA expression in peripheral blood mononuclear cells in hepatitis C virus infection.,J Med Virol,2013年07月
Ishii R, Saito T, Shao L, Okumoto K, Nishise Y, Watanabe H, Makino N, Fukao A, Kitanaka C, Kayama T, Ueno Y, Kawata S.
単著
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Resveratrol promotes proteasome-dependent degradation of Nanog via p53 activation and induces differentiation of glioma stem cells.,Stem Cell Res,11(1) 601-610,2013年07月
Sato Atsushi, Okada Masashi, Shibuya Keita, Watanabe Eriko, Seino Shizuka, Suzuki Kaori, Narita Yoshitaka, Shibui Soichiro, Kayama Takamasa, Kitanaka Chifumi
共著(国内のみ)
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Symptomatic recurrence of intracranial arterial dissections: follow-up study of 143 consecutive cases and pathological investigation.,Stroke,44(1) 126-131,2013年01月
Ono Hideaki, Nakatomi Hirofumi, Tsutsumi Kazuo, Inoue Tomohiro, Teraoka Akira, Yoshimoto Yuhei, Ide Takafumi, Kitanaka Chifumi, Ueki Keisuke, Imai Hideaki, Saito Nobuhito
共著(国内のみ)
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Constructing a contemporary gene-environmental cohort: study design of the Yamagata Molecular Epidemiological Cohort Study.,J Hum Genet,58(1) 54-56,2013年01月
Narimatsu Hiroto, Yamagata University Genomic Cohort Consortium
共著(国内のみ)
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Glioma-initiating cell elimination by metformin activation of FOXO3 via AMPK.,Stem Cells Transl Med,1(11) 811-824,2012年11月
Sato Atsushi, Sunayama Jun, Okada Masashi, Watanabe Eriko, Seino Shizuka, Shibuya Keita, Suzuki Kaori, Narita Yoshitaka, Shibui Soichiro, Kayama Takamasa, Kitanaka Chifumi
共著(国内のみ)
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Targeting JNK for therapeutic depletion of stem-like glioblastoma cells.,Sci Rep,2 516,2012年
Matsuda Ken-ichiro, Sato Atsushi, Okada Masashi, Shibuya Keita, Seino Shizuka, Suzuki Kaori, Watanabe Eriko, Narita Yoshitaka, Shibui Soichiro, Kayama Takamasa, Kitanaka Chifumi
共著(国内のみ)
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MEK-ERK signaling dictates DNA-repair gene MGMT expression and temozolomide resistance of stem-like glioblastoma cells via the MDM2-p53 axis.,Stem Cells,29(12) 1942-1951,2011年12月
Sato Atsushi, Sunayama Jun, Matsuda Ken-ichiro, Seino Shizuka, Suzuki Kaori, Watanabe Eriko, Tachibana Ken, Tomiyama Arata, Kayama Takamasa, Kitanaka Chifumi
共著(国内のみ)
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FoxO3a functions as a key integrator of cellular signals that control glioblastoma stem-like cell differentiation and tumorigenicity.,Stem Cells,29(9) 1327-1337,2011年09月
Sunayama Jun, Sato Atsushi, Matsuda Ken-Ichiro, Tachibana Ken, Watanabe Eriko, Seino Shizuka, Suzuki Kaori, Narita Yoshitaka, Shibui Soichiro, Sakurada Kaori, Kayama Takamasa, Tomiyama Arata, Kitanaka...
共著(国内のみ)
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Establishment of a novel monoclonal antibody SMab-1 specific for IDH1-R132S mutation.,Biochem Biophys Res Commun,406(4) 608-613,2011年03月
Kaneko Mika Kato, Tian Wei, Takano Shingo, Suzuki Hiroyuki, Sawa Yoshihiko, Hozumi Yasukazu, Goto Kaoru, Yamazaki Kentaro, Kitanaka Chifumi, Kato Yukinari
共著(国内のみ)
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Dual blocking of mTor and PI3K elicits a prodifferentiation effect on glioblastoma stem-like cells.,Neuro Oncol,12(12) 1205-1219,2010年12月
Sunayama Jun, Sato Atsushi, Matsuda Ken-ichiro, Tachibana Ken, Suzuki Kaori, Narita Yoshitaka, Shibui Soichiro, Sakurada Kaori, Kayama Takamasa, Tomiyama Arata, Kitanaka Chifumi
共著(国内のみ)
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Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells.,Stem Cells,28(11) 1930-1939,2010年11月
Sunayama Jun, Matsuda Ken-Ichiro, Sato Atsushi, Tachibana Ken, Suzuki Kaori, Narita Yoshitaka, Shibui Soichiro, Sakurada Kaori, Kayama Takamasa, Tomiyama Arata, Kitanaka Chifumi
共著(国内のみ)
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MEK-ERK-dependent multiple caspase activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation-induced glioma cell death.,Cell Death Dis,1 e60,2010年07月
Tomiyama A, Tachibana K, Suzuki K, Seino S, Sunayama J, Matsuda K-i, Sato A, Matsumoto Y, Nomiya T, Nemoto K, Yamashita H, Kayama T, Ando K, Kitanaka C
共著(国内のみ)
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Association of stem cell marker CD133 expression with dissemination of glioblastomas.,Neurosurg Rev,33(2) 175-83; discussion 183,2010年04月
Sato Atsushi, Sakurada Kaori, Kumabe Toshihiro, Sasajima Toshio, Beppu Takaaki, Asano Kenichiro, Ohkuma Hiroki, Ogawa Akira, Mizoi Kazuo, Tominaga Teiji, Kitanaka Chifumi, Kayama Takamasa, Tohoku Brai...
共著(国内のみ)
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Regulation of neural stem/progenitor cell maintenance by PI3K and mTOR.,Neurosci Lett,470(2) 115-120,2010年02月
Sato Atsushi, Sunayama Jun, Matsuda Ken-ichiro, Tachibana Ken, Sakurada Kaori, Tomiyama Arata, Kayama Takamasa, Kitanaka Chifumi
共著(国内のみ)
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Activin inhibits cell growth and induces differentiation in human retinoblastoma y79 cells.,Curr Eye Res,34(8) 652-659,2009年08月
Kanno Chikako, Kashiwagi Yoshiko, Horie Kuniko, Inomata Motoko, Yamamoto Teiko, Kitanaka Chifumi, Yamashita Hidetoshi
共著(国内のみ)
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Downregulation of Ras C-terminal processing by JNK inhibition.,Biochem Biophys Res Commun,371(2) 273-277,2008年06月
Mouri Wataru, Tachibana Ken, Tomiyama Arata, Sunayama Jun, Sato Atsushi, Sakurada Kaori, Kayama Takamasa, Kitanaka Chifumi
共著(国内のみ)
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Nestin expression in central nervous system germ cell tumors.,Neurosurg Rev,31(2) 173-6; discussion 176,2008年04月
Sakurada K, Saino M, Mouri W, Sato A, Kitanaka C, Kayama T
共著(国内のみ)
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Ras protein expression and autophagic tumor cell death in neuroblastoma.,Am J Surg Pathol,31(1) 153-5; author reply 155,2007年01月
Kitanaka Chifumi, Kato Keisuke, Tanaka Yukichi
共著(国内のみ)
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Critical role for mitochondrial oxidative phosphorylation in the activation of tumor suppressors Bax and Bak.,J Natl Cancer Inst,98(20) 1462-1473,2006年10月
Tomiyama Arata, Serizawa Shinobu, Tachibana Ken, Sakurada Kaori, Samejima Hirotsugu, Kuchino Yoshiyuki, Kitanaka Chifumi
共著(国内のみ)
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The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson's disease.,J Neurosci,26(36) 9227-9238,2006年09月
Arawaka Shigeki, Wada Manabu, Goto Saori, Karube Hiroki, Sakamoto Masahiro, Ren Chang-Hong, Koyama Shingo, Nagasawa Hikaru, Kimura Hideki, Kawanami Toru, Kurita Keiji, Tajima Katsushi, Daimon Makoto, ...
共著(国内のみ)
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[Autophagy and autophagic cell death].,Tanpakushitsu Kakusan Koso,51(10 Suppl) 1519-1524,2006年08月
Tachibana Ken, Kitanaka Chifumi
共著(国内のみ)
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Physical and functional interaction between BH3-only protein Hrk and mitochondrial pore-forming protein p32.,Cell Death Differ,11(7) 771-781,2004年07月
Sunayama J, Ando Y, Itoh N, Tomiyama A, Sakurada K, Sugiyama A, Kang D, Tashiro F, Gotoh Y, Kuchino Y, Kitanaka C
共著(国内のみ)
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Forced expression of antisense 14-3-3beta RNA suppresses tumor cell growth in vitro and in vivo.,Carcinogenesis,24(9) 1549-1559,2003年09月
Sugiyama Akinori, Miyagi Yohei, Komiya Yuko, Kurabe Nobuya, Kitanaka Chifumi, Kato Naoko, Nagashima Yoji, Kuchino Yoshiyuki, Tashiro Fumio
共著(国内のみ)
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Guanine nucleotide exchange factor, Tiam1, directly binds to c-Myc and interferes with c-Myc-mediated apoptosis in rat-1 fibroblasts.,J Biol Chem,278(7) 5132-5140,2003年02月
Otsuki Yoshiro, Tanaka Masamitsu, Kamo Takaharu, Kitanaka Chifumi, Kuchino Yoshiyuki, Sugimura Haruhiko
共著(国内のみ)
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A cellular mechanism that reversibly inactivates pancaspase inhibitor zAsp-CH(2)-DCB: a potential pitfall causing discrepancy between in vitro and in vivo caspase assays.,Biochem Biophys Res Commun,291(4) 1022-1030,2002年03月
Sakurada Kaori, Kitanaka Chifumi, Kokubu Akiko, Tomiyama Arata, Sunayama Jun, Kayama Takamasa, Kuchino Yoshiyuki
共著(国内のみ)
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Increased Ras expression and caspase-independent neuroblastoma cell death: possible mechanism of spontaneous neuroblastoma regression.,J Natl Cancer Inst,94(5) 358-368,2002年03月
Kitanaka Chifumi, Kato Keisuke, Ijiri Rieko, Sakurada Kaori, Tomiyama Arata, Noguchi Kohji, Nagashima Yohji, Nakagawara Akira, Momoi Takashi, Toyoda Yasunori, Kigasawa Hisato, Nishi Toshiji, Shirouzu ...
共著(国内のみ)
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Akt protein kinase inhibits non-apoptotic programmed cell death induced by ceramide.,J Biol Chem,277(4) 2790-2797,2002年01月
Mochizuki Toshihiro, Asai Akio, Saito Nobuhito, Tanaka Sakae, Katagiri Hideki, Asano Tomoichiro, Nakane Makoto, Tamura Akira, Kuchino Yoshiyuki, Kitanaka Chifumi, Kirino Takaaki
共著(国内のみ)
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Rat neuronal leucine-rich repeat protein-3: cloning and regulation of the gene expression.,Biochem Biophys Res Commun,287(1) 257-263,2001年09月
Fukamachi K, Matsuoka Y, Kitanaka C, Kuchino Y, Tsuda H
共著(国内のみ)
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ASK1-signaling promotes c-Myc protein stability during apoptosis.,Biochem Biophys Res Commun,281(5) 1313-1320,2001年03月
Noguchi K, Kokubu A, Kitanaka C, Ichijo H, Kuchino Y
共著(国内のみ)
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Molecular mechanism of stop codon recognition by eRF1: a wobble hypothesis for peptide anticodons.,FEBS Lett,488(3) 105-109,2001年01月
Muramatsu T, Heckmann K, Kitanaka C, Kuchino Y
共著(国内のみ)
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Differential role of the JNK and p38 MAPK pathway in c-Myc- and s-Myc-mediated apoptosis.,Biochem Biophys Res Commun,267(1) 221-227,2000年01月
Noguchi K, Yamana H, Kitanaka C, Mochizuki T, Kokubu A, Kuchino Y
共著(国内のみ)
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Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase.,J Biol Chem,274(46) 32580-32587,1999年11月
Noguchi K, Kitanaka C, Yamana H, Kokubu A, Mochizuki T, Kuchino Y
共著(国内のみ)
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[Caspase-independent programmed cell death with necrotic morphology].,Tanpakushitsu Kakusan Koso,44(14) 2091-2100,1999年11月
Kitanaka C, Kuchino Y
共著(国内のみ)
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Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway.,J Biol Chem,274(26) 18659-18666,1999年06月
Mochizuki T, Kitanaka C, Noguchi K, Muramatsu T, Asai A, Kuchino Y
共著(国内のみ)
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Caspase-independent programmed cell death with necrotic morphology.,Cell Death Differ,6(6) 508-515,1999年06月
Kitanaka C, Kuchino Y
共著(国内のみ)
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Oncogenic Ras triggers cell suicide through the activation of a caspase-independent cell death program in human cancer cells.,Oncogene,18(13) 2281-2290,1999年04月
Chi S, Kitanaka C, Noguchi K, Mochizuki T, Nagashima Y, Shirouzu M, Fujita H, Yoshida M, Chen W, Asai A, Himeno M, Yokoyama S, Kuchino Y
共著(国内のみ)
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Molecular cloning and chromosomal mapping of mouse intronless myc gene acting as a potent apoptosis inducer.,Gene,226(2) 273-283,1999年01月
Sugiyama A, Noguchi K, Kitanaka C, Katou N, Tashiro F, Ono T, Yoshida M C, Kuchino Y
共著(国内のみ)
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Heparin-binding epidermal growth factor-like growth factor stimulates mitogenic signaling and is highly expressed in human malignant gliomas.,Acta Neuropathol,96(4) 322-328,1998年10月
Mishima K, Higashiyama S, Asai A, Yamaoka K, Nagashima Y, Taniguchi N, Kitanaka C, Kirino T, Kuchino Y
共著(国内のみ)
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A functional role for death proteases in s-Myc- and c-Myc-mediated apoptosis.,Mol Cell Biol,17(11) 6736-6745,1997年11月
Kagaya S, Kitanaka C, Noguchi K, Mochizuki T, Sugiyama A, Asai A, Yasuhara N, Eguchi Y, Tsujimoto Y, Kuchino Y
共著(国内のみ)
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Caspase-dependent apoptosis of COS-7 cells induced by Bax overexpression: differential effects of Bcl-2 and Bcl-xL on Bax-induced caspase activation and apoptosis.,Oncogene,15(15) 1763-1772,1997年10月
Kitanaka C, Namiki T, Noguchi K, Mochizuki T, Kagaya S, Chi S, Hayashi A, Asai A, Tsujimoto Y, Kuchino Y
共著(国内のみ)
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Pim-1 kinase stimulates c-Myc-mediated death signaling upstream of caspase-3 (CPP32)-like protease activation.,Oncogene,15(12) 1471-1480,1997年09月
Mochizuki T, Kitanaka C, Noguchi K, Sugiyama A, Kagaya S, Chi S, Asai A, Kuchino Y
共著(国内のみ)
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Proliferative activity of central neurocytoma: measurement of tumor volume doubling time, MIB-1 staining index and bromodeoxyuridine labeling index.,J Neurooncol,32(2) 103-109,1997年04月
Fujimaki T, Matsuno A, Sasaki T, Toyoda T, Matsuura R, Ogai M, Kitanaka C, Asai A, Matsutani M, Kirino T
共著(国内のみ)
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Apoptosis in cancer.,Hum Cell,9(3) 223-228,1996年09月
Kuchino Y, Kitanaka C
共著(国内のみ)
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[Apoptosis induced by myc family genes].,Nihon Rinsho,54(7) 1869-1875,1996年07月
Kagaya S, Kitanaka C, Kuchino Y
共著(国内のみ)
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Increased expression of schwannoma-derived growth factor (SDGF) mRNA in rat tumor cells: involvement of SDGF in the growth promotion of rat gliomas.,Int J Cancer,66(3) 352-357,1996年05月
Mishima K, Asai A, Sugiyama A, Miyagi Y, Kitanaka C, Kagaya S, Kirino T, Kuchino Y
共著(国内のみ)
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Chronic encapsulated expanding hematoma in association with gamma knife stereotactic radiosurgery for a cerebral arteriovenous malformation. Case report.,J Neurosurg,84(5) 874-878,1996年05月
Kurita H, Sasaki T, Kawamoto S, Taniguchi M, Kitanaka C, Nakaguchi H, Kirino T
共著(国内のみ)
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Myc-mediated apoptosis.,Prog Mol Subcell Biol,16 104-129,1996年
Kuchino Y, Asai A, Kitanaka C
共著(国内のみ)
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[Application of myc family genes to therapy of malignant brain tumors].,Tanpakushitsu Kakusan Koso,40(17) 2713-2719,1995年12月
Kuchino Y, Kitanaka C, Asai A
共著(国内のみ)
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Clinical features of progressive lacunar infarction--retrospective analysis of patients with motor syndromes.,Neurol Med Chir (Tokyo),35(9) 663-666,1995年09月
Kitanaka C, Teraoka A
共著(国内のみ)
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Functional prognosis after treatment of spinal radiculomeningeal arteriovenous malformations.,Surg Neurol,43(5) 453-7; discussion 458,1995年05月
Kohno M, Takahashi H, Kitanaka C, Sasaki T, Ishijima B
共著(国内のみ)
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s-Myc acts as a transcriptional activator and its sequence-specific DNA binding is required for induction of programmed cell death in glioma cells.,Cell Death Differ,2(2) 123-131,1995年04月
Kitanaka C, Sugiyama A, Kanazu S, Miyagi Y, Mishima K, Asai A, Kuchino Y
共著(国内のみ)
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Precocious puberty in a girl with an hCG-secreting suprasellar immature teratoma. Case report.,J Neurosurg,81(4) 601-604,1994年10月
Kitanaka C, Matsutani M, Sora S, Kitanaka S, Tanae A, Hibi I
共著(国内のみ)
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Nonsurgical treatment of unruptured intracranial vertebral artery dissection with serial follow-up angiography.,J Neurosurg,80(4) 667-674,1994年04月
Kitanaka C, Tanaka J, Kuwahara M, Teraoka A, Sasaki T, Takakura K, Tanaki J [corrected to Tanaka J ]
共著(国内のみ)
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Intracranial vertebral artery dissections: clinical, radiological features, and surgical considerations.,Neurosurgery,34(4) 620-6; discussion 626,1994年04月
Kitanaka C, Sasaki T, Eguchi T, Teraoka A, Nakane M, Hoya K
共著(国内のみ)
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Magnetic resonance imaging study of intracranial vertebrobasilar artery dissections.,Stroke,25(3) 571-575,1994年03月
Kitanaka C, Tanaka J, Kuwahara M, Teraoka A
共著(国内のみ)
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Malignant brain stem hyperthermia caused by brain stem hemorrhage.,Stroke,25(2) 518-520,1994年02月
Kitanaka C, Inoh Y, Toyoda T, Sasaki T, Eguchi T
共著(国内のみ)
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[Critical appraisal of CT grading in subarachnoid hemorrhage].,Nihon Rinsho,51 Suppl 303-308,1993年12月
Sasaki T, Kitanaka C
共著(国内のみ)
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Spontaneous cervical internal carotid dissection presenting with intracerebral hematoma.,Stroke,24(9) 1420-1421,1993年09月
Kitanaka C, Teraoka A
共著(国内のみ)
-
Intradural, purely extramedullary hemangioblastoma of the spinal cord--case report.,Neurol Med Chir (Tokyo),33(6) 377-380,1993年06月
Kitanaka C, Kuwahara M, Teraoka A
共著(国内のみ)
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Rebleeding from vertebral artery dissection after proximal clipping. Case report.,J Neurosurg,77(3) 466-468,1992年09月
Kitanaka C, Morimoto T, Sasaki T, Takakura K
共著(国内のみ)
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Retroflexion of holoprosencephaly: report of two cases.,Childs Nerv Syst,8(6) 317-321,1992年09月
Kitanaka C, Iwasaki Y, Yamada H
共著(国内のみ)
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Secondary malignant lymphoma of the central nervous system with delayed high uptake on 123I-IMP single-photon emission computerized tomography. Case report.,J Neurosurg,76(5) 871-873,1992年05月
Kitanaka C, Eguchi T, Kokubo T
共著(国内のみ)
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Avellis syndrome after minor head trauma: report of two cases.,Surg Neurol,37(3) 236-239,1992年03月
Kitanaka C, Sugaya M, Yamada H
共著(国内のみ)
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Postradiation astrocytoma. Report of two cases.,J Neurosurg,70(3) 469-474,1989年03月
Kitanaka C, Shitara N, Nakagomi T, Nakamura H, Genka S, Nakagawa K, Akanuma A, Aoyama H, Takakura K
共著(国内のみ)
総説・解説記事
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【グリオーマリサーチの展望と課題】 グリオーマ幹細胞 アップデート,日本脳神経外科コングレス,脳神経外科ジャーナル,27(10) 744-751,2018年10月
北中 千史, 岡田 雅司
学術関係受賞
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日本癌学会奨励賞,2002年10月,日本国,日本癌学会,北中 千史
受託研究受入実績
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がん幹細胞を標的とした初発膠芽腫の放射線+テモゾロミド+メトホルミン併用療法の第I・II相臨床試験,2020年04月 ~ 2021年03月,国立研究開発法人国立がん研究センター,一般受託研究
-
中枢神経系原発悪性リンパ腫に対するテモゾロミドを用いた標準治療確立に関する研究,2019年04月 ~ 2020年03月,学校法人埼玉医科大学,一般受託研究
研究発表
-
山形医学,国際会議,2019年02月,パーキンソン病薬として開発されたCEP-1347はがん幹細胞標的治療薬として働く,その他
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日本癌学会総会記事,国際会議,2018年09月,部分的ドパミン受容体アゴニストであるアリピプラゾールは癌幹細胞への抗腫瘍効果を示し、薬剤抵抗性を減弱させる(Aripiprazole, an Antipsychotic and Partial Dopamine Agonist, Inhibits Cancer Stem Cells and Reverses Chemoresistance),その他
相談に応じられる分野
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1)がんの分子細胞生物学