Updated on 2020/06/17

写真a

 
SHISHIDO Tetsuro
 
Title
Assistant Professor(Moving Out or Retirement)
Laboratory Phone number
+81-23-628-5302
 
Laboratory Fax number
+81-23-628-5305
 

Research Areas

  • Life Science / Cardiology

Graduating School

  • Akita University, Faculty of Medicine, Graduate School of Medicine

    1998.03, Graduated

Graduate School

  • Yamagata University, Graduate School, Division of Medical Sciences, Graduate School of Medical Science

    Doctor's Course, 2004.03, Completed

Degree

  • PhD, Yamagata University, 2004.03

  • MD, Akita University, 1998.03

External Career

  • Aab Cardiovascular Research Institute, University of Rochester Medical Center, Researcher, 2005.08 - 2008.01

 

Papers

  • Trends in Coronary Risk Factors Among Patients with Acute Myocardial Infarction Over the Last Decade: The Yamagata AMI Registry., J Atheroscler Thromb., 17 989-998, 2010.09

    Nishiyama S, Watanabe T, Arimoto T, Takahashi H, Shishido T, Miyashita T, Miyamoto T, Nitobe J, Shibata Y, Konta T, Kawata S, Kato T, Fukao A, Kubota I.

    Multiple Authorship (Including Foreigners)

  • Iodine-123-metaiodobenzylguanidine imaging can predict future cardiac events in heart failure patients with preserved ejection fraction., Ann Nucl Med., 2010.09

    Katoh S, Shishido T, Kutsuzawa D, Arimoto T, Netsu S, Funayama A, Ishino M, Niizeki T, Nishiyama S, Takahashi H, Miyashita T, Miyamoto T, Nitobe J, Watanabe T, Kubota I.

    Multiple Authorship (Including Foreigners)

  • Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor., FASEB J, 2010.08

    Woo CH, Le NT, Shishido T, Chang E, Lee H, Heo KS, Mickelsen DM, Lu Y, McClain C, Spangenberg T, Yan C, Molina CA, Yang J, Patterson C, Abe JI.

    Multiple Authorship (Including Foreigners)

  • Serum YKL-40 Predicts Adverse Clinical Outcomes in Patients With Chronic Heart Failure., J Card Fail., 2010.06

    Bilim O, Takeishi Y, Kitahara T, Ishino T, Sasaki T, Suzuki S, Shishido T, Kubota I.

    Multiple Authorship (Including Foreigners)

  • Low wall velocity of left atrial appendage measured by trans-thoracic echocardiography predicts thrombus formation caused by atrial appendage dysfunction., J Am Soc Echocardiogr., 23 545-552, 2010.05

    Tamura H, Watanabe T, Hirono O, Nishiyama S, Sasaki S, Shishido T, Miyashita T, Miyamoto T, Nitobe J, Kayama T, Kubota I.

    Multiple Authorship (Including Foreigners)

  • Suppressive effects of valsartan on microalbuminuria and CRP in patients with metabolic syndrome (Val-Mets)., Clin Exp Hypertens., 2010.05

    Shishido T, Konta T, Nishiyama S, Miyashita T, Miyamoto T, Takasaki S, Nitobe J, Watanabe T, Takeishi Y, Kubota I.

    Multiple Authorship (Including Foreigners)

  • High serum level of neopterin is a risk factor of patients with heart failure., Int J Cardiol. , 2010.03

    Sasaki T, Takeishi Y, Suzuki S, Niizeki T, Kitahara T, Katoh S, Ishino M, Shishido T, Watanabe T, Kubota I.

    Multiple Authorship (Including Foreigners)

  • Serum midkine as a predictor of cardiac events in patients with chronic heart failure., J Card Fail., 16 308-313, 2010.01

    Kitahara T, Shishido T, Suzuki S, Katoh S, Sasaki T, Ishino M, Nitobe J, Miyamoto T, Miyashita T, Watanabe T, Takeishi Y, Kubota I.

    Multiple Authorship (Including Foreigners)

  • Reactive oxygen species-induced activation of p90 ribosomal S6 kinase prolongs cardiac repolarization through inhibiting outward K+ channel activity., Circ Res., 103 269-278, 2008.07

    Lu Z, Abe J, Taunton J, Lu Y, Shishido T, McClain C, Yan C, Xu SP, Spangenberg TM, Xu H.

    Multiple Authorship (Including Foreigners)

  • Effects of MEK5/ERK5 association on small ubiquitin-related modification of ERK5: Implications for diabetic ventricular dysfunction after myocardial infarction., Circ Res., 102 1416-1425, 2008.06

    Shishido T, Woo CH, Ding B, McClain C, Molina CA, Yan C, Yang J, Abe J

    Multiple Authorship (Including Foreigners)

  • Extracellular signal-regulated kinase 5 SUMOylation antagonizes shear stress-induced antiinflammatory response and endothelial nitric oxide synthase expression in endothelial cells., Circ Res., 102 538-545, 2008.06

    Woo CH, Shishido T, McClain C, Lim JH, Li JD, Yang J, Yan C, Abe J

    Multiple Authorship (Including Foreigners)

  • Protease-activated receptor-1 contributes to cardiac remodeling and hypertrophy., Circulation., 116 2298-2306, 2007.12

    Pawlinski R, Tencati M, Hampton CR, Shishido T, Bullard TA, Casey LM, Andrade-Gordon P, Kotzsch M, Spring D, Luther T, Abe J, Pohlman TH, Verrier ED, Blaxall BC, Mackman N

    Multiple Authorship (Including Foreigners)

  • High serum level of pentosidine, an advanced placation end product (AGE), is a risk factor of patients with heart failure., J Card Fail., 13 199-206, 2007.08

    Koyama Y, Takeishi Y, Arimoto T, Niizeki T, Shishido T, Takahashi H, Nozaki N, Hirono O, Tsunoda Y, Nitobe J, Watanabe T, Kubota I

    Multiple Authorship (Including Foreigners)

  • Activation of extracellular signal-regulated kinase 5 reduces cardiac apoptosis and dysfunction via inhibition of a phosphodiesterase 3A/inducible cAMP early repressor feedback loop., Circ Res., 100 510-519, 2007.05

    Yan C, Ding B, Shishido T *, Woo CH, Itoh S, Jeon KI, Liu W, Xu H, McClain C, Molina CA, Blaxall BC, Abe J

    Multiple Authorship (Including Foreigners)

  • Azelnidipine inhibits H2O2-induced cell death in neonatal rat cardiomyocytes., Cardiovasc Drugs Ther., 21 69-72, 2007.02

    Koyama Y, Takeishi Y, Takahashi H, Shishido T, Arimoto T, Niizeki T, Harada M, Suzuki S, Kitahara T, Sasaki T, Kubota I

    Multiple Authorship (Including Foreigners)

  • Cardiac-specific overexpression of diacylglycerol kinase zeta attenuates left ventricular remodeling and improves survival after myocardial infarction., Am J Physiol Heart Circ Physiol., 292 1105-1112, 2007.02

    Niizeki T, Takeishi Y, Arimoto T, Takahashi H, Shishido T, Koyama Y, Goto K, Walsh RA, Kubota I

    Multiple Authorship (Including Foreigners)

  • ERK5 activation inhibits inflammatory responses via peroxisome proliferator-activated receptor delta (PPARdelta) stimulation., J Biol Chem., 281 32164-32174, 2006.10

    Woo CH, Massett MP, Shishido T, Itoh S, Ding B, McClain C, Che W, Vulapalli SR, Yan C, Abe J

    Multiple Authorship (Including Foreigners)

  • Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium., Circulation., 113 1787-1798, 2006.08

    Itoh S, Ding B, Shishido T, Lerner-Marmarosh N, Wang N, Maekawa N, Berk BC, Takeishi Y, Yan C, Blaxall BC, Abe J

    Multiple Authorship (Including Foreigners)

  • Central role of endogenous Toll-like receptor-2 activation in regulating inflammation, reactive oxygen species production, and subsequent neointimal formation after vascular injury., Biochem Biophys Res Commun., 345 1446-1453, 2006.07

    hishido T, Nozaki N, Takahashi H, Arimoto T, Niizeki T, Koyama Y, Abe J, Takeishi Y, Kubota I

    Multiple Authorship (Including Foreigners)

  • Inhibiting p90 ribosomal S6 kinase prevents (Na+)-H+ exchanger-mediated cardiac ischemia-reperfusion injury., Circulation., 113 2516-2523, 2006.05

    Maekawa N, Abe J, Shishido T, Itoh S, Ding B, Sharma VK, Sheu SS, Blaxall BC, Berk BC

    Multiple Authorship (Including Foreigners)

  • Cardiac-specific overexpression of diacylglycerol kinase zeta prevents Gq protein-coupled receptor agonist-induced cardiac hypertrophy in transgenic mice., Circulation., 113 60-66, 2006.01

    Arimoto T, Takeishi Y, Takahashi H, Shishido T, Niizeki T, Koyama Y, Shiga R, Nozaki N, Nakajima O, Nishimaru K, Abe J, Endoh M, Walsh RA, Goto K, Kubota I

    Multiple Authorship (Including Foreigners)

  • Ongoing myocardial damage relates to cardiac sympathetic nervous disintegrity in patients with heart failure., Ann Nucl Med., 19 535-540, 2005.10

    Arimoto T, Takeishi Y, Niizeki T, Koyama Y, Okuyama H, Nozaki N, Hirono O, Tsunoda Y, Miyashita T, Shishido T, Okada A, Takahashi K, Kubota I

    Multiple Authorship (Including Foreigners)

  • Pitavastatin inhibits cardiac hypertrophy in a rat model of progressive renal injury., J Cardiovasc Pharmacol., 46 487-493, 2005.10

    Takahashi H, Takeishi Y, Arimoto T, Shishido T, Konta T, Koyama Y, Niizeki T, Kubota I

    Multiple Authorship (Including Foreigners)

  • Cystatin C, a novel measure of renal function, is an independent predictor of cardiac events in patients with heart failure., J Card Fail., 11 595-601, 2005.10

    Arimoto T, Takeishi Y, Niizeki T, Takabatake N, Okuyama H, Fukui A, Tachibana H, Nozaki N, Hirono O, Tsunoda Y, Miyashita T, Shishido T, Takahashi H, Koyama Y, Kubota I

    Multiple Authorship (Including Foreigners)

  • Combination of heart-type fatty acid binding protein and brain natriuretic peptide can reliably risk stratify patients hospitalized for chronic heart failure., Circ J., 69 922-927, 2005.08

    Niizeki T, Takeishi Y, Arimoto T, Takahashi T, Okuyama H, Takabatake N, Nozaki N, Hirono O, Tsunoda Y, Shishido T, Takahashi H, Koyama Y, Fukao A, Kubota I

    Multiple Authorship (Including Foreigners)

  • Serum heart-type fatty acid binding protein predicts cardiac events in elderly patients with chronic heart failure., J Cardiol., 46 9-15, 2005.07

    Niizeki T, Takeishi Y, Arimoto T, Okuyama H, Takabatake N, Tachibana H, Nozaki N, Hirono O, Tsunoda Y, Miyashita T, Fukui A, Takahashi H, Koyama Y, Shishido T, Kubota I

    Multiple Authorship (Including Foreigners)

  • Adenovirus-mediated overexpression of diacylglycerol kinase inhibits endothelin-1-induced cardiomyocyte hypertrophy, Circulation., 111(1510) 1516, 2005.05

    Takahashi H, Takeishi Y, Seidler T, Arimoto T, Akiyama H, Hozumi Y, Koyama Y, Shishido T, Tsunoda Y, Niizeki T, Nozaki N, Abe J, Hasenfuss G, Goto K, Kubota I

    Multiple Authorship (Including Foreigners)

  • Diminution of angiotensin II-induced contraction of the abdominal aorta isolated from Watanabe heritable hyperlipidemic rabbits., J Smooth Muscle Res., 41 87-97, 2005.04

    asaki K, Wakabayashi I, Shishido T, Takasaki S, Takeishi Y, Kubota I, Ito T, Katano Y, Tomoike H

    Multiple Authorship (Including Foreigners)

  • Modulation of doxorubicin-induced cardiac dysfunction in toll-like receptor-2-knockout mice., Circulation., 110 2869-2874, 2004.11

    Nozaki N, Shishido T, Takeishi Y, Kubota I

    Multiple Authorship (Including Foreigners)

  • Activation of distinct signal transduction pathways in hypertrophied hearts by pressure and volume overload., Basic Res Cardiol., 99 328-337, 2004.09

    Miyamoto T, Takeishi Y, Takahashi H, Shishido T, Arimoto T, Tomoike H, Kubota I

    Multiple Authorship (Including Foreigners)

  • Fatty acid metabolism assessed by 125I-iodophenyl 9-methylpentadecanoic acid (9MPA) and expression of fatty acid utilization enzymes in volume-overloaded hearts., Eur J Clin Invest., 34 176-181, 2004.05

    Miyamoto T, Takeishi Y, Tazawa S, Inoue M, Aoyama T, Takahashi H, Arimoto T, Shishido T, Tomoike H, Kubota I

    Multiple Authorship (Including Foreigners)

  • Protein kinase C and extracellular signal regulated kinase are involved in cardiac hypertrophy of rats with progressive renal injury., Eur J Clin Invest., 34 85-93, 2004.02

    Takahashi H, Takeishi Y, Miyamoto T, Shishido T, Arimoto T, Konta T, Miyashita T, Ito M, Kubota I

    Multiple Authorship (Including Foreigners)

  • Chronic hypertriglyceridemia in young watanabe heritable hyperlipidemic rabbits impairs endothelial and medial smooth muscle function., Life Sci., 74 1487-1501, 2004.02

    Shishido T, Tasaki K, Takeishi Y, Takasaki S, Miyamoto T, Itoh M, Takahashi H, Kubota I, Ito T, Katano Y, Wakabayashi I, Tomoike H

    Multiple Authorship (Including Foreigners)

  • Toll-like receptor-2 modulates ventricular remodeling after myocardial infarction., Circulation., 108 2905-2910, 2003.12

    Shishido T, Nozaki N, Yamaguchi S, Shibata Y, Nitobe J, Miyamoto T, Takahashi H, Arimoto T, Maeda K, Yamakawa M, Takeuchi O, Akira S, Takeishi Y, Kubota I

    Multiple Authorship (Including Foreigners)

  • Role of nitric oxide in the progression of cardiovascular remodeling induced by carotid arterio-venous shunt in rabbits., Jpn Heart J., 44 127-137, 2003.01

    Miyamoto T, Takeishi Y, Shishido T, Takahashi H, Itoh M, Kubota I, Tomoike H

    Multiple Authorship (Including Foreigners)

  • Reverse redistribution of 99m Tc-sestamibi after direct percutaneous transluminal coronary angioplasty in acute myocardial infarction: relationship with wall motion and functional response to dobutamine stimulation., Nucl Med Commun., 22 1223-1230, 2001.10

    Fujiwara S, Takeishi Y, Hirono O, Fukui A, Okuyama M, Yamaguchi S, Ito M, Kaneko K, Shishido T, Miyamoto T, Yuki K, Miyashita T, Takahashi K, Minamihaba O, Tomoike H, Yamauchi S, Fatema K

    Multiple Authorship (Including Foreigners)

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Academic Awards Received

  • Academic Award Silver Prize, Yamagata University Medical Society, 2014.02.14, Japan

  • A Research Encouragement Award, The Japan Heart Foundation, 2011.04, Japan

  • the Mochida Memorial Foundation for Medical and Pharmaceutical Research Aword, 2005.10, Japan

Grant-in-Aid for Scientific Research

  • Grant-in-Aid for Scientific Research(C),2018.04 - 2022.03

  • Grant-in-Aid for Scientific Research(C),2018.04 - 2021.03

  • Grant-in-Aid for Young Scientists(B),2009.04 - 2011.03

Presentations

  • American Heart Association Scientific Sessions 2009, International presentation, 2009.11, Poster presentation

  • The 73rd Annual Scientific Meeting of the Japanese Circulation Society, Domestic presentation, 2009.03, Oral presentation (general)

 
      

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