Updated on 2024/05/15

写真a

 
KONNO Hiroyuki
 
Title
Professor
Date of Birth
1970
Contact information
メールアドレス
Laboratory Phone number
+81-238-26-3131
 
Laboratory Fax number
+81-238-26-3131
 

Research Areas

  • Life Science / Pharmaceutical chemistry and drug development sciences

  • Nanotechnology/Materials / Structural organic chemistry and physical organic chemistry

  • Life Science / Bioorganic chemistry

Graduating School

  • Tohoku University, Faculty of Agriculture

    1994.03, Graduated

Graduate School

  • Tohoku University, Graduate School, Division of Pharmaceutical Sciences

    Doctor's Course, 1999.03, Completed

Degree

  • Doctor(Pharmaceutical Science), Tohoku University, 1999.03

External Career

  • The University of Tokushima, Research Assistant, 2000.09 - 2003.12

  • Kyoto University, Research Assistant, 2004.01 - 2004.09

  • Kyoto Prefectural University of Medicine, Assistant Professor, 2004.10 - 2009.03

 

Papers

  • Synthesis and evaluation of catecholamine derivatives as amyloid-beta aggregation inhibitors., Bioorganic & medicinal chemistry letters, 129788, 2024.05

    Xu F, Takiguchi Y, Makabe K, Konno H

    Single Author

  • Redesign of a thioflavin-T-binding protein with a flat β-sheet to evaluate a thioflavin-T-derived photocatalyst with enhanced affinity., International journal of biological macromolecules, 269(Pt 1) 131992, 2024.04

    Miura Y, Namioka S, Iwai A, Yoshida N, Konno H, Sohma Y, Kanai M, Makabe K

    Single Author

  • SpyTag Peptide with Alkoxyl Aspartic Acids for pH-Dependent Activation of the SpyCatcher/Tag System., Bioconjugate chemistry, 2024.04

    Che S, Konno H, Makabe K

    Single Author

  • Synthesis and Structural Revision of the Cyclic Hexapeptide Dimers Antatollamides A and B, ORGANIC LETTERS, 26(16) 3375-3379, 2024.04

    Li, YT; Takamatsu, K; Aota, T; Konno, H

    Single Author

  • Development of 1,5-diarylpyrazoles as EGFR/JNK-2 dual inhibitors: design, synthesis, moleecular docking, and bioactivity evaluation, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 102 129673, 2024.04

    Soltan, OM; Abdel-Aziz, SA; Shaykoon, MS; Osawa, K; Narumi, A; Abdel-Aziz, M; Shoman, ME; Konno, H

    Single Author

  • Addition of α-1,3-glucan-binding domains to α-1,3-glucanase Agn1p from  Schizosaccharomyces pombe enhances hydrolytic activity of insoluble α-1,3-glucan., The Journal of general and applied microbiology, advpub(0) , 2024.02

    Horaguchi Y, Yokomichi M, Takahashi M, Xu F, Konno H, Makabe K, Yano S

    Single Author

  • α-1,3-Glucanase from the gram-negative bacterium <i>Flavobacterium</i> sp. EK-14 hydrolyzes fungal cell wall α-1,3-glucan, SCIENTIFIC REPORTS, 13(1) 21420, 2023.12

    Takahashi, M; Yano, S; Horaguchi, Y; Otsuka, Y; Suyotha, W; Makabe, K; Konno, H; Kokeguchi, S

    Single Author

  • Synthesis and evaluation of L-dopa and L-Tyr derivatives as amyloid-beta aggregation inhibitors, PHYTOCHEMISTRY LETTERS, 57 239-247, 2023.10

    Xu, FS; Okada, M; Makabe, K; Konno, H

    Single Author

  • Design of the peptide C-terminus protecting group and application for the peptide fragment coupling reaction, TETRAHEDRON LETTERS, 127 , 2023.09

    Okawara, A; Hada, K; Kurotani, R; Teruya, K; Konno, H

    Single Author

  • Development and Assessment of 1,5-Diarylpyrazole/Oxime Hybrids Targeting EGFR and JNK-2 as Antiproliferative Agents: A Comprehensive Study through Synthesis, Molecular Docking, and Evaluation, MOLECULES, 28(18) , 2023.09

    Abdelrahman, KS; Hassan, HA; Abdel-Aziz, SA; Marzouk, AA; Shams, R; Osawa, K; Abdel-Aziz, M; Konno, H

    Single Author

  • Design, Synthesis and Evaluation of Catechol-Based Amyloid Beta Aggregation Inhibitors, HETEROCYCLES, 106(5) 797, 2023

    Hiroyuki Konno, Kenta Teruya

    Single Author

  • Antimicrobial Activity of Polysorbate 80-iodine Complex: Polysorbate 80 Firmly Retains Iodine(タイトル和訳中), Journal of Oleo Science, 71(11) 1639-1645, 2022.11

    Yano Shigekazu, Terada Senri, Fukushi Misaki, Otsuka Yuitsu, Mizunuma Satomi, Asakura Satoshi, Kawai Takahiro, Konno Hiroyuki, Endo Masatoshi, Nonomura Yoshimune

    Single Author

  • Antimicrobial Activity of Polysorbate 80-iodine Complex: Polysorbate 80 Firmly Retains Iodine., Journal of oleo science, 71(11) 1639-1645, 2022.10

    Yano S, Terada S, Fukushi M, Otsuka Y, Mizunuma S, Asakura S, Kawai T, Konno H, Endo M, Nonomura Y

    Single Author

  • Synthesis and Configuration Confirmation of the ATHOD Fatty Amino Acid Residue in the Burkholdines., Journal of natural products, 85(8) 2052-2061, 2022.08

    Toma Kadowaki, Rin Kainuma, Seiya Kato, Hiroyuki Konno

    Single Author

  • Construction of a fusion protein consisting of α-1,3-glucan-binding domains and tetrameric red fluorescent protein, which is involved in the aggregation of α-1,3-glucan and inhibition of fungal biofilm formation, Journal of Bioscience and Bioengineering, 133(6) 524-532, 2022.06

    Yuitsu Otsuka, Kai Sasaki, Wasana Suyotha, Hiroyuki Hurusawa, Ken Miyazawa, Hiroyuki Konno, Shigekazu Yano

    Single Author

  • Activities of curcumin-related compounds in two cell lines persistently infected with different prion strains., Biochimica et biophysica acta. General subjects, 1866(4) 130094, 2022.04

    Kenta Teruya, Sara Iwabuchi, Yuki Watanabe, Rikiya Tsuchida, Miki Watanabe-Matsui, Hiroyuki Konno, Katsumi Doh-Ura

    Single Author

  • The Hydrophobicity and Antifungal Potentiation of Burkholdine Analogues., Molecules (Basel, Switzerland), 27(4) , 2022.02

    Hiroyuki Konno, Mio Sasaki, Hinata Sano, Keima Osawa, Kazuto Nosaka, Shigekazu Yano

    Single Author

  • Surface Engineering of Top7 to Facilitate Structure Determination, International Journal of Molecular Sciences, 23(2) 701, 2022.01

    Yuki Ito, Takuya Araki, Shota Shiga, Hiroyuki Konno, Koki Makabe

    Single Author

  • GH-16 Type β-1,3-Glucanase from <i>Lysobacter </i>sp. MK9-1 Enhances Antifungal Activity of GH-19 Type Chitinase, and Its Glucan-binding Domain Binds to Fungal Cell-wall, Journal of Applied Glycoscience, 69(3) 49-56, 2022

    Otsuka Yuitsu, Sato Koki, Yano Shigekazu, Kanno Haruki, Suyotha Wasana, Konno Hiroyuki, Makabe Koki, Taira Toki

    Single Author

  • Synthesis of xylose-binding cyclic octalipopeptides burkholdine-1213 analogues, TETRAHEDRON LETTERS, 87 , 2021.12

    Mio Sasaki, Toma Kadowaki, Seiya Kato, So Chida, Shigekazu Yano, Kazuto Nosaka, Hiroyuki Konno

    Single Author

  • Tailor-Made Amino Acids in Pharmaceutical Industry: Synthetic Approaches to Aza-Tryptophan Derivatives., Chemistry (Weinheim an der Bergstrasse, Germany), 27(70) 17510-17528, 2021.12

    Jianlin Han, Nataliya V Lyutenko, Alexander E Sorochinsky, Ayaka Okawara, Hiroyuki Konno, Sarah White, Vadim A Soloshonok

    Single Author

  • Molecular hybrids: A five-year survey on structures of multiple targeted hybrids of protein kinase inhibitors for cancer therapy., European journal of medicinal chemistry, 225 113768, 2021.12

    Osama M Soltan, Mai E Shoman, Salah A Abdel-Aziz, Atsushi Narumi, Hiroyuki Konno, Mohamed Abdel-Aziz

    Single Author

  • Nitric oxide protects against ferroptosis by aborting the lipid peroxidation chain reaction., Nitric oxide : biology and chemistry, 115 34-43, 2021.10

    Takujiro Homma, Sho Kobayashi, Marcus Conrad, Hiroyuki Konno, Chikako Yokoyama, Junichi Fujii

    Single Author

  • Carnosine dipeptidase II (CNDP2) protects cells under cysteine insufficiency by hydrolyzing glutathione-related peptides., Free radical biology & medicine, 174 12-27, 2021.10

    Sho Kobayashi, Takujiro Homma, Nobuaki Okumura, Jia Han, Keita Nagaoka, Hideyo Sato, Hiroyuki Konno, Sohsuke Yamada, Toshifumi Takao, Junichi Fujii

    Single Author

  • Comparative study of different chiral ligands for dynamic kinetic resolution of amino acids., Chirality, 33(10) 685-702, 2021.10

    Keita Nagaoka, Arina Nakano, Jianlin Han, Tsubasa Sakamoto, Hiroyuki Konno, Hiroki Moriwaki, Hidenori Abe, Kunisuke Izawa, Vadim A Soloshonok

    Single Author

  • Tailor-made amino acids in the design of small-molecule blockbuster drugs., European journal of medicinal chemistry, 220 113448, 2021.08

    Jianlin Han, Hiroyuki Konno, Tatsunori Sato, Vadim A Soloshonok, Kunisuke Izawa

    Single Author

  • Asymmetric synthesis of the two enantiomers of β-phosphorus-containing α-amino acids via hydrophosphinylation and hydrophosphonylation of chiral Ni(ii)-complexes, Organic Chemistry Frontiers, 8(10) 2190-2195, 2021.05

    Yoshinori Tokairin, Hiroyuki Konno, Angéline Noireau, Caroline West, Hiroki Moriwaki, Vadim A. Soloshonok, Cyril Nicolas, Isabelle Gillaizeau

    Single Author

  • The total synthesis of berberine and selected analogues, and their evaluation as amyloid beta aggregation inhibitors., European journal of medicinal chemistry, 215 113289, 2021.04

    Misato Tajiri, Ryo Yamada, Mayumi Hotsumi, Koki Makabe, Hiroyuki Konno

    Single Author

  • JNK signaling as a target for anticancer therapy., Pharmacological reports : PR, 73(2) 405-434, 2021.04

    Kamal S Abdelrahman, Heba A Hassan, Salah A Abdel-Aziz, Adel A Marzouk, Atsushi Narumi, Hiroyuki Konno, Mohamed Abdel-Aziz

    Single Author

  • Maltotriose-Chlorin e6 Conjugate Linked via Tetraethyleneglycol as an Advanced Photosensitizer for Photodynamic Therapy. Synthesis and Antitumor Activities against Canine and Mouse Mammary Carcinoma Cells., ACS omega, 6(10) 7023-7033, 2021.03

    Atsushi Narumi, Rioko Rachi, Hiromi Yamazaki, Seigou Kawaguchi, Moriya Kikuchi, Hiroyuki Konno, Tomohiro Osaki, Yoshiharu Okamoto, Xiande Shen, Toyoji Kakuchi, Hiromi Kataoka, Akihiro Nomoto, Tomokazu...

    Single Author

  • Preparation of SARS-CoV 3CL Protease and Synthesis of its Inhibitors, Journal of Synthetic Organic Chemistry, Japan, 79(1) 2-10, 2021

    Konno Hiroyuki, Akaji Kenichi

    Single Author

  • Synthetic study of cyclic depsipeptide callipeltin Q, Symposium on the Chemistry of Natural Products, symposium papers, 62(0) 313-318, 2020

    Tokairin Y., Nagaoka K., Shigeno Y., Gillaizeau I., Soloshonok V., Konno H.

    Single Author

  • Improved synthesis of 2,4,6-trialkylpyridines from 1,5-diketoalkanes: total synthesis of anibamine., Org. Biomol. Chem., 2018.12

    Miyakoshi, T.; Konno, H.

    Multiple Authorship (Including Foreigners)

  • Convergent synthesis of trans-2,6-disubstituted piperidine alkaloid, (-)-iso-6-spectaline by palladium-catalyzed cyclization., Chem. Pharm. Bull. , 2018.12

    79. Kameda, R.; Soma, T.; Kobayashi, K.; Uchiyama, R.; Nosaka, K.; Konno, H.; Akaji, K.; Hattori

    Multiple Authorship (Including Foreigners)

  • Deletion of uncharacterized domain from α-1,3-glucanase of Bacillis circulans KA-304 enhance heterologous enzyme production in Escherichia coli., J. Gen. Appl. Microbiol. , 64 212-220, 2018.11

    Yano, S.; Suyotha, W.; Zanma, S.; Konno, H.; Wakamiya, M.

    Multiple Authorship (Including Foreigners)

  • Asymmetric synthesis of (2S,3S)-3-Me-glutamine and (R)-allo-threonine derivatives proper for solid phase peptide coupling., Amino Acids, 2018.11

    Tokairin, Y.; Soloshonok, V. A.; Moriwaki, H.; Konno, H.

    Multiple Authorship (Including Foreigners)

  • Investigation for the cyclization of linear tetrapeptides: Synthesis of tentoxin B and dihydrotentoxin., Tetrahedron, 74 6173-6181, 2018.09

    Sato, R.; Oyama, K.; Konno, H.

    Multiple Authorship (Including Foreigners)

  • Design, synthesis and evaluation of curcumin-based fluorescent probes for the detection of A fibrils., Bioorg. Med. Chem. Lett., 28 3520-3525, 2018.09

    Sato, T.; Hotsumi, M.; Makabe, K.; Konno, H.

    Multiple Authorship (Including Foreigners)

  • 20190820, KAGAKU TO SEIBUTSU, 56(9) 627-634, 2018

    KONNO Hiroyuki

    Single Author

  • Synthesis of secretogrobin 3A2 type C (98-139) fragment by Dawson’s native chemical ligation, Tetrahedron Lett. , 58 4145-4148, 2017.10

    Kikuchi, M.; Kurotani, R.; Konno, H.

    Multiple Authorship (Including Foreigners)

  • Ralstonins A and B, unusual lipopeptides with chlamydospore-inducing and phytotoxic activities from the plant pathogen Ralstonia solanacearum., Org. Lett., 19 4175-4178, 2017.05

    Murai, Y.; Mori, S.; Konno H.; Hikichi, Y.; Kai, K.

    Multiple Authorship (Including Foreigners)

  • Synthesis and evaluation of phenylisoserine derivatives for the SARS-CoV 3CL protease inhibitor., Bioorg. Med. Chem. Lett. , 27 2746-2751, 2017.04

    Konno, H.; Onuma, T.; Nitanai, I.; Wakabayashi, M.; Yano, S.; Teruya, K.; Akaji, K.

    Multiple Authorship (Including Foreigners)

  • Synthesis of fully protected (2R,3R,4S)-4-amino-7-guanidino-2,3-dihydroxy heptanoic acid., Tetrahedron Lett. , 58 1604-1606, 2017.03

    Yoshino, R.; Tokairin, Y.; Konno, H.

    Multiple Authorship (Including Foreigners)

  • Preparation of (2R,3R,4R)-3-hydroxy-2,4,6-trimethyl heptanoic acid via enzymatic desymmetrization., Tetrahedron, 73 39-45, 2017.02

    Tokairin, Y.; Konno, H.

    Multiple Authorship (Including Foreigners)

  • Fmoc-OPhth, the reagent of Fmoc protection., Tetrahedron Lett. , 58 1600-1603, 2017.01

    Yoshino, R.; Tokairin, Y.; Kikuchi, M.; Konno, H.

    Multiple Authorship (Including Foreigners)

  • Design and Synthesis of a Series of Serine Derivatives as the Small Molecule Inhibitors of the SARS Coronavirus 3CL Protease., Bioorg. Med. Chem., 24 1241-1254, 2016.03

    Konno, H.; Wakabayashi, M.; Takanuma, D.; Saito, Y.; Akaji, K.

    Single Author

  • Synthesis of β-Hydroxytyrosine, A Component of Burkholdines., Nat. Prod. Commun., 11 213-218, 2016.02

    Konno, H.; Sasaki, Y.; Sato, R.; Zhu, X.-M.; Otsuki, Y.; Ikoma, M.

    Multiple Authorship (Including Foreigners)

  • Cytotoxic evaluation of natural and synthetic callipeltins: a revision of cytotoxicity of callipeltin B., Biosci. Biotechnol. Biochem., 80(6) 1066-1069, 2016.01

    Kikuchi, M.; Konno, H.

    Multiple Authorship (Including Foreigners)

  • Structure activity relationship study of burkholdine analogues toward simple antifungal agents, Bioorg. Med. Chem. Lett., 25 3199-3202, 2015.05

    Konno, H.; Abumi, K.; Sasaki, Y.; Yano, S.; Nosaka, K.

    Multiple Authorship (Including Foreigners)

  • Synthetic studies on homophymine B: solid phase synthesis of a cyclic fragment, Tetrahedron Lett. , 56 2809-2812, 2015.04

    Tokairin, Y.; Takeda, S.; Kikuchi, M.; Konno, H.

    Multiple Authorship (Including Foreigners)

  • Synthetic study of peptide aldehydes via acetal/thioacetal transformation: application for Lys/Ser-containing peptides, Tetrahedron , 71 3433-3438, 2015.03

    Konno, H.; Sema, Y.; Tokairin, Y.

    Single Author

  • Synthesis and evaluation of aminopyridine derivatives as potential BACE1 inhibitors., Bioorg. Med. Chem. Lett. , 25 5127-5132, 2015.02

    Konno, H.; Sato, T.; Saito Y.; Sakamoto, I.; Akaji, K.

    Multiple Authorship (Including Foreigners)

  • Synthesis of orthogonally protected (2R,3R,4S)-4-amino-2,3-dihydroheptan-1,7-dioic acid, Synthesis , 47 351-358, 2015.01

    Tokairin, Y.; Maita, K.; Takeda, S.; Konno, H.

    Multiple Authorship (Including Foreigners)

  • Structure activity relationship study of curcumin analogues toward the amyloid-beta aggregation inhibitor, Bioorg. Med. Chem. Lett., 24 5621-5626, 2014.10

    Endo, H.; Nikaido, Y.; Nakadate, M.; Ise, S.; Konno, H.

    Multiple Authorship (Including Foreigners)

  • Total synthesis of callipeltin B and M, peptidyl marine natural products, Org. Lett. , 16 4324-4327, 2014.08

    Kikuchi, M.; Konno, H.

    Multiple Authorship (Including Foreigners)

  • Effect of prome-site sequence of retro-inverso-modified HTLV-1 protease inhibitor., Bioorg. Med. Chem., 22 2482-2488, 2014.07

    Awahara, C.; Tatsumi, T.; Furuta, S.; Shinjoh, G.; Konno, H.; Nosaka, K.; Kobayashi, K.; Hattori, Y.; Akaji, K.

    Multiple Authorship (Including Foreigners)

  • Stereochemical assignment of four diastereomers of dimethylpyroglutamic acid, a component of callipeltin B, Heterocycles , 89 1620-1631, 2014.06

    Kikuchi, M.; Konno, H.

    Single Author

  • Enzymatic and structural characterization of an archaeal thiamin phosphate synthase., BBA-Proteins and Proteomics, 1844 803-809, 2014.05

    Hayashi, M.; Kobayashi, K.; Esaki, H.; Konno, H.; Akaji, K.; Tazuya, K.; Yamada, K.; Nosaka, K.

    Multiple Authorship (Including Foreigners)

  • Synthesis and evaluation of inhibitory activity of the curcumin derivatives toward the inhibitor of beta-site amyloid precursor protein cleaving enzyme 1, Bioorg. Med. Chem. Lett. , 24 685-690, 2014.03

    Konno, H.; Endo, H.; Ise, S.; Miyazaki, K.; Aoki, H.; Sanjo, A.; Hattori, Y.; Akaji, K.

    Multiple Authorship (Including Foreigners)

  • Synthetic Study of Callipeltin B: Solid Phase Synthesis and Stereochemical Assignment, Peptide Science 2013, 131-132, 2014.03

    Kikuchi, M.; Konno, H.

    Multiple Authorship (Including Foreigners)

  • Synthetic Study on Homophymine A: Stereoselective Synthesis of Unusual Amino Acids and Solid Phase Synthesis of the Cyclic Fragment, Peptide Science 2013, 123-126, 2014.03

    Takeda, S.; Tokairin, Y.; Kikuchi, M.; Konno, H.

    Multiple Authorship (Including Foreigners)

  • Total synthesis of (+)-azimine via diastereoselective aminopalladation, Tetrahedron, 69 8349-8352, 2013.12

    Kurogome, Y.; Kosugi, M.; Looi, K. K.; Hattori, Y.; Konno, H.; Hirota, M.; Makabe, H.

    Multiple Authorship (Including Foreigners)

  • Practical synthesis of peptide C-terminal aldehyde on a solid support., Tetrahedron Lett. , 54 4848-4850, 2013.10

    Konno, H.; Sema, Y.; Ishii, M.; Hattori, Y.; Nosaka, K.; Akaji, K.

    Multiple Authorship (Including Foreigners)

  • Synthesis and antifungal activities of cyclic octa-lipopeptide burkholdine analogues, Bioorg. Med. Chem. Lett. , 23 4244-4247, 2013.08

    Konno, H.; Otsuki, Y.; Matsuzaki, K.; Nosaka, K.

    Multiple Authorship (Including Foreigners)

  • Improved synthesis of D-allothreonine derivatives from L-threonine, Tetrahedron , 69 7098-7101, 2013.06

    Kikuchi, M.; Konno, H.

    Multiple Authorship (Including Foreigners)

  • Education project for Innovation, Executed in Faculty of Engineering at Yamagata University in 2010 –Two Education programs about biomass and snow vehicle-, J. Engineering Edu. Res, 14 21-29, 2012.10

    Furukawa, H.; Watanabe, K.; Konno, H.; Matsushima, Y.; Matsuba, G.; Nomoto, K.

    Multiple Authorship (Including Foreigners)

  • Synthesis and evaluation of SARS 3CL protease inhibitors using the serine template, Proceedings of 32nd European Peptide Symposium, 478-479, 2012.10

    Takanuma, D.; Akaji, K.; Konno, H.

    Multiple Authorship (Including Foreigners)

  • Synthesis of cyclic lipo-peptide derivatives of burkholdines and its antifungal activity, Proceedings of 32nd European Peptide Symposium, 80-81, 2012.10

    Konno, H.; Otsuki, Y.

    Multiple Authorship (Including Foreigners)

  • Synthetic study of callipeltin B analogues and its cytotoxicity, Proceedings of 32nd European Peptide Symposium, 636-637, 2012.10

    Kikuchi, M.; Watanabe, Y.; Tanaka, M.; Akaji, K.; Konno, H.

    Multiple Authorship (Including Foreigners)

  • Facilitated recruitment of Pdc2p, a yeast transcriptional activator, in response to thiamin starvation, FEMS Microbiol. Lett. , 330 140-147, 2012.06

    Nosaka, K.; Esaki, H.; Onozuka, M.; Konno, H.; Hattori, Y.; Akaji, K.

    Multiple Authorship (Including Foreigners)

  • Structure-Based Design, Synthesis, and Evaluation of Peptide-mimetics SARS 3CL Protease Inhibitors, J. Med. Chem. , 54 7962-7973, 2011.12

    Akaji, K.; Konno, H.; Mitsui H.; Teruya, K.; Hattori, Y.; Ozaki, T.; Kusunoki, M.; Sanjho, A.

    Multiple Authorship (Including Foreigners)

  • Synthesis of N1- and N8-(γ-L-Glutamyl)spermidines and (γ-L-Glutamyl)putrescine. , Lett. In Org. Chem., 8 1-5, 2011.04

    Toho, K.; Abe, N.; Yamada, T.; the late Ito, Y.; Konno, H.; Kuwahara, S.; Kiyota, H.

    Multiple Authorship (Including Foreigners)

  • Synthesis of tokaramide A, a cysteine protease inhibitor from marine sponge Theonella mirabilis., Konno, H.; Nosaka, K.; Akaji, K., 67 9067-9071, 2011.04

    Konno, H.; Nosaka, K.; Akaji, K.

    Multiple Authorship (Including Foreigners)

  • Synthesis and cytotoxicity of callipeltin B analogues., Bioorg. Med. Chem. Lett., 21 4865-4868, 2011.04

    Kikuchi, M.; Watanabe, Y; Tanaka, M.; Akaji, K.; Konno, H.

    Multiple Authorship (Including Foreigners)

  • Solid Phase Total Synthesis of Callipeltin E isolated from marine sponge Latrunculia sp., Tetrahedron Lett. , 52(30) 3872-3875, 2011.04

    Kikuchi, M.; Nosaka, K.; Akaji, K.; Konno, H.

    Multiple Authorship (Including Foreigners)

  • Synthetic Studies on Callipeltins: stereoselective syntheses of (3S, 4R)-3,4-dimethyl-L-pyroglutamic acid and Fmoc-D-allothreonine., Heterocycles, 81(1) 79-89, 2010.04

    Konno, H.; Takebayashi, Y.; Nosaka, K.; Akaji, K.

    Multiple Authorship (Including Foreigners)

  • Synthesis of solamin type mono-THF acetogenins using cross-metathesis, Tetrahedron , 66 7946-7953, 2010.04

    Konno, H.; Makabe, H.; Yattori, Y.; Nosaka, K.; Akaji, K.

    Multiple Authorship (Including Foreigners)

  • Synthesis of Annonacin, Biosci. Biotetcnol. Biochem. , 76(4) 1274-1275, 2010.04

    Oasa, M.; Hattori, Y.; Konno, H.; Makabe, H.

    Multiple Authorship (Including Foreigners)

  • Evaluation of retro-inverso modifications of HTLV-1 protease inhibitors containing a hydroxyethylamine isoster., Bioorg. Med. Chem., 18 2720-2727, 2010.04

    Tatsumi, T.; Awahara, C.; Naka, H.; Aimoto, S.; Konno, H.; Nosaka, K.; Akaji, K.

    Multiple Authorship (Including Foreigners)

  • Evaluation of Lipid-Binding Propaties of the N-Terminal Helical Segments in Human Apolipoprotein A-I Using Fragment Peptides, J. Peptide Sci. , 15(1) 36-42, 2009.04

    Tanaka, M.; Tanaka, T.; Ohta, S.; Kawakami, T.; Konno, H.; Akaji, K.; Aimoto, S.; Saito, H.

    Multiple Authorship (Including Foreigners)

  • Synthesis of [19.35.36-13C3]-Labeled TAK779 as a moleculer probe, Bioorg. Med. Chem., 17 5769-5774, 2009.04

    Konno, H.; Aimoto, S.; Smith, S. O.; Nosaka, K.; Akaji, K.

    Multiple Authorship (Including Foreigners)

  • A Concise Synthesis of Solamin and cis-Solamin, Mono-THF Acetogenins from Annona muricata, Heterocycles, 78(9) 2369-2376, 2009.04

    Makabe, H.; Kuwabara, A.; Hattori, Y.; Konno, H.

    Multiple Authorship (Including Foreigners)

  • Possible involvement of thiaminase II encoded by the THI20 gene in thiamine salvage of Saccharomyces cerevisiae, Journal of FEMS Yeast Research, 8(2) 266-275, 2008.01

    Onozuka, M.; Konno, H.; Kawasaki, Y.; Akaji, K.; Nosaka, K.

    Multiple Authorship (Including Foreigners)

  • Synthesis of Pyranicin and its Inhibitory Action with Bovine Heart Mitochondrial Complex I, Organic Letters, 10(5) 717-720, 2008.01

    Hattori, N.; Furuhata, S.; Okajima, M.; Konno, H.; Abe, M.; Miyoshi, H.; Goto, T, Makabe, H.

    Multiple Authorship (Including Foreigners)

  • Total synthesis of pyranicin and its deoxygenated analogues and their inhibitory action with bovine heart mitochondrial complex I, Tetrahedron, 64 7695-7703, 2008.01

    Furuhata, S.; Hattori, Y.; Okajima, M.; Konno, H.; Abe, M.; Miyoshi, H.; Goto, T.; Makabe, H.

    Multiple Authorship (Including Foreigners)

  • Thiamin-dependent transactivation activity of PDC2 in Saccharomyces, FEBS Letters, 582(29) 3991-3996, 2008.01

    Nosaka, K.; Onozuka, M.; Konno, H.; Akaji, K.

    Multiple Authorship (Including Foreigners)

  • Evaluation of Peptide Aldehyde Inhibitors using R188I Mutant of SARS 3CL Protease as a proteolysis-resistant mutant, Bioorganic Medicinal Chemistry, 16 9400-9408, 2008.01

    Akaji, K.; Konno, H.; Onozuka, M.; Makino, A.; Nosaka, K.

    Multiple Authorship (Including Foreigners)

  • Total synthesis of cis-solamin A, a mono-tetrahydrofuran acetogenin isolated from Annona muricata. , Tetrahedron Letters, 49(5) 782-785, 2008.01

    Konno, H.; Okuno, Y.; Makabe, H.; Nosaka, K.; Onishi, A.; Abe, N.; Sugimoto, A.; Akaji, K.

    Multiple Authorship (Including Foreigners)

  • Synthesis of All Stereoisomers of β-Methoxy Tyrosine Derivatives and Identification of the Absolute Configration in Callipeltin E, Synthesis, (23) 3666-3672, 2007.12

    Konno, H.; Aoyama, S.; Nosaka, K.; Akaji, K.

    Multiple Authorship (Including Foreigners)

  • Total Synthesis of Miraziridine A and Identification of Its Major Reactive Site for Cathepsin B, Tetrahedron, 63(38) 9502-9513, 2007.10

    Konno, H.; Kubo, K.; Makabe, H.; Toshiro, E.; Nosaka, K.; Akaji, K.

    Multiple Authorship (Including Foreigners)

  • Studies on Substrate Specificity at PR/p3 Cleavage Site of HTVL-1 Protease, Int. J. Peptide Res., 13 173-179, 2007.08

    Bang, J. K.; Teruya, K.; Aimoto, S.; Konno, H.; Nosaka, K.; Tatsumi, T.; Akaji, K.

    Multiple Authorship (Including Foreigners)

  • Total Synthesis of Miraziridine A and Its Analogues, Peptides, 1-2, 2007.08

    Konno, H.; Kubo, K.; Makabe, H.; Nosaka, K.; Akaji, K.

    Multiple Authorship (Including Foreigners)

  • Synthesis of (17S, 18S)- and (17R, 18R)-tonkinelin and their inhibitory action with bovine heart mitochondorial complex I, Bioorg. Med. Chem. , 15 3026-3031, 2007.04

    Hattori, Y.; Konno, H.; Abe, M.; Miyoshi, H.; Goto, T.; Makabe, H.

    Multiple Authorship (Including Foreigners)

  • First syntheses of Trans- and Cis-dendrochrysanines, Heterocycles, 68(12) 2579-2585, 2006.12

    Konno, H.; Kusumoto, S.; Kanai, S.; Yamahana, Y.; Nosaka, K.; Akaji, K.

    Multiple Authorship (Including Foreigners)

  • Synthesis of Murisolin, (15R, 16R, 19R, 20S)-Murisolin-A, (15R, 16R, 19R, 20S)-16,19-cis-Murisolin-A, and Their Inhibitory Action with Bovine Heart Mitochondrial Complex I, Chemistry-Asian Journal , 1 894-904, 2006.11

    Hattori, Y.; Kimura, Y.; Moroda, A.; Konno, H.; Abe, M.; Miyoshi, H.; Goto, T, Makabe, H.

    Single Author

  • Evaluations of Substrate Specificity and Inhibition at PR/p3 Cleavage Site of HTLV-1 Protease, Bioorg. Med. Chem. Lett. , 16 3761-3764, 2006.10

    Naka, H.; Teruya, K.; Bang, J. K.; Aimoto, S.; Tatsumi, T.; Konno, H.; Nosaka, K.; Akaji, K.

    Multiple Authorship (Including Foreigners)

  • Synthesis of (4R, 15R, 16R, 21S)-and (4R, 15S, 16S, 21S)-rollicosin and squamostolide, and their inhibitory action with bovine heart mitochondeial complex I, Bioorg. Med. Chem. Lett. , 14 3119-3130, 2006.09

    22. Makabe, H.; Kimura, Y.; Higuchi, M.; Konno, H.; Murai, M.; Miyoshi, H.

    Multiple Authorship (Including Foreigners)

  • Synthetic Studies on Miraziridine A, a Cysteine Protease Inhibitor Isolated from Theonella aff. mirabilis., Proceedings of 43JPS/PEM4, 37-38, 2006.05

    Konno, H.; Kubo, K.; Makabe, H.; Nosaka, K.; Akaji, K.

    Multiple Authorship (Including Foreigners)

  • Solid-Phase Synthesis of Olefin-containing Inhibitors for HTLV-1 Protease using the Horner-Emmons Reaction, J. Org. Chem., 70 10596-10599, 2005.12

    Bang, J. K.; Naka, H.; Teruya, K.; Aimoto, S.; Konno, H.; Nosaka, K.; Akaji, K.

    Multiple Authorship (Including Foreigners)

  • Genetic regulation mediated by thiamin pyrophosphate-binding motif in Saccharomyces cerevisiae, Mol. Microbiol., 58 467-479, 2005.11

    Nosaka, K.; Onozuka, M.; Konno, H.; Kawasaki, Y.; Nishino, H.; Sano, M.; Akaji, K.

    Multiple Authorship (Including Foreigners)

  • Molecular Cloning and Analysis of the 5’-Flanking Region of the Human Thiamin Pyrophosphokinase gene, J. Nutr. Sci. Vitaminol. , 51 274-277, 2005.10

    Onozuka, M.; Konno, H.; Akaji, K.; Nishino, H.; Nosaka, K.

    Multiple Authorship (Including Foreigners)

  • Synthesis of (4R, 15R, 16R, 21S)-and (4R, 15S, 16S, 21S)-rollicosin and squamostolide, and their inhibitory action with bovine heart mitochondeial complex I, Tetrahedron Lett. , 46 4671-4675, 2005.09

    Makabe, H.; Higuchi, M.; Konno, H.; Murai, M.; Miyoshi, H.

    Multiple Authorship (Including Foreigners)

  • Genetic Regulation Mediated by Thiamin Pyrophosphate-binding Motif in Saccharomyces cerevisiae. , Proceeding of the XXIInd International Conference on Yeast Genetics &Molecular Biology, -22, 2005.08

    Nosaka, K.; Onozuka, M.; Kawasaki, Y.; Konno, H.; Akaji, K.

    Multiple Authorship (Including Foreigners)

  • Total Synthesis of cis-Solamin and Its Inhibitory Action with Mitochondrial Complex I, Tetrahedron Lett. , 60 10651-10657, 2004.12

    Makabe, H.; Hattori, Y.; Kimura, Y.; Konno, H.; Abe, M.; Miyoshi, H.; Tanaka, A.; Oritani, T.

    Multiple Authorship (Including Foreigners)

  • Synthesis of Two Possible Diastereoisomers of Reticulatain-1, Tetrahedron Lett. , 45 973-977, 2004.11

    Makabe, H.; Miyawaki, A.; Takahashi, R.; Hattori, Y.; Konno, H.; Abe, M.; Miyoshi, H.

    Multiple Authorship (Including Foreigners)

  • Synthesis and Mitochondrial Inhibition of Dihydroxy-Cohibin A, Non-THF Annonaceous Acetogenin Analogue, Bioorg. Med. Chem. Lett. , 13 629-632, 2004.10

    Konno, H.; Hiura, N.; Makabe, H.; Abe, M.; Miyoshi, H.

    Multiple Authorship (Including Foreigners)

  • Synthesis and Mitochondrial Complex I Inhibitoin of Mono- and Non-THF Acetogneins, Proceeding of the 6th Japan/Australia Symposium on Drug Design and Development, 22, 2004.04

    Konno, H.; Hiura, H.; Okuno, Y.; Makabe, H.; Hattori, Y.; Miyoshi, H.; Abe, M.; Fujii, N.

    Multiple Authorship (Including Foreigners)

  • Efficient Synthesis of Akolactone via Pd-Catalyzed Carbonylation, Biosci. Biotechnol. Biochem., 67(12) 2658-2660, 2003.12

    Makabe, H.; Okajima, M.; Konno, H.; Kamo, T.; Hirota, M.

    Multiple Authorship (Including Foreigners)

  • An Epoxide Ring-Opening Reaction via Hypervalent Silicates Intermediate: Synthesis of Statine, Synthesis, 2161-2164, 2003.11

    Konno, H.; Toshiro, E.; Hinoda, N.

    Multiple Authorship (Including Foreigners)

  • Structural Revision of Epoxyrollins A and B, Biosynthetic Precursor of Annnonaceous Acetogenins, Biosci. Biotechnol. Biochem., 67(6) 1438-1441, 2003.06

    Konno, H.; Makabe, H.

    Multiple Authorship (Including Foreigners)

  • Syntheses of (4S, 5R)- and (4R, 5S)-Muricatacins and (4R, 5S)-aza-muricatacin, Unnatural Analogues of The Annonaceous Acetogenin, Heterocycles, 57(10) 1793-1797, 2002.10

    Konno, H.; Hiura, N.; Yanaru, M.

    Multiple Authorship (Including Foreigners)

  • Metal Assisted Stabilization and Probing of Collagenous Triple Helices, J. Am. Chem. Soc. , 124 9388-9289, 2002.09

    Koide, T.; Yuguchi, M.; Kawakita, M.; Konno, H.

    Multiple Authorship (Including Foreigners)

  • Preparation of a Synthetic Equivalent of Chiral Methyl 2,5-Dihydroxycyclohexane 1,4-dienecarboxylate, Tetrahedron: Asymmetry, 10 3849-3857, 1999.10

    Yoshida, N.; Konno, H.; Kamikubo, T.; Takahashi, M.; Ogasawara, K.

    Multiple Authorship (Including Foreigners)

  • A Practical Preparation of Versatile Cyclohexenoid Chiral Building Blocks, Synthesis , 1135-1140, 1999.09

    Konno, H.; Ogasawara, K.

    Multiple Authorship (Including Foreigners)

  • Enantioselective Construction and Utilization of 2-(cyclohex-2-enyl)phenols, Synlett , 1004-1008, 1998.12

    Konno, H.; Ogasawara, K.

    Multiple Authorship (Including Foreigners)

  • An Enantio- and Diastereoselective Synthesis of (-)-Isoretronecanol and (+)-Trachelanthamidine from A Meso Precursor, Heterocycles , 49 22-26, 1998.01

    Konno, H.; Kishi, M.; Hiroya, K.; Ogasawara, K.

    Multiple Authorship (Including Foreigners)

  • A New Tactic for Diastereo- and Enantilcontrolled synthesis of (-)-Malyngolide via Catalytic Meso-Asymmetrization, Tetrahedron Lett. , 38 6023-6026, 1997.01

    Konno, H.; Hiroya, K.; Ogasawara, K.

    Multiple Authorship (Including Foreigners)

  • Total Synthesis of (15S, 16R, 19S, 20R, 34S)-Diepomuricanin, Tetrahedron Lett. , 37 5393-5396, 1996.10

    Konno, H.; Makabe, H.; Tanaka, A.; Oritani, T.

    Multiple Authorship (Including Foreigners)

  • ynthesis of Two Possible Diastereoisomers of the Epoxy Lactone Proposed for an Annonaceous Acetogenins, Epoxyrollin A, Tetrahedron Lett. , 52 9399-9408, 1996.08

    Konno, H.; Makabe, H.; Tanaka, A.; Oritani, T.

    Multiple Authorship (Including Foreigners)

  • Synthesis of Squamostanal-A, Biosci. Biotechnol. Biochem., 60 526-527, 1996.06

    Konno, H.; Makabe, H.; Tanaka, A.; Oritani, T.

    Multiple Authorship (Including Foreigners)

  • Synthesis of Two Possible Diastereoisomers of the Lactone Proposed for Epoxyrollin A, Biosci. Biotechnol. Biochem., 59 2355-2357, 1995.12

    Konno, H.; Makabe, H.; Tanaka, A.; Oritani, T.

    Multiple Authorship (Including Foreigners)

display all >>

Review Papers

  • Synthetic study of bioactive natural product as protein inhibitors, Biosci. Biotechnol. Biochem., 76 1-5, 2012.01

    Konno, H.

  • Current Topics of Organic and Biological Chemistry of Annonaceous Acetogenins and their Synthetic Mimics, Current Drug Discovery Technologies, 3 213-229, 2008.01

    Makabe, H.; Konno, H.; Miyoshi, H.

Grant-in-Aid for Scientific Research

  • Grant-in-Aid for Scientific Research(C),2021.04 - 2023.03

  • Grant-in-Aid for Scientific Research(C),2021.04 - 2023.03

  • Grant-in-Aid for Scientific Research(C),2018.04 - 2020.03

  • Grant-in-Aid for Scientific Research(C),2016.04 - 2019.03

Other external funds procured

  • Mechanism of thiamin transport in Helicobacter pylori providing a basis for complementary therapy for the infection.,2015.04 - 2018.03,Mechanism of thiamin transport in Helicobacter pylori providing a basis for complementary therapy for the infection.

    Helicobacter pylori lacks the genes involved in the de novo synthesis of thiamin, and therefore is a thiamin auxotroph. In this study, we found that thiamin is incorporated into H. pylori SS1 strain via a facilitated diffusion with an apparent Km value of 19 μM, and that the transport system seems to recognize the pyrimidine moiety of thiamin. In addition, when the pnuT gene was expressed in a thiamin transport-deficient Escherichia coli strain, the transport activity with a Km value of 3.5 μM was restored. Further, the pnuT-deficient H. pylori strain exhibited reducing thiamin transport activity to less than 20% of the wild-type strain, and required 100 times more thiamin than the wild-type strain to achieve growth equal to that of the wild-type. These findings reflect the presence of multiple routes for entry of thiamin into H. pylori, and it is likely that PnuT is responsible for the high affinity thiamin transport and serves as target for antimicrobial agent for H. pylori.

    Japan Society for the Promotion of Science

  • Basic research aiming at the application of SCGB3A2 for chronic obstructive pulmonary disease therapeutic drug.,2015.04 - 2018.03,Basic research aiming at the application of SCGB3A2 for chronic obstructive pulmonary disease therapeutic drug.

    In this study, we aimed at basic research aiming at application of secretoglobin (SCGB) 3A2 to chronic obstructive pulmonary disease (COPD) treatment. COPD is a lung disease considered to be one of lifestyle-related diseases caused by long-term smoking, and shows features such as thickening, stenosis of the peripheral airway wall and destruction of the alveolar wall. SCGB3A2 has an anti-inflammatory effect, an improvement effect of pulmonary fibrosis, and a growth promoting effect in lung development. Therefore, we expected that SCGB 3 A 2 will also have an effective effect on COPD. Mainly, the improvement effect of SCGB3A2 on COPD was examined using COPD mouse model prepared using Scgb3a2 gene modified mouse. In addition, we clarified the COPD improvement mechanism in the cell culture system. This study suggested that SCGB3A2 upregulates the expression of alpha 1 antitrypsin by phosphorylation of STAT3, and SCGB3A2 showed an effect of improving pulmonary emphysema, in particular.

    Japan Society for the Promotion of Science