Updated on 2023/11/21

写真a

 
OKUNO Takashi
 
Title
Professor

Research Areas

  • Life Science / Biophysics

Graduate School

  • Nagoya University, Graduate School, Division of Natural Science

    Doctor's Course, 2000.03, Completed

External Career

  • , Researcher, 2002.04 - 2005.03

  • , Research Assistant, 2005.04 - 2007.05

  • , Assistant Professor, 2007.06 - 2008.09

  • , Associate Professor, 2008.10 - 2011.03

 

Papers

  • Improvement of Blood-Brain Barrier Permeability Prediction using Cosine Similarity, Journal of Computer Chemistry, Japan, 2023.04

    Hiroshi Sakiyama, Ryushi Motoki, Takashi Okuno, Jian-Qiang Liu

    Multiple Authorship (Including Foreigners)

  • Central Object Segmentation by Deep Learning to Continuously Monitor Fruit Growth through RGB Images, Sensors, 21(21) 6999, 2021.10

    M. Fukuda, T. Okuno, S. Yuki

    Multiple Authorship (Only Japanese)

  • Inchworm-type PNA-PEG conjugate regulates gene expression based on single nucleotide recognition, International Journal of Biological Macromolecules, 181 471-477, 2021.06

    Yusuke Hamashita, Takahiro Shibata, Akiko Takeuchi, Takashi Okuno, Naoki Kise, Toshihiko Sakurai

    Multiple Authorship (Only Japanese)

  • Structural Analysis of Streptococcus pyogenes NADH Oxidase: Conformational Dynamics Involved in Formation of the C(4a)-Peroxyflavin Intermediate, Biochemistry, 54(45) 6815-6829, 2015

    Jamie R Wallen, T Conn Mallett, Takashi Okuno, Derek Parsonage, Hiroaki Sakai, Tomitake Tsukihara, Al Claiborne

    Multiple Authorship (Only Japanese)

  • Crystal Structure of Mox-1, a Unique Plasmid-Mediated Class C β-Lactamase with Hydrolytic Activity towards Moxalactam, Antimicrob Agents Chemother, 58 3914-3920, 2014

    Oguri T., Furuyama T., Okuno T., Ishii Y., Tateda K., Bonomo RA., Shimizu-Ibuka A.

    Single Author

  • Quantitative comparison of Adipocytokine gene expression during adipocyte maturation in non-obes and obese rats., Biol. Pharm. Bull., 2011.05

    Y.Ikeda, S.Hama, K.Kajimoto, T.Okuno, H.Tsuchiya, K.Kogure

    Multiple Authorship (Including Foreigners)

  • Eavaluation of Aβ fibrillization inhibitory effect by a PEG-peptide conjugated based on an Aβ peptide fragment with intramolecular FRET., Chem. Commun., 2011.03

    T.Sakurai, T.Iwasaki, T.Okuno, Y.Kawata, N.Kise

    Multiple Authorship (Including Foreigners)

  • A new method to evaluate unfolding activity unit ClpA based on Fe-S cluster disruption., Chem. Pharm. Bul, 2011.03

    T.Ohgita, T.Okuno, S.Hama, H.Tsuchiya, K.Kogure

    Multiple Authorship (Including Foreigners)

  • Fluorescence polarization analysis for revealing molecular mechanism of nucleotide-dependent phospholipid membrane binding of MinD ATPase., Biol. Pharm. Bull, 2010.07

    T.Okuno, T.Ohgita, T.Sasa, A.Nonaka, N.Funasaki, K.Kogure

    Multiple Authorship (Including Foreigners)

  • FtsH cleavage of non-native conformations of proteins., J. Struct. Biol, 2010.05

    S.Ayuso-Tejedor, S.Nishikori, T.Okuno, T.Ogura, J.Sancho

    Multiple Authorship (Including Foreigners)

  • Comparison of intracellular localization between Nubp1 and Nubp2 utilizing GFP fusion protein., Mol.Biol.Rep., 2010

    Okuno T., Yamabayashi H., Kogure K.

    Multiple Authorship (Only Japanese)

  • Direct monitoring of interaction between Escherichia coli proteins, MinC and monomeric FtsZ, in solution., Biol. Pharm. Bull., 2009.05

    T.Okuno, M.Ogoh, H.Tanina, N.Funasaki, K.Kogure

    Multiple Authorship (Including Foreigners)

  • Characterization of mutants of the Escherichia coli AAA protease, FtsH, carrying a mutation in the central pore region., J. Struct. Biol., 156 109-114, 2006

    Okuno T., Yamanaka K., Ogura T.

    Multiple Authorship (Only Japanese)

  • An AAA protease FtsH can initiate proteolysis from internal sites of a model substrate, apo-flavodoxin., Genes Cells, 2006

    Okuno T., Yamanaka K., Ogura T.

    Multiple Authorship (Only Japanese)

  • Micelle formation of bile salts and zwitterionic derivative as studied by two-dimensional NMR spectroscopy., Chem. Phys. Lipids., 2006

    Funasaki N., Fukuba M., Hattori T., Ishikawa S., Okuno T., Hirota S.

    Multiple Authorship (Only Japanese)

  • Masking mechanisms of bitter taste of drugs studied with ion selective electrodes., Chem. Pharm. Bull., 54 1155-1161, 2006

    Funasaki N., Uratsuji I., Okuno T., Hirota S., Neya S.

    Multiple Authorship (Only Japanese)

  • Flavodoxin, a new fluorescent substrate for monitoring proteolytic activity of FtsH lacking a robust unfolding activity., J. Struct. Biol., 156 115-119, 2006

    Okuno T., Yamanaka K., Ogura T

    Multiple Authorship (Only Japanese)

  • Allelic characterization of the leaf-variegated mutation var2 identifies the conserved amino acid residues of FtsH that are important for ATP hydrolysis and proteolysis., Plant. Mol. Biol., 56 705-716, 2005

    Sakamoto W., Miura E., Kaji Y., Okuno T., Nishizono M., Ogura T.

    Multiple Authorship (Only Japanese)

  • Spectrometric analysis of degradation of a physiological substrate sigma32 by Escherichia coli AAA protease FtsH., J. Struct. Biol., 146 148-154, 2004

    Okuno T., Yamada-Inagawa T., Karata K., Yamanaka K., Ogura T.

    Multiple Authorship (Only Japanese)

  • Conserved pore residues in the AAA protease, FtsH, are important for proteolysis and its coupling to ATP hydrolysis., J. Biol.Chem., 278 50182-50187, 2003

    Yamada-Inagawa T., Okuno T., Karata K., Yamanaka K., Ogura T.

    Multiple Authorship (Only Japanese)

  • Folding Character of Cytochrome c Studied by o-Nitrobenzyl Modification of Methionine 65 and Subsequent Ultraviolet Light Irradiation., Biochemistry, 2000

    Okuno T., Hirota H., Yamauchi O

    Multiple Authorship (Only Japanese)

  • Folding Properties of Cytochrome c Studied by Photocleavable o-Nitrobenzyl Modification of Methionine 65 and 80., Chem. Lett., 290-291, 2000

    Okuno T., Hirota H., Yamauchi O.

    Multiple Authorship (Only Japanese)

  • Spectroscopic and Electrochemical Studies on Structural Change of Plastocyanin and Its Tyrosine 83 Mutants Induced by Interaction with Lysine Peptides, Biochemistry, 39 6357-6364, 2000

    Hirota S., Hayamizu K., Okuno T., Kishi M., Iwasaki H., Kondo T., Hibino T., Takabe T., Kohzuma T., Yamauchi O.

    Multiple Authorship (Only Japanese)

  • DNA Degradation by the Copper (II) Complex with Tripodal-ligands Containing Peptide Group., Polyhedron, 17 1553-1559, 1998

    Kobayashi T., Okuno T., Suzuki T., Kumita M., Ohba S., Nishida Y.

    Multiple Authorship (Only Japanese)

  • New Insight into Reaction of Iron (III)-peroxide Adduct with Alkans. An Alternative Model for Cytochrome P450 and Methane Monooxygenase., Z. Naturforsh., 52 612-615, 1997

    Nishida Y., Itoh S., Okuno T., Ohba S.

    Multiple Authorship (Only Japanese)

  • Chemical Basis for High Activity in Oxygenation of Cyclohexane Catalyzed by Dinuclear Iron (III) Complexes with Ethereal Oxygen Containing Ligand and Hydrogen Peroxide System., Z. Naturforsh., 52 719-727, 1997

    Itoh S., Okuno T., Itoh H., Matsushima H., Tokii N., Nishida Y

    Multiple Authorship (Only Japanese)

  • Oxidation of Cyclohexane with Hydrogen Peroxide Catalysed by Copper(II) Complexes Containing N,N-Bis(2-pyrydylmethyl)-alanineamide Ligands., Polyhedron, 16 3765-3774, 1997

    Okuno T., Ohba S., Nishida Y.

    Single Author

  • μ-Oxo Bridged Diiron(III) Complexes and Hydrogen Peroxide: Oxygenation and Catalase-like Activities., J. Chem. Soc.,Dalton Trans., 1997

    Okuno T., Itoh S., Ohba S., Nishida Y.

    Multiple Authorship (Only Japanese)

  • Chemical Origin of High Activity in Oxygenation of Cyclohexane by H2O2 Catalysed by Dinuclear Iron (III) Complexes with Amidecontaining Ligands., J. Chem. Soc., Dalton Trans., 4479-4484, 1996

    Itoh S., Okuno T., Matsushima H., Tokii N., Nishida Y.

    Multiple Authorship (Only Japanese)

  • Isolation of Two Geometrical Isomers of Bis(μ-acetato) (μ-oxo)Diiron(III) Complexes with Tridentate Ligands and Their Activities for Functionalization of Cyclohexane in the Presence of Hydrogen Peroxide., J. Chem. Soc., Dalton Trans., 4037-4039, 1996

    Itoh S., Okuno T., Matsushima H., Tokii N., Nishida Y.

    Multiple Authorship (Only Japanese)

  • Electron Delocalization in Binuclear Manganese(III/IV) Complexes with di-μ-oxo Bridges., Polyhedron, 15 1509-1515, 1996

    Okuno T., Nishida Y.

    Multiple Authorship (Only Japanese)

  • Important Role of Tetrahydrofuran Ring in Activation of Hydrogen Peroxide in the Presence of Binuclear Iron(III) Complexes with Linear μ-oxo Bridge., Chem.Lett., 559-886, 1995

    Nishida Y., Okuno T., Itoh S., Harada A., Ohba S., Matsushima H., Tokii N.

    Multiple Authorship (Only Japanese)

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Books

  • Regulated Proteolysis in Microorganisms, Springer, 2013

    Takashi Okuno, Teru Ogura

  • ATP-dependent protease, Research Signpost, 2008

    Okuno T., Ogura T.

Grant-in-Aid for Scientific Research

  • Grant-in-Aid for Scientific Research(C),2018.04 - 2021.03

  • Grant-in-Aid for Scientific Research(C),2015.04 - 2017.03

  • Grant-in-Aid for Scientific Research on Innovative Areas,2015.04 - 2017.03

  • Grant-in-Aid for Young Scientists(B),2012.04 - 2015.03

  • Grant-in-Aid for Scientific Research(B),2008.04 - 2011.03

  • Grant-in-Aid for Young Scientists(B),2008.04 - 2010.03

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Media Coverage

  • アラート機能強化 山形県上山市農作物栽培支援アプリ,2023.04

  • アプリ活用し 農作物守る 上山 凍霜害アラートなど説明会 ,2023.04

  • 農業の未来」考えるワークショップ…担い手不足解消に加え居住環境・教育の充実も重要,2023.02

  • 突然変異で出現した「赤い洋ナシ」生産広がる 山形・上山 ラ・フランスの3倍の値も,2022.11

  • 果実、アプリで栽培管理 山形大・奥野准教授と上山市開発,2022.09

  • 科学の視点で果物学ぶ,2022.05

  • アプリで凍霜害通知,2022.01

  • 上山市と山形大の果樹栽培支援アプリ 翌朝の気温予測、通知へ ,2022.01

  • 凍霜害 アプリで警告 上山市・山形大 システム開発 ,2021.12

  • 凍霜害警報システム開発 山大生 ,2021.12

  • 児童ら果樹栽培の講座 上山,2021.12

  • 「未来創造ラボ」最終回 上山 ,2021.12

  • 西洋ナシ、上山の特産に 市と奥野山形大准教授が栽培支援,2021.10

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