Research Areas
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Life Science / Biophysics
Graduate School
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Nagoya University, Graduate School, Division of Natural Science
Doctor's Course, 2000.03, Completed
External Career
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, Researcher, 2002.04 - 2005.03
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, Research Assistant, 2005.04 - 2007.05
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, Assistant Professor, 2007.06 - 2008.09
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, Associate Professor, 2008.10 - 2011.03
Papers
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Improvement of Blood-Brain Barrier Permeability Prediction using Cosine Similarity, Journal of Computer Chemistry, Japan, 2023.04
Hiroshi Sakiyama, Ryushi Motoki, Takashi Okuno, Jian-Qiang Liu
Multiple Authorship (Including Foreigners)
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Central Object Segmentation by Deep Learning to Continuously Monitor Fruit Growth through RGB Images, Sensors, 21(21) 6999, 2021.10
M. Fukuda, T. Okuno, S. Yuki
Multiple Authorship (Only Japanese)
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Inchworm-type PNA-PEG conjugate regulates gene expression based on single nucleotide recognition, International Journal of Biological Macromolecules, 181 471-477, 2021.06
Yusuke Hamashita, Takahiro Shibata, Akiko Takeuchi, Takashi Okuno, Naoki Kise, Toshihiko Sakurai
Multiple Authorship (Only Japanese)
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Structural Analysis of Streptococcus pyogenes NADH Oxidase: Conformational Dynamics Involved in Formation of the C(4a)-Peroxyflavin Intermediate, Biochemistry, 54(45) 6815-6829, 2015
Jamie R Wallen, T Conn Mallett, Takashi Okuno, Derek Parsonage, Hiroaki Sakai, Tomitake Tsukihara, Al Claiborne
Multiple Authorship (Only Japanese)
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Crystal Structure of Mox-1, a Unique Plasmid-Mediated Class C β-Lactamase with Hydrolytic Activity towards Moxalactam, Antimicrob Agents Chemother, 58 3914-3920, 2014
Oguri T., Furuyama T., Okuno T., Ishii Y., Tateda K., Bonomo RA., Shimizu-Ibuka A.
Single Author
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Quantitative comparison of Adipocytokine gene expression during adipocyte maturation in non-obes and obese rats., Biol. Pharm. Bull., 2011.05
Y.Ikeda, S.Hama, K.Kajimoto, T.Okuno, H.Tsuchiya, K.Kogure
Multiple Authorship (Including Foreigners)
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Eavaluation of Aβ fibrillization inhibitory effect by a PEG-peptide conjugated based on an Aβ peptide fragment with intramolecular FRET., Chem. Commun., 2011.03
T.Sakurai, T.Iwasaki, T.Okuno, Y.Kawata, N.Kise
Multiple Authorship (Including Foreigners)
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A new method to evaluate unfolding activity unit ClpA based on Fe-S cluster disruption., Chem. Pharm. Bul, 2011.03
T.Ohgita, T.Okuno, S.Hama, H.Tsuchiya, K.Kogure
Multiple Authorship (Including Foreigners)
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Fluorescence polarization analysis for revealing molecular mechanism of nucleotide-dependent phospholipid membrane binding of MinD ATPase., Biol. Pharm. Bull, 2010.07
T.Okuno, T.Ohgita, T.Sasa, A.Nonaka, N.Funasaki, K.Kogure
Multiple Authorship (Including Foreigners)
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FtsH cleavage of non-native conformations of proteins., J. Struct. Biol, 2010.05
S.Ayuso-Tejedor, S.Nishikori, T.Okuno, T.Ogura, J.Sancho
Multiple Authorship (Including Foreigners)
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Comparison of intracellular localization between Nubp1 and Nubp2 utilizing GFP fusion protein., Mol.Biol.Rep., 2010
Okuno T., Yamabayashi H., Kogure K.
Multiple Authorship (Only Japanese)
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Direct monitoring of interaction between Escherichia coli proteins, MinC and monomeric FtsZ, in solution., Biol. Pharm. Bull., 2009.05
T.Okuno, M.Ogoh, H.Tanina, N.Funasaki, K.Kogure
Multiple Authorship (Including Foreigners)
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Characterization of mutants of the Escherichia coli AAA protease, FtsH, carrying a mutation in the central pore region., J. Struct. Biol., 156 109-114, 2006
Okuno T., Yamanaka K., Ogura T.
Multiple Authorship (Only Japanese)
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An AAA protease FtsH can initiate proteolysis from internal sites of a model substrate, apo-flavodoxin., Genes Cells, 2006
Okuno T., Yamanaka K., Ogura T.
Multiple Authorship (Only Japanese)
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Micelle formation of bile salts and zwitterionic derivative as studied by two-dimensional NMR spectroscopy., Chem. Phys. Lipids., 2006
Funasaki N., Fukuba M., Hattori T., Ishikawa S., Okuno T., Hirota S.
Multiple Authorship (Only Japanese)
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Masking mechanisms of bitter taste of drugs studied with ion selective electrodes., Chem. Pharm. Bull., 54 1155-1161, 2006
Funasaki N., Uratsuji I., Okuno T., Hirota S., Neya S.
Multiple Authorship (Only Japanese)
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Flavodoxin, a new fluorescent substrate for monitoring proteolytic activity of FtsH lacking a robust unfolding activity., J. Struct. Biol., 156 115-119, 2006
Okuno T., Yamanaka K., Ogura T
Multiple Authorship (Only Japanese)
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Allelic characterization of the leaf-variegated mutation var2 identifies the conserved amino acid residues of FtsH that are important for ATP hydrolysis and proteolysis., Plant. Mol. Biol., 56 705-716, 2005
Sakamoto W., Miura E., Kaji Y., Okuno T., Nishizono M., Ogura T.
Multiple Authorship (Only Japanese)
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Spectrometric analysis of degradation of a physiological substrate sigma32 by Escherichia coli AAA protease FtsH., J. Struct. Biol., 146 148-154, 2004
Okuno T., Yamada-Inagawa T., Karata K., Yamanaka K., Ogura T.
Multiple Authorship (Only Japanese)
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Conserved pore residues in the AAA protease, FtsH, are important for proteolysis and its coupling to ATP hydrolysis., J. Biol.Chem., 278 50182-50187, 2003
Yamada-Inagawa T., Okuno T., Karata K., Yamanaka K., Ogura T.
Multiple Authorship (Only Japanese)
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Folding Character of Cytochrome c Studied by o-Nitrobenzyl Modification of Methionine 65 and Subsequent Ultraviolet Light Irradiation., Biochemistry, 2000
Okuno T., Hirota H., Yamauchi O
Multiple Authorship (Only Japanese)
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Folding Properties of Cytochrome c Studied by Photocleavable o-Nitrobenzyl Modification of Methionine 65 and 80., Chem. Lett., 290-291, 2000
Okuno T., Hirota H., Yamauchi O.
Multiple Authorship (Only Japanese)
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Spectroscopic and Electrochemical Studies on Structural Change of Plastocyanin and Its Tyrosine 83 Mutants Induced by Interaction with Lysine Peptides, Biochemistry, 39 6357-6364, 2000
Hirota S., Hayamizu K., Okuno T., Kishi M., Iwasaki H., Kondo T., Hibino T., Takabe T., Kohzuma T., Yamauchi O.
Multiple Authorship (Only Japanese)
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DNA Degradation by the Copper (II) Complex with Tripodal-ligands Containing Peptide Group., Polyhedron, 17 1553-1559, 1998
Kobayashi T., Okuno T., Suzuki T., Kumita M., Ohba S., Nishida Y.
Multiple Authorship (Only Japanese)
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New Insight into Reaction of Iron (III)-peroxide Adduct with Alkans. An Alternative Model for Cytochrome P450 and Methane Monooxygenase., Z. Naturforsh., 52 612-615, 1997
Nishida Y., Itoh S., Okuno T., Ohba S.
Multiple Authorship (Only Japanese)
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Chemical Basis for High Activity in Oxygenation of Cyclohexane Catalyzed by Dinuclear Iron (III) Complexes with Ethereal Oxygen Containing Ligand and Hydrogen Peroxide System., Z. Naturforsh., 52 719-727, 1997
Itoh S., Okuno T., Itoh H., Matsushima H., Tokii N., Nishida Y
Multiple Authorship (Only Japanese)
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Oxidation of Cyclohexane with Hydrogen Peroxide Catalysed by Copper(II) Complexes Containing N,N-Bis(2-pyrydylmethyl)-alanineamide Ligands., Polyhedron, 16 3765-3774, 1997
Okuno T., Ohba S., Nishida Y.
Single Author
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μ-Oxo Bridged Diiron(III) Complexes and Hydrogen Peroxide: Oxygenation and Catalase-like Activities., J. Chem. Soc.,Dalton Trans., 1997
Okuno T., Itoh S., Ohba S., Nishida Y.
Multiple Authorship (Only Japanese)
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Chemical Origin of High Activity in Oxygenation of Cyclohexane by H2O2 Catalysed by Dinuclear Iron (III) Complexes with Amidecontaining Ligands., J. Chem. Soc., Dalton Trans., 4479-4484, 1996
Itoh S., Okuno T., Matsushima H., Tokii N., Nishida Y.
Multiple Authorship (Only Japanese)
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Isolation of Two Geometrical Isomers of Bis(μ-acetato) (μ-oxo)Diiron(III) Complexes with Tridentate Ligands and Their Activities for Functionalization of Cyclohexane in the Presence of Hydrogen Peroxide., J. Chem. Soc., Dalton Trans., 4037-4039, 1996
Itoh S., Okuno T., Matsushima H., Tokii N., Nishida Y.
Multiple Authorship (Only Japanese)
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Electron Delocalization in Binuclear Manganese(III/IV) Complexes with di-μ-oxo Bridges., Polyhedron, 15 1509-1515, 1996
Okuno T., Nishida Y.
Multiple Authorship (Only Japanese)
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Important Role of Tetrahydrofuran Ring in Activation of Hydrogen Peroxide in the Presence of Binuclear Iron(III) Complexes with Linear μ-oxo Bridge., Chem.Lett., 559-886, 1995
Nishida Y., Okuno T., Itoh S., Harada A., Ohba S., Matsushima H., Tokii N.
Multiple Authorship (Only Japanese)
Books
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Regulated Proteolysis in Microorganisms, Springer, 2013
Takashi Okuno, Teru Ogura
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ATP-dependent protease, Research Signpost, 2008
Okuno T., Ogura T.
Grant-in-Aid for Scientific Research
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Grant-in-Aid for Scientific Research(C),2018.04 - 2021.03
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Grant-in-Aid for Scientific Research(C),2015.04 - 2017.03
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Grant-in-Aid for Scientific Research on Innovative Areas,2015.04 - 2017.03
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Grant-in-Aid for Young Scientists(B),2012.04 - 2015.03
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Grant-in-Aid for Scientific Research(B),2008.04 - 2011.03
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Grant-in-Aid for Young Scientists(B),2008.04 - 2010.03
Media Coverage
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アラート機能強化 山形県上山市農作物栽培支援アプリ,2023.04
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アプリ活用し 農作物守る 上山 凍霜害アラートなど説明会 ,2023.04
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農業の未来」考えるワークショップ…担い手不足解消に加え居住環境・教育の充実も重要,2023.02
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突然変異で出現した「赤い洋ナシ」生産広がる 山形・上山 ラ・フランスの3倍の値も,2022.11
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果実、アプリで栽培管理 山形大・奥野准教授と上山市開発,2022.09
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科学の視点で果物学ぶ,2022.05
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アプリで凍霜害通知,2022.01
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上山市と山形大の果樹栽培支援アプリ 翌朝の気温予測、通知へ ,2022.01
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凍霜害 アプリで警告 上山市・山形大 システム開発 ,2021.12
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凍霜害警報システム開発 山大生 ,2021.12
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児童ら果樹栽培の講座 上山,2021.12
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「未来創造ラボ」最終回 上山 ,2021.12
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西洋ナシ、上山の特産に 市と奥野山形大准教授が栽培支援,2021.10