ERK5 inhibitor BIX02189 attenuates methamphetamine-induced hyperactivity by modulating microglial activation in the striatum, JOURNAL OF PHARMACOLOGICAL SCIENCES, 148(3) 326-330, 2022.03

Nakagawasai Osamu, Takahashi Kohei, Miura Yuki, Nemoto Wataru, Obara Yutaro, Tan-No Koichi

Multiple Authorship (Only Japanese)

Azelnidipine treatment reduces the expression of Ca_v1.2 protein., Life sciences, 269 119043, 2021.03

Nasu F, Obara Y, Okamoto Y, Yamaguchi H, Kurakami K, Norota I, Ishii K

Multiple Authorship (Only Japanese)

Reply to: MIDN locus structural variants and Parkinson's disease risk., Ann. Clin. Transl. Neurol., 7 602-603, 2020

Yutaro Obara, Hidenori Sato, Takahiro Nakayama, Takeo Kato, Kuniaki Ishii.

Multiple Authorship (Only Japanese)

KCNQ1 is internalized by activation of α₁ adrenergic receptors., Biochemical pharmacology, 169 113628, 2019.11

Kurakami K, Norota I, Nasu F, Ohshima S, Nagasawa Y, Konno Y, Obara Y, Ishii K

Multiple Authorship (Only Japanese)

Midnolin is a confirmed genetic risk factor for Parkinson's disease., Annals of clinical and translational neurology, 2019.10

Obara Y, Sato H, Nakayama T, Kato T, Ishii K

Multiple Authorship (Only Japanese)

Molecular identification of HSPA8 as an accessory protein of a hyperpolarization-activated chloride channel from rat pulmonary vein cardiomyocytes., The Journal of biological chemistry, 2019.09

Okamoto Y, Nagasawa Y, Obara Y, Ishii K, Takagi D, Ono K

Multiple Authorship (Only Japanese)

ERK5 phosphorylates Kv4.2 and inhibits inactivation of the A-type current in PC12 cells., Int. J. Mol. Sci. , 2018

Yurina Kashino, Yutaro Obara*, Yosuke Okamoto, Takeo Saneyoshi, Yasunori Hayashi, Kuniaki Ishii.

Multiple Authorship (Only Japanese)

Transcriptome analysis reveals that midnolin regulates mRNA expression levels of multiple Parkinson's disease causative genes. , Biol. Pharm. Bull. , 2018

Yutaro Obara*, Kuniaki Ishii.

Multiple Authorship (Only Japanese)

Licochalcones extracted from Glycyrrhiza inflata inhibit platelet aggregation accompanied by inhibition of COX-1 activity. , PLoS ONE , 2017

Asa Okuda-Tanino, Daiki Sugawara, Takumi Tashiro, Masaya Iwashita, Yutaro Obara*, Takahiro Moriya, Chisato Tsushima, Daisuke Saigusa, Yoshihisa Tomioka, Kuniaki Ishii, Norimichi Nakahata.

Multiple Authorship (Only Japanese)

Midnolin is a novel regulator of parkin expression and is associated with Parkinson’s Disease. , Sci. Rep. , 2017

Yutaro Obara*, Toru Imai, Hidenori Sato, Yuji Takeda, Takeo Kato, Kuniaki Ishii.

Multiple Authorship (Only Japanese)

Insulin treatment augments KCNQ1/KCNE1 currents but not KCNQ1 currents, which is associated with an increase in KCNE1 expression. , Biochem. Biophys. Res. Commun. , 2017

Minghua Wu, Yutaro Obara, Shingo Ohshima, Yoshinobu Nagasawa, Kuniaki Ishii.

Multiple Authorship (Only Japanese)

Expression of extracellular signal-regulated kinase 5 and ankyrin repeat domain 1 in composite pheochromocytoma and ganglioneuroblastoma detected incidentally in the adult adrenal gland: a case report. , Intern. Med. , 2016

Shinta Suenaga, Osamu Ichiyanagi, Hiromi Ito, Sei Naito, Tomoyuki Kato, Akira Nagaoka, Tomoya Kato, Mitsunori Yamakawa, Yutaro Obara, Norihiko Tsuchiya.

Multiple Authorship (Only Japanese)

ERK5 induces ankrd1 for catecholamine biosynthesis and homeostasis in adrenal medullary cells. , Cell. Signal., 2016

Yutaro Obara*, Ryusuke Nagasawa, Wataru Nemoto, Michael J Pellegrino, Maho Takahashi, Beth A Habecker, Philip J.S Stork, Osamu Ichiyanagi, Hiromi Ito, Yoshihiko Tomita, Kuniaki Ishii, Norimichi Nakaha...

Multiple Authorship (Including Foreigners)

Phosphorylation of ERK5 on Thr732 is associated with ERK5 nuclear localization and ERK5-dependent transcription. , PLoS ONE , 2015

Takuto Honda, Yutaro Obara*, Arata Yamauchi, Anthony D. Couvillon, Justin J. Mason, Kuniaki Ishii, Norimichi Nakahata.

Multiple Authorship (Including Foreigners)

Insulin suppresses IKs (KCNQ1/KCNE1) currents, which require β-subunit KCNE1. , Pflügers Arch. – Eur. J. Physiol. , 2014

Minghua Wu, Yutaro Obara, Ikuo Norota, Yoshinobu Nagasawa, Kuniaki Ishii.

Multiple Authorship (Only Japanese)

Neurite Outgrowth of PC12 Cells by 4'-O-β-D-glucopyranosyl-3',4-dimethoxychalcone from Brassica rapa L. 'hidabeni' was enhanced by pretreatment with p38MAPK inhibitor. , Neurochem. Res. , 2013

Atsuyoshi Nishina, Hirokazu Kimura, Hiroyuki Tsukagoshi, Kunihisa Kozawa, Mamoru Koketsu, Masayuki Ninomiya, Daisuke Sato, Yutaro Obara, Shoei Furukawa.

Multiple Authorship (Only Japanese)

Gah/transglutaminase-2 activity is required for maximal activation of adenylylcyclase 8 in human and rat glioma cells. , Cell. Signal. , 2013

Yutaro Obara*, Yoshimi Yanagihata, Tomohiro Abe, Laila Dafik, Kuniaki Ishii, Norimichi Nakahata.

Multiple Authorship (Including Foreigners)

Rap1 potentiates endothelial cell junctions by spatially controlling myosin II activity and actin organization. , J. Cell. Biol. , 2013

Koji Ando, Shigetomo Fukuhara, Takahiro Moriya, Yutaro Obara, Norimichi Nakahata, Naoki Mochizuki.

Multiple Authorship (Only Japanese)

Involvement of lipid rafts in multiple signal transductions mediated by two isoforms of thromboxane A2 receptor: dependency on receptor isoforms and downstream signaling types. , Eur. J. Pharmacol., 2012

Shinji Goto, Masaki Saito, Yutaro Obara, Takahiro Moriya, Norimichi Nakahata.

Multiple Authorship (Only Japanese)

Dihydrobenzofurans as cannabinoid receptor ligands, from Cordyceps annullata, an entomopathogenic fungus, cultivated in the presence of HDAC inhibitor. , Tetrahedron lett. , 2012

Teigo Asai, Luo Dan, Yutaro Obara, Toru Taniguchi, Kenji Monde, Kouwa Yamashita, Yoshiteru Oshima.

Multiple Authorship (Only Japanese)

Functional interaction between purinergic receptors: effect of ligands for A2A and P2Y12 receptors on P2Y1 receptor function. , FEBS letter, 2011

Tokiko Suzuki, Yutaro Obara, Takahiro Moriya, Hiroyasu Nakata, Norimichi Nakahata.

Multiple Authorship (Only Japanese)

Basic fibroblast growth factor promotes glial cell-derived neurotrophic factor gene expression mediated by activation of ERK5 in rat C6 glioma cells. , Cell. Signal., 2011

Yutaro Obara*, Wataru Nemoto, Susumu Kohno, Tomiyasu Murata, Norio Kaneda, Norimichi Nakahata.

Multiple Authorship (Only Japanese)

Effect of Hericium erinaceus on amyloid b (25-35) peptide-induced learning and memory deficits in mice. , Biomed. Res. , 2011

Koichiro Mori, Yutaro Obara, Takahiro Moriya, Satoshi Inatomi, Norimichi, Nakahata.

Multiple Authorship (Only Japanese)

A synthetic cannabinoid, CP55940, inhibits lipopolysaccharide-induced cytokine mRNA expression in acannabinoid receptor-independent mechanism in rat cerebellar granule cells. , J. Pharm. Pharmacol. , 2011

Toshiki Chiba, Sanae Ueno, Yutaro Obara*, Norimichi Nakahata.

Multiple Authorship (Only Japanese)

Lyconadins D and E, and complanadine E, new Lycopodium alkaloids from Lycopodium complanatum. , Bioorg. Med. Chem. , 2011

Kan’ichiro Ishiuchi, Takaaki Kubota, Haruaki Ishiyama, Shigeki Hayashi, Toshiro Shibata, Koichiro Mori, Yutaro Obara, Norimichi Nakahata, Jun’ichi Kobayashi.

Multiple Authorship (Only Japanese)

Lysophosphatidylinositol causes neurite retraction via GPR55, G13 and RhoA in PC12 cells. , PLoS ONE , 2011

Yutaro Obara*, Sanae Ueno, Yoshimi Yanagihata, Norimichi Nakahata.

Multiple Authorship (Only Japanese)

P2Y2 receptor-Gq/11 signaling at lipid rafts is required for UTP-induced cell migration in NG 108-15 cells. , J. Pharmacol. Exp. Ther. , 2010

Koji Ando, Yutaro Obara, Jun Sugama, Atsushi Kotani, Nobuyuki Koike, Satoko Ohkubo, Norimichi Nakahata.

Multiple Authorship (Only Japanese)

Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation., Phytomedicine , 2010

Koichiro Mori, Haruhisa Kikuchi, Yutaro Obara, Masaya Iwashita, Yoshihito Azumi, Satomi Kinugasa, Satoshi Inatomi, Yoshiteru Oshima, Norimichi Nakahata.

Multiple Authorship (Only Japanese)

Thromboxane A2 receptor-mediated epidermal growth factor receptor transactivation: Involvement of PKC-delta and PKC-epsilon in the shedding of epidermal growth factor receptor ligands. , Eur. J. Pharm. Sci. , 2009

Kotomi Uchiyama, Masaki Saito, Masako Sasaki, Yutaro Obara, Shigeki Higashiyama, Norimichi Nakahata.

Multiple Authorship (Only Japanese)

ERK5 activity is required for NGF-induced neurite outgrowth and stabilization of tyrosine hydroxylase in PC12 cells. , J. Biol. Chem. , 2009

Yutaro Obara*, Arata Yamauchi, Shin Takehara, Wataru Nemoto, Maho Takahashi, Philip J.S. Stork, Norimichi Nakahata.

Multiple Authorship (Including Foreigners)

Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. , Biol. Pharm. Bull. , 2008

Koichiro Mori, Yutaro Obara, Mitsuru Hirota, Yoshihito, Adumi, Satomi Kinugasa, Satoshi Inatomi, and Norimichi Nakahata.

Multiple Authorship (Only Japanese)

Calyciphyllines H–M, new Daphniphyllum alkaloids from Daphniphyllum calycinum. , Tetrahedron , 2008

Shizuka Saito, Hiroko Yahata, Takaaki Kubota, Yutaro Obara, Norimichi Nakahata and Jun'ichi Kobayashi.

Multiple Authorship (Only Japanese)

Beta-gamma subunits of Gi/o suppress EGF-induced ERK5 phosphorylation, whereas ERK1/2 phosphorylation is enhanced., Cell. Signal. , 2008

Yutaro Obara*, Yumiko Okano, Sachiko Ono, Arata Yamauchi, Tomohiro Hoshino, Hitoshi Kurose, Norimichi Nakahata.

Multiple Authorship (Only Japanese)

Lycopladine E, a new C16N1-type alkaloid from Lycopodium complanatum. , Heterocycles , 2007

Takaaki Kubota, Hiroko Yahata, Kan’ichiro Ishiuchi, Yutaro Obara, Norimichi Nakahata,

Multiple Authorship (Only Japanese)

Kan’ichiro Ishiuchi, Takaaki Kubota, Yuzuru Mikami, Yutaro Obara, Norimichi Nakahata, Jun’ichi Konayashi. Complanadines C and D, new dimeric alkaloids from Lycopodium complanatum., Bioorg. Med. Chem. 1, 2007

Kan’ichiro Ishiuchi, Takaaki Kubota, Yuzuru Mikami, Yutaro Obara, Norimichi Nakahata, Jun’ichi Konayashi.

Multiple Authorship (Only Japanese)

The requirement of Ras and Rap1 for the activation of ERKs by cAMP, PACAP, and KCl in cerebellar granule cells. , J. Neurochem. , 2007

Yutaro Obara, Angela Horgan, Philip J.S. Stork.

Multiple Authorship (Including Foreigners)

A novel cyathane diterpene, cyrneine A, induces neurite outgrowth in a Rac1-dependent mechanism in PC12 cells. , Life Sci. , 2007

Yutaro Obara*, Tomohiro Hoshino, Maria Carla Marcotullio, Rita Pagiotti, Norimichi Nakahata.

Multiple Authorship (Including Foreigners)

Cyathane diterpenes from Sarcodon cyrneus and evaluation of their activities of neuritegenesis and nerve growth factor production. , Bioorg. Med. Chem. , 2007

Maria Carla Marcotullio, Rita Pagiotti, Federica Maltese, Gildas Norbert Oball-Mond Mwankie, Tomohiro Hoshino, Yutaro Obara, Norimichi Nakahata.

Multiple Authorship (Including Foreigners)

5,19-cyclo-9b, 10x-androstane-3,17 dione promotes neurotrophic factor biosynthesis in 1321N1 human astrocytoma cells and improves passive avoidance learning impairment. , Brain Res. , 2007

Yutaro Obara*, Asami Haganuma, Shinsuke Murakami, Toshiki Chiba, Koichiro Mori, Osamu Nakagawasai, Takeshi Tadano, Haruhisa Kikuchi, Yoshiteru Oshima, Norimichi Nakahata.

Multiple Authorship (Only Japanese)

Lycovatine A, a C16N-type quaternary alkaloid from Lycopodium clavatum var. robustum. , Heterocycles , 2006

Takaaki Kubota, Tomoe Sunaura, Hiroshi Morita, Yuzuru Mikami, Tomohiro Hoshino, Yutaro Obara, Norimichi Nakahata, Jun’ichi Kobayashi.

Multiple Authorship (Only Japanese)

Inhibitory effect of naringin on lipopolysaccharide (LPS)-induced endotoxin shock in mice and nitric oxide production in RAW 264.7 macrophages. , Life Sci. , 2006

Syu-ichi Kanno, Ai Shouji, Ayako Tomizawa, Takako Hiura, Yuu Osanai, Mayuko Ujibe, Yutaro Obara, Norimichi Nakahata, Masaaki Ishikawa.

Multiple Authorship (Only Japanese)

Neurotrophic factor production in human astrocytoma cells by 2,5,6-tribromogramine via activation of epsilon isoform of protein kinase C. , Eur. J. Pharm. Sci. , 2006

Masaki Saito, Megumi Hori, Yutaro Obara, Yasushi Ohizumi, Satoko Ohkubo, Norimichi Nakahata.

Multiple Authorship (Only Japanese)

Neurite outgrowth activity of cyathane diterpenes from Sarcodon cyrneus, Cyrneines A and B. , Planta Med. , 2006

Maria Carla Marcotullio, Rita Pagiotti, Federica Maltese, Yutaro Obara, Tomohiro Hoshino, Norimichi Nakahata, Massimo Curini.

Multiple Authorship (Including Foreigners)

Lycopladines B-D and lyconadin B, new alkaloids from Lycopodium complanatum. , Bioorg. Med. Chem. , 2006

Kan’ichiro Ishiuchi, Takaaki Kubota, Tomohiro Hoshino, Yutaro Obara, Norimichi Nakahata, Jun’ichi Kobayashi.

Multiple Authorship (Only Japanese)

Nankakurine B, a new alkaloid from Lycopodium hamiltonii and revised stereostructure of nankakurine A. , Heterocycles , 2006

Yusuke Hirasawa, Jun’ichi Kobayashi, Yutaro Obara, Norimichi Nakahata, Nobuo Kawahara, Yukihiro Goda, Hiroshi Morita.

Multiple Authorship (Only Japanese)

Thromboxane A2 promotes interleukin-6 biosynthesis mediated by an activation of cyclic AMP-response element binding protein in 1321N1 human astrocytoma cells. , Mol. Pharmacol. , 2005

Yutaro Obara*, Hitoshi Kurose, Norimichi Nakahata.

Multiple Authorship (Only Japanese)

Daphmanidins C and D, novel pentacyclic alkaloids from Daphniphyllum teijsmanii. , Org. Lett. , 2005

Hiroshi Morita, Nozomi Ishioka, Hiroshi Takatsu, Takakazu Shinzato, Yutaro Obara, Norimichi Nakahata, Jun’ichi Kobayashi.

Multiple Authorship (Only Japanese)

Complanadine B, obscurumines A and B, new alkaloids from two species of Lycopodium. , Tetrahedron , 2005

Hiroshi Morita, Kan’ichiro Ishiuchi, Asami Haganuma, Tomohiro Hoshino, Yutaro Obara, Norimichi Nakahata, Jun’ichi Kobayashi.

Multiple Authorship (Only Japanese)

Lannotinidines A-G, new alkaloids from two species of Lycopodium., Tetrahedron , 2005

Koichiro Koyama, Hiroshi Morita, Yusuke Hirasawa, Miwa Yoshinaga, Tomohiro Hoshino, Yutaro Obara, Norimichi Nakahata, Jun’ichi Kobayashi.

Multiple Authorship (Only Japanese)

Neurofilament measurement for quantitative evaluation of the differentiation of PC-12 cells. , Pharmacometrics , 2004

Norimichi Nakahata, Megumi Hori, Asami Haganuma, Yutaro Obara, Yasushi Ohizumi.

Multiple Authorship (Only Japanese)

PKA phosphorylation of Src mediates Rap1 activation in NGF and cAMP signaling in PC12 cells. , J. Cell Sci. , 2004

Yutaro Obara, Kirstin Labudda, Tara Dillon, Philip J.S. Stork.

Multiple Authorship (Including Foreigners)

Tricholomalides A-C, new neurotrophic diterpenes from the mushroom tricholoma sp. , J. Nat. Prod. , 2003

Sachiko Tsukamoto, Abdulgafor D Macabalang, Keigo Nakatani, Yutaro Obara, Norimichi Nakahata, Tomihisa Ohta.

Multiple Authorship (Only Japanese)

Theonezolide A, a novel marine macrolide, induces drastic shape change in rabbit platelets by reorganization of microtubules., Thromb. Res. , 2003

Minori Mitsui-Saito, Satoko Ohkubo, Yutaro Obara, Teruyuki Yanagisawa, Jun’ichi Kobayashi, Yasushi Ohizumi, Norimichi Nakahata.

Multiple Authorship (Only Japanese)

b-Eudesmol induces neurite outgrowth in rat pheochromocytoma cells accompanied by an activation of mitogen-activated protein kinase. , J. Pharmacol. Exp. Ther. , 2002

Yutaro Obara*, Takashi Aoki, Masayoshi Kusano, Yasushi Ohizumi.

Multiple Authorship (Only Japanese)

Scabronine G-methyl ester enhances secretion of neurotrophic factors mediated by an activation of protein kinase C-z. , Mol. Pharmacol. , 2001

Yutaro Obara, Hironori Kobayashi, Tomihisa Ohta, Yasushi Ohizumi, Norimichi Nakahata.

Multiple Authorship (Only Japanese)

Differentiation of rat pheochromocytoma cells by fomitellic acids, specific DNA polymerase inhibitors. , Life Sci. , 2000

Yutaro Obara, Norimichi Nakahata, Yoshiyuki Mizushina, Fumio Sugawara, Kengo Sakaguchi, Yasushi Ohizumi.

Multiple Authorship (Only Japanese)

Maitotoxin-induced nerve growth factor production accompanied by the activation of a voltage-insensitive Ca2+ channel in C6-BU-1 glioma cells., Brit. J. Pharmacol. , 1999

Yutaro Obara, Masami Takahashi, Norimichi Nakahata, Yasushi Ohizumi.

Multiple Authorship (Only Japanese)

Stimulation of neurotrophic factor secretion from 1321N1 human astrocytoma cells by novel diterpenoids, scabronines A and G. , Eur. J. Pharmacol. , 1999

Yutaro Obara, Norimichi Nakahata, Takako Kita, Yoshiaki Takaya, Hironori Kobayashi, Shinzo Hosoi, Fumiyuki Kiuchi, Tomihisa Ohta, Yoshiteru Oshima, Yasushi Ohizumi.

Multiple Authorship (Only Japanese)

A new factor derived from 1321N1 human astrocytoma cells causes differentiation of PC-12 cells mediated through mitogen-activated protein kinase cascade., Brain Res. , 1998

Yutaro Obara, Norimichi Nakahata, Yasushi Ohizumi.

Multiple Authorship (Only Japanese)

Scabronine A, a novel diterpenoid having potent inductive activity of the nerve growth factor synthesis, isolated from the mushroom, Sarcodon scabrosus. , Tetrahedron Lett. , 1998

Tomihisa Ohta, Takako Kita, Norihiro Kobayashi, Yutaro Obara, Norimichi Nakahata, Yasushi Ohizumi, Yoshiaki Takaya, Yoshiteru Oshima.

Multiple Authorship (Only Japanese)