Research Career
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Clarification of mechanism of neuronal differentiation by neurotrophic factors, 2002.04 -
NGF, MAPK, tyrosine hyroxylase
Papers
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Structural Variants of Midnolin, a Genetic Risk Factor for Parkinson's Disease, in a Yamagata Cohort., Biological & pharmaceutical bulletin, 46(3) 379-381, 2023
Sato H, Ishii K, Obara Y
Multiple Authorship (Only Japanese)
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Reply to: MIDN locus structural variants and Parkinson's disease risk., Ann. Clin. Transl. Neurol., 7 602-603, 2020
Yutaro Obara, Hidenori Sato, Takahiro Nakayama, Takeo Kato, Kuniaki Ishii.
Multiple Authorship (Only Japanese)
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ERK5 phosphorylates Kv4.2 and inhibits inactivation of the A-type current in PC12 cells., Int. J. Mol. Sci. , 2018
Yurina Kashino, Yutaro Obara*, Yosuke Okamoto, Takeo Saneyoshi, Yasunori Hayashi, Kuniaki Ishii.
Multiple Authorship (Including Foreigners)
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Transcriptome analysis reveals that midnolin regulates mRNA expression levels of multiple Parkinson's disease causative genes. , Biol. Pharm. Bull. , 2018
Yutaro Obara*, Kuniaki Ishii.
Multiple Authorship (Including Foreigners)
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Insulin treatment augments KCNQ1/KCNE1 currents but not KCNQ1 currents, which is associated with an increase in KCNE1 expression. , Biochem. Biophys. Res. Commun. , 2017
Minghua Wu, Yutaro Obara, Shingo Ohshima, Yoshinobu Nagasawa, Kuniaki Ishii.
Multiple Authorship (Including Foreigners)
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Licochalcones extracted from Glycyrrhiza inflata inhibit platelet aggregation accompanied by inhibition of COX-1 activity. , PLoS ONE , 2017
Asa Okuda-Tanino, Daiki Sugawara, Takumi Tashiro, Masaya Iwashita, Yutaro Obara*, Takahiro Moriya, Chisato Tsushima, Daisuke Saigusa, Yoshihisa Tomioka, Kuniaki Ishii, Norimichi Nakahata.
Multiple Authorship (Including Foreigners)
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Midnolin is a novel regulator of parkin expression and is associated with Parkinson’s Disease. , Sci. Rep. , 2017
Yutaro Obara*, Toru Imai, Hidenori Sato, Yuji Takeda, Takeo Kato, Kuniaki Ishii.
Multiple Authorship (Including Foreigners)
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Expression of extracellular signal-regulated kinase 5 and ankyrin repeat domain 1 in composite pheochromocytoma and ganglioneuroblastoma detected incidentally in the adult adrenal gland: a case report. , Intern. Med. , 2016
Shinta Suenaga, Osamu Ichiyanagi, Hiromi Ito, Sei Naito, Tomoyuki Kato, Akira Nagaoka, Tomoya Kato, Mitsunori Yamakawa, Yutaro Obara, Norihiko Tsuchiya.
Multiple Authorship (Including Foreigners)
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ERK5 induces ankrd1 for catecholamine biosynthesis and homeostasis in adrenal medullary cells. , Cell. Signal., 2016
Yutaro Obara*, Ryusuke Nagasawa, Wataru Nemoto, Michael J Pellegrino, Maho Takahashi, Beth A Habecker, Philip J.S Stork, Osamu Ichiyanagi, Hiromi Ito, Yoshihiko Tomita, Kuniaki Ishii, Norimichi Nakaha...
Multiple Authorship (Including Foreigners)
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Phosphorylation of ERK5 on Thr732 is associated with ERK5 nuclear localization and ERK5-dependent transcription. , PLoS ONE , 2015
Takuto Honda, Yutaro Obara*, Arata Yamauchi, Anthony D. Couvillon, Justin J. Mason, Kuniaki Ishii, Norimichi Nakahata.
Multiple Authorship (Including Foreigners)
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Insulin suppresses IKs (KCNQ1/KCNE1) currents, which require β-subunit KCNE1. , Pflügers Arch. – Eur. J. Physiol. , 2014
Minghua Wu, Yutaro Obara, Ikuo Norota, Yoshinobu Nagasawa, Kuniaki Ishii.
Multiple Authorship (Including Foreigners)
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Neurite Outgrowth of PC12 Cells by 4'-O-β-D-glucopyranosyl-3',4-dimethoxychalcone from Brassica rapa L. 'hidabeni' was enhanced by pretreatment with p38MAPK inhibitor. , Neurochem. Res. , 2013
Atsuyoshi Nishina, Hirokazu Kimura, Hiroyuki Tsukagoshi, Kunihisa Kozawa, Mamoru Koketsu, Masayuki Ninomiya, Daisuke Sato, Yutaro Obara, Shoei Furukawa.
Multiple Authorship (Including Foreigners)
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Gah/transglutaminase-2 activity is required for maximal activation of adenylylcyclase 8 in human and rat glioma cells. , Cell. Signal. , 2013
Yutaro Obara*, Yoshimi Yanagihata, Tomohiro Abe, Laila Dafik, Kuniaki Ishii, Norimichi Nakahata.
Multiple Authorship (Including Foreigners)
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Rap1 potentiates endothelial cell junctions by spatially controlling myosin II activity and actin organization. , J. Cell. Biol. , 2013
Koji Ando, Shigetomo Fukuhara, Takahiro Moriya, Yutaro Obara, Norimichi Nakahata, Naoki Mochizuki.
Multiple Authorship (Including Foreigners)
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Involvement of lipid rafts in multiple signal transductions mediated by two isoforms of thromboxane A2 receptor: dependency on receptor isoforms and downstream signaling types. , Eur. J. Pharmacol., 2012
Shinji Goto, Masaki Saito, Yutaro Obara, Takahiro Moriya, Norimichi Nakahata.
Multiple Authorship (Including Foreigners)
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Dihydrobenzofurans as cannabinoid receptor ligands, from Cordyceps annullata, an entomopathogenic fungus, cultivated in the presence of HDAC inhibitor. , Tetrahedron lett. , 2012
Teigo Asai, Luo Dan, Yutaro Obara, Toru Taniguchi, Kenji Monde, Kouwa Yamashita, Yoshiteru Oshima.
Multiple Authorship (Including Foreigners)
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Functional interaction between purinergic receptors: effect of ligands for A2A and P2Y12 receptors on P2Y1 receptor function. , FEBS letter, 2011
Tokiko Suzuki, Yutaro Obara, Takahiro Moriya, Hiroyasu Nakata, Norimichi Nakahata.
Multiple Authorship (Including Foreigners)
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Basic fibroblast growth factor promotes glial cell-derived neurotrophic factor gene expression mediated by activation of ERK5 in rat C6 glioma cells. , Cell. Signal., 2011
Yutaro Obara*, Wataru Nemoto, Susumu Kohno, Tomiyasu Murata, Norio Kaneda, Norimichi Nakahata.
Multiple Authorship (Including Foreigners)
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Effect of Hericium erinaceus on amyloid b (25-35) peptide-induced learning and memory deficits in mice. , Biomed. Res. , 2011
Koichiro Mori, Yutaro Obara, Takahiro Moriya, Satoshi Inatomi, Norimichi, Nakahata.
Multiple Authorship (Including Foreigners)
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A synthetic cannabinoid, CP55940, inhibits lipopolysaccharide-induced cytokine mRNA expression in acannabinoid receptor-independent mechanism in rat cerebellar granule cells. , J. Pharm. Pharmacol. , 2011
Toshiki Chiba, Sanae Ueno, Yutaro Obara*, Norimichi Nakahata.
Multiple Authorship (Including Foreigners)
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Lyconadins D and E, and complanadine E, new Lycopodium alkaloids from Lycopodium complanatum. , Bioorg. Med. Chem. , 2011
Kan’ichiro Ishiuchi, Takaaki Kubota, Haruaki Ishiyama, Shigeki Hayashi, Toshiro Shibata, Koichiro Mori, Yutaro Obara, Norimichi Nakahata, Jun’ichi Kobayashi.
Multiple Authorship (Including Foreigners)
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Lysophosphatidylinositol causes neurite retraction via GPR55, G13 and RhoA in PC12 cells. , PLoS ONE , 2011
Yutaro Obara*, Sanae Ueno, Yoshimi Yanagihata, Norimichi Nakahata.
Multiple Authorship (Including Foreigners)
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P2Y2 receptor-Gq/11 signaling at lipid rafts is required for UTP-induced cell migration in NG 108-15 cells. , J. Pharmacol. Exp. Ther. , 2010
Koji Ando, Yutaro Obara, Jun Sugama, Atsushi Kotani, Nobuyuki Koike, Satoko Ohkubo, Norimichi Nakahata.
Multiple Authorship (Including Foreigners)
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Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation., Phytomedicine , 2010
Koichiro Mori, Haruhisa Kikuchi, Yutaro Obara, Masaya Iwashita, Yoshihito Azumi, Satomi Kinugasa, Satoshi Inatomi, Yoshiteru Oshima, Norimichi Nakahata.
Multiple Authorship (Including Foreigners)
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Thromboxane A2 receptor-mediated epidermal growth factor receptor transactivation: Involvement of PKC-delta and PKC-epsilon in the shedding of epidermal growth factor receptor ligands. , Eur. J. Pharm. Sci. , 2009
Kotomi Uchiyama, Masaki Saito, Masako Sasaki, Yutaro Obara, Shigeki Higashiyama, Norimichi Nakahata.
Multiple Authorship (Including Foreigners)
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ERK5 activity is required for NGF-induced neurite outgrowth and stabilization of tyrosine hydroxylase in PC12 cells. , J. Biol. Chem. , 2009
Yutaro Obara*, Arata Yamauchi, Shin Takehara, Wataru Nemoto, Maho Takahashi, Philip J.S. Stork, Norimichi Nakahata.
Multiple Authorship (Including Foreigners)
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Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. , Biol. Pharm. Bull. , 2008
Koichiro Mori, Yutaro Obara, Mitsuru Hirota, Yoshihito, Adumi, Satomi Kinugasa, Satoshi Inatomi, and Norimichi Nakahata.
Multiple Authorship (Including Foreigners)
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Calyciphyllines H–M, new Daphniphyllum alkaloids from Daphniphyllum calycinum. , Tetrahedron , 2008
Shizuka Saito, Hiroko Yahata, Takaaki Kubota, Yutaro Obara, Norimichi Nakahata and Jun'ichi Kobayashi.
Multiple Authorship (Including Foreigners)
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Beta-gamma subunits of Gi/o suppress EGF-induced ERK5 phosphorylation, whereas ERK1/2 phosphorylation is enhanced., Cell. Signal. , 2008
Yutaro Obara*, Yumiko Okano, Sachiko Ono, Arata Yamauchi, Tomohiro Hoshino, Hitoshi Kurose, Norimichi Nakahata.
Multiple Authorship (Including Foreigners)
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Lycopladine E, a new C16N1-type alkaloid from Lycopodium complanatum. , Heterocycles , 2007
Takaaki Kubota, Hiroko Yahata, Kan’ichiro Ishiuchi, Yutaro Obara, Norimichi Nakahata,
Multiple Authorship (Including Foreigners)
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Kan’ichiro Ishiuchi, Takaaki Kubota, Yuzuru Mikami, Yutaro Obara, Norimichi Nakahata, Jun’ichi Konayashi. Complanadines C and D, new dimeric alkaloids from Lycopodium complanatum., Bioorg. Med. Chem. 1, 2007
Kan’ichiro Ishiuchi, Takaaki Kubota, Yuzuru Mikami, Yutaro Obara, Norimichi Nakahata, Jun’ichi Konayashi.
Multiple Authorship (Including Foreigners)
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The requirement of Ras and Rap1 for the activation of ERKs by cAMP, PACAP, and KCl in cerebellar granule cells. , J. Neurochem. , 2007
Yutaro Obara, Angela Horgan, Philip J.S. Stork.
Multiple Authorship (Including Foreigners)
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A novel cyathane diterpene, cyrneine A, induces neurite outgrowth in a Rac1-dependent mechanism in PC12 cells. , Life Sci. , 2007
Yutaro Obara*, Tomohiro Hoshino, Maria Carla Marcotullio, Rita Pagiotti, Norimichi Nakahata.
Multiple Authorship (Including Foreigners)
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Cyathane diterpenes from Sarcodon cyrneus and evaluation of their activities of neuritegenesis and nerve growth factor production. , Bioorg. Med. Chem. , 2007
Maria Carla Marcotullio, Rita Pagiotti, Federica Maltese, Gildas Norbert Oball-Mond Mwankie, Tomohiro Hoshino, Yutaro Obara, Norimichi Nakahata.
Multiple Authorship (Including Foreigners)
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5,19-cyclo-9b, 10x-androstane-3,17 dione promotes neurotrophic factor biosynthesis in 1321N1 human astrocytoma cells and improves passive avoidance learning impairment. , Brain Res. , 2007
Yutaro Obara*, Asami Haganuma, Shinsuke Murakami, Toshiki Chiba, Koichiro Mori, Osamu Nakagawasai, Takeshi Tadano, Haruhisa Kikuchi, Yoshiteru Oshima, Norimichi Nakahata.
Multiple Authorship (Including Foreigners)
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Lycovatine A, a C16N-type quaternary alkaloid from Lycopodium clavatum var. robustum. , Heterocycles , 2006
Takaaki Kubota, Tomoe Sunaura, Hiroshi Morita, Yuzuru Mikami, Tomohiro Hoshino, Yutaro Obara, Norimichi Nakahata, Jun’ichi Kobayashi.
Multiple Authorship (Including Foreigners)
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Inhibitory effect of naringin on lipopolysaccharide (LPS)-induced endotoxin shock in mice and nitric oxide production in RAW 264.7 macrophages. , Life Sci. , 2006
Syu-ichi Kanno, Ai Shouji, Ayako Tomizawa, Takako Hiura, Yuu Osanai, Mayuko Ujibe, Yutaro Obara, Norimichi Nakahata, Masaaki Ishikawa.
Multiple Authorship (Including Foreigners)
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Neurotrophic factor production in human astrocytoma cells by 2,5,6-tribromogramine via activation of epsilon isoform of protein kinase C. , Eur. J. Pharm. Sci. , 2006
Masaki Saito, Megumi Hori, Yutaro Obara, Yasushi Ohizumi, Satoko Ohkubo, Norimichi Nakahata.
Multiple Authorship (Including Foreigners)
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Neurite outgrowth activity of cyathane diterpenes from Sarcodon cyrneus, Cyrneines A and B. , Planta Med. , 2006
Maria Carla Marcotullio, Rita Pagiotti, Federica Maltese, Yutaro Obara, Tomohiro Hoshino, Norimichi Nakahata, Massimo Curini.
Multiple Authorship (Including Foreigners)
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Lycopladines B-D and lyconadin B, new alkaloids from Lycopodium complanatum. , Bioorg. Med. Chem. , 2006
Kan’ichiro Ishiuchi, Takaaki Kubota, Tomohiro Hoshino, Yutaro Obara, Norimichi Nakahata, Jun’ichi Kobayashi.
Multiple Authorship (Including Foreigners)
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Nankakurine B, a new alkaloid from Lycopodium hamiltonii and revised stereostructure of nankakurine A. , Heterocycles , 2006
Yusuke Hirasawa, Jun’ichi Kobayashi, Yutaro Obara, Norimichi Nakahata, Nobuo Kawahara, Yukihiro Goda, Hiroshi Morita.
Multiple Authorship (Including Foreigners)
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Thromboxane A2 promotes interleukin-6 biosynthesis mediated by an activation of cyclic AMP-response element binding protein in 1321N1 human astrocytoma cells. , Mol. Pharmacol. , 2005
Yutaro Obara*, Hitoshi Kurose, Norimichi Nakahata.
Multiple Authorship (Including Foreigners)
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Daphmanidins C and D, novel pentacyclic alkaloids from Daphniphyllum teijsmanii. , Org. Lett. , 2005
Hiroshi Morita, Nozomi Ishioka, Hiroshi Takatsu, Takakazu Shinzato, Yutaro Obara, Norimichi Nakahata, Jun’ichi Kobayashi.
Multiple Authorship (Including Foreigners)
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Complanadine B, obscurumines A and B, new alkaloids from two species of Lycopodium. , Tetrahedron , 2005
Hiroshi Morita, Kan’ichiro Ishiuchi, Asami Haganuma, Tomohiro Hoshino, Yutaro Obara, Norimichi Nakahata, Jun’ichi Kobayashi.
Multiple Authorship (Including Foreigners)
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Lannotinidines A-G, new alkaloids from two species of Lycopodium., Tetrahedron , 2005
Koichiro Koyama, Hiroshi Morita, Yusuke Hirasawa, Miwa Yoshinaga, Tomohiro Hoshino, Yutaro Obara, Norimichi Nakahata, Jun’ichi Kobayashi.
Multiple Authorship (Including Foreigners)
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Neurofilament measurement for quantitative evaluation of the differentiation of PC-12 cells. , Pharmacometrics , 2004
Norimichi Nakahata, Megumi Hori, Asami Haganuma, Yutaro Obara, Yasushi Ohizumi.
Multiple Authorship (Including Foreigners)
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PKA phosphorylation of Src mediates Rap1 activation in NGF and cAMP signaling in PC12 cells. , J. Cell Sci. , 2004
Yutaro Obara, Kirstin Labudda, Tara Dillon, Philip J.S. Stork.
Multiple Authorship (Including Foreigners)
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Tricholomalides A-C, new neurotrophic diterpenes from the mushroom tricholoma sp. , J. Nat. Prod. , 2003
Sachiko Tsukamoto, Abdulgafor D Macabalang, Keigo Nakatani, Yutaro Obara, Norimichi Nakahata, Tomihisa Ohta.
Multiple Authorship (Only Japanese)
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Theonezolide A, a novel marine macrolide, induces drastic shape change in rabbit platelets by reorganization of microtubules., Thromb. Res. , 2003
Minori Mitsui-Saito, Satoko Ohkubo, Yutaro Obara, Teruyuki Yanagisawa, Jun’ichi Kobayashi, Yasushi Ohizumi, Norimichi Nakahata.
Multiple Authorship (Only Japanese)
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b-Eudesmol induces neurite outgrowth in rat pheochromocytoma cells accompanied by an activation of mitogen-activated protein kinase. , J. Pharmacol. Exp. Ther. , 2002
Yutaro Obara*, Takashi Aoki, Masayoshi Kusano, Yasushi Ohizumi.
Multiple Authorship (Only Japanese)
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Scabronine G-methyl ester enhances secretion of neurotrophic factors mediated by an activation of protein kinase C-z. , Mol. Pharmacol. , 2001
Yutaro Obara, Hironori Kobayashi, Tomihisa Ohta, Yasushi Ohizumi, Norimichi Nakahata.
Multiple Authorship (Only Japanese)
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Differentiation of rat pheochromocytoma cells by fomitellic acids, specific DNA polymerase inhibitors. , Life Sci. , 2000
Yutaro Obara, Norimichi Nakahata, Yoshiyuki Mizushina, Fumio Sugawara, Kengo Sakaguchi, Yasushi Ohizumi.
Multiple Authorship (Only Japanese)
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Maitotoxin-induced nerve growth factor production accompanied by the activation of a voltage-insensitive Ca2+ channel in C6-BU-1 glioma cells., Brit. J. Pharmacol. , 1999
Yutaro Obara, Masami Takahashi, Norimichi Nakahata, Yasushi Ohizumi.
Multiple Authorship (Only Japanese)
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Stimulation of neurotrophic factor secretion from 1321N1 human astrocytoma cells by novel diterpenoids, scabronines A and G. , Eur. J. Pharmacol. , 1999
Yutaro Obara, Norimichi Nakahata, Takako Kita, Yoshiaki Takaya, Hironori Kobayashi, Shinzo Hosoi, Fumiyuki Kiuchi, Tomihisa Ohta, Yoshiteru Oshima, Yasushi Ohizumi.
Multiple Authorship (Only Japanese)
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A new factor derived from 1321N1 human astrocytoma cells causes differentiation of PC-12 cells mediated through mitogen-activated protein kinase cascade., Brain Res. , 1998
Yutaro Obara, Norimichi Nakahata, Yasushi Ohizumi.
Multiple Authorship (Only Japanese)
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Scabronine A, a novel diterpenoid having potent inductive activity of the nerve growth factor synthesis, isolated from the mushroom, Sarcodon scabrosus. , Tetrahedron Lett. , 1998
Tomihisa Ohta, Takako Kita, Norihiro Kobayashi, Yutaro Obara, Norimichi Nakahata, Yasushi Ohizumi, Yoshiaki Takaya, Yoshiteru Oshima.
Multiple Authorship (Only Japanese)
Books
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Principles of Pharmacology: The pathophysiologic Basis of Drug Therapy 3rd Ed, 2015.06
Review Papers
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Is PIP2 involved in the insulin effect? , Channels , 2014
Kuniaki Ishii, Minghua Wu, Yutaro Obara.
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Endocytic regulation of voltage-dependent potassium channels in heart. , J. Pharmacol. Sci. , 2012
Kuniaki Ishii, Ikuo Norota, Yutaro Obara.
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The signaling pathway leading to ERK5 activation via G-proteins and ERK5-dependent neurotrophic effects. , Mol. Pharmacol. , 2010
Yutaro Obara*, Norimichi Nakahata.
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The signaling pathway of neurotrophic factor biosynthesis. , Drug News and Perspective , 2002
Yutaro Obara, Norimichi Nakahata.
Grant-in-Aid for Scientific Research
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Grant-in-Aid for Scientific Research(C),2021.04 -
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Grant-in-Aid for Scientific Research(C),2020.04 - 2023.03
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Grant-in-Aid for Scientific Research(C),2018.04 - 2021.03
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Grant-in-Aid for Scientific Research(C),2015.04 - 2018.03