取得学位
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博士(医学),山形大学,2019年09月
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博士(薬学),東北大学,2002年03月
所属学会・委員会
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日本薬理学会
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日本生化学会
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日本薬学会
研究テーマ
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1)神経栄養因子による神経細胞の分化誘導メカニズムの解明
2)パーキンソン病の新しいリスク遺伝子に関する研究
研究経歴
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神経栄養因子による神経細胞の分化誘導メカニズムの解明,2002年04月 ~ 継続中
NGF, MAPK, チロシンヒドロキシラーゼ
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MIDN遺伝子異常とパーキンソン病の関連性の解明,2012年04月 ~ 継続中
論文
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Midnolin, a genetic risk factor for Parkinson’s Disease, promotes neurite outgrowth accompanied by early growth response 1 activation in PC12 Cells,Molecular and Cellular Biology,2024年
Ayano Chiba, Chisato Kato, Tadashi Nakagawa, Tsukasa Osaki, Kohei Nakamura, Ikuo Norota, Mikako Nagashima, Toru Hosoi, Kuniaki Ishii, Yutaro Obara
共著(国内のみ)
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Structural Variants of Midnolin, a Genetic Risk Factor for Parkinson's Disease, in a Yamagata Cohort.,Biological & Pharmaceutical Bulletin,46(3) 379-381,2023年
Sato H, Ishii K, Obara Y
共著(国内のみ)
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Effect of Extracellular Signal-Regulated Protein Kinase 5 Inhibition in Clear Cell Renal Cell Carcinoma,INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,23(15) ,2022年08月
Kanno Hidenori, Naito Sei, Obara Yutaro, Ito Hiromi, Ichiyanagi Osamu, Narisawa Takafumi, Kato Tomoyuki, Nagaoka Akira, Tsuchiya Norihiko
共著(国内のみ)
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Insulin Enhances Gene Expression of Midnolin, a Novel Genetic Risk Factor for Parkinson's Disease, via Extracellular Signal-Regulated Kinase, Phosphoinositide 3-Kinase and Multiple Transcription Factors in SH-SY5Y Cells,JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS,381(2) 68-78,2022年05月
Sagehashi Naoki, Obara Yutaro, Maruyama Ohki, Nakagawa Tadashi, Hosoi Toru, Ishii Kuniaki
共著(国内のみ)
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ERK5 inhibitor BIX02189 attenuates methamphetamine-induced hyperactivity by modulating microglial activation in the striatum,JOURNAL OF PHARMACOLOGICAL SCIENCES,148(3) 326-330,2022年03月
Nakagawasai Osamu, Takahashi Kohei, Miura Yuki, Nemoto Wataru, Obara Yutaro, Tan-No Koichi
共著(国内のみ)
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Azelnidipine treatment reduces the expression of Ca<sub>v</sub>1.2 protein.,Life sciences,269 119043,2021年03月
Nasu F, Obara Y, Okamoto Y, Yamaguchi H, Kurakami K, Norota I, Ishii K
共著(国内のみ)
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Reply to: MIDN locus structural variants and Parkinson's disease risk.,Ann. Clin. Transl. Neurol.,7 602-603,2020年
Yutaro Obara, Hidenori Sato, Takahiro Nakayama, Takeo Kato, Kuniaki Ishii.
共著(国内のみ)
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KCNQ1 is internalized by activation of α<sub>1</sub> adrenergic receptors.,Biochemical pharmacology,169 113628,2019年11月
Kurakami K, Norota I, Nasu F, Ohshima S, Nagasawa Y, Konno Y, Obara Y, Ishii K
共著(国内のみ)
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Midnolin is a confirmed genetic risk factor for Parkinson's disease.,Annals of clinical and translational neurology,2019年10月
Obara Y, Sato H, Nakayama T, Kato T, Ishii K
共著(国内のみ)
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Molecular identification of HSPA8 as an accessory protein of a hyperpolarization-activated chloride channel from rat pulmonary vein cardiomyocytes.,The Journal of biological chemistry,2019年09月
Okamoto Y, Nagasawa Y, Obara Y, Ishii K, Takagi D, Ono K
共著(国内のみ)
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ERK5 phosphorylates Kv4.2 and inhibits inactivation of the A-type current in PC12 cells.,Int. J. Mol. Sci. ,2018年
Yurina Kashino, Yutaro Obara*, Yosuke Okamoto, Takeo Saneyoshi, Yasunori Hayashi, Kuniaki Ishii.
共著(国内のみ)
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Transcriptome analysis reveals that midnolin regulates mRNA expression levels of multiple Parkinson's disease causative genes. ,Biol. Pharm. Bull. ,2018年
Yutaro Obara*, Kuniaki Ishii.
共著(国内のみ)
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Insulin treatment augments KCNQ1/KCNE1 currents but not KCNQ1 currents, which is associated with an increase in KCNE1 expression. ,Biochem. Biophys. Res. Commun. ,2017年
Minghua Wu, Yutaro Obara, Shingo Ohshima, Yoshinobu Nagasawa, Kuniaki Ishii.
共著(国内のみ)
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Licochalcones extracted from Glycyrrhiza inflata inhibit platelet aggregation accompanied by inhibition of COX-1 activity. ,PLoS ONE ,2017年
Asa Okuda-Tanino, Daiki Sugawara, Takumi Tashiro, Masaya Iwashita, Yutaro Obara*, Takahiro Moriya, Chisato Tsushima, Daisuke Saigusa, Yoshihisa Tomioka, Kuniaki Ishii, Norimichi Nakahata.
共著(国内のみ)
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Midnolin is a novel regulator of parkin expression and is associated with Parkinson’s Disease. ,Sci. Rep. ,2017年
Yutaro Obara*, Toru Imai, Hidenori Sato, Yuji Takeda, Takeo Kato, Kuniaki Ishii.
共著(国内のみ)
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Expression of extracellular signal-regulated kinase 5 and ankyrin repeat domain 1 in composite pheochromocytoma and ganglioneuroblastoma detected incidentally in the adult adrenal gland: a case report. ,Intern. Med. ,2016年
Shinta Suenaga, Osamu Ichiyanagi, Hiromi Ito, Sei Naito, Tomoyuki Kato, Akira Nagaoka, Tomoya Kato, Mitsunori Yamakawa, Yutaro Obara, Norihiko Tsuchiya.
共著(国内のみ)
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ERK5 induces ankrd1 for catecholamine biosynthesis and homeostasis in adrenal medullary cells. ,Cell. Signal.,2016年
Yutaro Obara*, Ryusuke Nagasawa, Wataru Nemoto, Michael J Pellegrino, Maho Takahashi, Beth A Habecker, Philip J.S Stork, Osamu Ichiyanagi, Hiromi Ito, Yoshihiko Tomita, Kuniaki Ishii, Norimichi Nakaha...
共著(海外含む)
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Phosphorylation of ERK5 on Thr732 is associated with ERK5 nuclear localization and ERK5-dependent transcription. ,PLoS ONE ,2015年
Takuto Honda, Yutaro Obara*, Arata Yamauchi, Anthony D. Couvillon, Justin J. Mason, Kuniaki Ishii, Norimichi Nakahata.
共著(海外含む)
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Insulin suppresses IKs (KCNQ1/KCNE1) currents, which require β-subunit KCNE1. ,Pflügers Arch. – Eur. J. Physiol. ,2014年
Minghua Wu, Yutaro Obara, Ikuo Norota, Yoshinobu Nagasawa, Kuniaki Ishii.
共著(国内のみ)
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Neurite Outgrowth of PC12 Cells by 4'-O-β-D-glucopyranosyl-3',4-dimethoxychalcone from Brassica rapa L. 'hidabeni' was enhanced by pretreatment with p38MAPK inhibitor. ,Neurochem. Res. ,2013年
Atsuyoshi Nishina, Hirokazu Kimura, Hiroyuki Tsukagoshi, Kunihisa Kozawa, Mamoru Koketsu, Masayuki Ninomiya, Daisuke Sato, Yutaro Obara, Shoei Furukawa.
共著(国内のみ)
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Gah/transglutaminase-2 activity is required for maximal activation of adenylylcyclase 8 in human and rat glioma cells. ,Cell. Signal. ,2013年
Yutaro Obara*, Yoshimi Yanagihata, Tomohiro Abe, Laila Dafik, Kuniaki Ishii, Norimichi Nakahata.
共著(海外含む)
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Rap1 potentiates endothelial cell junctions by spatially controlling myosin II activity and actin organization. ,J. Cell. Biol. ,2013年
Koji Ando, Shigetomo Fukuhara, Takahiro Moriya, Yutaro Obara, Norimichi Nakahata, Naoki Mochizuki.
共著(国内のみ)
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Involvement of lipid rafts in multiple signal transductions mediated by two isoforms of thromboxane A2 receptor: dependency on receptor isoforms and downstream signaling types. ,Eur. J. Pharmacol.,2012年
Shinji Goto, Masaki Saito, Yutaro Obara, Takahiro Moriya, Norimichi Nakahata.
共著(国内のみ)
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Dihydrobenzofurans as cannabinoid receptor ligands, from Cordyceps annullata, an entomopathogenic fungus, cultivated in the presence of HDAC inhibitor. ,Tetrahedron lett. ,2012年
Teigo Asai, Luo Dan, Yutaro Obara, Toru Taniguchi, Kenji Monde, Kouwa Yamashita, Yoshiteru Oshima.
共著(国内のみ)
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Functional interaction between purinergic receptors: effect of ligands for A2A and P2Y12 receptors on P2Y1 receptor function. ,FEBS letter,2011年
Tokiko Suzuki, Yutaro Obara, Takahiro Moriya, Hiroyasu Nakata, Norimichi Nakahata.
共著(国内のみ)
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Basic fibroblast growth factor promotes glial cell-derived neurotrophic factor gene expression mediated by activation of ERK5 in rat C6 glioma cells. ,Cell. Signal.,2011年
Yutaro Obara*, Wataru Nemoto, Susumu Kohno, Tomiyasu Murata, Norio Kaneda, Norimichi Nakahata.
共著(国内のみ)
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Effect of Hericium erinaceus on amyloid b (25-35) peptide-induced learning and memory deficits in mice. ,Biomed. Res. ,2011年
Koichiro Mori, Yutaro Obara, Takahiro Moriya, Satoshi Inatomi, Norimichi, Nakahata.
共著(国内のみ)
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A synthetic cannabinoid, CP55940, inhibits lipopolysaccharide-induced cytokine mRNA expression in acannabinoid receptor-independent mechanism in rat cerebellar granule cells. ,J. Pharm. Pharmacol. ,2011年
Toshiki Chiba, Sanae Ueno, Yutaro Obara*, Norimichi Nakahata.
共著(国内のみ)
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Lyconadins D and E, and complanadine E, new Lycopodium alkaloids from Lycopodium complanatum. ,Bioorg. Med. Chem. ,2011年
Kan’ichiro Ishiuchi, Takaaki Kubota, Haruaki Ishiyama, Shigeki Hayashi, Toshiro Shibata, Koichiro Mori, Yutaro Obara, Norimichi Nakahata, Jun’ichi Kobayashi.
共著(国内のみ)
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Lysophosphatidylinositol causes neurite retraction via GPR55, G13 and RhoA in PC12 cells. ,PLoS ONE ,2011年
Yutaro Obara*, Sanae Ueno, Yoshimi Yanagihata, Norimichi Nakahata.
共著(国内のみ)
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P2Y2 receptor-Gq/11 signaling at lipid rafts is required for UTP-induced cell migration in NG 108-15 cells. ,J. Pharmacol. Exp. Ther. ,2010年
Koji Ando, Yutaro Obara, Jun Sugama, Atsushi Kotani, Nobuyuki Koike, Satoko Ohkubo, Norimichi Nakahata.
共著(国内のみ)
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Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation.,Phytomedicine ,2010年
Koichiro Mori, Haruhisa Kikuchi, Yutaro Obara, Masaya Iwashita, Yoshihito Azumi, Satomi Kinugasa, Satoshi Inatomi, Yoshiteru Oshima, Norimichi Nakahata.
共著(国内のみ)
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Thromboxane A2 receptor-mediated epidermal growth factor receptor transactivation: Involvement of PKC-delta and PKC-epsilon in the shedding of epidermal growth factor receptor ligands. ,Eur. J. Pharm. Sci. ,2009年
Kotomi Uchiyama, Masaki Saito, Masako Sasaki, Yutaro Obara, Shigeki Higashiyama, Norimichi Nakahata.
共著(国内のみ)
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ERK5 activity is required for NGF-induced neurite outgrowth and stabilization of tyrosine hydroxylase in PC12 cells. ,J. Biol. Chem. ,2009年
Yutaro Obara*, Arata Yamauchi, Shin Takehara, Wataru Nemoto, Maho Takahashi, Philip J.S. Stork, Norimichi Nakahata.
共著(海外含む)
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Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. ,Biol. Pharm. Bull. ,2008年
Koichiro Mori, Yutaro Obara, Mitsuru Hirota, Yoshihito, Adumi, Satomi Kinugasa, Satoshi Inatomi, and Norimichi Nakahata.
共著(国内のみ)
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Calyciphyllines H–M, new Daphniphyllum alkaloids from Daphniphyllum calycinum. ,Tetrahedron ,2008年
Shizuka Saito, Hiroko Yahata, Takaaki Kubota, Yutaro Obara, Norimichi Nakahata and Jun'ichi Kobayashi.
共著(国内のみ)
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Beta-gamma subunits of Gi/o suppress EGF-induced ERK5 phosphorylation, whereas ERK1/2 phosphorylation is enhanced.,Cell. Signal. ,2008年
Yutaro Obara*, Yumiko Okano, Sachiko Ono, Arata Yamauchi, Tomohiro Hoshino, Hitoshi Kurose, Norimichi Nakahata.
共著(国内のみ)
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Lycopladine E, a new C16N1-type alkaloid from Lycopodium complanatum. ,Heterocycles ,2007年
Takaaki Kubota, Hiroko Yahata, Kan’ichiro Ishiuchi, Yutaro Obara, Norimichi Nakahata,
共著(国内のみ)
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Kan’ichiro Ishiuchi, Takaaki Kubota, Yuzuru Mikami, Yutaro Obara, Norimichi Nakahata, Jun’ichi Konayashi. Complanadines C and D, new dimeric alkaloids from Lycopodium complanatum.,Bioorg. Med. Chem. 1,2007年
Kan’ichiro Ishiuchi, Takaaki Kubota, Yuzuru Mikami, Yutaro Obara, Norimichi Nakahata, Jun’ichi Konayashi.
共著(国内のみ)
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The requirement of Ras and Rap1 for the activation of ERKs by cAMP, PACAP, and KCl in cerebellar granule cells. ,J. Neurochem. ,2007年
Yutaro Obara, Angela Horgan, Philip J.S. Stork.
共著(海外含む)
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A novel cyathane diterpene, cyrneine A, induces neurite outgrowth in a Rac1-dependent mechanism in PC12 cells. ,Life Sci. ,2007年
Yutaro Obara*, Tomohiro Hoshino, Maria Carla Marcotullio, Rita Pagiotti, Norimichi Nakahata.
共著(海外含む)
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Cyathane diterpenes from Sarcodon cyrneus and evaluation of their activities of neuritegenesis and nerve growth factor production. ,Bioorg. Med. Chem. ,2007年
Maria Carla Marcotullio, Rita Pagiotti, Federica Maltese, Gildas Norbert Oball-Mond Mwankie, Tomohiro Hoshino, Yutaro Obara, Norimichi Nakahata.
共著(海外含む)
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5,19-cyclo-9b, 10x-androstane-3,17 dione promotes neurotrophic factor biosynthesis in 1321N1 human astrocytoma cells and improves passive avoidance learning impairment. ,Brain Res. ,2007年
Yutaro Obara*, Asami Haganuma, Shinsuke Murakami, Toshiki Chiba, Koichiro Mori, Osamu Nakagawasai, Takeshi Tadano, Haruhisa Kikuchi, Yoshiteru Oshima, Norimichi Nakahata.
共著(国内のみ)
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Lycovatine A, a C16N-type quaternary alkaloid from Lycopodium clavatum var. robustum. ,Heterocycles ,2006年
Takaaki Kubota, Tomoe Sunaura, Hiroshi Morita, Yuzuru Mikami, Tomohiro Hoshino, Yutaro Obara, Norimichi Nakahata, Jun’ichi Kobayashi.
共著(国内のみ)
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Inhibitory effect of naringin on lipopolysaccharide (LPS)-induced endotoxin shock in mice and nitric oxide production in RAW 264.7 macrophages. ,Life Sci. ,2006年
Syu-ichi Kanno, Ai Shouji, Ayako Tomizawa, Takako Hiura, Yuu Osanai, Mayuko Ujibe, Yutaro Obara, Norimichi Nakahata, Masaaki Ishikawa.
共著(国内のみ)
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Neurotrophic factor production in human astrocytoma cells by 2,5,6-tribromogramine via activation of epsilon isoform of protein kinase C. ,Eur. J. Pharm. Sci. ,2006年
Masaki Saito, Megumi Hori, Yutaro Obara, Yasushi Ohizumi, Satoko Ohkubo, Norimichi Nakahata.
共著(国内のみ)
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Neurite outgrowth activity of cyathane diterpenes from Sarcodon cyrneus, Cyrneines A and B. ,Planta Med. ,2006年
Maria Carla Marcotullio, Rita Pagiotti, Federica Maltese, Yutaro Obara, Tomohiro Hoshino, Norimichi Nakahata, Massimo Curini.
共著(海外含む)
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Lycopladines B-D and lyconadin B, new alkaloids from Lycopodium complanatum. ,Bioorg. Med. Chem. ,2006年
Kan’ichiro Ishiuchi, Takaaki Kubota, Tomohiro Hoshino, Yutaro Obara, Norimichi Nakahata, Jun’ichi Kobayashi.
共著(国内のみ)
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Nankakurine B, a new alkaloid from Lycopodium hamiltonii and revised stereostructure of nankakurine A. ,Heterocycles ,2006年
Yusuke Hirasawa, Jun’ichi Kobayashi, Yutaro Obara, Norimichi Nakahata, Nobuo Kawahara, Yukihiro Goda, Hiroshi Morita.
共著(国内のみ)
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Thromboxane A2 promotes interleukin-6 biosynthesis mediated by an activation of cyclic AMP-response element binding protein in 1321N1 human astrocytoma cells. ,Mol. Pharmacol. ,2005年
Yutaro Obara*, Hitoshi Kurose, Norimichi Nakahata.
共著(国内のみ)
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Daphmanidins C and D, novel pentacyclic alkaloids from Daphniphyllum teijsmanii. ,Org. Lett. ,2005年
Hiroshi Morita, Nozomi Ishioka, Hiroshi Takatsu, Takakazu Shinzato, Yutaro Obara, Norimichi Nakahata, Jun’ichi Kobayashi.
共著(国内のみ)
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Complanadine B, obscurumines A and B, new alkaloids from two species of Lycopodium. ,Tetrahedron ,2005年
Hiroshi Morita, Kan’ichiro Ishiuchi, Asami Haganuma, Tomohiro Hoshino, Yutaro Obara, Norimichi Nakahata, Jun’ichi Kobayashi.
共著(国内のみ)
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Lannotinidines A-G, new alkaloids from two species of Lycopodium.,Tetrahedron ,2005年
Koichiro Koyama, Hiroshi Morita, Yusuke Hirasawa, Miwa Yoshinaga, Tomohiro Hoshino, Yutaro Obara, Norimichi Nakahata, Jun’ichi Kobayashi.
共著(国内のみ)
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Neurofilament measurement for quantitative evaluation of the differentiation of PC-12 cells. ,Pharmacometrics ,2004年
Norimichi Nakahata, Megumi Hori, Asami Haganuma, Yutaro Obara, Yasushi Ohizumi.
共著(国内のみ)
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PKA phosphorylation of Src mediates Rap1 activation in NGF and cAMP signaling in PC12 cells. ,J. Cell Sci. ,2004年
Yutaro Obara, Kirstin Labudda, Tara Dillon, Philip J.S. Stork.
共著(海外含む)
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Tricholomalides A-C, new neurotrophic diterpenes from the mushroom tricholoma sp. ,J. Nat. Prod. ,2003年
Sachiko Tsukamoto, Abdulgafor D Macabalang, Keigo Nakatani, Yutaro Obara, Norimichi Nakahata, Tomihisa Ohta.
共著(国内のみ)
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Theonezolide A, a novel marine macrolide, induces drastic shape change in rabbit platelets by reorganization of microtubules.,Thromb. Res. ,2003年
Minori Mitsui-Saito, Satoko Ohkubo, Yutaro Obara, Teruyuki Yanagisawa, Jun’ichi Kobayashi, Yasushi Ohizumi, Norimichi Nakahata.
共著(国内のみ)
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b-Eudesmol induces neurite outgrowth in rat pheochromocytoma cells accompanied by an activation of mitogen-activated protein kinase. ,J. Pharmacol. Exp. Ther. ,2002年
Yutaro Obara*, Takashi Aoki, Masayoshi Kusano, Yasushi Ohizumi.
共著(国内のみ)
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Scabronine G-methyl ester enhances secretion of neurotrophic factors mediated by an activation of protein kinase C-z. ,Mol. Pharmacol. ,2001年
Yutaro Obara, Hironori Kobayashi, Tomihisa Ohta, Yasushi Ohizumi, Norimichi Nakahata.
共著(国内のみ)
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Differentiation of rat pheochromocytoma cells by fomitellic acids, specific DNA polymerase inhibitors. ,Life Sci. ,2000年
Yutaro Obara, Norimichi Nakahata, Yoshiyuki Mizushina, Fumio Sugawara, Kengo Sakaguchi, Yasushi Ohizumi.
共著(国内のみ)
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Maitotoxin-induced nerve growth factor production accompanied by the activation of a voltage-insensitive Ca2+ channel in C6-BU-1 glioma cells.,Brit. J. Pharmacol. ,1999年
Yutaro Obara, Masami Takahashi, Norimichi Nakahata, Yasushi Ohizumi.
共著(国内のみ)
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Stimulation of neurotrophic factor secretion from 1321N1 human astrocytoma cells by novel diterpenoids, scabronines A and G. ,Eur. J. Pharmacol. ,1999年
Yutaro Obara, Norimichi Nakahata, Takako Kita, Yoshiaki Takaya, Hironori Kobayashi, Shinzo Hosoi, Fumiyuki Kiuchi, Tomihisa Ohta, Yoshiteru Oshima, Yasushi Ohizumi.
共著(国内のみ)
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A new factor derived from 1321N1 human astrocytoma cells causes differentiation of PC-12 cells mediated through mitogen-activated protein kinase cascade.,Brain Res. ,1998年
Yutaro Obara, Norimichi Nakahata, Yasushi Ohizumi.
共著(国内のみ)
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Scabronine A, a novel diterpenoid having potent inductive activity of the nerve growth factor synthesis, isolated from the mushroom, Sarcodon scabrosus. ,Tetrahedron Lett. ,1998年
Tomihisa Ohta, Takako Kita, Norihiro Kobayashi, Yutaro Obara, Norimichi Nakahata, Yasushi Ohizumi, Yoshiaki Takaya, Yoshiteru Oshima.
共著(国内のみ)
著書
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薬理学へのいざない〜くすりのしくみを知ろう〜,日本薬理学会,2022年
日本薬理学会研究推進委員会 10名共同執筆
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臨床薬理学 原書版,丸善出版,2015年06月
渡邉 裕司 他
総説・解説記事
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Is PIP2 involved in the insulin effect? ,Channels ,2014年
Kuniaki Ishii, Minghua Wu, Yutaro Obara.
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ようやく見えて来た神経系におけるERK5の機能. ,日本薬理学雑誌 ,2013年
小原 祐太郎*.
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神経系におけるERK5の役割について. ,日本薬理学雑誌 ,2013年
小原 祐太郎*, 石井 邦明.
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多彩な機能を有するGh/トランスグルタミナーゼ2. ,日本薬理学雑誌 ,2013年
小原 祐太郎*, 石井 邦明.
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Endocytic regulation of voltage-dependent potassium channels in heart. ,J. Pharmacol. Sci. ,2012年
Kuniaki Ishii, Ikuo Norota, Yutaro Obara.
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The signaling pathway leading to ERK5 activation via G-proteins and ERK5-dependent neurotrophic effects. ,Mol. Pharmacol. ,2010年
Yutaro Obara*, Norimichi Nakahata.
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PKA融合ホタルルシフェラーゼを用いた細胞内cAMPレベル の測定法. ,日本薬理学雑誌 ,2010年
小原 祐太郎*, 中畑 則道.
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神経系細胞におけるcAMPによるERK1/2活 性化のシグナル伝達について. ,日本薬理学雑誌 ,2009年
小原 祐太郎*, 中畑 則道.
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神経栄養因子関連化合物の抗認知症薬の開発について. ,薬学雑誌 ,2006年
小原 祐太郎*.
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The signaling pathway of neurotrophic factor biosynthesis. ,Drug News and Perspective ,2002年
Yutaro Obara, Norimichi Nakahata.
その他研究活動
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プレスリリース(新しいパーキンソン病の関連遺伝子を発見)
その他
科研費(文科省・学振)獲得実績
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基盤研究(C),2021年04月 ~ 継続中,パーキンソン病の新しいリスク遺伝子Midnolin(MIDN)の分子基盤の構築
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基盤研究(C),2020年04月 ~ 2023年03月,受容体刺激によるKチャネル発現量低下の病態生理学的意義
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基盤研究(C),2018年04月 ~ 2021年03月,新規パーキンソン病関連遺伝子midnolinの生理的、病理的な役割の解明
薬理学関連
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基盤研究(C),2015年04月 ~ 2018年03月,ERK5によるカテコラミン生合成促進機構とその生理的・病理的な役割の解明
担当授業科目
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2022年度,生体薬理学
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2022年度,人体の仕組みと病気(健康・スポーツ科学)
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2021年度,人体の仕組みと病気(健康・スポーツ科学)
学会・委員会等活動
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日本薬理学会,学術評議員,2005年 ~ 継続中
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日本薬学会,薬理系薬学部会 若手世話人,2009年 ~ 2019年
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日本薬理学会,次世代の会 世話人,2012年 ~ 2020年
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日本薬理学会,代議員,2014年 ~ 2018年
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日本薬理学会,常置委員会委員(研究推進委員会),2020年 ~ 継続中
相談に応じられる分野
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シグナル伝達