Updated on 2025/04/20

写真a

 
TAKEDA Yuji
 
Title
Associate Professor
Contact information
メールアドレス
Laboratory Phone number
+81-23-628-5265
　
Laboratory Fax number
+81-23-628-5267
　

Research Areas

  • Life Science / Immunology

  • Life Science / Hygiene and public health (laboratory)

External Career

  • , Lecturer, 2009.02 - 2012.03

  • Yamagata University, Assistant Professor, 2012.04 - 2018.03

  • Yamagata University, Associate Professor, 2018.04 -

 

Research Career

  • Improvement of various diseases by regulation of immune reactions, 2010.04 - 2012.03

  • Analysis of signal transducers using flow cytometry is useful for detection of contractive and fluctuating signals., 2015.04 -

Papers

  • 5-Aminolevulinic Acid (5-ALA) Plays an Important Role in the Function of Innate Immune Cells, INFLAMMATION, 2024.12

    Saitoh, S; Takeda, Y; Araki, A; Nouchi, Y; Yamaguchi, R; Nakajima, O; Asao, H

    Single Author

  • A loss of tuning of both pro-coagulant and inflammatory responses in monocytes in patients with preeclampsia, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 166 104334, 2024.12

    Nagashima, M; Takeda, Y; Saitoh, S; Sabrina, S; Araki, A; Nagase, S; Asao, H

    Single Author

  • Intracellular Major Histocompatibility Complex Class II and C-X-C Motif Chemokine Ligand 10-Expressing Neutrophils Indicate the State of Anti-Tumor Activity Induced by <i>Bacillus Calmette-Guérin</i>, BIOMEDICINES, 11(11) , 2023.11

    Takeda, Y; Kato, T; Sabrina, S; Naito, S; Ito, H; Emi, N; Kuboki, Y; Takai, Y; Fukuhara, H; Ushijima, M; Narisawa, T; Yagi, M; Kanno, H; Sakurai, T; Nishida, H; Araki, A; Shimotai, Y; Nagashima, M; No...

    Single Author

  • Hemoglobin β Expression Is Associated with Poor Prognosis in Clear Cell Renal Cell Carcinoma, BIOMEDICINES, 11(5) , 2023.04

    Kurota, Y; Takeda, Y; Ichiyanagi, O; Saitoh, S; Ito, H; Naito, S; Asao, H; Tsuchiya, N

    Single Author

  • Initial Myeloid Cell Status Is Associated with Clinical Outcomes of Renal Cell Carcinoma, BIOMEDICINES, 11(5) , 2023.04

    Sabrina, S; Takeda, Y; Kato, T; Naito, S; Ito, H; Takai, Y; Ushijima, M; Narisawa, T; Kanno, H; Sakurai, T; Saitoh, S; Araki, A; Tsuchiya, N; Asao, H

    Single Author

  • MDSCs function analysis as a prediction of therapeutic effect for patients with advanced renal cell carcinoma, CANCER SCIENCE, 114 1406, 2023.02

    Sabrina, S; Kato, T; Takeda, Y; Naito, S; Ito, H; Takai, Y; Ushijima, M; Narisawa, T; Kanno, H; Sakurai, Y; Tsuchiya, N; Asao, H

    Single Author

  • Preferential Expression of Ca2+-Stimulable Adenylyl Cyclase III in the Supraventricular Area, including Arrhythmogenic Pulmonary Vein of the Rat Heart., Biomolecules, 12(5) , 2022.05

    Yosuke Okamoto, Naing Ye Aung, Masahiro Tanaka, Yuji Takeda, Daichi Takagi, Wataru Igarashi, Kuniaki Ishii, Mitsunori Yamakawa, Kyoichi Ono

    Single Author

  • 細胞の挙動に関連する細胞シグナル伝達の5つのパターン(Five Patterns of Cell Signaling Associated with Cell Behavior), 山形医学, 40(1) 1-20, 2022.02

    武田 裕司, 河野 和晴, 馬 鋭, 斉藤 真一, 浅尾 裕信

    Single Author

  • 細胞の挙動に関連する細胞シグナル伝達の5つのパターン(Five Patterns of Cell Signaling Associated with Cell Behavior), 山形医学, 40(1) 1-20, 2022.02

    武田 裕司, 河野 和晴, 馬 鋭, 斉藤 真一, 浅尾 裕信

    Single Author

  • GPI-80 Augments NF-κB Activation in Tumor Cells., International journal of molecular sciences, 22(21) , 2021.11

    Yuji Takeda, Yuta Kurota, Tomoyuki Kato, Hiromi Ito, Akemi Araki, Hidetoshi Nara, Shinichi Saitoh, Nobuyuki Tanaka, Norihiko Tsuchiya, Hironobu Asao

    Single Author

  • 生理的加温は顆粒球・単球吸着除去療法中の抗炎症反応を増強する　in vitro研究(Physiological heating augments the anti-inflammatory reactions during granulocyte/monocyte apheresis: A in vitro study), Therapeutic Apheresis and Dialysis, 25(5) 671-680, 2021.10

    Nishise Shoichi, Takeda Yuji, Abe Yasuhiko, Sasaki Yu, Saitoh Shinichi, Nara Hidetoshi, Asao Hironobu, Ueno Yoshiyuki

    Single Author

  • 腎がんおよび尿路上皮癌の免疫チェックポイント阻害剤治療における好中球多様性, 日本癌学会総会記事, 80回 [P12-3], 2021.09

    サイマ・サブリナ, 加藤 智幸, 武田 裕司, 内藤 整, 伊藤 裕美, 高井 優季, 牛島 正毅, 小澤 迪喜, 成澤 貴史, 菅野 秀典, 櫻井 俊彦, 土谷 順彦, 浅尾 裕信

    Single Author

  • インターロイキン-21はCD8陽性エフェクター記憶T細胞を介してリステリア菌の再感染を軽減する(Interleukin-21 reduces Listeria monocytogenes secondary infection via CD8+ effector memory T cells), 山形医学, 39(1) 45-51, 2021.02

    Gazi Md. Yeashin, Takeda Yuji, Nara Hidetoshi, Araki Akemi, Nemoto Nobuhito, Asao Hironobu

    Single Author

  • インターロイキン-21はCD8陽性エフェクター記憶T細胞を介してリステリア菌の再感染を軽減する(Interleukin-21 reduces Listeria monocytogenes secondary infection via CD8+ effector memory T cells), 山形医学, 39(1) 45-51, 2021.02

    Gazi Md. Yeashin, Takeda Yuji, Nara Hidetoshi, Araki Akemi, Nemoto Nobuhito, Asao Hironobu

    Single Author

  • Midnolin promotes neurite outgrowth and expression of parkin ubiquitin ligase, and is associated with Parkinson's Disease., Proceedings for Annual Meeting of The Japanese Pharmacological Society, 92(0) 1-O-17, 2019

    Obara Yutaro, Imai Toru, Sagehashi Naoki, Sato Hidenori, Takeda Yuji, Kato Takeo, Ishii Kuniaki

    Single Author

  • Augmentation of the expression of the eotaxin receptor on duodenal neutrophils by IL-21, Cytokine, 110 194-203, 2018.05

    Takeda, Y. Kato, T. Nemoto, N. Araki, A. Gazi, M. Y. Nara, H. Asao, H.

    Multiple Authorship (Including Foreigners)

  • Adsorption of Soluble Immunoglobulin-Type Adhesion Molecules to Cellulose Acetate Beads, Ther Apher Dial, 22(3) 261-265, 2018.05

    Nishise, S. Takeda, Y. Nara, H. Abe, Y. Sasaki, Y. Asao, H. Ueno, Y.

    Multiple Authorship (Including Foreigners)

  • IL-21は十二指腸遊走型好中球の分化を促進する , 臨床免疫・アレルギー科, 69(5) 442-449, 2018.05

    武田裕司, 奈良英利, 荒木明美, 浅尾裕信

    Multiple Authorship (Including Foreigners)

  • IL-21は十二指腸遊走型好中球の分化を促進する, 臨床免疫・アレルギー科, 69(5) 442-449, 2018.05

    武田裕司, 奈良英利, 荒木明美, 浅尾裕信

    Single Author

  • Protein Tyrosine Phosphatase SHP-2 Is Involved in the Interleukin-21-Induced Activation of Extracellular Signal-Regulated Kinase 1/2, Tohoku J Exp Med, 244(3) 187-193, 2018.03

    Jin, L. Nara, H. Rahman, M. Takeda, Y. Araki, A. Asao, H.

    Multiple Authorship (Including Foreigners)

  • Hyper-IgE syndrome, Journal of Japan Society of Immunology & Allergology in Otolaryngology, 36(4) 267-269, 2018

    Furukawa Takatoshi, Takada Yuji, Asao Hironobu, Ohta Nobuo, Kakehata Seiji

    Single Author

  • Analysis of signal transducers using flow cytometry is useful for detection of contractive and fluctuating signals, Bulletin of the Yamagata University. Medical science : Yamagata medical journal, 35(2) 21-32, 2017.08

    Takeda, Y. Nara, H. Asao, H.

    Multiple Authorship (Including Foreigners)

  • Midnolin is a novel regulator of parkin expression and is associated with Parkinson's Disease, Sci Rep, 7(1) 5885, 2017.07

    Obara, Y. Imai, T. Sato, H. Takeda, Y. Kato, T. Ishii, K.

    Multiple Authorship (Including Foreigners)

  • Effect of Temperature on Granulocyte and Monocyte Adsorption to Cellulose Acetate Beads, Ther Apher Dial, 21(3) 248-254, 2017.07

    Nishise, S. Takeda, Y. Abe, Y. Sasaki, Y. Nara, H. Asao, H. Ueno, Y.

    Multiple Authorship (Including Foreigners)

  • Relationship between Immunological Abnormalities in Rat Models of Diabetes Mellitus and the Amplification Circuits for Diabetes, J Diabetes Res, 2017 4275851, 2017.03

    Takeda, Y. Shimomura, T. Asao, H. Wakabayashi, I.

    Multiple Authorship (Including Foreigners)

  • Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 (Ape1/Ref-1) Modulates Antigen Presenting Cell-mediated T Helper Cell Type 1 Responses, J Biol Chem, 2016.11

    Akhter N, Takeda Y, Nara H, Araki A, Ishii N, Asao N, Asao H,

    Multiple Authorship (Including Foreigners)

  • The pattern of GPI-80 expression is a useful marker for unusual myeloid maturation in peripheral blood, Clinical and Experimental Immunology , 2016.08

    Takeda Y, Kato T, Ito H, Kurota Y, Yamagishi A, Sakurai T, Araki A, Nara H, Tsuchiya N, Asao H,

    Multiple Authorship (Including Foreigners)

  • Circulating miR-223 in Oral Cancer: Its Potential as a Novel Diagnostic Biomarker and Therapeutic Target., PLoS One, 2016.07

    Tachibana H, Sho R, Takeda Y, Zhang X, Yoshida Y, Narimatsu H, Otani K, Ishikawa S, Fukao A, Asao H, Iino M,

    Single Author

  • Selective induction of anti-inflammatory monocyte-platelet aggregates in a model of pulsatile blood flow at low shear rates, Platelets, 27(6) 583-592, 2016.04

    Takeda Y, Marumo M, Nara H, Feng ZG, Asao H, Wakabayashi I,

    Multiple Authorship (Including Foreigners)

  • Immunological disorders of diabetes mellitus in experimental rat models, Nihon Eiseigaku Zasshi, 69(3) 166-176, 2014.09

    Takeda, Y. Shimomura, T. Wakabayashi, I.

    Multiple Authorship (Only Japanese)

  • Human Peripheral Neutrophils Express Functional IL-21 Receptors, Inflammation, 37(5) 1521-1532, 2014.04

    Takeda, Y. Nara, H. Araki, A. Asao, H.

    Multiple Authorship (Including Foreigners)

  • Vitamin D(3) derivatives increase soluble CD14 release through ERK1/2 activation and decrease IL-8 production in intestinal epithelial cells, Eur J Pharmacol, 721(1-3) 305-312, 2013.09

    Hidaka, M. Wakabayashi, I. Takeda, Y. Fukuzawa, K.

    Multiple Authorship (Including Foreigners)

  • Suppression of Th1 cytokine production by a peptide derived from C4b, Inflammation research, 62(11) 951-959, 2013.08

    Takeda, Y. Kaneda, K. Jimma, F. Shiobara, N. Saniabadi, A. R. Wakabayashi, I.

    Multiple Authorship (Including Foreigners)

  • Inhibitory effects of resveratrol on MCP-1, IL-6, and IL-8 production in human coronary artery smooth muscle cells, Naunyn-Schmiedeberg's archives of pharmacology, 386(9) 835-839, 2013.05

    Wakabayashi, I. Takeda, Y.

    Multiple Authorship (Including Foreigners)

  • Role of interleukin-21 isoform in dextran sulfate sodium (DSS)-induced colitis, Cytokine, 62(2) 262-271, 2013.04

    Araki, A. Nara, H. Rahman, M. Onoda, T. Li, J. Juliana, F. M. Jin, L. Murata, K. Takeda, Y. Asao, H.

    Multiple Authorship (Including Foreigners)

  • IL-21 isoform is a membrane-bound ligand and activates directly interacted cells, Cytokine, 61(2) 656-663, 2013.01

    Nara, H. Rahman, M. Araki, A. Jin, L. Takeda, Y. Asao, H.

    Multiple Authorship (Including Foreigners)

  • Inhibition of thrombin-induced Ca(2)(+) influx in platelets by R59949, an inhibitor of diacylglycerol kinase, J Pharm Pharmacol, 64(6) 855-861, 2012.05

    Marumo, M. Nakano, T. Takeda, Y. Goto, K. Wakabayashi, I.

    Multiple Authorship (Including Foreigners)

  • Alteration in lymphocyte population and humoral immune response in type 2 diabetic Goto-Kakizaki rats, Life Sci, 90(13-14) 545-552, 2012.03

    Takeda, Y. Wakabayashi, I.

    Multiple Authorship (Including Foreigners)

  • Inhibition of CXCL10 release by monomeric C3bi and C4b, Clin Exp Immunol, 167(1) 149-157, 2012.01

    Takeda, Y., K. Kaneda, F. Jimma, N. Shiobara, M. Hidaka, A. R. Saniabadi, and I. Wakabayashi.

    Multiple Authorship (Including Foreigners)

  • Attenuated phagocytic activity of monocytes in type 2 diabetic Goto-Kakizaki rats. , Immunobiology, 216(10) 1094-1102, 2011.10

    Takeda, Y., M. Marumo, and I. Wakabayashi.

    Multiple Authorship (Including Foreigners)

  • Cellulose acetate beads activate the complement system but inactivate the anaphylatoxins generated., Artif Organs , 34(12) 1144-1149, 2010.12

    Takeda, Y., M. Ohba, M. Ueno, A. R. Saniabadi, and I. Wakabayashi.

    Multiple Authorship (Including Foreigners)

  • Release of interleukin-1 receptor antagonist by combining a leukocyte adsorption carrier with ulinastatin., Ther Apher Dial , 14(4) 386-391, 2010.08

    Nishise, S., Y. Takeda, S. Fujishima, T. Orii, T. Sato, Y. Sasaki, Y. Nishise, H. Takeda, and S. Kawata.

    Multiple Authorship (Including Foreigners)

  • Induction of Foxp3 expression in T cells by cellulose acetate beads in vitro., J Clin Apher , 25(4) 216-222, 2010.06

    Jimma, F., Y. Takeda, K. Kaneda, and I. Wakabayashi.

    Multiple Authorship (Including Foreigners)

  • The mode of actions of the Adacolumn therapeutic leucocytapheresis in patients with inflammatory bowel disease: a concise review. , Clin Exp Immunol , 163(1) 50-58, 2010.01

    Hanai, H., Y. Takeda, M. Eberhardson, R. Gruber, A. R. Saniabadi, O. Winqvist, and R. Lofberg.

    Multiple Authorship (Including Foreigners)

  • Biological effect of anaphylatoxin C5a on the generation of anti-inflammatory substances in leukocyte adsorption., Ther Apher Dial, 13(6) 509-514, 2009.12

    Nishise, S., Y. Takeda, Y. Nishise, S. Fujishima, T. Orii, S. Otake, T. Sato, Y. Sasaki, H. Takeda, and S. Kawata.

    Multiple Authorship (Including Foreigners)

  • A multi center study of granulocyte and monocyte adsorption apheresis therapy for ulcerative colitis-Clinical efficacy and production of interleukin-1 receptor antagonist., J Clin Apher, 23(3) 105-110, 2008.04

    Takeda, H., Y. Suzuki, Y. Takeda, S. Nishise, T. Fukui, S. Fujishima, T. Orii, S. Otake, T. Sato, K. Suzuki, Y. Nakamuara, and S. Kawata.

    Multiple Authorship (Including Foreigners)

  • Assessment of rabbit spleen size using ultrasonography, J Vet Med Sci, 69(8) 841-842, 2007.08

    Takeda, Y., H. Asaoka, M. Ueno, F. Jimma, M. Hidaka, H. Shibusawa, K. Kaneda, A. R. Saniabadi, K. Hiraishi, and N. Kashiwagi.

    Multiple Authorship (Including Foreigners)

  • Structural divergence of GPI-80 in activated human neutrophils. , Biochem Biophys Res Commun , 359(2) 227-233, 2007.07

    Nitto, T., Y. Takeda, H. Yoshitake, F. Sendo, and Y. Araki.

    Multiple Authorship (Including Foreigners)

  • Clinical response is associated with elevated plasma interleukin-1 receptor antagonist during selective granulocyte and monocyte apheresis in patients with ulcerative colitis., Dig Dis Sci, 51(9) 1525-1531, 2006.09

    Sakimura, K., T. Omori, E. Iwashita, T. Yoshida, Y. Tsuzuki, K. Fujimori, F. Konishi, Y. Yoshida, H. Anzai, H. Suzuki, S. Sugawara, Y. Takeda, K. Hiraishi, A. R. Saniabadi, T. Ide, S. Miura, and S. Ot...

    Multiple Authorship (Including Foreigners)

  • Complement activation is involved in biological responses to leukocyte adsorptive apheresis., Dig Dis Sci , 51(5) 934-941, 2006.03

    Nishise, S., Y. Takeda, H. Takeda, K. Ishihama, T. Fukui, and S. Kawata.

    Multiple Authorship (Including Foreigners)

  • Stent-induced neutrophil activation is associated with an oxidative burst in the inflammatory process, leading to neointimal thickening. , Thromb Haemost, 95(1) 43-48, 2006.01

    Inoue, T., T. Kato, Y. Hikichi, S. Hashimoto, T. Hirase, T. Morooka, Y. Imoto, Y. Takeda, F. Sendo, and K. Node.

    Multiple Authorship (Including Foreigners)

  • Adacolumn for selective leukocytapheresis as a non-pharmacological treatment for patients with disorders of the immune system: an adjunct or an alternative to drug therapy?, J Clin Apher, 20(3) 171-184, 2005.10

    Saniabadi, A. R., H. Hanai, Y. Suzuki, T. Ohmori, K. Sawada, N. Yoshimura, Y. Saito, Y. Takeda, K. Umemura, K. Kondo, Y. Ikeda, K. Fukunaga, M. Nakashima, A. Beretta, I. Bjarnason, and R. Lofberg.

    Multiple Authorship (Including Foreigners)

  • Inhibition of cell spreading in CHO cells transfected with cDNA of a glycosylphosphatidyl inositol-anchored protein, GPI-80.(共著）, Immunobiology, 210(1) 1-10, 2005.04

    Anzai-Takeda, Y., Y. Takeda, F. Sendo, and Y. Araki.

    Multiple Authorship (Including Foreigners)

  • Adhesion dependent release of hepatocyte growth factor and interleukin-1 receptor antagonist from human blood granulocytes and monocytes: evidence for the involvement of plasma IgG, complement C3 and beta2 integrin, Inflamm Res, 2004.07

    Takeda, Y. Shiobara, N. Saniabadi, A. R. Adachi, M. Hiraishi, K.

    Multiple Authorship (Including Foreigners)

  • Molecular proximity of complement receptor type 3 (CR3) and the glycosylphosphatidylinositol-linked protein GPI-80 on neutrophils: effects of cell adherence, exogenous saccharides, and lipid raft disrupting agents, Mol Immunol, 40(17) 1249-1256, 2004.03

    Huang, J. B. Takeda, Y. Araki, Y. Sendo, F. Petty, H. R.

    Multiple Authorship (Including Foreigners)

  • Glycosylphosphatidyl inositol-anchored protein (GPI-80) gene expression is correlated with human thymoma stage, Cancer Sci, 94(9) 809-13, 2003.09

    Sasaki, H. Ide, N. Sendo, F. Takeda, Y. Adachi, M. Fukai, I. Fujii, Y.

    Multiple Authorship (Including Foreigners)

  • Expression of GPI-80, a beta2-integrin-associated glycosylphosphatidylinositol-anchored protein, requires neutrophil differentiation with dimethyl sulfoxide in HL-60 cells, Exp Cell Res, 286(2) 199-208, 2003.06

    Takeda, Y. Fu, J. Suzuki, K. Sendo, D. Nitto, T. Sendo, F. Araki, Y.

    Multiple Authorship (Including Foreigners)

  • Studies on the mechanisms of leukocyte adhesion to cellulose acetate beads: an in vitro model to assess the efficacy of cellulose acetate carrier-based granulocyte and monocyte adsorptive apheresis, Ther Apher Dial, 7(3) 334-340, 2003.06

    Hiraishi, K. Takeda, Y. Shiobara, N. Shibusawa, H. Jimma, F. Kashiwagi, N. Saniabadi, A. R. Adachi, M.

    Multiple Authorship (Including Foreigners)

  • Cellulose acetate beads induce release of interleukin-1 receptor antagonist, but not tumour necrosis factor-alpha or interleukin-1beta in human peripheral blood, Inflamm Res, 52(7) 287-290, 2003.06

    Takeda, Y. Hiraishi, K. Takeda, H. Shiobara, N. Shibusawa, H. Saniabadi, A. R. Adachi, M. Kawata, S.

    Single Author

  • Localization of GPI-80, a beta2-integrin-associated glycosylphosphatidyl-inositol anchored protein, on strongly CD14-positive human monocytes, Immunobiology, 207(3) 217-221, 2003

    Sendo, D. Takeda, Y. Ishikawa, H. Sendo, F. Araki, Y.

    Multiple Authorship (Including Foreigners)

  • GPI-80, a beta2 integrin associated glycosylphosphatidylinositol-anchored protein, concentrates on pseudopodia without association with beta2 integrin during neutrophil migration, Immunobiology, 208(4) 391-399, 2003

    Yoshitake, H. Takeda, Y. Nitto, T. Sendo, F. Araki, Y.

    Multiple Authorship (Including Foreigners)

  • Pharmacological analysis for mechanisms of GPI-80 release from tumour necrosis factor-alpha-stimulated human neutrophils, Br J Pharmacol, 137(3) 353-360, 2002.10

    Nitto, T. Araki, Y. Takeda, Y. Sendo, F.

    Multiple Authorship (Including Foreigners)

  • Cross-linking of GPI-80, a possible regulatory molecule of cell adhesion, induces up-regulation of CD11b/CD18 expression on neutrophil surfaces and shedding of L-selectin, J Leukoc Biol, 71(2) 205-211, 2002.02

    Yoshitake, H. Takeda, Y. Nitto, T. Sendo, F.

    Multiple Authorship (Including Foreigners)

  • Immunohistochemical localization in human tissues of GPI-80, a novel glycosylphosphatidyl inositol-anchored protein that may regulate neutrophil extravasation, Cell Tissue Res, 307(1) 91-99, 2002.01

    Koike, S. Takeda, Y. Hozumi, Y. Okazaki, S. Aoyagi, M. Sendo, F.

    Multiple Authorship (Including Foreigners)

  • A sandwich ELISA for detection of soluble GPI-80, a glycosylphosphatidyl-inositol (GPI)-anchored protein on human leukocytes involved in regulation of neutrophil adherence and migration--its release from activated neutrophils and presence in synovial fluid of rheumatoid arthritis patients., Microbiol Immunol, 45(6) 467-71, 2001

    Huang, J. Takeda, Y. Watanabe, T. Sendo, F.

    Multiple Authorship (Including Foreigners)

  • A novel glycosylphosphatidyl inositol-anchored protein on human leukocytes: a possible role for regulation of neutrophil adherence and migration, J Immunol, 1999.04

    Suzuki K, Watanabe T, Sakurai S, Ohtake K, Kinoshita T, Araki A, Fujita T, Takei H, Takeda Y, Sato Y, Yamashita T, Araki Y, Sendo F,

    Multiple Authorship (Including Foreigners)

  • Modulation of leukocyte transendothelial migration by integrin-associated glycosyl phosphatidyl inositol (GPI)-anchored proteins, Inflamm Res, 1998.01

    Sendo F, Suzuki K, Watanabe T, Takeda Y, Araki Y

    Multiple Authorship (Including Foreigners)

  • Apoptosis and in vivo distribution and clearance of eosinophils in normal and Trichinella spiralis-infected rats, J Leukoc Biol, 1997.09

    Gon S, Saito S, Takeda Y, Miyata H, Takatsu K, Sendo F,

    Multiple Authorship (Including Foreigners)

  • TNF/TNFR gene and apoptosis, 日本臨床, 54(7) 1888-1894, 1996.06

    Takeda, Y. Gon, S. Takei, H. Sendo, F.

    Multiple Authorship (Including Foreigners)

  • Inhibition by dexamethasone of human neutrophil apoptosis in vitro, Nat Immun, 1995.04

    Kato T, Takeda Y, Nakada T, Sendo F

    Multiple Authorship (Including Foreigners)

  • In vivo regulation of rat neutrophil apoptosis occurring spontaneously or induced with TNF-alpha or cycloheximide, J Immunol, 1995.03

    Tsuchida H, Takeda Y, Takei H, Shinzawa H, Takahashi T, Sendo F

    Single Author

  • Inhibition by bacterial lipopolysaccharide of spontaneous and TNF-alpha-induced human neutrophil apoptosis in vitro, Microbiol Immunol, 1995.01

    Hachiya O, Takeda Y, Miyata H, Watanabe H, Yamashita T, Sendo F

    Multiple Authorship (Including Foreigners)

  • Rapid acceleration of neutrophil apoptosis by tumor necrosis factor-alpha, International Immunology, 1993.06

    Takeda Y, Watanabe H, Yonehara S, Yamashita T, Saito S, Sendo F

    Multiple Authorship (Including Foreigners)

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Review Papers

  • 5-アミノレブリン酸(5-ALA)生合成不全マウスにおける非肥満型インスリン抵抗性の発症と免疫応答・サイトカイン産生能の低下, 日本分子生物学会年会プログラム・要旨集(Web), 44th , 2021

    斉藤真一, 武田裕司, VAN WIJK Koen, 中島修, 浅尾裕信

  • 5-アミノレブリン酸(5-ALA)生合成不全マウスにおける非肥満型インスリン抵抗性の発症と免疫応答・サイトカイン産生能の低下, 日本インターフェロン・サイトカイン学会学術集会抄録集, 85th (CD-ROM) , 2021

    斉藤真一, 武田裕司, VAN WIJK Koen, 中島修, 浅尾裕信

  • An Analysis of the Intracellular Signal Transduction of Peripheral Blood Leukocytes in Animal Models of Diabetes Using Flow Cytometry, Methods Mol Biol , 1916 177-193, 2019.12

    Takeda, Y. Asao, H. Wakabayashi, I.

  • 5-アミノレブリン酸(ALA)生合成不全マウスにおける非肥満型糖尿病モデルの検討と免疫異常の解析, 日本分子生物学会年会プログラム・要旨集(Web), 42nd , 2019

    斉藤真一, 武田裕司, WIJK Koen Van, 木村朋寛, 岡野聡, 中島修, 浅尾裕信

  • 転移性腎細胞癌患者の末梢血におけるGPI-80発現の臨床的意義(Clinical significance of GPI-80 expression in peripheral blood of metastatic renal cell cancer patients), 日本癌学会, 日本癌学会総会記事, 77回 1681, 2018.09

    加藤 智幸, 武田 裕司, 黒田 悠太, 伊藤 裕美, 成澤 貴史, 菅野 秀典, 八木 真由, 櫻井 俊彦, 内藤 整, 川添 久, 山辺 拓也, 浅尾 裕信, 土谷 順彦

  • IL-21 promotes the differentiation of duodenum migration-type neutrophils., 69(5) 442-449, 2018.05

    Takeda,Y. Nara, H. Araki, A. Asao, H.

  • Relationship between Immunological Abnormalities in Rat Models of Diabetes Mellitus and the Amplification Circuits for Diabetes, Journal of Diabetes Research, 2017.02

    Takeda, Y., T. Shimomura, H. Asao, I. Wakabayashi

  • The mode of actions of the Adacolumn therapeutic leucocytapheresis in patients with inflammatory bowel disease: a concise review., Clin Exp Immunol , 163(1) 50-58, 2010.11

    Hanai, H. Takeda, Y. Eberhardson, M. Gruber, R. Saniabadi, A. R. Winqvist, O. Lofberg, R.

  • Regulation of neutrophil apoptosis--its biological significance in inflammation and the immune response, Hum Cell, 1996.09

    Sendo F, Tsuchida H, Takeda Y, Gon S, Takei H, Kato T, Hachiya O, Watanabe H

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Academic Awards Received

  • Yamagata University Medical Society Research Special Award (Silver medal), 2017.02.15, Japan, Yuji Takeda

Grant-in-Aid for Scientific Research

  • Grant-in-Aid for Scientific Research(C)，2023.04 - 2026.03

  • Grant-in-Aid for Scientific Research(C)，2023.04 - 2024.03

  • Grant-in-Aid for Scientific Research(C)，2022.04 - 2023.03

  • Grant-in-Aid for Scientific Research(C)，2020.04 - 2023.03

  • Grant-in-Aid for Scientific Research(C)，2019.04 - 2022.03

  • Grant-in-Aid for Scientific Research(C)，2019.04 - 2022.03

  • Grant-in-Aid for Scientific Research(C)，2018.04 - 2021.03

  • Grant-in-Aid for Scientific Research(C)，2018.04 - 2019.03

  • Grant-in-Aid for Scientific Research(C)，2017.04 - 2020.03

  • Grant-in-Aid for Scientific Research(C)，2015.04 - 2018.03

  • Grant-in-Aid for Scientific Research(C)，2013.04 - 2016.03

  • Grant-in-Aid for Scientific Research(C)，2010.04 - 2013.03

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Other external funds procured

  • Clinical application of cancer immunity-induced neutrophils and immunosuppressive neutrophils，2023.04 - 2026.03，Clinical application of cancer immunity-induced neutrophils and immunosuppressive neutrophils

    Japan Society for the Promotion of Science

  • Search for TPO for immunotherapy using immunosuppressive neutrophils and cancer immune-promoting neutrophils，2020.04 - 2023.03，Search for TPO for immunotherapy using immunosuppressive neutrophils and cancer immune-promoting neutrophils

    Japan Society for the Promotion of Science

  • Expression and function analysis of MDSC as a predictive factor of novel immunotherapy with GPI-80，2019.04 - 2022.03，Expression and function analysis of MDSC as a predictive factor of novel immunotherapy with GPI-80

    In chronic inflammatory conditions such as renal cancer, MDSCs appear and suppress the cancer immune response. We have previously established a method for analyzing MDSCs in the peripheral blood of patients with renal cancer using the expression level and coefficient variation of GPI-80, combining with myeloid-differentiation markers. We investigated changes in the number and function of MDSCs using peripheral blood before and during cancer therapies.
    The increasing MDSCs indexes (CD16 and LAP-1 expression level) were associated with poor response to each cancer therapy. In cases of immune-related side effects, GPI-80 coefficient variation, which is other MDSCs indicators, was reduced. In the case of complete response, neutrophils with increased GPI-80 expression level were significantly observed before the therapie. Since GPI-80 was involved in the activation of NF-κB, it is possible that it is involved in neutrophil function that enhances the cancer immune response.

    Japan Society for the Promotion of Science

  • A novel model of the non-obese diabetes and investigation of immune abnormality，2019.04 - 2022.03，A novel model of the non-obese diabetes and investigation of immune abnormality

    The chronic inflammation caused by obesity is thought to be the underlying pathology of type 2 diabetes and its complications. Elucidation of the mechanism of inflammation-induced insulin resistance is important in the prevention of intervention in metabolic syndrome. We establish a novel animal model for non-obese diabetes and uncover a link between glucose metabolism and inflammatory response.
    5-Aminolevulinic acid (5-ALA) is a natural amino acid and the first precursor of heme biosynthesis. 5-ALA or heme is associated with glucose metabolism in vivo. We previously showed that 5-ALA synthase ALAS1 heterozygous (Alas1+/-) mice displayed insulin resistance, which was cured by 5-ALA administration.
    Here, we test whether 5-ALA have any potential effect on innate immune system. Alas1+/- mice exhibited reduced inflammatory responses and 5-ALA administration increased ROS production in neutrophils. These findings show that 5-ALA is a potential therapeutic target against metabolic syndrome.

    Japan Society for the Promotion of Science

  • Defective biosynthesis of ascorbic acid in Sod1-deficient mice results in lethal damage to lung tissue，2018.07 - 2020.10，Defective biosynthesis of ascorbic acid in Sod1-deficient mice results in lethal damage to lung tissue

    Superoxide dismutase 1 (Sod1) plays pivotal roles in antioxidation via accelerating the conversion of superoxide anion radicals into hydrogen peroxide, thus inhibiting the subsequent radical chain reactions. While Sod1 deficient cells inevitably undergo death in culture conditions, Sod1-knockout (KO) mice show relatively mild phenotypes and live approximately two years. We hypothesized that the presence of abundant levels of ascorbic acid (AsA), which is naturally produced in mice, contributes to the elimination of reactive oxygen species (ROS) in Sod1-KO mice. To verify this hypothesis, we employed mice with a genetic ablation of aldehyde reductase (Akr1a), an enzyme that is involved in the biosynthesis of AsA, and established double knockout (DKO) mice that lack both Sod1 and Akr1a. Supplementation of AsA (1.5 mg/ml in drinking water) was required for the DKO mice to breed, and, upon terminating the AsA supplementation, they died within approximately two weeks regardless of age or gender. We explored the etiology of the death from pathophysiological standpoints in principal organs of the mice. Marked changes were observed in the lungs in the form of macroscopic damage after the AsA withdrawal. Histological and immunological analyses of the lungs indicated oxidative damage of tissue and activated immune responses. Thus, preferential oxidative injury that occurred in pulmonary tissues appeared to be primary cause of the death in the mice. These collective results suggest that the pivotal function of AsA in coping with ROS in vivo, is largely in pulmonary tissues that are exposed to a hyperoxygenic microenvironment.

    Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University

  • Enhancement of anti-tumor immunity with membrane-bound interleukin 12 (IL-12)，2018.04 - 2021.03，Enhancement of anti-tumor immunity with membrane-bound interleukin 12 (IL-12)

    IL-12 is an important cytokine for the induction of Th1 cell-mediated immunity. There are secretory and membrane-bound types of IL-12, and we have reported that membrane-bound IL-12 exhibits stronger Th1 inducibility than the secretory type. Therefore, we thought that regulation of membrane-bound IL-12 expression might promote anti-tumor immunity mediated by Th1 response. To this end, we first attempted to elucidate the secretory mechanism of membrane-bound IL-12, and found that a proteolytic enzyme called ADAM17 may be indirectly involved. Membrane-bound IL-12 is expected to be associated with some molecule that is cleaved by ADAM17 and is currently being searched for that molecule.

    Japan Society for the Promotion of Science

  • Establishment of separation method for immunosuppressive neutrophils and antitumor neutrophils in renal cancer and bladder cancer，2017.04 - 2020.03，Establishment of separation method for immunosuppressive neutrophils and antitumor neutrophils in renal cancer and bladder cancer

    In renal cancer patients, immunosuppressive neutrophils called myeloid-derived suppressor cells (MDSCs) appear due to cancerous chronic inflammation. On the other hand, intravesical BCG instillation therapy for non-muscle invasive bladder cancer induces strong inflammation and provides a strong anti-tumor immune response. In this study, we investigated the BCG-induced inflammatory response and tried to find the indicators of neutrophil-like cells associated with anti-tumor immune response. As a result, no increase in MDSCs was observed during the BCG treatment. While, the expression of HLA-II and CXCL10 were increased in neutrophil-like cells in urine. Since it is known that HLA-II and CXCL10 induce activation of the adaptive immune system, it was considered that they could be useful indicators of anti-tumor neutrophil-like cells.

    Japan Society for the Promotion of Science

  • Physiological heating augments the anti-inflammatory reactions during granulocyte/monocyte apheresis: A in vitro study，2015.11 - 2020.10，Physiological heating augments the anti-inflammatory reactions during granulocyte/monocyte apheresis: A in vitro study

    Granulocyte and monocyte adsorptive apheresis (GMA), an effective therapy for inflammatory disorders, exerts an anti-inflammatory influence by utilizing the biological reaction between blood and cellulose acetate (CA) beads, which are the carriers of the GMA column. Although the biological reaction has an optimum temperature, blood contacts the CA beads below body temperature as GMA is performed in an extracorporeal circulation system. We investigated various soluble factors in blood treated with CA beads at 25 degrees C and 37 degrees C. Here, the optimal temperature for IL-1 receptor antagonist (IL-1ra) release induced by CA beads was 37 degrees C, and IL-6 production from monocytic cells was inhibited by the addition of plasma prepared from the CA bead-treated blood at 37 degrees C, rather than at 25 degrees C. These results indicated that physiological heating of the apheresis carrier augmented the anti-inflammatory reaction in vitro. Thus, heating during GMA may be a new approach for augmenting clinical efficacy.

    Department of Gastroenterology, Yamagata University Faculty of Medicine

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Joint Research activities

  • Defective biosynthesis of ascorbic acid in Sod1-deficient mice results in lethal damage to lung tissue, 2018.07 - 2020.10, Collaboration in College

  • Physiological heating augments the anti-inflammatory reactions during granulocyte/monocyte apheresis: A in vitro study, 2015.11 - 2020.10, Collaboration in College

  • Midnolin is a novel regulator of parkin expression and is associated with Parkinson's Disease, 2015.07 - 2017.07, Collaboration in College

 

Social Activities

  • Topic Editor of International Journal of Molecular Sciences，2021.01 - 2021.08

    Section Topics Board Editors for 'Molecular Immunology'

    Guest editor for special issue 'The Role of Interleukin in Health and Diseases'
    https://www.mdpi.com/journal/ijms/special_issues/interleukin

  • Topic Editor of International Journal of Molecular Sciences，2021.01 - 2021.08

    Section Topics Board Editors for 'Molecular Immunology'

    Guest editor for special issue 'The Role of Interleukin in Health and Diseases'
    https://www.mdpi.com/journal/ijms/special_issues/interleukin