Updated on 2024/04/04

写真a

 
MIZUNO Dai
 
Contact information
メールアドレス

Research Areas

  • Life Science / Pharmaceutical hygiene and biochemistry

External Career

  • , Part-time Lecturer, 2012.04 -

  • Yamagata University, Associate Professor, 2015.04 -

 

Papers

  • Toxic Effects of Two Redox States of Thallium on Immortalised Hypothalamic GT1-7 Neuronal Cells, International Journal of Molecular Sciences, 24(11583) 1-14, 2023.07

    Mizuno D, Kawahara M, Konoha-Mizuno K, Ogawara T, Hama R, Yamazaki K

    Multiple Authorship (Only Japanese)

  • Enhancing Cytotoxicity of Tamoxifen Using Geranium Oil, Evidence-Based Complementary and Alternative Medicine, 2022(8091339) 1-9, 2022.03

    Mizuno D, Konoha–Mizuno K, Kawahara M, Yamazaki K

    Multiple Authorship (Only Japanese)

  • Induction of protective immunity and maintenance of its memory against influenza A virus by nasal vaccination using a new mucosal adjuvant SF-10 derived from pulmonary surfactant in young cynomolgus monkeys, Vaccine, 34(16) 1181-1188, 2016.04

    Mizuno D, Kimoto T, Sakai S, Takahashi E, Kim H, Kido H

    Multiple Authorship (Including Foreigners)

  • An in vitro system comprising immortalized hypothalamic neuronal cells (GT1–7 cells) for evaluation of the neuroendocrine effects of essential oils., Evidence-Based Complementary and Alternative Medicine, 2015(343942) 1-7, 2015.10

    Mizuno D, Konoha–Mizuno K, Mori M, Yamazaki K, Haneda T, Koyama H, Kawahara M

    Multiple Authorship (Including Foreigners)

  • Protective activity of carnosine and anserine against zinc-induced neurotoxicity: a possible treatment for vascular dementia., Metallomics, 7 1233-1239, 2015

    Mizuno D, Konoha-Mizuno K, Mori M, Sadakane Y, Koyama H, Ohkawara S, Kawahara M

    Multiple Authorship (Only Japanese)

  • Carnosine: A Possible Drug for Vascular Dementia., Journal of Vascular Medicine & Surgery, 2 146, 2014

    Mizuno D, Kawahara M

    Multiple Authorship (Including Foreigners)

  • Involvement of trace elements in the pathogenesis of prion diseases., Current Pharmaceutical Biotechnology, 15 1049-1057, 2014

    Mizuno D, Koyama H, Ohkawara S, Sadakane Y , Kawahara M

    Multiple Authorship (Only Japanese)

  • The involvement of endoplasmic reticulum-stress in zinc neurotoxicity and the pathogenesis of vascular type senile dementia., International Journal of Molecular Sciences, 14 22067-22081, 2013

    Mizuno D, Kawahara M

    Multiple Authorship (Including Foreigners)

  • Surfactant protein C is an essential constituent for mucosal adjuvanticity of Surfacten, acting as an antigen delivery vehicle and inducing both local and systemic immunity, Vaccine, 29 5368-5378, 2011

    Mizuno D, Kimoto T, Takei T, Fukuta A, Shinahara W, Takahashi E, Yano M, Kido H

    Multiple Authorship (Including Foreigners)

  • Modified pulmonary surfactant is a potent adjuvant that stimulates the mucosal IgA production in response to the influenza virus antigen., The Journal of Immunology, 176 1122-1130, 2006

    Mizuno D, Ide-Kurihara M, Ichinomiya T, Kubo I, Kido H

    Multiple Authorship (Only Japanese)

  • Regulation of CYP2D expression in rat brain by toluene, Osaka City Medical Journal, 49 49-56, 2003

    Mizuno D, Hiroi T, Ng PS, Kishimoto W, Imaoka S, and Funae Y

    Multiple Authorship (Including Foreigners)

  • A novel transcriptional element which regulates expression of the CYP2D4 gene by Oct-1 and YY-1 binding, Biochimica et Biophysica Acta, 1627 121-128, 2003

    Mizuno D, Takahashi Y, Hiroi T, Imaoka S, Kamataki T, and Funae Y

    Multiple Authorship (Including Foreigners)

  • Chlorzoxazone: a probe drug whose metabolism can be used to monitor toluene exposure in rats, Archives of Toxicology , 74 139-144, 2000

    Mizuno D, Tanaka E, Tanno K, Misawa S

    Multiple Authorship (Only Japanese)

  • Quantitative analysis of carnosine and anserine in foods by performing high performance liquid chromatography, Biomedical Research on Trace Elements, 26(3) 147-152, 2015.12

    Mori M, Mizuno D, Konoha-Mizuno K, Sadakane Y, Kawahara M

    Multiple Authorship (Including Foreigners)

  • Oral Administration of Lactobacillus pentosus Strain S-PT84 Enhances Anti-Influenza Virus-Specific IgG Production in Plasma after Limited Dose of Influenza Virus Vaccination in Mice., J Vac Immunotechnol, 2 1-5, 2015

    Maekawa T, Kimoto T, Mizuno D, Furukawa Y, Ida M, Takahashi E, Izumo T, Ono Y, Shibata H, Kido H

    Multiple Authorship (Including Foreigners)

  • Carnosine concentration in the muscle of thoroughbred horses and its implications in exercise performance, Trace Element Research, 32 49-53, 2015

    Mori M, Mizuno D, Konoha-Mizuno K, Sadakane Y, Kawahara M

    Multiple Authorship (Including Foreigners)

  • Disruption of Zinc Homeostasis and the Pathogenesis of Senile Dementia., Metallomics, 6 209-219, 2014

    Kawahara M, Mizuno D, Koyama H, Konoha K, Ohkawara S, Sadakane Y

    Multiple Authorship (Including Foreigners)

  • Intranasal influenza vaccination using a new synthetic mucosal adjuvant SF-10: induction of potent local and systemic immunity with balanced Th1 and Th2 responses, Influenza Other Respi Viruses, 7 1218-1226, 2013

    Kimoto T, Mizuno D, Takei T, Kunimi T, Ono S, Sakai S, Kido H

    Multiple Authorship (Including Foreigners)

  • Immunomodulator clarithromycin enhances mucosal and systemic immune responses and reduces re-infection rate in pediatric patients with influenza treated with antiviral neuraminidase inhibitors: a retrospective analysis., PLoS One, 8 e70060, 2013

    Shinahara W, Takahashi E, Sawabuchi T, Arai M, Hirotsu N, Takasaki Y, Shindo S, Shibao K, Yokoyama T, Nishikawa K, Mino M, Iwaya M, Yamashita Y, Suzuki S, Mizuno D, Kido H

    Multiple Authorship (Including Foreigners)

  • Oral clarithromycin enhances airway IgA immunity through induction of IgA class switching recombination and B-cell activating factor of the tumor necrosis factor family molecule on mucosal dendritic cells in mice infected with influenza A virus., J Virol, 86 10924-10934, 2012

    Takahashi E, Kataoka K, Indalao I, Konoha K, Fujii K, Chida J, Mizuno D, Fujihashi K, Kido H

    Multiple Authorship (Including Foreigners)

  • Attenuation of inducible respiratory immune responses by oseltamivir treatment in mice infected with influenza A virus, Microbes Infect, 12 778-783, 2010

    Takahashi E, Kataoka K, Fujii K, Chida J, Mizuno D, Fukui M, Hiro-O Ito, Fujihashi K, Kido H

    Multiple Authorship (Including Foreigners)

  • Influenza vaccine with Surfacten, a modified pulmonary surfactant, induces systemic and mucosal immune responses without side effects in minipigs. , Vaccine, 27 5620-5627, 2009

    Nishino M, Mizuno D, Kimoto T, Shinahara W, Fukuta A, Takei T, Sumida K, Kitamura S, Shiota H, Kido H

    Multiple Authorship (Including Foreigners)

  • Evaluation of nasal IgA secretion in normal subjects by nasal spray and aspiration, Auris Nasus Larynx, 6 300-304, 2009

    Fujimoto C, Kido H, Sawabuchi T, Mizuno D, Hayama M, Yanagawa H, Takeda N

    Multiple Authorship (Including Foreigners)

  • New effective nasal immunization of influenza vaccine by a natural mucosal adjuvant from the lung and its synthetic compound, Options for the Control of Influenza, 4 616-618, 2008

    Kido H, Mizuno D, Takei T, Nishino M, Shinahara W

    Multiple Authorship (Including Foreigners)

  • Boost of mucosal secretory immunoglobulin A response by clarithromycin in paediatric influenza, Respirology, 14 1173-1179, 2006

    Sawabuchi T, Suzuki S, Iwase K, Ito C, Mizuno D, Togari H, Watanabe I, Talukder SR, Chida J, Kido H

    Multiple Authorship (Including Foreigners)

  • Secretory leukoprotease inhibitor and pulmonary surfactant serve as principal defenses against influenza A virus infection in the airway and chemical agents up-regulating their levels may have therapeutic potential, Biol Chem, 385 1029-1034, 2004

    Cui P, Sharmin S, Okumura Y, Yamada H, Yano M, Mizuno D, and Kido H

    Multiple Authorship (Including Foreigners)

  • Age- and sex-related changes in toluene metabolism by rat hepatic microsomes in vitro, Res Commun Mol Pathol Pharmacol, 104 265-276, 1999

    Shimamoto A, Tanaka E, Mizuno D, Misawa S

    Multiple Authorship (Including Foreigners)

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Books

  • Link between metal homeostasis and neurodegenerative diseases: crosstalk of metals and amyloidogenic proteins at the synapse. In Metallomics - Analytical Techniques and Applications, Springer, 2017

    Mizuno D, Kawahara M

  • Disruption of Metal Homeostasis and the Pathogenesis of Prion Diseases. In Prion - An Overview, InTech, 2017

    Kawahara M, Tanaka K, Mizuno D

  • Neuroprotective Effects of Carnosine: Possible Treatment for Neurodegenerative Disease. In Carnosine: Physiological Effects and Research Insights, Nova Science Publishers, 2016

    Kawahara M, Tanaka K, Mizuno D

  • Oligomerization of proteins and neurodegenerative diseases. In Oligomerization of Chemical and Biological Compounds, InTech, 2014

    Mizuno D, Kawahara M

Grant-in-Aid for Scientific Research

  • Grant-in-Aid for Scientific Research(C),2024.04 - 2026.03

  • Grant-in-Aid for Scientific Research(C),2014.04 - 2017.03

  • Grant-in-Aid for Scientific Research(C),2012.04 - 2015.03

  • Grant-in-Aid for Young Scientists(B),2010.04 - 2011.03

  • Grant-in-Aid for Young Scientists(B),2006.04 - 2009.03

Other external funds procured

  • 21st Century COE Program,2005.04 - 2006.03

    Ministry of Education, Culture, Sports, Science and Technology

 

Academic Activity

  • 日本社会医療学会, 2015.10 -

Academic Activities

  • Biological and Pharmaceutical Bulletin 論文審査,2018.10