Life Science / Molecular biology

LAT1 inhibitor JPH203 sensitizes cancer cells to radiation by enhancing radiation-induced cellular senescence, TRANSLATIONAL ONCOLOGY, 14(11) 101212, 2021.11

Bo Tomoki, Kobayashi Sho, Inanami Osamu, Fujii Junichi, Nakajima Osamu, Ito Tsunekata, Yasui Hironobu

Single Author

Nitric oxide protects against ferroptosis by aborting the lipid peroxidation chain reaction, NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 115 34-43, 2021.10

Homma Takujiro, Kobayashi Sho, Conrad Marcus, Konno Hiroyuki, Yokoyama Chikako, Fujii Junichi

Single Author

Carnosine dipeptidase II (CNDP2) protects cells under cysteine insufficiency by hydrolyzing glutathione-related peptides, FREE RADICAL BIOLOGY AND MEDICINE, 174 12-27, 2021.10

Kobayashi Sho, Homma Takujiro, Okumura Nobuaki, Han Jia, Nagaoka Keita, Sato Hideyo, Konno Hiroyuki, Yamada Sohsuke, Takao Toshifumi, Fujii Junichi

Single Author

Nitric oxide produced by NOS2 copes with the cytotoxic effects of superoxide in macrophages., Biochemistry and biophysics reports, 26 100942, 2021.07

Kobayashi S, Homma T, Fujii J

Single Author

Superoxide produced by mitochondrial complex III plays a pivotal role in the execution of ferroptosis induced by cysteine starvation, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 700 108775, 2021.03

Homma Takujiro, Kobayashi Sho, Sato Hideyo, Fujii Junichi

Single Author

Characterization of a rat monoclonal antibody raised against ferroptotic cells, JOURNAL OF IMMUNOLOGICAL METHODS, 489 112912, 2021.02

Kobayashi Sho, Harada Yumi, Homma Takujiro, Yokoyama Chikako, Fujii Junichi

Single Author

Erythrocytes as a preferential target of oxidative stress in blood, FREE RADICAL RESEARCH, 1-19, 2021.01

Fujii Junichi, Homma Takujiro, Kobayashi Sho, Warang Prashant, Madkaikar Manisha, Mukherjee Malay B.

Single Author

Iron loading exerts synergistic action via a different mechanistic pathway from that of acetaminophen-induced hepatic injury in mice, FREE RADICAL RESEARCH, 54(8-9) 606-619, 2020.09

Moon Gyul, Kobayashi Sho, Naing Ye Aung, Yamada Ken-ichi, Yamakawa Mitsunori, Fujii Junichi

Single Author

Cysteine preservation confers resistance to glutathione-depleted cells against ferroptosis via CDGSH iron sulphur domain-containing proteins (CISDs), FREE RADICAL RESEARCH, 54(6) 397-407, 2020.06

Homma Takujiro, Kobayashi Sho, Fujii Junichi

Single Author

gamma-Glutamylcysteine synthetase and gamma-glutamyl transferase as differential enzymatic sources of gamma-glutamylpeptides in mice, AMINO ACIDS, 52(4) 555-566, 2020.04

Kobayashi Sho, Ikeda Yoshitaka, Shigeno Yuhei, Konno Hiroyuki, Fujii Junichi

Single Author

Heterozygous SOD1 deficiency in mice with an NZW background causes male infertility and an aberrant immune phenotype, FREE RADICAL RESEARCH, 53(11-12) 1060-1072, 2019.12

Homma Takujiro, Takeda Yuji, Sakahara Satoshi, Ishii Naoki, Kobayashi Sho, Abe Hiroyuki, Asao Hironobu, Fujii Junichi

Single Author

Ascorbic acid insufficiency impairs spatial memory formation in juvenile AKR1A-knockout mice, JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 65(3) 209-216, 2019.11

Kurihara Kazuki, Homma Takujiro, Kobayashi Sho, Shichiri Mototada, Fujiwara Hiroki, Fujii Satoshi, Yamada Ken-ichi, Nakane Masaki, Kawamae Kaneyuki, Fujii Junichi

Single Author

Edaravone, a free radical scavenger, protects against ferroptotic cell death in vitro, EXPERIMENTAL CELL RESEARCH, 384(1) 111592, 2019.11

Homma Takujiro, Kobayashi Sho, Sato Hideyo, Fujii Junichi

Single Author

Induction of ferroptosis by singlet oxygen generated from naphthalene endoperoxide, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 518(3) 519-525, 2019.10

Homma Takujiro, Kobayashi Sho, Fujii Junichi

Single Author

Ferroptosis caused by cysteine insufficiency and oxidative insult, FREE RADICAL RESEARCH, 1-12, 2019.09

Fujii Junichi, Homma Takujiro, Kobayashi Sho

Single Author

Oxidative stress triggers systemic organ disorders associated with impaired lipid catabolism in mice during fasting, FREE RADICAL BIOLOGY AND MEDICINE, 139 S29, 2019.08

Homma Takujiro, Lee Jaeyong, Kobayashi Sho, Ishii Naoki, Fujii Junichi

Single Author

Quantitative analysis of γ-glutamylpeptides by liquid chromatography-mass spectrometry and application for γ-glutamyltransferase assays, Anal Biochem, 2019

Kobayashi S, Tokairin Y, Miyakoshi T, Saito T, Nagaoka K, Ikeda Y, Fujii J, Konno H

Multiple Authorship (Only Japanese)

Mutual interaction between oxidative stress and endoplasmic reticulum stress in the pathogenesis of diseases specifically focusing on non-alcoholic fatty liver disease., World journal of biological chemistry, 9(1) 1-15, 2018.10

Fujii J, Homma T, Kobayashi S, Seo HG

Single Author

Mice deficient in aldo-keto reductase 1a (Akr1a) are resistant to thioacetamide-induced liver injury, TOXICOLOGY LETTERS, 294 37-43, 2018.09

Homma Takujiro, Shirato Takaya, Akihara Ryusuke, Kobayashi Sho, Lee Jaeyong, Yamada Ken-ichi, Miyata Satoshi, Takahashi Motoko, Fujii Junichi

Single Author

Unveiling systemic organ disorders associated with impaired lipid catabolism in fasted SOD1-deficient mice, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 654 163-171, 2018.09

Lee Jaeyong, Homma Takujiro, Kobayashi Sho, Ishii Naoki, Fujii Junichi

Single Author

Cystine/glutamate transporter, system x(c)(-), is involved in nitric oxide production in mouse peritoneal macrophages, NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 78 32-40, 2018.08

Kobayashi Sho, Hamashima Shinji, Homma Takujiro, Sato Mami, Kusumi Ryosuke, Bannai Shiro, Fujii Junichi, Sato Hideyo

Single Author

The ferroptosis inducer erastin irreversibly inhibits system x(c)- and synergizes with cisplatin to increase cisplatin's cytotoxicity in cancer cells, SCIENTIFIC REPORTS, 8(1) 968, 2018.01

Sato Mami, Kusumi Ryosuke, Hamashima Shinji, Kobayashi Sho, Sasaki Satoru, Komiyama Yuhei, Izumikawa Takuji, Conrad Marcus, Bannai Shiro, Sato Hideyo

Single Author

Cystine/glutamate transporter, system xc-, is involved in nitric oxide production in mouse peritoneal macrophages. , Nitric Oxide, 78 32-40, 2018

Kobayashi S, Hamashima S, Homma T, Sato M, Kusumi R, Bannai S, Fujii J, Sato H.

Multiple Authorship (Including Foreigners)

Mice deficient in aldo-keto reductase 1a (Akr1a) are resistant to thioacetamide-induced liver injury., Toxicol Lett, 294 37-43, 2018

Homma T, Shirato T, Akihara R, Kobayashi S, Lee J, Yamada K, Miyata S, Fujii J.

Multiple Authorship (Including Foreigners)

Unveiling systemic organ disorders associated with impaired lipid catabolism in fasted SOD1-deficient mice. , Arch Biochem Biophys, 654 163-171, 2018

Lee J, Homma T, Kobayashi S, Ishii N, Fujii J.

Multiple Authorship (Only Japanese)

The ferroptosis inducer erastin irreversibly inhibits system xc- and synergizes with cisplatin to increase cisplatin's cytotoxicity in cancer cells., Sci Rep, 8 968, 2018

Sato M, Kusumi R, Hamashima S, Kobayashi S, Sasaki S, Komiyama Y, Izumikawa T, Conrad M, Bannai S, Sato H

Single Author

ACSL4 Dictates Ferroptosis Sensitivity by Shaping Cellular Lipid Composition., Nature Chemical Biology, 91-98, 2017

Sebastian Doll, Bettina Proneth, Yulia Y Tyurina, Elena Panzilius, Sho Kobayashi, Irina Ingold, Martin Irmler, Johannes Beckers, Michaela Aichler, Axel Walch, Holger Prokisch, Dietrich Trumbach, Gaowe...

Multiple Authorship (Including Foreigners)

xCT deficiency aggravates acetaminophen-induced hepatotoxicity under inhibition of the transsulfuration pathway, Free Radical Research, 2017

Eun Sil Kang, Jaeyong Lee, Takujiro Homma, Toshihiro Kurahashi, Sho Kobayashi, Atsunori Nabeshima, Sohsuke Yamada, Han Geuk Seo, Satoshi Miyata, Hideyo Sato, Junichi Fujii

Multiple Authorship (Including Foreigners)

The viability of primary hepatocytes is maintained under a low cysteine-glutathione redox state with a marked elevation in ophthalmic acid production., Exp Cell Res, 361 178-191, 2017

Lee J, Kang ES, Kobayashi S, Homma T, Sato H, Seo HG, Fujii J.

Multiple Authorship (Including Foreigners)

Decreased reproductive performance in xCT-knockout male mice., Free Radic Res, 51 851-860, 2017

Hamashima S, Homma T, Kobayashi S, Ishii N, Kurahashi T, Watanabe R, Kimura N, Sato H, Fujii J.

Multiple Authorship (Including Foreigners)

Increased ophthalmic acid production is supported by amino acid catabolism under fasting conditions in mice., Biochem Biophys Res Commun, 491 649-655, 2017

Hamashima S, Homma T, Kobayashi S, Ishii N, Kurahashi T, Watanabe R, Kimura N, Sato H, Fujii J.

Multiple Authorship (Including Foreigners)

Zonisamide attenuates lactacystin-induced parkinsonism in mice without affecting system xc-., Exp Neurol, 290 15-28, 2017

Bentea E, Van Liefferinge J, Verbruggen L, Martens K, Kobayashi S, Deneyer L, Demuyser T, Albertini G, Maes K, Sato H, Smolders I, Lewerenz J, Massie A.

Multiple Authorship (Including Foreigners)

Human thioredoxin 2 deficiency impairs mitochondrial redox homeostasis and causes early-onset neurodegeneration., Brain, 346-354, 2016

Holzerova, E., Danhauser, K., Haack. T. B., Kremer, L. S., Melcher, M., Ingold, I., Kobayashi, S., Terrile, C., Wolf, P., Schaper, J., Mayatepek, E., Baertling, F., Angeli, J. P. F., Conrad, M., Strom...

Multiple Authorship (Including Foreigners)

Cystathionine is a novel substrate of cystine/glutamate transporter: implications for immune function., J. Biol. Chem. , 8778-8788, 2015

Kobayashi, S., Sato, M., Kasakoshi, T., Tsutsui, T., Sugimoto, M., Osaki, M., Okada, F., Igarashi, K., Hiratake, J., Homma, T., Conrad, M., Fujii, J., Soga, T., Bannai, S and Sato, H.

Multiple Authorship (Including Foreigners)

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. , Nature Cell Biology, 1180-1191, 2014

Angeli, J.P.F., Schneider, M., Proneth, B, Hammond, V. J., Herbach, N., Aichler, M., Eggenhofer, E., Basavarajappa, D., Radmark, O., Seibt, T., Frauke Neff, F., Esposito, I., Kobayashi, S., Bornkam...

Multiple Authorship (Including Foreigners)

Enhanced expression of cystine/glutamate transporter in the lung caused by the oxidative-stress-inducing agent paraquat., Free Radical Biology & Medicine, 2197-2203, 2012

Kobayashi, S., Kuwata, K., Sugimoto, T., Igarashi, K., Osaki, M., Okada, F., Fujii, J., Bannai, S., and Sato, H.

Multiple Authorship (Including Foreigners)

Dopaminergic neurons of system x(c)(-)-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity, FASEB Journal, 1359-1369, 2011

Massie, A., Schallier, A., Kim, S. W., Fernando, R., Kobayashi, S., Beck, H., De Bundel, D., Vermoesen, K., Bannai, S., Smolders, I., Conrad, M., Plesnila, N., Sato, H., and Michotte, Y.

Multiple Authorship (Including Foreigners)

Grant-in-Aid for Research Activity start-up，2016 - 2018.03