

Research Areas
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Nanotechnology/Materials / Nano/micro-systems
Graduating School
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Tohoku University, Faculty of Engineering
2002.03, Graduated
Graduate School
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Tohoku University, Graduate School, Division of Environmental Science
Doctor's Course, 2007.03, Completed
Research Career
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Development of the electrochemical microdevice for single bacterial cell analysis , 2006.04 - 2007.03
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Development of the diagnostic device, 2007.04 - 2008.10
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Development of the nanoelectrode probe for SECM, 2008.11 - 2009.03
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Development of the electrochemical devices for biological applications, 2009.04 -
Papers
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Electric wiring of bacteria using redox polymers and selective measurement of metabolic activity in the presence of surrounding planktonic bacteria, Bioelectrochemistry, 160 108779, 2024.07
Aoba Ueki, Shoi Harada, Marika Aoyagi, Hirotaka Matsumoto, Riku Ueda, Kei Mizuguchi,Gábor Méhes, Kuniaki Nagamine
Multiple Authorship (Only Japanese)
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Touchpad-based immunochromatographic strip for detecting the skin surface proteins, Analytical Biochemistry, 692 115575, 2024.05
Hyugo Tsukada, Mai Wako, Syunsuke Ueda, Kuniaki Nagamine
Multiple Authorship (Only Japanese)
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Non-invasive and non-destructive chemical sensing using a wet-interfacing technique, Analytical Sciences, 40(4) 579-580, 2024.03
Kuniaki Nagamine
Single Author
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Screen-printed wearable skin surface pH sensor for real-time monitoring of the buffering capacity of human skin, Analytical and Bioanalytical Chemistry, 416 1635-1645, 2024.01
Kentaro Chiba, Yutaro Harada, Hirotaka Matsumoto, Hiroyuki Matsui, Naoya Ito, Tomohito Sekine, Kuniaki Nagamine
Multiple Authorship (Only Japanese)
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Investigating the blocking effect of alkanethiol self-assembled monolayer on electrochemical response of the split Gq-based DNA-NTs-based biosensor, Electrochemistry, 92(2) 022014, 2024.01
Kotaro KATO, Naoki NARISAWA, Hisakage FUNABASHI, Kuniaki NAGAMINE
Multiple Authorship (Only Japanese)
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Temperature correction of printed Na+, K+, and pH sensors with PEDOT:PSS‐based thermistors toward wearable sweat sensing, Advanced Sensor Research, 3(2) 2300106, 2023.11
Rei Shiwaku, Hiroyuki Matsui, Kuiaki Nagamine, Shizuo Tokito
Multiple Authorship (Only Japanese)
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A Flexible, 2.4-GHz Wireless Ion Sensor System Using Printed Organic Amplifiers with 3-V Single Supply, Advanced Electronic Materials, 9(11) 2300396, 2023.09
Rei Shiwaku, Hiroyuki Matsui, Kuiaki Nagamine, Shizuo Tokito
Multiple Authorship (Only Japanese)
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Continuous extraction and electrochemical monitoring of potassium ions in a plant leaf using a wearable ion sensor, Sensors and Materials, 35(10) 4751-4760, 2023.08
Kuniaki Nagamine, Natsuki Kudo, Hajime Sasaki, Arina Asano, Shigeyuki Iwasa
Multiple Authorship (Only Japanese)
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Minimally invasive current-controlled electrical stimulation system for bacteria using highly capacitive conducting polymer-modified electrodes, Bioelectrochemistry, 149 108290, 2022.10
Daiki Makino, Aoba Ueki, Hirotaka Matsumoto, Kuniaki Nagamine
Multiple Authorship (Only Japanese)
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Hydrogel-extraction technique for non-invasive detection of blue fluorescent substances in plant leaves, Scientific Reports, 12 13598, 2022.08
Shigeyuki Iwasa, Yuso Kobara, Katsumi Maeda, Kuniaki Nagamine
Multiple Authorship (Only Japanese)
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Development of a highly sensitive prussian-blue-based enzymatic biosensor for L-carnitine employing the thiol/disulfide exchange reaction, Analytical Sciences, 2022
Ryota Tango, Aya Koeda, Kuniaki Nagamine, Shizuo Tokito, Osamu Niwa, Shigeo Ishikawa, Masahiro Sugimoto
Multiple Authorship (Only Japanese)
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Wet Interface Engineering for At-rest Sweat Analysis, Sensors and Materials, 2022
Kuniaki Nagamine
Single Author
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Organic-transistor-based biosensors interfaced with human skin for non-invasive perspiration analysis, Sensors and Actuators B: Chemical, 349 130778, 2021.10
Kuniaki Nagamine, Shizuo Tokito
Multiple Authorship (Only Japanese)
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Stable immobilization of mediator in porous carbon material via capping technique for fabricating sensitive enzyme-based glucose sensor, Sensors and Materials, 33(9) 3245-3253, 2021.09
Kuniaki Nagamine, Ryota Izawa, Isao Shitanda, Shizuo Tokito
Multiple Authorship (Only Japanese)
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A fully screen-printed potentiometric chloride ion sensor employing a hydrogel-based touchpad for simple and non-invasive daily electrolyte analysis, Analytical and Bioanalytical Chemistry, 2021.01
Yusuke Ichimura, Takumi Kuritsubo, Kuiaki Nagamine, Ayako Nomura, Isao Shitanda, Shizuo Tokito
Multiple Authorship (Only Japanese)
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A heal-melt adhesive-assisted transferable electrode film, Scientific Reports, 2021(11) 36, 2021.01
Yuki Maruyama, Kuniaki Nagamine, Shigeyuki Iwasa, Atsushi Miyabo, Shizuo Tokito
Multiple Authorship (Only Japanese)
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Constructive Optimization of a Multienzymatic Film Based on a Cascade Reaction for Electrochemical Biosensors, ACS Omega, 5(50) 32844-32851, 2020.12
Kai Sasaki, Hiroyuki Furusawa, Kuniaki Nagamine, Shizuo Tokito
Multiple Authorship (Only Japanese)
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Electrochemical enzyme biosensor for carnitine detection based on cathodic stripping voltammetry, Sensors & Actuators B. Chemical, 321 128473, 2020.10
Zixin Zhang, Osamu Niwa, Shunsuke Shiba, Shizuo Tokito, Kuniaki Nagamine, Shigeo Ishikawa, Masahiro Sugimoto
Multiple Authorship (Including Foreigners)
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Hydrogel-based sealed microchamber arrays for rapid medium exchange and drug testing of cell spheroids, Biomedical Microdevices, 22(3) 49, 2020.07
Shotaro Yoshida, Kensuke Sumomozawa, Kuniaki Nagamine, Matsuhiko Nishizawa
Multiple Authorship (Only Japanese)
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Printed organic transistor-based biosensors for non-invasive sweat analysis, Analytical Sciences, 2020
Kuniaki Nagamine, Ayako Nomura, Yusuke Ichimura, Ryota Izawa, Shiori Sasaki, Hiroyuki Furusawa, Hiroyuki Matsui, and Shizuo Tokito
Multiple Authorship (Only Japanese)
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Electrochemical characterization of TEMPO radical in ionic liquids, Electrochemistry, 88(1) 34-38, 2020
Yuki Maruyama, Kuniaki Nagamine, Ayako Nomura, Shigeyuki Iwasa, Shizuo Tokito
Multiple Authorship (Only Japanese)
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Noninvasive Sweat-Lactate Biosensor Emplsoying a Hydrogel-Based Touch Pad., Scientific reports, 9(1) 10102, 2019.07
Nagamine K, Mano T, Nomura A, Ichimura Y, Izawa R, Furusawa H, Matsui H, Kumaki D, Tokito S
Multiple Authorship (Including Foreigners)
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Detection of 1,5-anhydroglucitol as a Biomarker for Diabetes Using an Organic Field-Effect Transistor-Based Biosensor, TECHNOLOGIES, 6(3) , 2018.09
Hiroyuki Furusawa, Yusuke Ichimura, Kuniaki Nagamine, Rei Shiwaku, Hiroyuki Matsui, Shizuo Tokito
Multiple Authorship (Including Foreigners)
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An array of porous microneedles for transdermal monitoring of intercellular swelling, BIOMEDICAL MICRODEVICES, 19(3) 68-74, 2017.09
Nagamine Kuniaki, Kubota Jun, Kai Hiroyuki, Ono Yoshinobu, Nishizawa Matsuhiko
Multiple Authorship (Including Foreigners)
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Intrinsically Stretchable Electrochromic Display by a Composite Film of Poly(3,4-ethylenedioxythiophene) and Polyurethane, ACS APPLIED MATERIALS & INTERFACES, 9(23) 19513-19518, 2017.06
Kai Hiroyuki, Suda Wataru, Ogawa Yudai, Nagamine Kuniaki, Nishizawa Matsuhiko
Multiple Authorship (Including Foreigners)
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Microfluidic co-cultures of retinal pigment epithelial cells and vascular endothelial cells to investigate choroidal angiogenesis, SCIENTIFIC REPORTS, 7(1) 3538, 2017.06
Chen Li-Jiun, Ito Shuntaro, Kai Hiroyuki, Nagamine Kuniaki, Nagai Nobuhiro, Nishizawa Matsuhiko, Abe Toshiaki, Kaji Hirokazu
Multiple Authorship (Including Foreigners)
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Totally shape-conformable electrode/hydrogel composite for on-skin electrophysiological measurements, SENSORS AND ACTUATORS B-CHEMICAL, 237 49-53, 2016.12
Nagamine Kuniaki, Chihara Shun, Kai Hiroyuki, Kaji Hirokazu, Nishizawa Matsuhiko
Multiple Authorship (Including Foreigners)
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Minimally-invasive transepidermal potentiometry with microneedle salt bridge, BIOMEDICAL MICRODEVICES, 18(4) 55-6, 2016.08
Abe Yuina, Nagamine Kuniaki, Nakabayashi Mayu, Kai Hiroyuki, Kaji Hirokazu, Yamauchi Takeshi, Yamasaki Kenshi, Nishizawa Matsuhiko
Multiple Authorship (Including Foreigners)
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Porous polymer microneedles with interconnecting microchannels for rapid fluid transport, RSC Advances, 6 48630, 2016
Liming Liu, Hiroyuki Kai, Kuniaki Nagamine, Yudai Ogawa, Matsuhiko Nishizawa
Multiple Authorship (Including Foreigners)
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Portable Micropatterns of Neuronal Cells Supported by Thin Hydrogel Films, ACS BIOMATERIALS SCIENCE & ENGINEERING, 1(5) 329-334, 2015.05
Nagamine Kuniaki, Hirata Takuya, Okamoto Kohei, Abe Yuina, Kaji Hirokazu, Nishizawa Matsuhiko
Multiple Authorship (Including Foreigners)
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Organic Transdermal Iontophoresis Patch with Built-in Biofuel Cell, ADVANCED HEALTHCARE MATERIALS, 4(4) 506-510, 2015.03
Ogawa Yudai, Kato Koichiro, Miyake Takeo, Nagamine Kuniaki, Ofuji Takuya, Yoshino Syuhei, Nishizawa Matsuhiko
Multiple Authorship (Including Foreigners)
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Highly stretchable cell-cultured hydrogel sheet, RSC Advances, 5 66334-66338, 2015
Kuniaki Nagamine, Yuina Abe, Hiroyuki Kai, Hirokazu Kaji, Matsuhiko Nishizawa
Multiple Authorship (Including Foreigners)
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Stretchable, transparent and molecular permeable honeycomb electrodes and their hydrogel hybrids prepared by the breath figure method and sputtering of metals, RSC Advances, 5 88414-88418, 2015
Hiroshi Yabu, Kuniaki Nagamine, Jun Kamei, Yuta Saito, Taiki Okabe, Tatsuaki Shimazaki, Matsuhiko Nishizawa
Multiple Authorship (Including Foreigners)
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Highly Conductive Stretchable and Biocompatible Electrode-Hydrogel Hybrids for Advanced Tissue Engineering, ADVANCED HEALTHCARE MATERIALS, 3(11) 1919-1927, 2014.11
Sasaki Masato, Karikkineth Bijoy Chandapillai, Nagamine Kuniaki, Kaji Hirokazu, Torimitsu Keiichi, Nishizawa Matsuhiko
Multiple Authorship (Including Foreigners)
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Bonding of synthetic hydrogels with fibrin as the glue to engineer hydrogel-based biodevices, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 118(1) 94-97, 2014.07
Nagamine Kuniaki, Okamoto Kohei, Kaji Hirokazu, Nishizawa Matsuhiko
Multiple Authorship (Including Foreigners)
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Electroporation of Adherent Cells by Direct Lamination of Hydrogel-based Microelectrode Substrates, CHEMISTRY LETTERS, 43(4) 444-446, 2014.04
Takahashi Daisuke, Sasaki Masato, Nagamine Kuniaki, Torimitsu Keiichi, Nishizawa Matsuhiko
Multiple Authorship (Including Foreigners)
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Hydrogel-based bioassay sheets for in-vitro evaluation of contraction-dependent metabolic regulation in skeletal muscle cells, Biomaterials Science, 2(2) 252-256, 2014
Kuniaki Nagamine, Kohei Okamoto, Shingo Otani, Hirokazu kaji, Makoto Kanzaki, Matsuhiko Nishizawa
Multiple Authorship (Including Foreigners)
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An Oxygen Responsive Microparticle-Patterned Hydrogel Sheet for Enzyme Activity Imaging, ELECTROCHEMISTRY, 80(5) 318-320, 2012.05
Nagamine Kuniaki, Ito Shuntaro, Takeda Mai, Otani Shingo, Nishizawa Matsuhiko
Multiple Authorship (Including Foreigners)
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Conducting Polymer Microelectrodes Anchored to Hydrogel Films, ACS MACRO LETTERS, 1(3) 400-403, 2012.03
Ido Yuichiro, Takahashi Daisuke, Sasaki Masato, Nagamine Kuniaki, Miyake Takeo, Jasinski Piotr, Nishizawa Matsuhiko
Multiple Authorship (Including Foreigners)
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Microfluidic Devices for Electrochemical Measurement of Photosynthetic Activity of Cyanobacteria Microcystis Cells, ANALYTICAL SCIENCES, 28(1) 69-72, 2012.01
Koide Masahiro, Yasukawa Tomoyuki, Horiguchi Yoshiko, Nagamine Kuniaki, Shiku Hitoshi, Matsue Tomokazu, Itayama Tomoaki
Multiple Authorship (Including Foreigners)
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Influence of Tip Size on Single Yeast Cell Imaging Using Scanning Electrochemical Microscopy, ELECTROANALYSIS, 23(5) 1168-1174, 2011.05
Nagamine Kuniaki, Takahashi Yasufumi, Ino Kosuke, Shiku Hitoshi, Matsue Tomokazu
Multiple Authorship (Including Foreigners)
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An electrochemical device with microwells for determining the photosynthetic activity of a single cyanobacterium, SENSORS AND ACTUATORS B-CHEMICAL, 153(2) 474-478, 2011.04
Koide Masahiro, Yasukawa Tomoyuki, Nagamine Kuniaki, Shiku Hitoshi, Itayama Tomoaki, Matsue Tomokazu
Multiple Authorship (Including Foreigners)
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Spatiotemporally controlled contraction of micropatterned skeletal muscle cells on a hydrogel sheet, Lab on a chip, 11(3) 513-517, 2011
Kuniaki Nagamine, Takeaki Kawashima, Soichiro Sekine, Yuichiro Ido, Makoto Kanzaki, Matsuhiko Nishizawa
Multiple Authorship (Including Foreigners)
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Conducting Polymer Electrodes Printed on Hydrogel, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 132(38) 13174-13175, 2010.09
Sekine Soichiro, Ido Yuichiro, Miyake Takeo, Nagamine Kuniaki, Nishizawa Matsuhiko
Multiple Authorship (Including Foreigners)
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Electrically induced contraction of C2C12 myotubes cultured on a porous membrane-based substrate with muscle tissue-like stiffness, BIOMATERIALS, 31(27) 6981-6986, 2010.09
Kaji Hirokazu, Ishibashi Takeshi, Nagamine Kuniaki, Kanzaki Makoto, Nishizawa Matsuhiko
Multiple Authorship (Including Foreigners)
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Electrodes Combined with an Agarose Stamp for Addressable Micropatterning, LANGMUIR, 26(13) 11526-11529, 2010.07
Sekine Soichiro, Nakanishi Shinya, Miyake Takeo, Nagamine Kuniaki, Kaji Hirokazu, Nishizawa Matsuhiko
Multiple Authorship (Including Foreigners)
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Micropatterning Contractile C2C12 Myotubes Embedded in a Fibrin Gel, BIOTECHNOLOGY AND BIOENGINEERING, 105(6) 1161-1167, 2010.04
Nagamine Kuniaki, Kawashima Takeaki, Ishibashi Takeshi, Kaji Hirokazu, Kanzaki Makoto, Nishizawa Matsuhiko
Multiple Authorship (Including Foreigners)
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Topographic imaging of convoluted surface of live cells by scanning ion conductance microscopy in a standing approach mode, Physical Chemistry Chemical Physics, 12(34) 10012-10017, 2010
Yasufumi Takahashi, Yumi Murakami, Kuniaki Nagamine, Hitoshi Shiku, Shigeo Aoyagi, Tomoyuki Yasukawa, Makoto Kanzaki, Tomokazu Matsue
Multiple Authorship (Including Foreigners)
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Electrochemical characterization of enzymatic activity of yeast cells entrapped in a poly(dimethylsiloxane) microwell on the basis of limited diffusion system, Analyst, 134(1) 182-187, 2009
Hitoshi Shiku, Shun Goto, Sungbong Jung, Kuniaki Nagamine, Masahiro Koide, Tomosato Itayama, Tomoyuki Yasukawa
Multiple Authorship (Including Foreigners)
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Electrophoretic cell manipulation and electrochemical gene-function analysis based on a yeast two-hybrid system in a microfluidic device, ANALYTICAL CHEMISTRY, 80(10) 3722-3727, 2008.05
Yasukawa Tomoyuki, Nagamine Kuniaki, Horiguchi Yoshiko, Shiku Hitoshi, Koide Masahiro, Itayama Tomoaki, Shiraishi Fujio, Matsue Tomokazu
Multiple Authorship (Including Foreigners)
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Electrochemical screening of recombinant protein solubility in Escherichia coli using scanning electrochemical microscopy (SECM), BIOTECHNOLOGY AND BIOENGINEERING, 96(5) 1008-1013, 2007.04
Nagamine Kuniaki, Onodera Shiho, Kurihara Ai, Yasukawa Tomoyuki, Shiku Hitoshi, Asano Ryutaro, Kumagai Izumi, Matsue Tomokazu
Multiple Authorship (Including Foreigners)
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Electrochemical monitoring of cellular signal transduction with a secreted alkaline phosphatase reporter system, ANALYTICAL CHEMISTRY, 78(22) 7625-7631, 2006.11
Torisawa Yu-suke, Ohara Noriko, Nagamine Kuniaki, Kasai Shigenobu, Yasukawa Tomoyuki, Shiku Hitoshi, Matsue Tomokazu
Multiple Authorship (Including Foreigners)
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Cytokine assay on a cellular chip by combining collagen gel embedded culture with scanning electrochemical microscopy, ANALYTICA CHIMICA ACTA, 566(1) 55-59, 2006.04
Kasai S, Shiku H, Torisawa YS, Nagamine K, Yasukawa T, Watanabe T, Matsue T
Multiple Authorship (Including Foreigners)
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Electrochemical mutagen screening using microbial chip, BIOSENSORS & BIOELECTRONICS, 21(7) 1202-1209, 2006.01
Matsui N, Kaya T, Nagamine K, Yasukawa T, Shiku H, Matsue T
Multiple Authorship (Including Foreigners)
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Application of microbial chip for amperometric detection of metabolic alteration in bacteria, SENSORS AND ACTUATORS B-CHEMICAL, 108(1-2) 676-682, 2005.07
Nagamine K, Kaya T, Yasukawa T, Shiku H, Matsue T
Multiple Authorship (Including Foreigners)
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Amperometric detection of the bacterial metabolic regulation with a microbial array chip, BIOSENSORS & BIOELECTRONICS, 21(1) 145-151, 2005.07
Nagamine K, Matsui N, Kaya T, Yasukawa T, Shiku H, Nakayama T, Nishino T, Matsue T
Multiple Authorship (Including Foreigners)
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On-chip transformation of bacteria, ANALYTICAL CHEMISTRY, 77(13) 4278-4281, 2005.07
Nagamine K, Onodera S, Torisawa Y, Yasukawa T, Shiku H, Matsue T
Multiple Authorship (Including Foreigners)
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On-chip electrochemical measurement of beta-galactosidase expression using a microbial chip, CHEMICAL COMMUNICATIONS, (2) 248-249, 2004.01
Kaya T, Nagamine K, Matsui N, Yasukawa T, Shiku H, Matsue T
Multiple Authorship (Including Foreigners)
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Respiration activity of Escherichia coli entrapped in a cone-shaped microwell and cylindrical micropore monitored by scanning electrochemical microscopy (SECM), Analyst, 129(6) 529-534, 2004
3. Takatoshi Kaya, Daisuke Numai, Kuniaki Nagamine, Shigeo Aoyagi, Hitoshi Shiku, Tomokazu Matsue
Multiple Authorship (Including Foreigners)
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A microbial chip for glucose sensing studied with scanning electrochemical microscopy (SECM), ELECTROCHEMISTRY, 71(6) 436-438, 2003.06
Kaya T, Nagamine K, Oyamatsu D, Nishizawa M, Matsue T
Multiple Authorship (Including Foreigners)
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Fabrication of microbial chip using collagen gel microstructure, Lab on a Chip, 3(4) 313-317, 2003
Takatoshi Kaya, Kuniaki Nagamine, Daisuke Oyamatsu, Hitoshi Shiku, Matsuhiko Nishizawa, Tomokazu Matsue
Multiple Authorship (Including Foreigners)
Review Papers
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Wet interface technologies for the wearable sweat sensors, Springer, Wearable Biosensing in Medicine and Healthcare, 211-216, 2024.01
Kuniaki Nagamine, Shizuo Tokito
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Printed electronics-enabled wearable/portable physical and chemical sensors for personal digital healthcare, Elsevier, Encyclopedia of Sensors and Biosensors, 3 68-79, 2022.10
Kuniaki Nagamine, Tomohito Sekine, Shizuo Tokito
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Flexible and printed biosensors based on organic TFT devices, CHEMICAL, GAS, AND BIOSENSORS FOR INTERNET OF THINGS AND RELATED APPLICATIONS, 2019
Kuniaki Nagamine, Shizuo Tokito
Grant-in-Aid for Scientific Research
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Grant-in-Aid for Scientific Research(B),2024.04 - 2027.03
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Grant-in-Aid for Scientific Research(B),2023.04 - 2026.03
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Grant-in-Aid for Scientific Research(B),2021.04 - 2024.03
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Grant-in-Aid for Scientific Research(C),2018.04 - 2021.03
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Grant-in-Aid for Scientific Research(C),2016.04 - 2019.03
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Grant-in-Aid for Scientific Research(A),2013.04 - 2017.03
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Grant-in-Aid for Scientific Research(B),2013.04 - 2016.03
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Grant-in-Aid for Young Scientists(B),2013.04 - 2015.03
Available Technology
Academic Activity
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電気化学会, 2018.04 -
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日本分析化学会, 2023.03 -
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電気化学会, 2023.04 -
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日本分析化学会, 2023.04 -
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日本分析化学会, 2024.03 -
Media Coverage
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トマト「青枯れ病」早期発見,2022.09
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トマト病原菌感染指標 非破壊検出に成功,2022.09
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トマトの病原菌の感染指標となる植物体内成分の非破壊検出に成功,2022.09
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トマトの病原菌の感染指標に 植物体内成分の非破壊検出に成功,2022.09
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青枯病 拡大防止に期待,2022.09
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トマトの青枯病 (あおがれびょう) ―非破壊・早期診断に新技術,2022.09
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山形大・農研機構、トマトの病原菌の感染指標となる植物体内成分の非破壊検出に成功,2022.09
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トマトの病原菌の感染指標となる植物体内成分の非破壊検出に成功,2022.09