Updated on 2026/04/27

写真a

 
SEINO Manabu
 
Title
Lecturer

Degree

  • Doctor (Medicine), Yamagata University, 2016.09

 

Papers

  • Genomic Landscape and Therapeutic Implications of Metaplastic Breast Carcinoma: Insights from a Nationwide Database Including Diagnostic Mimickers, PHARMACEUTICALS, 19(2) , 2026.02

    Suzuki, S; Seino, M; Sato, H; Kawai, M; Ogura, J; Hoshi, Y; Saito, Y; Saito, K; Yamada, Y; Takahashi, K; Kumanishi, R; Fukui, T; Takahashi, M

    Single Author

  • Clinical Implications of Coexisting EWSR1 Rearrangements in Ewing Sarcoma: A Database Analysis and Representative Cases, INTERNAL MEDICINE, advpub(0) , 2025.11

    Saito, Y; Suzuki, N; Suzuki, S; Sato, M; Seino, M; Saito, K; Yamada, Y; Takahashi, K; Kumanishi, R; Fukui, T; Yoshioka, T

    Single Author

  • The MDM4 Inhibitor CEP-1347 Activates Wild-type p53 in Ovarian Clear Cell Carcinoma Cells and Potently Inhibits their Growth, ANTICANCER RESEARCH, 45(11) 4881-4890, 2025.11

    Ito, Y; Nakamura, K; Nakagawa-Saito, Y; Suzuki, S; Togashi, K; Takenouchi, S; Sugai, A; Seino, M; Ohta, T; Nagase, S; Kitanaka, C; Okada, M

    Single Author

  • Senolytic Elimination of Senescent Ovarian Clear Cell Carcinoma Cells Induced by CEP-1347 With the BH3 Mimetic Navitoclax, ANTICANCER RESEARCH, 45(11) 4841-4851, 2025.11

    Ito, Y; Nakamura, K; Nakagawa-Saito, Y; Takenouchi, S; Suzuki, S; Togashi, K; Sugai, A; Mitobe, Y; Seino, M; Ohta, T; Nagase, S; Kitanaka, C; Okada, M

    Single Author

  • Revision of quality indicators for cervical cancer and trend analysis of existing indicators in Japan, JOURNAL OF GYNECOLOGIC ONCOLOGY, 36(5) e78, 2025.09

    Kakuwa, T; Rikitake, R; Nagase, S; Mikami, M; Baba, T; Kaneuchi, M; Tokunaga, H; Seino, M; Muramatsu, T; Yamagami, W; Takehara, K; Niikura, H; Hirashima, Y; Yoshino, K; Ichinose, Y; Kawata, A; Higashi...

    Single Author

  • Quality indicators for endometrial cancer care in Japan, JOURNAL OF GYNECOLOGIC ONCOLOGY, 36(5) e77, 2025.09

    Kakuwa, T; Ichinose, Y; Rikitake, R; Ishii, T; Nagase, S; Kobayashi, Y; Kaneuchi, M; Tokunaga, H; Seino, M; Kajiyama, H; Takekuma, M; Tabata, T; Terai, Y; Terao, Y; Morisada, T; Watari, H; Yamamoto, Y...

    Single Author

  • Potential Resistance to Oxaliplatin-Based Regimens in Gastric Cancer Patients with ERBB2 R678Q Mutation: Evidence from a National Genomic Database, CURRENT ISSUES IN MOLECULAR BIOLOGY, 47(6) , 2025.06

    Suzuki, S; Seino, M; Sato, H; Saito, Y; Saito, K; Yamada, Y; Takahashi, K; Kumanishi, R; Fukui, T

    Single Author

  • Communication skills training program for medical staff in cancer genomic testing: A mixed-methods assessment of an educational initiative., JOURNAL OF CLINICAL ONCOLOGY, 43(16_SUPPL) , 2025.06

    Suzuki, S; Suzuki, R; Seino, M; Saito, Y; Saito, K; Yamada, Y; Takahashi, K; Kumanishi, R; Fukui, T; Yoshioka, T

    Single Author

  • Investigation of tumor mutation burden using the comprehensive genomic profiling data of vulvar and vaginal malignant tumors: an observational study using C-CAT database, INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 30(5) 1033-1039, 2025.05

    Seino, M; Sano, S; Gonai, Y; Horikawa, S; Nakamura, F; Okui, Y; Matsukawa, J; Sakaki, H; Watanabe, N; Yamauchi, K; Ohta, T; Hoshi, Y; Suzuki, S; Kawai, M; Nagase, S

    Single Author

  • Clinical Characteristics and Chemosensitivity in Germline TP53 Pathogenic Variant Cases Identified by Cancer Genomic Testing, CANCER GENOMICS & PROTEOMICS, 22(2) 354-362, 2025.03

    Saito, Y; Hoshi, Y; Sato, M; Seino, M; Watanabe, N; Kawai, M; Suzuki, S

    Single Author

  • Comparison of Treatment Outcomes Between First-Line Chemotherapy With or Without Bevacizumab for Advanced Ovarian Clear Cell Carcinoma (Tohoku Gynecologic Cancer Unit: TGCU-RS001A Study), CANCERS, 16(22) 3801, 2024.11

    Shoji, T; Takatori, E; Nagasawa, T; Kagabu, M; Baba, T; Shigeto, T; Matsumura, Y; Shimizu, D; Terada, Y; Seino, M; Ohta, T; Nagase, S; Shigeta, S; Tokunaga, H; Shimada, M; Kaiho-Sakuma, M; Furukawa, S...

    Single Author

  • Profiling of metabolic dysregulation in ovarian cancer tissues and biofluids, SCIENTIFIC REPORTS, 14(1) 21555, 2024.09

    Ohta, T; Sugimoto, M; Ito, Y; Horikawa, S; Okui, Y; Sakaki, H; Seino, M; Sunamura, M; Nagase, S

    Single Author

  • Japan Society of Gynecologic Oncology 2022 guidelines for uterine cervical neoplasm treatment, JOURNAL OF GYNECOLOGIC ONCOLOGY, 35(1) e15, 2024.01

    Seino, M; Nagase, S; Tokunaga, H; Yamagami, W; Kobayashi, Y; Tabata, T; Kaneuchi, M; Hirashima, Y; Niikura, H; Yoshino, K; Takehara, K; Baba, T; Katabuchi, H; Mikami, M

    Single Author

  • がんゲノム検査に携わる医療スタッフへのコミュニケーションスキルトレーニング, 日本癌治療学会学術集会抄録集, 61回 PR-4, 2023.10

    鈴木 修平, 鏡 優子, 鈴木 理恵, 齋藤 陽介, 佐藤 正道, 清野 学, 永瀬 智

    Single Author

  • Mechanism of Cell Death by Combined Treatment with an xCT Inhibitor and Paclitaxel: An Alternative Therapeutic Strategy for Patients with Ovarian Clear Cell Carcinoma, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(14) , 2023.07

    Idei, U; Ohta, T; Yamatani, H; Seino, M; Nagase, S

    Single Author

  • Impact of adjuvant chemotherapy on the overall survival of patients with resectable bulky small cell neuroendocrine cervical cancer: a JSGO-JSOG joint study, JOURNAL OF GYNECOLOGIC ONCOLOGY, 34(1) , 2023.01

    Seino, M; Nagase, S; Ohta, T; Yamagami, W; Ebina, Y; Kobayashi, Y; Tabata, T; Kaneuchi, M; Enomoto, T; Mikami, M

    Single Author

  • Comparison of treatment outcomes between first-line chemotherapy with or without bevacizumab for advanced ovarian, fallopian tube, and primary peritoneal cancer (Tohoku gynecologic cancer unit: TGCU-RS001 study), INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 27(12) 1874-1880, 2022.12

    Shoji, T; Takatori, E; Nagasawa, T; Kagabu, M; Baba, T; Shigeto, T; Matsumura, Y; Shimizu, D; Terada, Y; Seino, M; Ohta, T; Nagase, S; Shigeta, S; Tokunaga, H; Shimada, M; Kaiho-Sakuma, M; Furukawa, S...

    Single Author

  • Early menopause and a low body mass index are associated with an increased risk of coronary heart disease in Japanese women, MENOPAUSE-THE JOURNAL OF THE MENOPAUSE SOCIETY, 29(7) 850-855, 2022.07

    Yamanouchi, K; Ohta, T; Konta, T; Nakamura, F; Horikawa, S; Nakai, N; Sakai, K; Fukase, M; Seino, M; Yamatani, H; Watanabe, M; Ueno, Y; Nagase, S

    Single Author

  • xCT inhibitor sulfasalazine depletes paclitaxel-resistant tumor cells through ferroptosis in uterine serous carcinoma, ONCOLOGY LETTERS, 20(3) 2689-2700, 2020.09

    Sugiyama, A; Ohta, T; Obata, M; Takahashi, K; Seino, M; Nagase, S

    Single Author

  • METABOLOMIC ANALYSIS OF OVARIAN CANCER CELLS TREATED WITH PACLITAXEL, INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 28 831, 2018.09

    Seino, M; Ohta, T; Suzuki, Y; Sakaki, H; Sudo, T; Nagase, S

    Single Author

  • Metabolomic analysis of uterine serous carcinoma with acquired resistance to paclitaxel, CANCER RESEARCH, 78(13) , 2018.07

    Seino, M; Ohta, T; Sakaki, H; Sudo, T; Nagase, S

    Single Author

  • Oxidative Stress in the Visceral Fat Is Elevated in Postmenopausal Women with Gynecologic Cancer, JOURNAL OF WOMENS HEALTH, 27(1) 99-106, 2018.01

    Narumi, M; Takahashi, K; Yamatani, H; Seino, M; Yamanouchi, K; Ohta, T; Takahashi, T; Kurachi, H; Nagase, S

    Single Author

  • The novel JNK inhibitor AS602801 inhibits cancer stem cells in vitro and in vivo, CANCER SCIENCE, 109 269, 2018.01

    Okada, M; Suzuki, S; Seino, M; Takeda, H; Kitanaka, C

    Single Author

  • Activation of estrogen receptor α by estradiol and cisplatin induces platinum-resistance in ovarian cancer cells., Cancer biology & therapy, 18(9) 730-739, 2017.09

    Matsumura S, Ohta T, Yamanouchi K, Liu Z, Sudo T, Kojimahara T, Seino M, Narumi M, Tsutsumi S, Takahashi T, Takahashi K, Kurachi H, Nagase S

    Multiple Authorship (Only Japanese)

  • The novel JNK inhibitor AS602801 inhibits cancer stem cells <i>in vitro</i> and <i>in vivo</i>, ONCOTARGET, 7(19) 27021-27032, 2016.05

    Okada, M; Kuramoto, K; Takeda, H; Watarai, H; Sakaki, H; Seino, S; Seino, M; Suzuki, S; Kitanaka, C

    Single Author

  • Time-staggered inhibition of JNK effectively sensitizes chemoresistant ovarian cancer cells to cisplatin and paclitaxel, Oncology Report, 35(1) 593-601, 2016.01

    Manabu Seino, Masashi Okada, Hirotsugu Sakaki, Hiroaki Takeda, Hikaru Watarai, Shuhei Suzuki, Sizuka Seino, Kenta Kuramoto, Tsuyoshi Ohta, Satoru Nagase, Hirohisa Kurachi, Chifumi Kitanaka

    Multiple Authorship (Only Japanese)

  • GSKJ4, A Selective Jumonji H3K27 Demethylase Inhibitor, Effectively Targets Ovarian Cancer Stem Cells., Anticancer research, 35(12) 6607-6614, 2015.12

    Sakaki H, Okada M, Kuramoto K, Takeda H, Watarai H, Suzuki S, Seino S, Seino M, Ohta T, Nagase S, Kurachi H, Kitanaka C

    Multiple Authorship (Only Japanese)

  • Requirement of JNK signaling for self-renewal and tumor-initiating capacity of ovarian cancer stem cells, CANCER RESEARCH, 75 , 2015.08

    Seino, M; Okada, M; Shibuya, K; Seino, S; Suzuki, S; Takeda, H; Ohta, T; Kurachi, H; Ito, K; Nagase, S; Kitanaka, C

    Single Author

  • JNK suppression of chemotherapeutic agents-induced ROS confers chemoresistance on pancreatic cancer stem cells., Oncotarget, 6(1) 458-470, 2015.01

    Suzuki S, Okada M, Shibuya K, Seino M, Sato A, Takeda H, Seino S, Yoshioka T, Kitanaka C

    Multiple Authorship (Only Japanese)

  • Differential contribution of ROS to resveratrol-induced cell death and loss of self-renewal capacity of ovarian cancer stem cells., Anticancer research, 35(1) 85-96, 2015.01

    Seino M, Okada M, Shibuya K, Seino S, Suzuki S, Takeda H, Ohta T, Kurachi H, Kitanaka C

    Multiple Authorship (Only Japanese)

  • Targeting the facilitative glucose transporter GLUT1 inhibits the self-renewal and tumor-initiating capacity of cancer stem cells., Oncotarget, 6(2) 651-661, 2015.01

    Shibuya K, Okada M, Suzuki S, Seino M, Seino S, Takeda H, Kitanaka C

    Multiple Authorship (Only Japanese)

  • Requirement of JNK signaling for self-renewal and tumor-initiating capacity of ovarian cancer stem cells., Anticancer Research, 34(9) 4723-4731, 2014.09

    Manabu Seino, Masashi Okada, Keita Shibuya, Sizuka Seino, Shuhei Suzuki, Tsuyoshi Ohta, Hirohisa Kurachi, Chifumi Kitanaka

    Multiple Authorship (Only Japanese)

  • Requirement of JNK Signaling for Self-renewal and Tumor-initiating Capacity of Ovarian Cancer Stem Cells, ANTICANCER RESEARCH, 34(9) 4723-4731, 2014.09

    Seino, M; Okada, M; Shibuya, K; Seino, S; Suzuki, S; Ohta, T; Kurachi, H; Kitanaka, C

    Single Author

  • Targeting the K-Ras--JNK axis eliminates cancer stem-like cells and prevents pancreatic tumor formation., Oncotarget, 5(13) 5100-5112, 2014.07

    Okada M, Shibuya K, Sato A, Seino S, Suzuki S, Seino M, Kitanaka C

    Multiple Authorship (Only Japanese)

  • High levels of Wilms' tumor 1 (WT1) expression were associated with aggressive clinical features in ovarian cancer., Anticancer research, 34(5) 2331-2340, 2014.05

    Liu Z, Yamanouchi K, Ohtao T, Matsumura S, Seino M, Shridhar V, Takahashi T, Takahashi K, Kurachi H

    Multiple Authorship (Only Japanese)

  • JNK contributes to temozolomide resistance of stem-like glioblastoma cells via regulation of MGMT expression., International journal of oncology, 44(2) 591-599, 2014.02

    Okada M, Sato A, Shibuya K, Watanabe E, Seino S, Suzuki S, Seino M, Narita Y, Shibui S, Kayama T, Kitanaka C

    Multiple Authorship (Only Japanese)

  • Specific role of JNK in the maintenance of the tumor-initiating capacity of A549 human non-small cell lung cancer cells., Oncology reports, 30(4) 1957-1964, 2013.10

    Okada M, Shibuya K, Sato A, Seino S, Watanabe E, Suzuki S, Seino M, Kitanaka C

    Multiple Authorship (Only Japanese)

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Grant-in-Aid for Scientific Research

  • Grant-in-Aid for Scientific Research(C),2025.04 - 2026.03

  • Grant-in-Aid for Scientific Research(C),2024.04 - 2026.03

  • Grant-in-Aid for Scientific Research(C),2021.04 - 2023.03

  • Grant-in-Aid for Scientific Research(C),2021.04 - 2023.03

  • Grant-in-Aid for Scientific Research(C),2018.04 - 2021.03

  • Grant-in-Aid for Scientific Research(C),2018.04 - 2020.03

  • Grant-in-Aid for Scientific Research(C),2018.04 - 2019.03

  • Grant-in-Aid for Young Scientists(B),2017.04 - 2019.03

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