Updated on 2023/11/30

写真a

 
YAMAGUCHI Hiroaki
 
Date of Birth
1976
Contact information
メールアドレス

Research Areas

  • Life Science / Clinical pharmacy

  • Life Science / Clinical pharmacy

Graduating School

  • Tohoku University, Faculty of Pharmaceutical Science

    1999.03, Graduated

Graduate School

  • Kyoto University, Graduate School, Division of Pharmaceutical Sciences

    Doctor's Course, 2004.03, Completed

External Career

  • Yamagata University, Professor, 2019.04 -

Academic Society Affiliations

  • THE JAPANESE SOCIETY OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

  • JAPANESE SOCIETY FOR BIOMEDICAL MASS SPECTROMETRY

 

Research Career

  • Real-time imaging of carrier-mediated transport, 2007 - 2008

  • Proteomics of bile acid signals, 2008 - 2010

  • Analysis of functional significance of a newly discovered brain-specific transporter, 2008 - 2010

  • Characterization of kidney specific organic anion transporter SLCO4C1, 2011 - 2012

  • Mechanisms of prostanoids release from the cells, 2013.04 - 2016.03

  • Medicinal chemistry studies based on the three-dimensional structural diversity-oriented molecular design of pharmacologically active compounds, 2015.04 - 2020.03

  • Participation of OATP4C1 in the pharmacokinetics of drugs, 2018.04 - 2021.03

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Papers

  • Effect of the Opioid Administration Period before the Initiation of Naldemedine Administration on the Prevalence of Diarrhea(和訳中), 医療薬学, 47(8) 411-417, 2021.08

    Shirata Chinami, Shida Toshihiro, Hatakeyama Shiro, Ogura Jiro, Yamakawa Mayumi, Suzuki Naoki, Yamaguchi Hiroaki

    Single Author

  • Enhancement and evaluation of a prescription audit system for direct oral anticoagulants using a check sheet(和訳中), Journal of Pharmaceutical Health Care and Sciences, 7 1 of 6-6 of 6, 2021.06

    Ishikawa Naoto, Oshikiri Hanae, Takasaki Shinya, Kikuchi Masafumi, Obara Taku, Akasaka Kazutoshi, Matsuura Masaki, Yamaguchi Hiroaki, Mano Nariyasu

    Single Author

  • Glucose-induced oxidative stress leads to in S-nitrosylation of protein disulfide isomerase in neuroblastoma cells, Biochimica et Biophysica Acta (BBA) - General Subjects, 1865(11) 129998, 2021.11

    Jiro Ogura, Hiroki Sugiura, Atsushi Tanaka, Shinji Ono, Toshiyuki Sato, Toshihiro Sato, Masamitsu Maekawa, Hiroaki Yamaguchi, Nariyasu Mano

    Single Author

  • KRP-203 is a Desirable Immunomodulator for Islet Allotransplantation., Transplantation, 2021.07

    Fathi I, Nishimura R, Imura T, Inagaki A, Kanai N, Ushiyama A, Kikuchi M, Maekawa M, Yamaguchi H, Goto M

    Single Author

  • Enhancement and evaluation of a prescription audit system for direct oral anticoagulants using a check sheet., Journal of pharmaceutical health care and sciences, 7(1) 22, 2021.06

    Ishikawa N, Oshikiri H, Takasaki S, Kikuchi M, Obara T, Akasaka K, Matsuura M, Yamaguchi H, Mano N

    Single Author

  • Azelnidipine treatment reduces the expression of Cav1.2 protein., Life sciences, 269 119043, 2021.03

    Fumiaki Nasu, Yutaro Obara, Yosuke Okamoto, Hiroaki Yamaguchi, Kazuya Kurakami, Ikuo Norota, Kuniaki Ishii

    Single Author

  • Simultaneous analysis of drugs administered to lung-transplanted patients using liquid chromatography-tandem mass spectrometry for therapeutic drug monitoring., Biomedical chromatography : BMC, 35(6) e5067, 2021.01

    Shinya Takasaki, Tensei Hirasawa, Yu Sato, Masamitsu Maekawa, Taku Tsukamoto, Masafumi Kikuchi, Jiro Ogura, Yoshihiro Hayakawa, Yasushi Matsuda, Hisashi Oishi, Tetsu Sado, Masafumi Noda, Yoshinori Oka...

    Single Author

  • Role of OATP4C1 in Renal Handling of Remdesivir and its Nucleoside Analog GS-441524: The First Approved Drug for Patients with COVID-19., Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 24 227-236, 2021

    Sato T, Maekawa M, Mano N, Abe T, Yamaguchi H

    Single Author

  • Clinical Importance of Plasma Drug Concentration of Oral Molecular Targeted Drugs for Renal Cell Carcinoma., Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 24 127-136, 2021

    Takasaki S, Kawasaki Y, Kikuchi M, Ito A, Yamaguchi H, Mano N

    Single Author

  • Plasma mycophenolic acid concentration and the clinical outcome after lung transplantation., Clinical transplantation, 34(12) e14088, 2020.09

    Hiroshi Yabuki, Yasushi Matsuda, Tatsuaki Watanabe, Shunsuke Eba, Fumihiko Hoshi, Takashi Hirama, Hisashi Oishi, Tetsu Sado, Masafumi Noda, Akira Sakurada, Masafumi Kikuchi, Hiroaki Yamaguchi, Nariyas...

    Single Author

  • Development of a precise quantitative method for monitoring sirolimus in whole blood using LC/ESI-MS/MS, BIOMEDICAL CHROMATOGRAPHY, e4853, 2020.05

    Shigeta Kensuke, Kikuchi Masafumi, Tanaka Masaki, Takasaki Shinya, Oishi Hisashi, Sado Tetsu, Matsuda Yasushi, Noda Masafumi, Okada Yoshinori, Mano Nariyasu, Yamaguchi Hiroaki

    Multiple Authorship (Only Japanese)

  • Stimulatory effect on the transport mediated by organic anion transporting polypeptide 2B1., Asian journal of pharmaceutical sciences, 15(2) 181-191, 2020.03

    Ogura J, Yamaguchi H, Mano N

    Multiple Authorship (Only Japanese)

  • Comprehensive and semi-quantitative analysis of carboxyl-containing metabolites related to gut microbiota on chronic kidney disease using 2-picolylamine isotopic labeling LC-MS/MS., Scientific reports, 9(1) 19075, 2019.12

    Kanemitsu Y, Mishima E, Maekawa M, Matsumoto Y, Saigusa D, Yamaguchi H, Ogura J, Tsukamoto H, Tomioka Y, Abe T, Mano N

    Multiple Authorship (Only Japanese)

  • Development of a simultaneous analytical method for five conjugated cholesterol metabolites in urine and investigation of their performance as diagnostic markers for Niemann-Pick disease type C., Journal of lipid research, 60(12) 2074-2081, 2019.12

    Maekawa M, Jinnoh I, Narita A, Iida T, Saigusa D, Iwahori A, Nittono H, Okuyama T, Eto Y, Ohno K, Clayton PT, Yamaguchi H, Mano N

    Multiple Authorship (Including Foreigners)

  • Structural Determination of Lysosphingomyelin-509 and Discovery of Novel Class Lipids from Patients with Niemann-Pick Disease Type C., International journal of molecular sciences, 20(20) , 2019.10

    Masamitsu Maekawa, Isamu Jinnoh, Yotaro Matsumoto, Aya Narita, Ryuichi Mashima, Hidenori Takahashi, Anna Iwahori, Daisuke Saigusa, Kumiko Fujii, Ai Abe, Katsumi Higaki, Shosei Yamauchi, Yuji Ozeki, Ka...

    Multiple Authorship (Including Foreigners)

  • Involvement of H+-gradient dependent transporter in PGE2 release from A549 cells., Prostaglandins, leukotrienes, and essential fatty acids, 149 30-36, 2019.10

    Tanaka N, Yamaguchi H, Mano N

    Multiple Authorship (Only Japanese)

  • Organogermanium suppresses cell death due to oxidative stress in normal human dermal fibroblasts., Scientific reports, 9(1) 13637, 2019.09

    Takeda T, Doiyama S, Azumi J, Shimada Y, Tokuji Y, Yamaguchi H, Nagata K, Sakamoto N, Aso H, Nakamura T

    Multiple Authorship (Only Japanese)

  • Drug Prescriptions for Children With ADHD in Japan: A Study Based on Health Insurance Claims Data Between 2005 and 2015., Journal of attention disorders, 1087054719843179, 2019.05

    Yoshida M, Obara T, Kikuchi S, Satoh M, Morikawa Y, Ooba N, Yamaguchi H, Mano N

    Multiple Authorship (Only Japanese)

  • Characterization of conjugated and unconjugated bile acid transport via human organic solute transporter α/β., Biochimica et biophysica acta. Biomembranes, 1861(5) 1023-1029, 2019.05

    Suga T, Yamaguchi H, Ogura J, Mano N

    Multiple Authorship (Only Japanese)

  • Fundamental Study of Behaviors of In-Source Collision Induced Dissociation and Shifting the Linear Range of Calibration Curves of Various Drugs and the Metabolites Used for Therapeutic Drug Monitoring., Chromatography, 40(2) 71-78, 2019.05

    Maekawa M, Tsukamoto T, Takasaki S, Kikuchi M, Sato Y, Ogura J, Hayakawa Y, Yamaguchi H, Mano N

    Single Author

  • Estimation of blood sirolimus concentration based on tacrolimus concentration/dose normalized by body weight ratio in lung transplant patients., Therapeutic drug monitoring, 2019.04

    Kikuchi M, Shigeta K, Tanaka M, Takasaki S, Akiba M, Oishi H, Sado T, Matsuda Y, Noda M, Okada Y, Mano N, Yamaguchi H

    Multiple Authorship (Only Japanese)

  • Development of a Highly Potent Analogue and a Long-Acting Analogue of Oxytocin for the Treatment of Social Impairment-Like Behaviors., Journal of medicinal chemistry, 62(7) 3297-3310, 2019.04

    Ichinose W, Cherepanov SM, Shabalova AA, Yokoyama S, Yuhi T, Yamaguchi H, Watanabe A, Yamamoto Y, Okamoto H, Horike S, Terakawa J, Daikoku T, Watanabe M, Mano N, Higashida H, Shuto S

    Multiple Authorship (Only Japanese)

  • Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease., Nature communications, 10(1) 1835, 2019.04

    Kikuchi K, Saigusa D, Kanemitsu Y, Matsumoto Y, Thanai P, Suzuki N, Mise K, Yamaguchi H, Nakamura T, Asaji K, Mukawa C, Tsukamoto H, Sato T, Oikawa Y, Iwasaki T, Oe Y, Tsukimi T, Fukuda NN, Ho HJ, Nan...

    Multiple Authorship (Including Foreigners)

  • Diagnostic performance evaluation of sulfate-conjugated cholesterol metabolites as urinary biomarkers of Niemann-Pick disease type C., Clinica chimica acta; international journal of clinical chemistry, 494 58-63, 2019.03

    Maekawa M, Narita A, Jinnoh I, Iida T, Marquardt T, Mengel E, Eto Y, Clayton PT, Yamaguchi H, Mano N

    Single Author

  • Analysis of membrane transport mechanisms of endogenous substrates using chromatographic techniques., Biomedical chromatography : BMC, e4495, 2019.01

    Yamaguchi H, Mano N

    Single Author

  • Value of global metabolomics in association with diagnosis and clinicopathological factors of renal cell carcinoma., International journal of cancer, 2019.01

    Sato T, Kawasaki Y, Maekawa M, Takasaki S, Saigusa D, Ota H, Shimada S, Yamashita S, Mitsuzuka K, Yamaguchi H, Ito A, Kinoshita K, Koshiba S, Mano N, Arai Y

    Single Author

  • Long-term relationship between everolimus blood concentration and clinical outcomes in Japanese patients with metastatic renal cell carcinoma: a prospective study., Journal of pharmaceutical health care and sciences, 5 6, 2019

    Takasaki S, Yamaguchi H, Kawasaki Y, Kikuchi M, Tanaka M, Ito A, Mano N

    Single Author

  • Risk Factors for Severe Hyponatremia Related to Cisplatin: A Retrospective Case-Control Study., Biological & pharmaceutical bulletin, 42(11) 1891-1897, 2019

    Hatakeyama S, Shida T, Yamaguchi H

    Single Author

  • Limited Sampling Strategy for the Estimation of Mycophenolic Acid and its Acyl Glucuronide Metabolite Area under the Concentration-Time Curve in Japanese Lung Transplant Recipients., Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 22(1) 407-417, 2019

    Tanaka M, Kikuchi M, Takasaki S, Hirasawa T, Sigeta K, Noda A, Akiba M, Matsuda Y, Oishi H, Sado T, Noda M, Okada Y, Mano N, Yamaguchi H

    Single Author

  • Functional characterization of 40 CYP2B6 allelic variants by assessing efavirenz 8-hydroxylation., Biochemical pharmacology, 156 420-430, 2018.10

    Watanabe T, Saito T, Rico EMG, Hishinuma E, Kumondai M, Maekawa M, Oda A, Saigusa D, Saito S, Yasuda J, Nagasaki M, Minegishi N, Yamamoto M, Yamaguchi H, Mano N, Hirasawa N, Hiratsuka M

    Single Author

  • Relationships between sunitinib plasma concentration and clinical outcomes in Japanese patients with metastatic renal cell carcinoma., International journal of clinical oncology, 23(5) 936-943, 2018.10

    Takasaki S, Kawasaki Y, Kikuchi M, Tanaka M, Suzuka M, Noda A, Sato Y, Yamashita S, Mitsuzuka K, Saito H, Ito A, Yamaguchi H, Arai Y, Mano N

    Single Author

  • Functional Characterization of 21 Allelic Variants of Dihydropyrimidine Dehydrogenase Identified in 1070 Japanese Individuals., Drug metabolism and disposition: the biological fate of chemicals, 46(8) 1083-1090, 2018.08

    Hishinuma E, Narita Y, Saito S, Maekawa M, Akai F, Nakanishi Y, Yasuda J, Nagasaki M, Yamamoto M, Yamaguchi H, Mano N, Hirasawa N, Hiratsuka M

    Single Author

  • Simultaneous analysis of oral anticancer drugs for renal cell carcinoma in human plasma using liquid chromatography/electrospray ionization tandem mass spectrometry., Biomedical chromatography : BMC, 32(6) e4184, 2018.06

    Takasaki S, Tanaka M, Kikuchi M, Maekawa M, Kawasaki Y, Ito A, Arai Y, Yamaguchi H, Mano N

    Single Author

  • 肺移植患者における個別化薬物療法, 臨床薬理の進歩, (39) 104-116, 2018.06

    山口 浩明, 菊地 正史, 田中 雅樹, 高崎 新也, 野田 あおい, 重田 健介, 白木 美香, 高木 秀侑, 松田 安史, 野田 雅史, 岡田 克典, 眞野 成康

    Single Author

  • Impact of clinical factors and UGT1A9 and CYP2B6 genotype on inter-individual differences in propofol pharmacokinetics., Journal of anesthesia, 32(2) 236-243, 2018.04

    Kanaya A, Sato T, Fuse N, Yamaguchi H, Mano N, Yamauchi M

    Single Author

  • Functional characterization of 9 CYP2A13 allelic variants by assessment of nicotine C-oxidation and coumarin 7-hydroxylation., Drug metabolism and pharmacokinetics, 33(1) 82-89, 2018.02

    Kumondai M, Hosono H, Maekawa M, Yamaguchi H, Mano N, Oda A, Hirasawa N, Hiratsuka M

    Single Author

  • Interactions of crizotinib and gefitinib with organic anion-transporting polypeptides (OATP)1B1, OATP1B3 and OATP2B1: gefitinib shows contradictory interaction with OATP1B3., Xenobiotica; the fate of foreign compounds in biological systems, 48(1) 73-78, 2018.01

    Sato T, Ito H, Hirata A, Abe T, Mano N, Yamaguchi H

    Single Author

  • Comparison of PETINIA and LC-MS/MS for determining plasma mycophenolic acid concentrations in Japanese lung transplant recipients., Journal of pharmaceutical health care and sciences, 4 7, 2018

    Kikuchi M, Tanaka M, Takasaki S, Takahashi A, Akiba M, Matsuda Y, Noda M, Hisamichi K, Yamaguchi H, Okada Y, Mano N

    Single Author

  • Development of a Liquid Chromatography-Tandem Mass Spectrometric Method for Quantification of Mycophenolic Acid and Its Glucuronides in Dried Blood Spot Samples., Therapeutic drug monitoring, 39(6) 648-653, 2017.12

    Iboshi H, Yamaguchi H, Suzuki H, Kikuchi M, Tanaka M, Takasaki S, Takahashi A, Maekawa M, Shimada M, Matsuda Y, Okada Y, Mano N

    Single Author

  • Functional characterization of 21 allelic variants of dihydropyrimidinase., Biochemical pharmacology, 143 118-128, 2017.11

    Hishinuma E, Akai F, Narita Y, Maekawa M, Yamaguchi H, Mano N, Oda A, Hirasawa N, Hiratsuka M

    Single Author

  • Potential Drug Interactions Mediated by Renal Organic Anion Transporter OATP4C1., The Journal of pharmacology and experimental therapeutics, 362(2) 271-277, 2017.08

    Sato T, Mishima E, Mano N, Abe T, Yamaguchi H

    Single Author

  • Mitochonic Acid 5 (MA-5) Facilitates ATP Synthase Oligomerization and Cell Survival in Various Mitochondrial Diseases., EBioMedicine, 20 27-38, 2017.06

    Matsuhashi T, Sato T, Kanno SI, Suzuki T, Matsuo A, Oba Y, Kikusato M, Ogasawara E, Kudo T, Suzuki K, Ohara O, Shimbo H, Nanto F, Yamaguchi H, Saigusa D, Mukaiyama Y, Watabe A, Kikuchi K, Shima H, Mis...

    Single Author

  • Matrix effect-corrected liquid chromatography/tandem mass-spectrometric method for determining acylcarnitines in human urine., Clinica chimica acta; international journal of clinical chemistry, 468 187-194, 2017.05

    Abe K, Suzuki H, Maekawa M, Shimada M, Yamaguchi H, Mano N

    Single Author

  • Activation of the Hypoxia Inducible Factor 1α Subunit Pathway in Steatotic Liver Contributes to Formation of Cholesterol Gallstones., Gastroenterology, 152(6) 1521-1535.e8, 2017.05

    Asai Y, Yamada T, Tsukita S, Takahashi K, Maekawa M, Honma M, Ikeda M, Murakami K, Munakata Y, Shirai Y, Kodama S, Sugisawa T, Chiba Y, Kondo Y, Kaneko K, Uno K, Sawada S, Imai J, Nakamura Y, Yamaguch...

    Single Author

  • Functional Characterization of 34 CYP2A6 Allelic Variants by Assessment of Nicotine C-Oxidation and Coumarin 7-Hydroxylation Activities., Drug metabolism and disposition: the biological fate of chemicals, 45(3) 279-285, 2017.03

    Hosono H, Kumondai M, Maekawa M, Yamaguchi H, Mano N, Oda A, Hirasawa N, Hiratsuka M

    Single Author

  • Severe toxicity induced by accumulation of active sunitinib metabolite in a Japanese patient with renal cell carcinoma: a case report., Journal of medical case reports, 11(1) 28, 2017.02

    Takasaki S, Kikuchi M, Kawasaki Y, Ito A, Arai Y, Yamaguchi H, Mano N

    Single Author

  • [A Case of Renal Cell Carcinoma with High Everolimus Blood Concentrations and Hyperglycemia Due to Everolimus-Induced Hepatic Dysfunction]., Gan to kagaku ryoho. Cancer & chemotherapy, 44(1) 87-89, 2017.01

    Takasaki S, Kikuchi M, Kawasaki Y, Ito A, Arai Y, Yamaguchi H, Mano N

    Single Author

  • Preference of Conjugated Bile Acids over Unconjugated Bile Acids as Substrates for OATP1B1 and OATP1B3., PloS one, 12(1) e0169719, 2017

    Suga T, Yamaguchi H, Sato T, Maekawa M, Goto J, Mano N

    Single Author

  • A simultaneous determination method for 5-fluorouracil and its metabolites in human plasma with linear range adjusted by in-source collision-induced dissociation using hydrophilic interaction liquid chromatography-electrospray ionization-tandem mass spect, Biomedical chromatography : BMC, 30(11) 1882-1886, 2016.11

    Ishii H, Shimada M, Yamaguchi H, Mano N

    Single Author

  • Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage., Journal of the American Society of Nephrology : JASN, 27(7) 1925-1932, 2016.07

    Suzuki T, Yamaguchi H, Kikusato M, Hashizume O, Nagatoishi S, Matsuo A, Sato T, Kudo T, Matsuhashi T, Murayama K, Ohba Y, Watanabe S, Kanno S, Minaki D, Saigusa D, Shinbo H, Mori N, Yuri A, Yokoro M, ...

    Single Author

  • Shifting the Linear Range in Electrospray Ionization by In-Source Collision-Induced Dissociation., Chemical & pharmaceutical bulletin, 64(4) 356-359, 2016

    Ishii H, Yamaguchi H, Mano N

    Single Author

  • Identification of Two Sulfated Cholesterol Metabolites Found in the Urine of a Patient with Niemann-Pick Disease Type C as Novel Candidate Diagnostic Markers., Mass spectrometry (Tokyo, Japan), 5(2) S0053, 2016

    Maekawa M, Omura K, Sekiguchi S, Iida T, Saigusa D, Yamaguchi H, Mano N

    Single Author

  • Reactive oxygen species derived from xanthine oxidase interrupt dimerization of breast cancer resistance protein, resulting in suppression of uric acid excretion to the intestinal lumen., Biochemical pharmacology, 97(1) 89-98, 2015.09

    Ogura J, Kuwayama K, Sasaki S, Kaneko C, Koizumi T, Yabe K, Tsujimoto T, Takeno R, Takaya A, Kobayashi M, Yamaguchi H, Iseki K

    Single Author

  • Focused metabolomics using liquid chromatography/electrospray ionization tandem mass spectrometry for analysis of urinary conjugated cholesterol metabolites from patients with Niemann-Pick disease type C and 3β-hydroxysteroid dehydrogenase deficiency., Annals of clinical biochemistry, 52(Pt 5) 576-587, 2015.09

    Maekawa M, Shimada M, Ohno K, Togawa M, Nittono H, Iida T, Hofmann AF, Goto J, Yamaguchi H, Mano N

    Single Author

  • Mitochonic Acid 5 (MA-5), a Derivative of the Plant Hormone Indole-3-Acetic Acid, Improves Survival of Fibroblasts from Patients with Mitochondrial Diseases., The Tohoku journal of experimental medicine, 236(3) 225-232, 2015.07

    Suzuki T, Yamaguchi H, Kikusato M, Matsuhashi T, Matsuo A, Sato T, Oba Y, Watanabe S, Minaki D, Saigusa D, Shimbo H, Mori N, Mishima E, Shima H, Akiyama Y, Takeuchi Y, Yuri A, Kikuchi K, Toyohara T, S...

    Single Author

  • Simultaneous quantification of leukotrienes and hydroxyeicosatetraenoic acids in cell culture medium using liquid chromatography/tandem mass spectrometry., Biomedical chromatography : BMC, 29(7) 1084-1093, 2015.07

    Furugen A, Yamaguchi H, Mano N

    Single Author

  • Erratum to: Determination of ω-6 and ω-3 PUFA metabolites in human urine samples using UPLC/MS/MS., Analytical and bioanalytical chemistry, 407(10) 2939-2940, 2015.04

    Sasaki A, Fukuda H, Shiida N, Tanaka N, Furugen A, Ogura J, Shuto S, Mano N, Yamaguchi H

    Single Author

  • A novel extraction method based on a reversible chemical conversion for the LC/MS/MS analysis of the stable organic germanium compound Ge-132., Analytical chemistry, 87(4) 2042-2047, 2015.02

    Yamaguchi H, Shimada Y, Takeda T, Nakamura T, Mano N

    Single Author

  • Determination of ω-6 and ω-3 PUFA metabolites in human urine samples using UPLC/MS/MS., Analytical and bioanalytical chemistry, 407(6) 1625-1639, 2015.02

    Sasaki A, Fukuda H, Shiida N, Tanaka N, Furugen A, Ogura J, Shuto S, Mano N, Yamaguchi H

    Single Author

  • Successful Colistin Treatment of Multidrug-Resistant Pseudomonas aeruginosa Infection Using a Rapid Method for Determination of Colistin in Plasma: Usefulness of Therapeutic Drug Monitoring., Biological & pharmaceutical bulletin, 38(9) 1430-1433, 2015

    Yamada T, Ishiguro N, Oku K, Higuchi I, Nakagawa I, Noguchi A, Yasuda S, Fukumoto T, Iwasaki S, Akizawa K, Furugen A, Yamaguchi H, Iseki K

    Single Author

  • Quantification of intracellular and extracellular digoxin and ouabain by liquid chromatography/electrospray ionization tandem mass spectrometry., Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 972 73-80, 2014.12

    Yamaguchi H, Miyamori K, Sato T, Ogura J, Kobayashi M, Yamada T, Mano N, Iseki K

    Single Author

  • Quantification of intracellular and extracellular eicosapentaenoic acid-derived 3-series prostanoids by liquid chromatography/electrospray ionization tandem mass spectrometry., Prostaglandins Leukot Essent Fatty Acids, 91(3) 61-71, 2014.09

    Tanaka, Nobuaki Yamaguchi, Hiroaki Furugen, Ayako Ogura, Jiro Kobayashi, Masaki Yamada, Takehiro Mano, Nariyasu Iseki, Ken

    Single Author

  • Quercetin-3-rhamnoglucoside (rutin) stimulates transport of organic anion compounds mediated by organic anion transporting polypeptide 2B1., Biopharm Drug Dispos, 35(3) 173-182, 2014.04

    Ogura, Jiro Koizumi, Takahiro Segawa, Masahiro Yabe, Keisuke Kuwayama, Kaori Sasaki, Shunichi Kaneko, Chihiro Tsujimoto, Takashi Kobayashi, Masaki Yamaguchi, Hiroaki Iseki, Ken

    Single Author

  • Intestinal P-glycoprotein expression is multimodally regulated by intestinal ischemia-reperfusion., J Pharm Pharm Sci, 17(2) 266-276, 2014

    Terada, Yusuke Ogura, Jiro Tsujimoto, Takashi Kuwayama, Kaori Koizumi, Takahiro Sasaki, Shunichi Maruyama, Hajime Kobayashi, Masaki Yamaguchi, Hiroaki Iseki, Ken

    Single Author

  • Organic anion transporting polypeptides 1B1 and 1B3 play an important role in uremic toxin handling and drug-uremic toxin interactions in the liver., Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 17(4) 475-484, 2014

    Sato T, Yamaguchi H, Kogawa T, Abe T, Mano N

    Single Author

  • Involvement of Histidine Residue His382 in pH Regulation of MCT4 Activity., PloS one, 10(4) e0122738, 2014

    Sasaki S, Kobayashi M, Futagi Y, Ogura J, Yamaguchi H, Iseki K

    Single Author

  • Immunoprotective effect of epigallocatechin-3-gallate on oral anticancer drug-induced alpha-defensin reduction in Caco-2 cells., Biol Pharm Bull, 37(3) 490-492, 2014

    Takahashi, Natsuko Kobayashi, Masaki Ogura, Jiro Yamaguchi, Hiroaki Satoh, Takashi Watanabe, Kazuhiro Iseki, Ken

    Single Author

  • Alteration of pharmacokinetics of grepafloxacin in type 2 diabetic rats., J Pharm Pharm Sci, 17(1) 25-33, 2014

    Watanabe, Meguho Kobayashi, Masaki Ogura, Jiro Takahashi, Natsuko Yamaguchi, Hiroaki Iseki, Ken

    Single Author

  • Effect of oxidative stress on expression and function of human and rat organic anion transporting polypeptides in the liver., Int J Pharm, 458(2) 262-271, 2013.12

    Tsujimoto, Takashi Ogura, Jiro Kuwayama, Kaori Koizumi, Takahiro Sasaki, Shunichi Terada, Yusuke Kobayashi, Masaki Yamaguchi, Hiroaki Iseki, Ken

    Single Author

  • Megalin contributes to kidney accumulation and nephrotoxicity of colistin., Antimicrob Agents Chemother, 57(12) 6319-6324, 2013.12

    Suzuki, Takahiro Yamaguchi, Hiroaki Ogura, Jiro Kobayashi, Masaki Yamada, Takehiro Iseki, Ken

    Single Author

  • Effect of oxidative stress on expression and function of human and rat organic anion transporting polypeptides in the liver., Int J Pharm, 2013.10

    Tsujimoto, Takashi Ogura, Jiro Kuwayama, Kaori Koizumi, Takahiro Sasaki, Shunichi Terada, Yusuke Kobayashi, Masaki Yamaguchi, Hiroaki Iseki, Ken

    Single Author

  • Contribution of multidrug resistance-associated proteins (MRPs) to the release of prostanoids from A549 cells., Prostaglandins Other Lipid Mediat, 106 37-44, 2013.10

    Furugen, Ayako Yamaguchi, Hiroaki Tanaka, Nobuaki Shiida, Narumi Ogura, Jiro Kobayashi, Masaki Iseki, Ken

    Single Author

  • LC/ESI-MS/MS analysis of urinary 3beta-sulfooxy-7beta-N-acetylglucosaminyl-5-cholen-24-oic acid and its amides: new biomarkers for the detection of Niemann-Pick type C disease., Steroids, 78(10) 967-972, 2013.10

    Maekawa, Masamitsu Misawa, Yasushi Sotoura, Ayako Yamaguchi, Hiroaki Togawa, Masami Ohno, Kousaku Nittono, Hiroshi Kakiyama, Genta Iida, Takashi Hofmann, Alan F Goto, Junichi Shimada, Miki Mano, Nariy...

    Single Author

  • Regulation of multidrug resistance protein 2 (MRP2, ABCC2) expression by statins: involvement of SREBP-mediated gene regulation., Int J Pharm, 452(1-2) 36-41, 2013.08

    Kobayashi, Masaki Gouda, Keisuke Chisaki, Ikumi Asada, Koji Ogura, Jiro Takahashi, Natsuko Konishi, Toru Koshida, Yusuke Sasaki, Shotaro Yamaguchi, Hiroaki Iseki, Ken

    Single Author

  • Quantitative determination of paclitaxel and its metabolites, 6alpha-hydroxypaclitaxel and p-3'-hydroxypaclitaxel, in human plasma using column-switching liquid chromatography/tandem mass spectrometry., Biomed Chromatogr, 27(4) 539-544, 2013.04

    Yamaguchi, Hiroaki Fujikawa, Asuka Ito, Hajime Tanaka, Nobuaki Furugen, Ayako Miyamori, Kazuaki Takahashi, Natsuko Ogura, Jiro Kobayashi, Masaki Yamada, Takehiro Mano, Nariyasu Iseki, Ken

    Single Author

  • Renal uptake of substrates for organic anion transporters Oat1 and Oat3 and organic cation transporters Oct1 and Oct2 is altered in rats with adenine-induced chronic renal failure., J Pharm Sci, 102(3) 1086-1094, 2013.03

    Komazawa, Hiroki Yamaguchi, Hiroaki Hidaka, Kazuhiro Ogura, Jiro Kobayashi, Masaki Iseki, Ken

    Single Author

  • Quantification of intact carboplatin in human plasma ultrafitrates using hydrophilic interaction liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study., J Chromatogr B Analyt Technol Biomed Life Sci, 917-918 18-23, 2013.02

    Ito, Hajime Yamaguchi, Hiroaki Fujikawa, Asuka Shiida, Narumi Tanaka, Nobuaki Ogura, Jiro Kobayashi, Masaki Yamada, Takehiro Mano, Nariyasu Iseki, Ken

    Single Author

  • Intestinal ischemia-reperfusion suppresses biliary excretion of hepatic organic anion transporting polypeptides substrate., J Pharm Pharm Sci, 16(5) 722-731, 2013

    Maruyama, Hajime Ogura, Jiro Fujikawa, Asuka Terada, Yusuke Tsujimoto, Takashi Koizumi, Takahiro Kuwayama, Kaori Kobayashi, Masaki Yamaguchi, Hiroaki Iseki, Ken

    Single Author

  • Rapid stimulating effect of the antiarrhythmic agent amiodarone on absorption of organic anion compounds., Drug Metab Pharmacokinet, 28(3) 178-186, 2013

    Segawa, Masahiro Ogura, Jiro Seki, Satoru Itagaki, Shirou Takahashi, Natsuko Kobayashi, Masaki Hirano, Takeshi Yamaguchi, Hiroaki Iseki, Ken

    Single Author

  • Crucial residue involved in L-lactate recognition by human monocarboxylate transporter 4 (hMCT4)., PLoS One, 8(7) e67690, 2013

    Sasaki, Shotaro Kobayashi, Masaki Futagi, Yuya Ogura, Jiro Yamaguchi, Hiroaki Takahashi, Natsuko Iseki, Ken

    Single Author

  • Regulation of the expression and activity of glucose and lactic acid metabolism-related genes by protein kinase C in skeletal muscle cells., Biol Pharm Bull, 36(9) 1435-1439, 2013

    Otake, Sho Kobayashi, Masaki Narumi, Katsuya Sasaki, Shotaro Kikutani, Yurika Furugen, Ayako Watanabe, Meguho Takahashi, Natsuko Ogura, Jiro Yamaguchi, Hiroaki Iseki, Ken

    Single Author

  • A full validated hydrophilic interaction liquid chromatography-tandem mass spectrometric method for the quantification of oxaliplatin in human plasma ultrafiltrates., J Pharm Biomed Anal, 71 99-103, 2012.12

    Ito, Hajime Yamaguchi, Hiroaki Fujikawa, Asuka Tanaka, Nobuaki Furugen, Ayako Miyamori, Kazuaki Takahashi, Natsuko Ogura, Jiro Kobayashi, Masaki Yamada, Takehiro Mano, Nariyasu Iseki, Ken

    Single Author

  • Simultaneous quantitation of sphingoid bases and their phosphates in biological samples by liquid chromatography/electrospray ionization tandem mass spectrometry., Anal Bioanal Chem, 403(7) 1897-1905, 2012.06

    Saigusa, Daisuke Shiba, Kanako Inoue, Asuka Hama, Kotaro Okutani, Michiyo Iida, Nagisa Saito, Masayoshi Suzuki, Kaori Kaneko, Tohru Suzuki, Naoto Yamaguchi, Hiroaki Mano, Nariyasu Goto, Junichi Hishin...

    Single Author

  • Regulation of human monocarboxylate transporter 4 in skeletal muscle cells: the role of protein kinase C (PKC)., Int J Pharm, 428(1-2) 25-32, 2012.05

    Narumi, Katsuya Kobayashi, Masaki Otake, Sho Furugen, Ayako Takahashi, Natsuko Ogura, Jiro Itagaki, Shirou Hirano, Takeshi Yamaguchi, Hiroaki Iseki, Ken

    Single Author

  • A rapid and sensitive LC/ESI-MS/MS method for quantitative analysis of docetaxel in human plasma and its application to a pharmacokinetic study., J Chromatogr B Analyt Technol Biomed Life Sci, 893-894 157-161, 2012.04

    Yamaguchi, Hiroaki Fujikawa, Asuka Ito, Hajime Tanaka, Nobuaki Furugen, Ayako Miyamori, Kazuaki Takahashi, Natsuko Ogura, Jiro Kobayashi, Masaki Yamada, Takehiro Mano, Nariyasu Iseki, Ken

    Single Author

  • Intestinal ischemia-reperfusion increases efflux for uric acid via paracellular route in the intestine, but decreases that via transcellular route mediated by BCRP., J Pharm Pharm Sci, 15(2) 295-304, 2012

    Ogura, Jiro Kuwayama, Kaori Takaya, Atsushi Terada, Yusuke Tsujimoto, Takashi Koizumi, Takahiro Maruyama, Hajime Fujikawa, Asuka Takahashi, Natsuko Kobayashi, Masaki Itagaki, Shirou Hirano, Takeshi Ya...

    Single Author

  • Effects of acidification and alkalinization agents on statins-induced muscle toxicity., Yakugaku Zasshi, 132(5) 609-615, 2012

    Kobayashi, Masaki Hidaka, Kazuhiro Chisaki, Ikumi Takahashi, Natsuko Ogura, Jiro Itagaki, Shirou Hirano, Takeshi Yamaguchi, Hiroaki Iseki, Ken

    Single Author

  • The decrease in farnesoid X receptor, pregnane X receptor and constitutive androstane receptor in the liver after intestinal ischemia-reperfusion., J Pharm Pharm Sci, 15(5) 616-631, 2012

    Ogura, Jiro Terada, Yusuke Tsujimoto, Takashi Koizumi, Takahiro Kuwayama, Kaori Maruyama, Hajime Fujikawa, Asuka Takaya, Atsushi Kobayashi, Masaki Itagaki, Shirou Takahashi, Natsuko Hirano, Takeshi Ya...

    Single Author

  • Quantification of intracellular and extracellular prostanoids stimulated by A23187 by liquid chromatography/electrospray ionization tandem mass spectrometry., J Chromatogr B Analyt Technol Biomed Life Sci, 879(30) 3378-3385, 2011.11

    Furugen, Ayako Yamaguchi, Hiroaki Tanaka, Nobuaki Ito, Hajime Miyamori, Kazuaki Fujikawa, Asuka Takahashi, Natsuko Ogura, Jiro Kobayashi, Masaki Yamada, Takehiro Mano, Nariyasu Iseki, Ken

    Single Author

  • An accurate quantitative LC/ESI-MS/MS method for sirolimus in human whole blood., J Chromatogr B Analyt Technol Biomed Life Sci, 879(13-14) 987-992, 2011.04

    Mano, Nariyasu Sato, Mayumi Nozawa, Marina Matsumoto, Yotaro Mori, Masaru Yamaguchi, Hiroaki Goto, Junichi Shimada, Miki

    Single Author

  • Identification and elimination of ion suppression in the quantitative analysis of sirolimus in human blood by LC/ESI-MS/MS., J Chromatogr B Analyt Technol Biomed Life Sci, 879(13-14) 968-974, 2011.04

    Mano, Nariyasu Nozawa, Marina Sato, Mayumi Mori, Masaru Yamaguchi, Hiroaki Kanda, Katsuhiro Nogami, Makoto Goto, Junichi Shimada, Miki

    Single Author

  • Screening of antibiotics that interact with organic anion-transporting polypeptides 1B1 and 1B3 using fluorescent probes., Biol Pharm Bull, 34(3) 389-395, 2011

    Yamaguchi, Hiroaki Takeuchi, Toshiko Okada, Masahiro Kobayashi, Minako Unno, Michiaki Abe, Takaaki Goto, Junichi Hishinuma, Takanori Shimada, Miki Mano, Nariyasu

    Single Author

  • Production of 18O-single labeled peptide fragments during trypsin digestion of proteins for quantitative proteomics using nanoLC-ESI-MS/MS., J Proteome Res, 9(7) 3741-3749, 2010.07

    Mori, Masaru Abe, Kohei Yamaguchi, Hiroaki Goto, Junichi Shimada, Miki Mano, Nariyasu

    Single Author

  • Transport of estrone 3-sulfate mediated by organic anion transporter OATP4C1: estrone 3-sulfate binds to the different recognition site for digoxin in OATP4C1., Drug Metab Pharmacokinet, 25(3) 314-317, 2010

    Yamaguchi, Hiroaki Sugie, Misa Okada, Masahiro Mikkaichi, Tsuyoshi Toyohara, Takafumi Abe, Takaaki Goto, Junichi Hishinuma, Takanori Shimada, Miki Mano, Nariyasu

    Single Author

  • SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation., J Am Soc Nephrol, 20(12) 2546-2555, 2009.12

    Toyohara, Takafumi Suzuki, Takehiro Morimoto, Ryo Akiyama, Yasutoshi Souma, Tomokazu Shiwaku, Hiromi O Takeuchi, Yoichi Mishima, Eikan Abe, Michiaki Tanemoto, Masayuki Masuda, Satohiro Kawano, Hiroaki...

    Single Author

  • Analysis of phosphorylated peptides by double pseudoneutral loss extraction coupled with derivatization using N-(4-bromobenzoyl)aminoethanethiol., Anal Chem, 81(22) 9395-9401, 2009.11

    Mano, Nariyasu Aoki, Sayaka Yamazaki, Takuma Nagaya, Yoko Mori, Masaru Abe, Kohei Shimada, Miki Yamaguchi, Hiroaki Goto, Takaaki Goto, Junichi

    Single Author

  • Introducing hazard prediction training 'KYT' to undergraduate pharmacy education on patient safety, Yakugaku Zasshi, 129(11) 1367-1373, 2009.11

    Murai, Yuriko Sato, Mayumi Yamaguchi, Hiroaki Shimada, Miki Mano, Nariyasu Goto, Junichi Hishinuma, Takanori

    Single Author

  • Contribution of the drug transporter ABCG2 (breast cancer resistance protein) to resistance against anticancer nucleosides., Mol Cancer Ther, 7(9) 3092-3102, 2008.09

    de Wolf, Cornelia Jansen, Robert Yamaguchi, Hiroaki de Haas, Marcel van de Wetering, Koen Wijnholds, Jan Beijnen, Jos Borst, Piet

    Single Author

  • Simple quantification of lansoprazole and rabeprazole concentrations in human serum by liquid chromatography/tandem mass spectrometry., J Chromatogr B Analyt Technol Biomed Life Sci, 870(1) 38-45, 2008.07

    Hishinuma, Takanori Suzuki, Kaori Yamaguchi, Hiroaki Yamagishi, Hatsushi Koike, Tomoyuki Ohara, Shuichi Shimosegawa, Toru Mano, Nariyasu Goto, Junichi

    Single Author

  • Rapid screening of antineoplastic candidates for the human organic anion transporter OATP1B3 substrates using fluorescent probes., Cancer Lett, 260(1-2) 163-169, 2008.02

    Yamaguchi, Hiroaki Kobayashi, Minako Okada, Masahiro Takeuchi, Toshiko Unno, Michiaki Abe, Takaaki Goto, Junichi Hishinuma, Takanori Mano, Nariyasu

    Single Author

  • Simultaneous quantification of seven prostanoids using liquid chromatography/tandem mass spectrometry: the effects of arachidonic acid on prostanoid production in mouse bone marrow-derived mast cells., Prostaglandins Leukot Essent Fatty Acids, 76(6) 321-329, 2007.06

    Hishinuma, Takanori Suzuki, Kaori Saito, Masayoshi Yamaguchi, Hiroaki Suzuki, Naoto Tomioka, Yoshihisa Kaneko, Izumi Ono, Masao Goto, Junichi

    Single Author

  • cGMP transport by vesicles from human and mouse erythrocytes., FEBS J, 274(2) 439-450, 2007.01

    de Wolf, Cornelia J F Yamaguchi, Hiroaki van der Heijden, Ingrid Wielinga, Peter R Hundscheid, Stefanie L Ono, Nobuhito Scheffer, George L de Haas, Marcel Schuetz, John D Wijnholds, Jan Borst, Piet

    Single Author

  • Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3., J Lipid Res, 47(6) 1196-1202, 2006.06

    Yamaguchi, Hiroaki Okada, Masahiro Akitaya, Shou Ohara, Hiroshi Mikkaichi, Tsuyoshi Ishikawa, Haruna Sato, Mayumi Matsuura, Masaki Saga, Toshihide Unno, Michiaki Abe, Takaaki Mano, Nariyasu Hishinuma,...

    Single Author

  • Genetic variation in ABCB1 influences paclitaxel pharmacokinetics in Japanese patients with ovarian cancer., Int J Gynecol Cancer, 16(3) 979-985, 2006.06

    Yamaguchi, H Hishinuma, T Endo, N Tsukamoto, H Kishikawa, Y Sato, M Murai, Y Hiratsuka, M Ito, K Okamura, C Yaegashi, N Suzuki, N Tomioka, Y Goto, J

    Single Author

  • Simultaneous determination of pancuronium, vecuronium and their related compounds using LC-ESI-MS., Leg Med (Tokyo), 8(3) 166-171, 2006.05

    Usui, Kiyotaka Hishinuma, Takanori Yamaguchi, Hiroaki Saga, Toshihide Wagatsuma, Toshihiro Hoshi, Kunihiko Tachiiri, Naoki Miura, Kuniaki Goto, Junichi

    Single Author

  • Preparation of neocarzinostatin apoprotein mutants and the randomized library on the chromophore-binding cavity., Biol Pharm Bull, 29(5) 1010-1014, 2006.05

    Tomioka, Yoshihisa Kisara, Shigeki Yoshizawa, Saki Ozawa, Mika Suzuki, Naoto Yamaguchi, Hiroaki Hishinuma, Takanori Mizugaki, Michinao Goto, Junichi

    Single Author

  • Determination of chlorhexidine (CHD) and nonylphenolethoxylates (NPEOn) using LC-ESI-MS method and application to hemolyzed blood., J Chromatogr B Analyt Technol Biomed Life Sci, 831(1-2) 105-109, 2006.02

    Usui, Kiyotaka Hishinuma, Takanori Yamaguchi, Hiroaki Tachiiri, Naoki Goto, Junichi

    Single Author

  • Effect of cisplatin-induced acute renal failure on bioavailability and intestinal secretion of quinolone antibacterial drugs in rats., Pharm Res, 21(2) 330-338, 2004.02

    Yamaguchi, Hiroaki Yano, Ikuko Saito, Hideyuki Inui, Ken-ichi

    Single Author

  • Pharmacokinetic role of P-glycoprotein in oral bioavailability and intestinal secretion of grepafloxacin in vivo., J Pharmacol Exp Ther, 300(3) 1063-1069, 2002.03

    Yamaguchi, Hiroaki Yano, Ikuko Saito, Hideyuki Inui, Ken-ichi

    Single Author

  • Transport characteristics of grepafloxacin and levofloxacin in the human intestinal cell line Caco-2., Eur J Pharmacol, 431(3) 297-303, 2001.11

    Yamaguchi, H Yano, I Saito, H Inui, K

    Single Author

  • Secretory mechanisms of grepafloxacin and levofloxacin in the human intestinal cell line caco-2., J Pharmacol Exp Ther, 295(1) 360-366, 2000.10

    Yamaguchi, H Yano, I Hashimoto, Y Inui, K I

    Single Author

  • Microdetermination of the 6,15-diketo-13,14-dihydroprostaglandin F1alpha in human plasma using gas chromatography/selected ion monitoring with [18O]6,15-diketo-13,14-dihydro-prostaglandin F1alpha as an internal standard., Prostaglandins Other Lipid Mediat, 58(2-4) 187-193, 1999.10

    Mizugaki, M Hishinuma, T Yamaguchi, H Kanno, K Hirose, Y Nakamura, H

    Single Author

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Review Papers

  • プラチナ感受性再発卵巣がんに対するオラパリブのコンパニオン診断による薬剤経済評価, 日本癌治療学会学術集会抄録集, 57回 P157-6, 2019.10

    志田 敏宏, 佐藤 一真, 中村 達也, 山口 浩明, 荒川 一郎, 井上 忠夫

  • LC/ESI‐MS/MSを用いる胆汁酸メタボローム解析系の基礎的検討, (一社)日本臨床化学会, 臨床化学, 48(Suppl.1) 289, 2019.08

    庄子彩織, 前川正充, 山口浩明, 山口浩明, 眞野成康, 眞野成康

  • 血清リン脂質類のLC‐MS/MS分析に基づくニーマンピック病C型の迅速スクリーニング法の検討, (一社)日本臨床化学会, 臨床化学, 48(Suppl.1) 290, 2019.08

    岩堀杏南, 前川正充, 山口浩明, 眞野成康, 眞野成康

  • LC‐MS/MSを用いる脂質メディエーター網羅的解析の基礎的検討, (一社)日本臨床化学会, 臨床化学, 48(Suppl.1) 290, 2019.08

    横田真希, 前川正充, 福田隼, 眞野成康, 眞野成康, 山口浩明

  • LC/MS/MSによるニーマンピック病C型モデル細胞中ステロイドホルモン類の挙動解析, (一社)日本臨床化学会, 臨床化学, 48(Suppl.1) 289, 2019.08

    阿部愛, 前川正充, 小倉次郎, 山口浩明, 山口浩明, 眞野成康, 眞野成康

  • グローバルメタボロミクスによるニーマンピック病C型患者血液に特徴的なピーク探索, (一社)日本医用マススペクトル学会, JSBMS Letters, 44(Supplement) 79, 2019.08

    前川正充, 前川正充, 岩堀杏南, 金光祥臣, 三枝大輔, 三枝大輔, 山口浩明, 山口浩明, 山口浩明, 眞野成康, 眞野成康

  • 【がん治療と薬物相互作用 ピットフォールに陥らないための基礎と実践】抗がん薬の薬物動態学的 薬力学的相互作用 薬物動態学的機序による抗がん薬の薬物相互作用, (株)南山堂, 薬局, 70(7) 1425-1431, 2019.06

    山口 浩明, 菊地 正史

  • 第2回病院薬剤師が実践するリバーストランスレーショナルリサーチの最前線〜分子標的探索と個別化医療への挑戦〜 経口分子標的薬の個別化投与設計に向けて, (公社)日本薬学会, 薬学雑誌, 139(6) 911-915, 2019.06

    山口 浩明, 高崎 新也, 菊地 正史, 川崎 芳英, 荒井 陽一, 眞野 成康

  • 血中エベロリムス濃度と臨床効果の関連性~腎癌治療における長期追跡調査~, TDM研究, 36(2) 138, 2019.05

    高崎新也, 川崎芳英, 菊地正史, 田中雅樹, 山口浩明, 伊藤明宏, 眞野成康

  • 経口がん分子標的薬の個別投与設計に向けた取り組み, 日本薬剤学会年会講演要旨集(Web), 34年会 34, 2019.05

    山口浩明, 高崎新也, 菊地正史, 川崎芳英, 伊藤明宏, 眞野成康

  • 日本人肺移植患者におけるミコフェノール酸およびミコフェノール酸アシルグルクロン酸抱合体のAUC0-12の推定式, (一社)日本TDM学会, TDM研究, 36(2) 135, 2019.05

    田中 雅樹, 菊地 正史, 高崎 新也, 野田 あおい, 秋場 美紀, 松田 安史, 大石 久, 野田 雅史, 岡田 克典, 眞野 成康, 山口 浩明

  • インソースCIDを利用したLC/ESI-MS/MSによる多種薬物の同時測定法の構築に向けた基礎検討, (公社)日本薬学会, 日本薬学会年会要旨集, 139年会(4) 114, 2019.03

    佐藤 裕, 前川 正充, 塚本 多矩, 高崎 新也, 菊地 正史, 早川 禎宏, 山口 浩明, 眞野 成康

  • Toward Personalized Cancer Therapy with Oral Molecular-targeted Agents, 薬学雑誌(Web), 139(6) 911‐915(J‐STAGE), 2019

    山口浩明, 高崎新也, 菊地正史, 川崎芳英, 荒井陽一, 眞野成康

  • LC/ESI‐MS/MSを用いるニーマンピック病C型モデル細胞のステロイドホルモン代謝解析, 日本薬学会年会要旨集(CD-ROM), 139th(2) ROMBUNNO.23PO‐am151-274, 2019

    阿部愛, 前川正充, 小倉次郎, 須賀隆浩, 檜垣克己, 山口浩明, 山口浩明, 山口浩明, 眞野成康, 眞野成康, 眞野成康

  • 腎癌治療における日本人のスニチニブ血中濃度と有害事象の関連性評価, 日本臨床腫瘍薬学会学術大会講演要旨集, 2019 151, 2019

    高崎新也, 川崎芳英, 菊地正史, 田中雅樹, 細野寛貴, 伊藤明宏, 山口浩明, 眞野成康

  • スニチニブのTDM普及に向けて, 日本臨床腫瘍薬学会学術大会講演要旨集, 2019 138, 2019

    山口浩明, 高崎新也, 菊地正史, 川崎芳英, 荒井陽一, 眞野成康

  • 中毒起因物質の実用的分析法 カルシウム拮抗剤の分析, (株)へるす出版, 中毒研究, 31(3) 302-307, 2018.09

    安藤 基純, 有吉 孝一, 臼井 聖尊, 斉藤 剛, 藤田 友嗣, 堀 寧, 三瀬 雅史, 山口 浩明, 芳澤 朋大, 日本中毒学会分析委員会

  • 治療効果の最大化を目指した経口抗がん薬の治療薬物モニタリング, JSBMS Letters, 43(Supplement) 49, 2018.08

    高崎新也, 川崎芳英, 菊地正史, 田中雅樹, 山口浩明, 眞野成康

  • LC/ESI-MS/MSを用いるコレステロール代謝物網羅的解析法の基礎的検討, (一社)日本臨床化学会, 臨床化学, 47(Suppl.1) 320, 2018.07

    前川 正充, 河俣 圭太, 阿部 愛, 三枝 大輔, 山口 浩明, 眞野 成康

  • 質量分析の活用事例とピットフォール 個別化医療における血中薬物濃度の精密測定, (一社)日本臨床化学会, 臨床化学, 47(Suppl.1) 179, 2018.07

    眞野 成康, 前川 正充, 菊地 正史, 山口 浩明

  • 薬学研究が支える臨床化学 臨床化学を基盤とした肺移植患者の個別化薬物療法構築への取り組み, (一社)日本臨床化学会, 臨床化学, 47(Suppl.1) 204, 2018.07

    菊地 正史, 山口 浩明, 眞野 成康

  • 肺移植患者における個別化薬物療法, (公財)臨床薬理研究振興財団, 臨床薬理の進歩, (39) 104-116, 2018.06

    山口 浩明, 菊地 正史, 田中 雅樹, 高崎 新也, 野田 あおい, 重田 健介, 白木 美香, 高木 秀侑, 松田 安史, 野田 雅史, 岡田 克典, 眞野 成康

  • インソースCIDを利用したLC/ESI-MS/MSによるチロシンキナーゼ阻害薬一斉測定法の構築, (公社)日本薬学会, 日本薬学会年会要旨集, 138年会(4) 175, 2018.03

    佐藤 裕, 高崎 新也, 田中 雅樹, 前川 正充, 菊地 正史, 川崎 芳英, 荒井 陽一, 山口 浩明, 眞野 成康

  • 第2回臨床化学の進歩が変える薬物治療〜臨床病態解析からのアプローチ〜 オミクス解析を基盤とした臨床化学分析, (公社)日本薬学会, 日本薬学会年会要旨集, 138年会(1) 174, 2018.03

    眞野 成康, 前川 正充, 山口 浩明

  • 第2回病院薬剤師が実践するリバーストランスレーショナルリサーチの最前線〜分子標的探索と個別化医療への挑戦〜 経口分子標的薬の個別化投与設計に向けて, (公社)日本薬学会, 日本薬学会年会要旨集, 138年会(1) 134, 2018.03

    山口 浩明, 高崎 新也, 菊地 正史, 川崎 芳英, 荒井 陽一, 眞野 成康

  • レセプトデータを利用した小児ADHD患者における処方実態の把握, (公社)日本薬学会, 日本薬学会年会要旨集, 138年会(4) 185, 2018.03

    吉田 真貴子, 小原 拓, 菊地 紗耶, 菊地 正史, 山口 浩明, 眞野 成康

  • アキシチニブにより薬剤性破壊性甲状腺炎を呈した腎癌患者の一例, 日本臨床腫瘍薬学会学術大会講演要旨集, 2018 183, 2018

    鈴鹿雅人, 高崎新也, 川崎芳英, 坪井真友子, 佐藤祐司, 山口浩明, 荒井陽一, 眞野成康

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Grant-in-Aid for Scientific Research

  • Grant-in-Aid for Scientific Research(C),2023.04 - 2026.03

  • Grant-in-Aid for Scientific Research(C),2022.04 - 2023.03

Other external funds procured

  • Participation of OATP4C1 in the pharmacokinetics of drugs,2018.04 - 2021.03,Participation of OATP4C1 in the pharmacokinetics of drugs

    Japan Society for the Promotion of Science

  • Medicinal chemistry studies based on the three-dimensional structural diversity-oriented molecular design of pharmacologically active compounds,2015.04 - 2020.03,Medicinal chemistry studies based on the three-dimensional structural diversity-oriented molecular design of pharmacologically active compounds

    Based on the three-dimensional structural diversity-oriented strategy using characteristic structural features of cyclopropane, medicinal chemistry studies have been carried out. As the result of these studies, various pharmacologically active compounds, such as, highly active congeners of pro-resolving lipid mediator RvE2, peptidomimetics including prorenin inhibitors and melanocortin receptor-4 selective ligands, membrane-permeable cyclic peptides, or the first GABA transporter GAT1-selective inhibitor, were identified. Thus, it was demonstrated that the three-dimensional structural diversity-oriented strategy effectively works for the theoretical development of desired pharmacologically active compounds. In addition, various synthetic procedures for the substituted chiral cyclopropanes, which can be effectively used in cyclopropane medicinal chemistry studies, have been developed.

    Japan Society for the Promotion of Science

Presentations

  • 臨床化学, Domestic presentation, 2019.08, 血清リン脂質類のLC‐MS/MS分析に基づくニーマンピック病C型の迅速スクリーニング法の検討, Oral presentation (general)

  • 臨床化学, Domestic presentation, 2019.08, LC‐MS/MSを用いる脂質メディエーター網羅的解析の基礎的検討, Oral presentation (general)

  • 臨床化学, Domestic presentation, 2019.08, LC/ESI‐MS/MSを用いる胆汁酸メタボローム解析系の基礎的検討, Oral presentation (general)

  • TDM研究, Domestic presentation, 2019.05, 血中エベロリムス濃度と臨床効果の関連性~腎癌治療における長期追跡調査~, Oral presentation (general)

  • 日本薬学会年会要旨集(CD-ROM), Domestic presentation, 2019, LC/ESI‐MS/MSを用いるニーマンピック病C型モデル細胞のステロイドホルモン代謝解析, Oral presentation (general)

  • 日本臨床腫瘍薬学会学術大会講演要旨集, Domestic presentation, 2019, スニチニブのTDM普及に向けて, Symposium, workshop panel (public)

  • 日本薬剤学会年会講演要旨集(Web), Domestic presentation, 2019, 経口がん分子標的薬の個別投与設計に向けた取り組み, Symposium, workshop panel (public)

  • 日本臨床腫瘍薬学会学術大会講演要旨集, Domestic presentation, 2019, 腎癌治療における日本人のスニチニブ血中濃度と有害事象の関連性評価, Oral presentation (general)

  • 日本臨床腫瘍薬学会学術大会講演要旨集, Domestic presentation, 2018, アキシチニブにより薬剤性破壊性甲状腺炎を呈した腎癌患者の一例, Oral presentation (general)

  • 日本先天代謝異常学会雑誌, Domestic presentation, 2017.09, 5種の尿中抱合型代謝物をマルチバイオマーカーとして用いるニーマンピック型C型の化学診断法の開発, Oral presentation (general)

  • 臨床化学, Domestic presentation, 2017.09, 尿中アシルカルニチンの一斉定量法の構築, Oral presentation (general)

  • 臨床化学, Domestic presentation, 2017.09, UHPLC-UVによるエルロチニブ及び代謝物の同時測定法と非小細胞肺がん患者血中濃度測定への応用, Oral presentation (general)

  • 臨床化学, Domestic presentation, 2017.09, PETINIAとLC-MS/MSで得られた肺移植患者のミコフェノール酸血中濃度の比較, Oral presentation (general)

  • 臨床化学, Domestic presentation, 2017.09, LC/ESI-MS/MSを用いたシロリムスの全血中濃度測定法の構築, Oral presentation (general)

  • 日本泌尿器科学会総会, Domestic presentation, 2017.04, スニチニブ投与により4年間完全奏功が維持できた腎細胞癌患者1症例のスニチニブ血中濃度推移, Oral presentation (general)

  • 日本薬学会年会要旨集, Domestic presentation, 2017.03, LC/ESI-MS/MSを用いた薬毒物中毒原因物質迅速スクリーニングの有用性, Oral presentation (general)

  • 日本臨床腫瘍薬学会学術大会講演要旨集, Domestic presentation, 2017, 外来治療中に経口抗がん薬の血中濃度測定により服薬アドヒアランスが向上した2例, Oral presentation (general)

  • 日本癌治療学会学術集会抄録集, Domestic presentation, 2016.10, 腎 腎がん分子標的治療の現況 切除不能腎癌治療におけるSunitinibの至適血中濃度の検討, Oral presentation (general)

  • 日本泌尿器科学会総会, Domestic presentation, 2016.04, 日本人の腎細胞癌患者におけるスニチニブの有効血中濃度域の検討, Oral presentation (general)

  • 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Domestic presentation, 2015.12, 肝臓におけるhypoxia-inducible factor 1αの活性化はコレステロール胆石形成を促進する, Oral presentation (general)

  • 日本医療薬学会年会講演要旨集, Domestic presentation, 2015.10, アキシチニブの血中濃度が上昇しなかった腎細胞癌患者の一例, Oral presentation (general)

  • 日本医薬品情報学会総会・学術大会講演要旨集, Domestic presentation, 2014.07, 医薬品リスク管理計画に関する薬剤師の認識, Oral presentation (general)

  • 日本薬学会年会要旨集(CD-ROM), Domestic presentation, 2014, ダプトマイシンは骨格筋細胞におけるモノカルボン酸輸送担体の発現を低下させる, Oral presentation (general)

  • 日本医薬品情報学会総会・学術大会講演要旨集, Domestic presentation, 2013.08, 薬剤師における医薬品安全性評価に関する認識および実践に関する調査, Oral presentation (general)

  • 日本薬学会年会要旨集(CD-ROM), Domestic presentation, 2013, 抗MRSA薬ダプトマイシンの骨格筋細胞毒性に関する基礎的検討, Oral presentation (general)

  • Chromatography, Domestic presentation, 2011.10, Quantitation of antineoplastic drug oxaliplatin from human plasma using HILIC/MS/MS, Oral presentation (general)

  • 日本医療薬学会年会講演要旨集, Domestic presentation, 2011.09, PKCを介した糖代謝制御およびMCT4発現変動への関連性, Oral presentation (general)

  • 日本薬学会年会要旨集, Domestic presentation, 2011.03, ABCトランスポーター発現変動と酸化障害の重度との関連, Oral presentation (general)

  • 日本薬学会年会要旨集, Domestic presentation, 2011.03, カラムスイッチング‐LC/MS/MSによるパクリタキセル血中濃度測定法の確立, Oral presentation (general)

  • 日本薬学会年会要旨集, Domestic presentation, 2011.03, 抗菌薬アミカシンの用法用量別にみた治療効果の比較, Oral presentation (general)

  • 移植, Domestic presentation, 2007.06, 当院における膵島移植後の免疫抑制剤シロリムス血中濃度測定(LC/ESI‐MS/MSとMEIAの有用性について), Oral presentation (general)

  • 日本薬学会年会要旨集, Domestic presentation, 2007.03, LC/ESI‐MS/MS法およびIMx法による免疫抑制剤シロリムスの血中濃度測定, Oral presentation (general)

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