Updated on 2026/01/20

写真a

 
FUTAKUCHI Mitsuru
 
Title
Professor
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Research Areas

  • Life Science / Tumor biology

 

Papers

  • Predicting anterior cruciate ligament degeneration using magnetic resonance imaging: Insights from histological evaluation, JOURNAL OF ORTHOPAEDIC SCIENCE, 30(2) 325-332, 2025.03

    Toyono, S; Suzuki, A; Wanezaki, Y; Takahara, D; Ohe, R; Fukushima, S; Futakuchi, M; Takagi, M

    Single Author

  • BRCA1-binding factor deficiency induces tumorigenesis dependent on estrogen-regulated centrosome amplification, CANCER SCIENCE, 116 1275, 2025.01

    Chiba, N; Ogoh, H; Iichi, Y; Sasaki, T; Yoshida, T; Ichimura, S; Fang, ZZ; Li, XM; Futakuchi, M; Nakamura, Y; Watanabe, T; Yoshino, Y

    Single Author

  • Quantification of Gremlin 1 throughout the tumor stroma using whole slide imaging and its clinicopathological significance in gastric cancer, VIRCHOWS ARCHIV, 485(6) 1107-1116, 2024.12

    Kitaoka, T; Harada, K; Sakashita, S; Kojima, M; Taki, T; Kuwata, T; Kinoshita, T; Futakuchi, M; Ishii, G; Sakamoto, N

    Single Author

  • 増大特集 学術研究支援の最先端 Ⅱ.先端モデル動物支援プラットフォーム(AdAMS) ⅱ.病理形態解析支援 腫瘍間質相互作用の組織学的空間解析, 生体の科学, 75(5) 440-441, 2024.10

    大江 倫太郎, 二口 充

    Single Author

  • Activation of fibroblasts by plasma cells via PDGF/PDGFR signaling in IgG4-related sialadenitis(タイトル和訳中), Journal of Clinical and Experimental Hematopathology, 64(3) 223-231, 2024.09

    Kitaoka Takumi, Ohe Rintaro, Kabasawa Takanobu, Kaneko Masayuki, Sasahara Nobuyuki, Kono Michihisa, Suzuki Kazushi, Uchiyama Naoya, Ogawa Rinako, Futakuchi Mitsuru

    Single Author

  • Knockout of Brca1-interacting factor Ola1 in female mice induces tumors with estrogen suppressible centrosome amplification, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1870(5) 167138, 2024.06

    Yoshino, Y; Ogoh, H; Iichi, Y; Sasaki, T; Yoshida, T; Ichimura, S; Nakayama, M; Xi, W; Fujita, H; Kikuchi, M; Fang, ZZ; Li, XM; Abe, T; Futakuchi, M; Nakamura, Y; Watanabe, T; Chiba, N

    Single Author

  • Lysophospholipid Acyltransferase 9 Promotes Emphysema Formation via Platelet-activating Factor, AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 70(6) 482-492, 2024.06

    Murano, H; Inoue, S; Hashidate-Yoshida, T; Shindou, H; Shimizu, T; Otaki, Y; Minegishi, Y; Kitaoka, T; Futakuchi, M; Igarashi, A; Nishiwaki, M; Nemoto, T; Sato, M; Kobayashi, M; Sato, K; Hanawa, T; Mi...

    Single Author

  • Neighboring macrophage-induced alteration in the phenotype of colorectal cancer cells in the tumor budding area, CANCER CELL INTERNATIONAL, 24(1) 107, 2024.03

    Ichiro Kawamura, Rintaro Ohe, Kazushi Suzuki, Takanobu Kabasawa, Takumi Kitaoka, Daiichiro Takahara, Michihisa Kono, Naoya Uchiyama, Hiroaki Musha, Mitsuru Futakuchi, Fuyuhiko Motoi

    Single Author

  • Neighboring macrophage-induced alteration in the phenotype of colorectal cancer cells in the tumor budding area., Cancer cell international, 24(1) 107, 2024.03

    Kawamura I, Ohe R, Suzuki K, Kabasawa T, Kitaoka T, Takahara D, Kono M, Uchiyama N, Musha H, Futakuchi M, Motoi F

    Single Author

  • Neighboring macrophage-induced alteration in the phenotype of colorectal cancer cells in the tumor budding area., Cancer cell international, 24(1) 107, 2024.03

    Ichiro Kawamura, Rintaro Ohe, Kazushi Suzuki, Takanobu Kabasawa, Takumi Kitaoka, Daiichiro Takahara, Michihisa Kono, Naoya Uchiyama, Hiroaki Musha, Mitsuru Futakuchi, Fuyuhiko Motoi

    Single Author

  • Neighboring macrophage-induced alteration in the phenotype of colorectal cancer cells in the tumor budding area., Cancer cell international, 24(1) 107, 2024.03

    Kawamura I, Ohe R, Suzuki K, Kabasawa T, Kitaoka T, Takahara D, Kono M, Uchiyama N, Musha H, Futakuchi M, Motoi F

    Single Author

  • Neighboring macrophage-induced alteration in the phenotype of colorectal cancer cells in the tumor budding area, CANCER CELL INTERNATIONAL, 24(1) , 2024.03

    Kawamura, I; Ohe, R; Suzuki, K; Kabasawa, T; Kitaoka, T; Takahara, D; Kono, M; Uchiyama, N; Musha, H; Futakuchi, M; Motoi, F

    Single Author

  • Neighboring macrophage-induced alteration in the phenotype of colorectal cancer cells in the tumor budding area, CANCER CELL INTERNATIONAL, 24(1) , 2024.03

    Kawamura, I; Ohe, R; Suzuki, K; Kabasawa, T; Kitaoka, T; Takahara, D; Kono, M; Uchiyama, N; Musha, H; Futakuchi, M; Motoi, F

    Single Author

  • Involvement of TAMs on tumor growth in the lymph node microenvironment but not in primary site, CANCER SCIENCE, 115 846, 2024.03

    Takanobu Kabasawa, Rintaro Ohe, Kazushi Suzuki, Takumi Kitaoka, Mitsuru Futakuchi

    Single Author

  • Involvement of TAMs on tumor growth in the lymph node microenvironment but not in primary site, CANCER SCIENCE, 115 846, 2024.03

    Kabasawa, T; Ohe, R; Suzuki, K; Kitaoka, T; Futakuchi, M

    Single Author

  • Histological spatial analysis on the induction of PD-L1+macrophages by CD8+T cells of triple-negative breast cancer, CANCER SCIENCE, 115 1588, 2024.03

    Takumi Kitaoka, Kazushi Suzuki, Takanobu Kabasawa, Rintaro Ohe, Mitsuru Futakuchi

    Single Author

  • Histological spatial analysis on the induction of PD-L1+macrophages by CD8+T cells of triple-negative breast cancer, CANCER SCIENCE, 115 1588, 2024.03

    Kitaoka, T; Suzuki, K; Kabasawa, T; Ohe, R; Futakuchi, M

    Single Author

  • Resident memory T cell contributes to the phenotype of inflammatory vitiligo, JOURNAL OF DERMATOLOGICAL SCIENCE, 113(2) 74-76, 2024.02

    Okamura, K; Kabasawa, T; Saito, T; Arai, Y; Futakuchi, M; Suzuki, T

    Single Author

  • BRCA1結合分子の欠損はエストロゲンで制御される中心体増幅に依存した悪性化を示す腫瘍を誘導する, 日本癌学会学術総会抄録集(Web), 83rd 1275, 2024

    千葉奈津子, 小河穂波, 飯地雄大, 佐々木伯大, 吉田貴大, 市村志織, 方震宙, 李星明, 二口充, 中村保宏, 渡邊利雄, 吉野優樹

    Single Author

  • Association of ADC of hyperintense lesions on FLAIR images with TERT promoter mutation status in glioblastoma IDH wild type., Surgical neurology international, 15 108, 2024

    Kamimura S, Mitobe Y, Nakamura K, Matsuda K, Kanemura Y, Kanoto M, Futakuchi M, Sonoda Y

    Single Author

  • Activation of fibroblasts by plasma cells via PDGF/PDGFR signaling in IgG4-related sialadenitis, JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY, 64(3) 223-231, 2024

    Kitaoka, T; Ohe, R; Kabasawa, T; Kaneko, M; Sasahara, N; Kono, M; Suzuki, K; Uchiyama, N; Ogawa, R; Futakuchi, M

    Single Author

  • Treatment Experience of Chemotherapy and Carbon-Ion Radiotherapy followed by Curative Conversion Surgery for Initially Locally Advanced Unresectable Pancreatic Cancer after Distal Gastrectomy, 癌と化学療法, 50(13) 1959-1961, 2023.12

    渡邊大史, 菅原秀一郎, 高橋良輔, 安次富裕哉, 川城壮平, 佐藤啓, 根本健二, 河野通久, 二口充, 元井冬彦

    Single Author

  • トリプルネガティブ乳癌の辺縁部微小環境のCD8陽性T細胞によるPD-L1陽性マクロファージの誘導に関する組織学的空間的解析(Histological spatial analysis on the induction of PD-L1+ macrophages by CD8+T cells at the marginal microenvironment of triple-negative breast cancer), Breast Cancer, 30(6) 1094-1104, 2023.11

    Suzuki Kazushi, Ohe Rintaro, Kabasawa Takanobu, Kitaoka Takumi, Kawai Masaaki, Motoi Fuyuhiko, Futakuchi Mitsuru

    Single Author

  • Histological spatial analysis on the induction of PD-L1<SUP>+</SUP> macrophages by CD8<SUP>+</SUP> T cells at the marginal microenvironment of triple-negative breast cancer, BREAST CANCER, 30(6) 1094-1104, 2023.11

    Suzuki, K; Ohe, R; Kabasawa, T; Kitaoka, T; Kawai, M; Motoi, F; Futakuchi, M

    Single Author

  • Targeting c-Jun Is a Potential Therapy for Luminal Breast Cancer Bone Metastasis, MOLECULAR CANCER RESEARCH, 21(9) 908-921, 2023.09

    Han, YX; Katayama, S; Futakuchi, M; Nakamichi, K; Wakabayashi, Y; Sakamoto, M; Nakayama, J; Semba, K

    Single Author

  • Identification of tumor-related genes via RNA sequencing of tumor tissues in<i> Xenopus tropicalis</i>, SCIENTIFIC REPORTS, 13(1) 13214, 2023.08

    Kitamura, K; Yamamoto, T; Ochi, H; Suzuki, M; Suzuki, N; Igawa, T; Yoshida, T; Futakuchi, M; Ogino, H; Michiue, T

    Single Author

  • A durable complete response resulting from treatment with nivolumab plus ipilimumab for metastatic collecting duct carcinoma of the kidney, ASIAN JOURNAL OF UROLOGY, 10(3) 376-378, 2023.07

    Funajima, K; Naito, S; Kabasawa, T; Nishida, H; Kato, T; Futakuchi, M; Tsuchiya, N

    Single Author

  • In vivo [<SUP>18</SUP>F]THK-5351 imaging detected reactive astrogliosis in argyrophilic grain disease with comorbid pathology: A clinicopathological study, JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 82(5) 427-437, 2023.04

    Kobayashi, R; Nakamura, T; Naganuma, F; Harada, R; Morioka, D; Kanoto, M; Furumoto, S; Kudo, Y; Kabasawa, T; Otani, K; Futakuchi, M; Kawakatsu, S; Okamura, N

    Single Author

  • Regular protocol liver biopsy is useful to adjust immunosuppressant dose after adult liver transplantation, CLINICAL TRANSPLANTATION, 37(3) e14873, 2023.03

    Shohei Narita, Satoshi Miuma, Sadayuki Okudaira, Yoshito Koga, Masanori Fukushima, Ryu Sasaki, Masafumi Haraguchi, Akihiko Soyama, Masaaki Hidaka, Hisamitsu Miyaaki, Mitsuru Futakuchi, Kazuhiro Nagai,...

    Single Author

  • Potential role of M2 TAMs around lymphatic vessels during lymphatic invasion of papillary thyroid carcinoma, CANCER SCIENCE, 114 575, 2023.02

    Kabasawa, T; Ohe, R; Futakuchi, M

    Single Author

  • Potential role of M2 TAMs around lymphatic vessels during lymphatic invasion of papillary thyroid carcinoma, CANCER SCIENCE, 114 575, 2023.02

    Takanobu Kabasawa, Rintaro Ohe, Mitsuru Futakuchi

    Single Author

  • Induction of heterogeneity of chemo-resistance by the interaction between colorectal cancer cells and TAMs, CANCER SCIENCE, 114 1783, 2023.02

    Goto, J; Ohe, R; Kabasawa, T; Futakuchi, M

    Single Author

  • Induction of heterogeneity of chemo-resistance by the interaction between colorectal cancer cells and TAMs, CANCER SCIENCE, 114 1783, 2023.02

    Junichi Goto, Rintaro Ohe, Takanobu Kabasawa, Mitsuru Futakuchi

    Single Author

  • Clinicopathological diversity of semantic dementia: Comparisons of patients with early-onset versus late-onset, left-sided versus right-sided temporal atrophy, and TDP-type A versus type C pathology, NEUROPATHOLOGY, 43(1) 5-26, 2023.02

    Kawakatsu, S; Kobayashi, R; Morioka, D; Hayashi, H; Utsunomiya, A; Kabasawa, T; Ohe, R; Futakuchi, M; Otani, K

    Single Author

  • Characterization of Luminal High-Osteolytic Breast Cancer Cell Lines, CANCER SCIENCE, 114 237, 2023.02

    Yuxuan Han, Jun Nakayama, Mitsuru Futakuchi, Emi Ito, Shinya Watanabe, Kentaro Semba

    Single Author

  • Characterization of Luminal High-Osteolytic Breast Cancer Cell Lines, CANCER SCIENCE, 114 237, 2023.02

    Han, YX; Nakayama, J; Futakuchi, M; Ito, E; Watanabe, S; Semba, K

    Single Author

  • 意味性認知症の臨床病理学的多様性 早発性と晩発性、左側側頭葉萎縮と右側側頭葉萎縮、TDPタイプAとTDPタイプC病理の比較検討(Neuropathology Case Cluster: Neuropathology of focal cortical, behavioral, and psychiatric syndromes in neurodegenerative diseases Clinicopathological diversity of semantic dementia: Comparisons of patients with early-onset versus late-onset, left-sided versus right-sided temporal atrophy, and TDP-type A versus type C pathology), NEUROPATHOLOGY, 43(1) 5-26, 2023.02

    Kawakatsu Shinobu, Kobayashi Ryota, Morioka Daichi, Hayashi Hiroshi, Utsunomiya Aya, Kabasawa Takanobu, Ohe Rintaro, Futakuchi Mitsuru, Otani Koichi

    Single Author

  • 幽門側胃切除後局所進行切除不能膵癌に対し重粒子線併用化学療法後根治切除を得た1例, 癌と化学療法, 50 1959-1961, 2023

    二口 充, 元井 冬彦

    Single Author

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Review Papers

  • A case of glioblastoma with mismatch repair gene mutation successfully treated with pembrolizumab, 脳神経外科速報, 34(5) e137-e145, 2024.09

    石毛良実, 水戸部祐太, 松田憲一朗, 北岡匠, 大江倫太郎, 二口充, 鈴木修平, 吉岡孝志, 金村米博, 園田順彦

  • がんの進展とともに加速するゲノム不安定性 BRCA1結合分子の欠損はエストロゲンで制御される中心体増幅に依存した悪性化を示す腫瘍を誘導する(Genomic instability: a cogwheel promoting cancer development and progression BRCA1-binding factor deficiency induces tumorigenesis dependent on estrogen-regulated centrosome amplification), 日本癌学会総会記事, 83回 S15-3, 2024.09

    千葉 奈津子, 小河 穂波, 飯地 雄大, 佐々木 伯大, 吉田 貴大, 市村 志織, 方 震宙, 李 星明, 二口 充, 中村 保宏, 渡邊 利雄, 吉野 優樹

  • レジデントメモリーT細胞は炎症性白斑の表現型に寄与する(Resident memory T cell contributes to the phenotype of inflammatory vitiligo), エルゼビア・ジャパン(株), Journal of Dermatological Science, 113(2) 74-76, 2024.02

    Okamura Ken, Kabasawa Takanobu, Saito Toru, Arai Yosuke, Futakuchi Mitsuru, Suzuki Tamio

  • 骨微小環境モデルを用いた腎癌の骨破壊メカニズムの解明(The mechanism of bone destruction in renal cancer using a bone microenvironment model), 日本病理学会会誌, 113(1) 292, 2024.02

    北岡 匠, 高原 大一郎, 大江 倫太郎, 樺澤 崇允, 二口 充

  • 肺腺癌リンパ節転移巣ではマクロファージ由来のIL-6が癌細胞の増殖を促進する(IL-6 derived from Mφ may promote proliferation of lung adenocarcinoma cells in lymph node metastasis), 日本病理学会会誌, 113(1) 313, 2024.02

    樺澤 崇允, 大江 倫太郎, 鈴木 一司, 内山 尚哉, 北岡 匠, 二口 充

  • 大腸がん肝転移巣を拡大させるマクロファージの同定と腫瘍細胞増殖シグナル解析(Identification of macrophages that expand liver metastases of colorectal cancer), 日本病理学会会誌, 113(1) 311, 2024.02

    大江 倫太郎, 内山 尚哉, 北岡 匠, 鈴木 一司, 樺澤 崇允, 二口 充

  • 口腔扁平上皮癌の骨浸潤に関与する腫瘍間質相互作用(Tumor stromal interaction involved in bone invasion of oral squamous cell carcinoma), 日本病理学会会誌, 113(1) 285, 2024.02

    内山 尚哉, 笹原 庸由, 北岡 匠, 樺澤 崇允, 大江 倫太郎, 二口 充

  • Luminal乳がん骨転移におけるc-jun機能解析と治療戦略, 日本がん転移学会学術集会・総会プログラム抄録集, 33rd , 2024

    中山淳, 中山淳, 韓宇軒, 二口充, 仙波憲太郎

  • 腫瘍関連マクロファージの浸潤は肺腺癌のリンパ節における増殖に関与するが原発巣での増殖には関与しない(Involvement of TAMs on tumor growth in the lymph node microenvironment but not in primary site), 日本癌学会総会記事, 82回 846, 2023.09

    樺澤 崇允, 大江 倫太郎, 鈴木 一司, 北岡 匠, 二口 充

  • トリプルネガティブ乳癌におけるCD8陽性T細胞によるPD-L1陽性MΦの誘導の組織学的空間解析(Histological spatial analysis on the induction of PD-L1+macrophages by CD8+ T cells of triple-negative breast cancer), 日本癌学会総会記事, 82回 1589, 2023.09

    北岡 匠, 鈴木 一司, 樺澤 崇允, 大江 倫太郎, 二口 充

  • 脊髄神経膠腫の臨床像についての検討, 日本脳腫瘍学会学術集会プログラム・抄録集, 41st , 2023

    中村和貴, 松田憲一朗, 大江倫太郎, 二口充, 金村米博, 園田順彦

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Grant-in-Aid for Scientific Research

  • Grant-in-Aid for Scientific Research(C),2024.04 - 2026.03

  • Grant-in-Aid for Scientific Research(C),2024.04 - 2026.03

  • Grant-in-Aid for Scientific Research(C),2024.04 - 2026.03

  • Grant-in-Aid for Scientific Research(C),2023.04 - 2026.03

  • Grant-in-Aid for Scientific Research(C),2023.04 - 2026.03

  • Grant-in-Aid for Scientific Research(C),2022.04 - 2025.03

  • Grant-in-Aid for Scientific Research(C),2022.04 - 2025.03

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Other external funds procured

  • Analysis of osteoclast induction mechanism by fibroblasts in bone invasion and periodontitis of oral squamous cell carcinoma.,2024.04 - 2027.03,Analysis of osteoclast induction mechanism by fibroblasts in bone invasion and periodontitis of oral squamous cell carcinoma.

    Japan Society for the Promotion of Science

  • Mechanism of recurence on bone metastasis,2023.04 - 2026.03,Mechanism of recurence on bone metastasis

    Japan Society for the Promotion of Science

  • mechanism of cancer cell proliferation in bone microenvironment of renal cell carcinoma,2022.04 - 2025.03,mechanism of cancer cell proliferation in bone microenvironment of renal cell carcinoma

    Japan Society for the Promotion of Science

  • Survival mechanism of breast cancer cells in the bone microenvironment at the latent stage of bone metastasis,2020.04 - 2023.03,Survival mechanism of breast cancer cells in the bone microenvironment at the latent stage of bone metastasis

    Transforming growth factor-beta (TGF-beta) plays a key role in bone metastasis formation; we hypothesized the possible involvement of TGF-beta in the induction of cancer stem cells (CSCs) in the bone microenvironment (micro-E), which may be responsible for chemo-resistance. We found treatment with R1-Ki decreased tumor volume and cell proliferation in the bone micro-E. The number of cells positive for the CSC markers, SOX2, and CD166 in the bone micro-E, were significantly higher than those in the subQ micro-E. R1-Ki treatment significantly decreased the number of CSC marker positive cells in the bone micro-E but not in the subQ micro-E. Our results indicated that the bone micro-E is a key niche for CSC generation, and TGF-beta signaling has important roles in generating CSCs and tumor cell proliferation in the bone micro-E.

    Japan Society for the Promotion of Science