Predicting anterior cruciate ligament degeneration using magnetic resonance imaging: Insights from histological evaluation，JOURNAL OF ORTHOPAEDIC SCIENCE，30(2) 325-332，2025年03月

Toyono, S; Suzuki, A; Wanezaki, Y; Takahara, D; Ohe, R; Fukushima, S; Futakuchi, M; Takagi, M

単著

BRCA1-binding factor deficiency induces tumorigenesis dependent on estrogen-regulated centrosome amplification，CANCER SCIENCE，116 1275，2025年01月

Chiba, N; Ogoh, H; Iichi, Y; Sasaki, T; Yoshida, T; Ichimura, S; Fang, ZZ; Li, XM; Futakuchi, M; Nakamura, Y; Watanabe, T; Yoshino, Y

単著

Effusion Reduction after Early Trastuzumab Deruxtecan Therapy for Unresectable HER2-Low Breast Cancer in an Older Patient: A Case Report，SURGICAL CASE REPORTS，11(1) n/a，2025年

Akabane, A; Kawai, M; Suzuki, K; Goto, A; Tanaka, T; Futakuchi, M; Motoi, F

単著

Quantification of Gremlin 1 throughout the tumor stroma using whole slide imaging and its clinicopathological significance in gastric cancer，VIRCHOWS ARCHIV，485(6) 1107-1116，2024年12月

Kitaoka, T; Harada, K; Sakashita, S; Kojima, M; Taki, T; Kuwata, T; Kinoshita, T; Futakuchi, M; Ishii, G; Sakamoto, N

単著

増大特集 学術研究支援の最先端 Ⅱ.先端モデル動物支援プラットフォーム(AdAMS) ⅱ.病理形態解析支援 腫瘍間質相互作用の組織学的空間解析，生体の科学，75(5) 440-441，2024年10月

大江 倫太郎, 二口 充

単著

Activation of fibroblasts by plasma cells via PDGF/PDGFR signaling in IgG4-related sialadenitis(タイトル和訳中)，Journal of Clinical and Experimental Hematopathology，64(3) 223-231，2024年09月

Kitaoka Takumi, Ohe Rintaro, Kabasawa Takanobu, Kaneko Masayuki, Sasahara Nobuyuki, Kono Michihisa, Suzuki Kazushi, Uchiyama Naoya, Ogawa Rinako, Futakuchi Mitsuru

単著

ミスマッチ修復遺伝子異常を伴う膠芽腫に対してペムブロリズマブが奏効した1例，脳神経外科速報，34(5) e137-e145，2024年09月

石毛 良実, 水戸部 祐太, 松田 憲一朗, 北岡 匠, 大江 倫太郎, 二口 充, 鈴木 修平, 吉岡 孝志, 金村 米博, 園田 順彦

単著

Knockout of Brca1-interacting factor Ola1 in female mice induces tumors with estrogen suppressible centrosome amplification，BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE，1870(5) 167138，2024年06月

Yoshino, Y; Ogoh, H; Iichi, Y; Sasaki, T; Yoshida, T; Ichimura, S; Nakayama, M; Xi, W; Fujita, H; Kikuchi, M; Fang, ZZ; Li, XM; Abe, T; Futakuchi, M; Nakamura, Y; Watanabe, T; Chiba, N

単著

Lysophospholipid Acyltransferase 9 Promotes Emphysema Formation via Platelet-activating Factor，AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY，70(6) 482-492，2024年06月

Murano, H; Inoue, S; Hashidate-Yoshida, T; Shindou, H; Shimizu, T; Otaki, Y; Minegishi, Y; Kitaoka, T; Futakuchi, M; Igarashi, A; Nishiwaki, M; Nemoto, T; Sato, M; Kobayashi, M; Sato, K; Hanawa, T; Mi...

単著

Neighboring macrophage-induced alteration in the phenotype of colorectal cancer cells in the tumor budding area，CANCER CELL INTERNATIONAL，24(1) 107，2024年03月

Ichiro Kawamura, Rintaro Ohe, Kazushi Suzuki, Takanobu Kabasawa, Takumi Kitaoka, Daiichiro Takahara, Michihisa Kono, Naoya Uchiyama, Hiroaki Musha, Mitsuru Futakuchi, Fuyuhiko Motoi

単著

Neighboring macrophage-induced alteration in the phenotype of colorectal cancer cells in the tumor budding area.，Cancer cell international，24(1) 107，2024年03月

Kawamura I, Ohe R, Suzuki K, Kabasawa T, Kitaoka T, Takahara D, Kono M, Uchiyama N, Musha H, Futakuchi M, Motoi F

単著

Neighboring macrophage-induced alteration in the phenotype of colorectal cancer cells in the tumor budding area.，Cancer cell international，24(1) 107，2024年03月

Ichiro Kawamura, Rintaro Ohe, Kazushi Suzuki, Takanobu Kabasawa, Takumi Kitaoka, Daiichiro Takahara, Michihisa Kono, Naoya Uchiyama, Hiroaki Musha, Mitsuru Futakuchi, Fuyuhiko Motoi

単著

Neighboring macrophage-induced alteration in the phenotype of colorectal cancer cells in the tumor budding area.，Cancer cell international，24(1) 107，2024年03月

Kawamura I, Ohe R, Suzuki K, Kabasawa T, Kitaoka T, Takahara D, Kono M, Uchiyama N, Musha H, Futakuchi M, Motoi F

単著

Neighboring macrophage-induced alteration in the phenotype of colorectal cancer cells in the tumor budding area，CANCER CELL INTERNATIONAL，24(1) ，2024年03月

Kawamura, I; Ohe, R; Suzuki, K; Kabasawa, T; Kitaoka, T; Takahara, D; Kono, M; Uchiyama, N; Musha, H; Futakuchi, M; Motoi, F

単著

Neighboring macrophage-induced alteration in the phenotype of colorectal cancer cells in the tumor budding area，CANCER CELL INTERNATIONAL，24(1) ，2024年03月

Kawamura, I; Ohe, R; Suzuki, K; Kabasawa, T; Kitaoka, T; Takahara, D; Kono, M; Uchiyama, N; Musha, H; Futakuchi, M; Motoi, F

単著

Involvement of TAMs on tumor growth in the lymph node microenvironment but not in primary site，CANCER SCIENCE，115 846，2024年03月

Takanobu Kabasawa, Rintaro Ohe, Kazushi Suzuki, Takumi Kitaoka, Mitsuru Futakuchi

単著

Involvement of TAMs on tumor growth in the lymph node microenvironment but not in primary site，CANCER SCIENCE，115 846，2024年03月

Kabasawa, T; Ohe, R; Suzuki, K; Kitaoka, T; Futakuchi, M

単著

Histological spatial analysis on the induction of PD-L1+macrophages by CD8+T cells of triple-negative breast cancer，CANCER SCIENCE，115 1588，2024年03月

Takumi Kitaoka, Kazushi Suzuki, Takanobu Kabasawa, Rintaro Ohe, Mitsuru Futakuchi

単著

Histological spatial analysis on the induction of PD-L1+macrophages by CD8+T cells of triple-negative breast cancer，CANCER SCIENCE，115 1588，2024年03月

Kitaoka, T; Suzuki, K; Kabasawa, T; Ohe, R; Futakuchi, M

単著

Resident memory T cell contributes to the phenotype of inflammatory vitiligo，JOURNAL OF DERMATOLOGICAL SCIENCE，113(2) 74-76，2024年02月

Okamura, K; Kabasawa, T; Saito, T; Arai, Y; Futakuchi, M; Suzuki, T

単著

BRCA1結合分子の欠損はエストロゲンで制御される中心体増幅に依存した悪性化を示す腫瘍を誘導する，日本癌学会学術総会抄録集(Web)，83rd 1275，2024年

千葉奈津子, 小河穂波, 飯地雄大, 佐々木伯大, 吉田貴大, 市村志織, 方震宙, 李星明, 二口充, 中村保宏, 渡邊利雄, 吉野優樹

単著

Association of ADC of hyperintense lesions on FLAIR images with TERT promoter mutation status in glioblastoma IDH wild type.，Surgical neurology international，15 108，2024年

Kamimura S, Mitobe Y, Nakamura K, Matsuda K, Kanemura Y, Kanoto M, Futakuchi M, Sonoda Y

単著

Activation of fibroblasts by plasma cells via PDGF/PDGFR signaling in IgG4-related sialadenitis，JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY，64(3) 223-231，2024年

Kitaoka, T; Ohe, R; Kabasawa, T; Kaneko, M; Sasahara, N; Kono, M; Suzuki, K; Uchiyama, N; Ogawa, R; Futakuchi, M

単著

[Treatment Experience of Chemotherapy and Carbon-Ion Radiotherapy followed by Curative Conversion Surgery for Initially Locally Advanced Unresectable Pancreatic Cancer after Distal Gastrectomy].，Gan to kagaku ryoho. Cancer & chemotherapy，50(13) 1959-1961，2023年12月

Watanabe H, Sugawara S, Takahashi R, Ashitomi Y, Kawashiro S, Sato H, Nemoto K, Kono M, Futakuchi M, Motoi F

単著

幽門側胃切除後局所進行切除不能膵癌に対し重粒子線併用化学療法後根治切除を得た1例，癌と化学療法，50(13) 1959-1961，2023年12月

渡邊大史, 菅原秀一郎, 高橋良輔, 安次富裕哉, 川城壮平, 佐藤啓, 根本健二, 河野通久, 二口充, 元井冬彦

単著

幽門側胃切除後局所進行切除不能膵癌に対し重粒子線併用化学療法後根治切除を得た1例，癌と化学療法，50(13) 1959-1961，2023年12月

渡邊 大史, 菅原 秀一郎, 高橋 良輔, 安次富 裕哉, 川城 壮平, 佐藤 啓, 根本 健二, 河野 通久, 二口 充, 元井 冬彦

単著

トリプルネガティブ乳癌の辺縁部微小環境のCD8陽性T細胞によるPD-L1陽性マクロファージの誘導に関する組織学的空間的解析(Histological spatial analysis on the induction of PD-L1+ macrophages by CD8+T cells at the marginal microenvironment of triple-negative breast cancer)，Breast Cancer，30(6) 1094-1104，2023年11月

Suzuki Kazushi, Ohe Rintaro, Kabasawa Takanobu, Kitaoka Takumi, Kawai Masaaki, Motoi Fuyuhiko, Futakuchi Mitsuru

単著

Histological spatial analysis on the induction of PD-L1<SUP>+</SUP> macrophages by CD8<SUP>+</SUP> T cells at the marginal microenvironment of triple-negative breast cancer，BREAST CANCER，30(6) 1094-1104，2023年11月

Suzuki, K; Ohe, R; Kabasawa, T; Kitaoka, T; Kawai, M; Motoi, F; Futakuchi, M

単著

Targeting c-Jun Is a Potential Therapy for Luminal Breast Cancer Bone Metastasis，MOLECULAR CANCER RESEARCH，21(9) 908-921，2023年09月

Han, YX; Katayama, S; Futakuchi, M; Nakamichi, K; Wakabayashi, Y; Sakamoto, M; Nakayama, J; Semba, K

単著

Identification of tumor-related genes via RNA sequencing of tumor tissues in<i> Xenopus tropicalis</i>，SCIENTIFIC REPORTS，13(1) ，2023年08月

Kitamura, K; Yamamoto, T; Ochi, H; Suzuki, M; Suzuki, N; Igawa, T; Yoshida, T; Futakuchi, M; Ogino, H; Michiue, T

単著

A durable complete response resulting from treatment with nivolumab plus ipilimumab for metastatic collecting duct carcinoma of the kidney，ASIAN JOURNAL OF UROLOGY，10(3) 376-378，2023年07月

Funajima, K; Naito, S; Kabasawa, T; Nishida, H; Kato, T; Futakuchi, M; Tsuchiya, N

単著

In vivo [<SUP>18</SUP>F]THK-5351 imaging detected reactive astrogliosis in argyrophilic grain disease with comorbid pathology: A clinicopathological study，JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY，82(5) 427-437，2023年04月

Kobayashi, R; Nakamura, T; Naganuma, F; Harada, R; Morioka, D; Kanoto, M; Furumoto, S; Kudo, Y; Kabasawa, T; Otani, K; Futakuchi, M; Kawakatsu, S; Okamura, N

単著

Regular protocol liver biopsy is useful to adjust immunosuppressant dose after adult liver transplantation，CLINICAL TRANSPLANTATION，37(3) ，2023年03月

Narita, S; Miuma, S; Okudaira, S; Koga, Y; Fukushima, M; Sasaki, R; Haraguchi, M; Soyama, A; Hidaka, M; Miyaaki, H; Futakuchi, M; Nagai, K; Ichikawa, T; Eguchi, S; Nakao, K

単著

意味性認知症の臨床病理学的多様性　早発性と晩発性、左側側頭葉萎縮と右側側頭葉萎縮、TDPタイプAとTDPタイプC病理の比較検討(Neuropathology Case Cluster: Neuropathology of focal cortical, behavioral, and psychiatric syndromes in neurodegenerative diseases　Clinicopathological diversity of semantic dementia: Comparisons of patients with early-onset versus late-onset, left-sided versus right-sided temporal atrophy, and TDP-type A versus type C pathology)，NEUROPATHOLOGY，43(1) 5-26，2023年02月

Kawakatsu Shinobu, Kobayashi Ryota, Morioka Daichi, Hayashi Hiroshi, Utsunomiya Aya, Kabasawa Takanobu, Ohe Rintaro, Futakuchi Mitsuru, Otani Koichi

単著

Potential role of M2 TAMs around lymphatic vessels during lymphatic invasion of papillary thyroid carcinoma，CANCER SCIENCE，114 575，2023年02月

Takanobu Kabasawa, Rintaro Ohe, Mitsuru Futakuchi

単著

Induction of heterogeneity of chemo-resistance by the interaction between colorectal cancer cells and TAMs，CANCER SCIENCE，114 1783，2023年02月

Junichi Goto, Rintaro Ohe, Takanobu Kabasawa, Mitsuru Futakuchi

単著

Characterization of Luminal High-Osteolytic Breast Cancer Cell Lines，CANCER SCIENCE，114 237，2023年02月

Yuxuan Han, Jun Nakayama, Mitsuru Futakuchi, Emi Ito, Shinya Watanabe, Kentaro Semba

単著

Clinicopathological diversity of semantic dementia: Comparisons of patients with early-onset versus late-onset, left-sided versus right-sided temporal atrophy, and TDP-type A versus type C pathology，NEUROPATHOLOGY，43(1) 5-26，2023年02月

Kawakatsu, S; Kobayashi, R; Morioka, D; Hayashi, H; Utsunomiya, A; Kabasawa, T; Ohe, R; Futakuchi, M; Otani, K

単著

Induction of heterogeneity of chemo-resistance by the interaction between colorectal cancer cells and TAMs，CANCER SCIENCE，114 1783，2023年02月

Goto, J; Ohe, R; Kabasawa, T; Futakuchi, M

単著

Characterization of Luminal High-Osteolytic Breast Cancer Cell Lines，CANCER SCIENCE，114 237，2023年02月

Han, YX; Nakayama, J; Futakuchi, M; Ito, E; Watanabe, S; Semba, K

単著

Potential role of M2 TAMs around lymphatic vessels during lymphatic invasion of papillary thyroid carcinoma，CANCER SCIENCE，114 575，2023年02月

Kabasawa, T; Ohe, R; Futakuchi, M

単著

幽門側胃切除後局所進行切除不能膵癌に対し重粒子線併用化学療法後根治切除を得た1例，癌と化学療法，50 1959-1961，2023年

二口 充, 元井 冬彦

単著

Oncogenic isoform switch of tumor suppressor BCL11B in adult T-cell leukemia/lymphoma，EXPERIMENTAL HEMATOLOGY，111 41-49，2022年07月

Permatasari, HK; Nakahata, S; Ichikawa, T; Fauzi, YR; Kiyonari, H; Shide, K; Kameda, T; Shimoda, K; Ono, M; Taki, T; Taniwaki, M; Futakuchi, M; Morishita, K

単著

Exploratory analysis on crosstalk between intra-tumor immunity and FGF/FGFR pathway in clear cell renal cell carcinoma.，JOURNAL OF CLINICAL ONCOLOGY，40(16) E16525，2022年06月

Narisawa, T; Naito, S; Mitsuda, Y; Oe, R; Sato, H; Kobayashi, C; Fukuda, M; Kitaoka, T; Miyano, Y; Ito, H; Kimura, M; Hamaguchi, M; Aoshima, K; Futakuchi, M; Tsuchiya, N

単著

The Utility and Safety of Liquid-Based Cytology in the Diagnosis of Intraocular Lymphoma，INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE，63(7) ，2022年06月

Kaneko, Y; Ohe, R; Futakuchi, M; Nishitsuka, K

単著

Pathogenesis of follicular thymic hyperplasia associated with rheumatoid arthritis，PATHOLOGY INTERNATIONAL，72(4) 252-260，2022年04月

Ohe, R; Yang, SR; Yamashita, D; Ichikawa, C; Saito, A; Kabasawa, T; Utsunomiya, A; Aung, NY; Urano, Y; Kitaoka, T; Suzuki, K; Takahara, D; Sasaki, A; Takakubo, Y; Takagi, M; Yamakawa, M; Futakuchi, M

単著

Characterization of Luminal High-Osteolytic Breast Cancer Cell Lines，CANCER SCIENCE，113 675，2022年02月

Han, YX; Nakayama, J; Futakuchi, M; Ito, E; Watanabe, S; Semba, K

単著

Establishment of Predicting Druggable Genes by Using Micro-specimens in gastric and colorectal cancers，CANCER SCIENCE，113 460，2022年02月

Ohe, R; Kabasawa, T; Futakuchi, M

単著

Utility of Liquid-Based Cytology and Cell Block Procedure Obtained by Vitrectomy to Diagnose Ocular Sarcoidosis-The Significance of Epithelioid Granuloma and Epithelioid Cells，CLINICAL OPHTHALMOLOGY，16 3289-3296，2022年

Ohe, R; Kaneko, Y; Namba, H; Nishi, K; Goto, JI; Futakuchi, M; Nishitsuka, K

単著

Pulmonary atherosclerosis in a patient with chronic thromboembolic pulmonary hypertension，PATHOLOGY INTERNATIONAL，71(2) 164-166，2021年02月

Furukawa, K; Kawano, H; Futakuchi, M; Ishijima, M; Yamgataga, Y; Ueno, Y; Koga, S; Ikeda, S; Eishi, K; Maemura, K

単著

Myocardial Damage and Microvasculopathy in a Patient With Systemic Sclerosis，CIRCULATION JOURNAL，85(2) 224，2021年02月

Kawano, H; Kudo, T; Umeda, M; Futakuchi, M; Sueyoshi, E; Maemura, K

単著

Effects of OPG on Osteolysis, Proliferation of Mammary Cancer Cells and Induction of CSCs in the Bone Microenvironment.，CANCER SCIENCE，112 541，2021年02月

Futakuchi, M; Tachibana, Y; Kris, L; Furukawa, M; Fukuoka, J

単著

The Effects of TGFβ Signaling on Cancer Cells and Cancer Stem Cells in the Bone Microenvironment，CANCER SCIENCE，112 348，2021年02月

Futakuchi, M; Tachibana, Y; Kris, L; Furukawa, M; Fukuoka, J

単著

Novel tumor suppressor gene NDRG2 deficiency promotes metabolic disorders and liver cancer development，CANCER SCIENCE，112 374，2021年02月

Ichikawa, T; Nakahata, S; Futakuchi, M; Yamaguchi, R; Morishita, K

単著

Establishment and characterization of highly osteolytic luminal breast cancer cell lines by intracaudal arterial injection (vol 25, pg 111, 2020)，GENES TO CELLS，25(5) 358，2020年05月

Han, Y; Nakayama, J; Hayashi, Y; Jeong, S; Futakuchi, M; Ito, E; Semba, K

単著

Establishment and characterization of highly osteolytic luminal breast cancer cell lines by intracaudal arterial injection，GENES TO CELLS，25(2) 111-123，2020年02月

Han, YX; Nakayama, J; Hayashi, Y; Jeong, S; Futakuchi, M; Ito, E; Watanabe, S; Semba, K

単著

Inferior Vena Cava Anomalies with Portal Vein System Continuation Presenting as Portal Hypertension with a Long-term Follow-up，INTERNAL MEDICINE，59(22) 2897-2901，2020年

Fukushima, M; Miyaaki, H; Sasaki, R; Haraguchi, M; Miuma, S; Ishimaru, H; Hidaka, M; Okudaira, S; Eguchi, S; Futakuchi, M; Kusano, H; Kage, M; Nakao, K

単著

Detection of Lung Cancer Lymph Node Metastases from Whole-Slide Histopathologic Images Using a Two-Step Deep Learning Approach，AMERICAN JOURNAL OF PATHOLOGY，189(12) 2428-2439，2019年12月

Pham, HHN; Futakuchi, M; Bychkov, A; Furukawa, T; Kuroda, K; Fukuoka, J

単著

The Effects of TGF-β Signaling on Cancer Cells and Cancer Stem Cells in the Bone Microenvironment，INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES，20(20) ，2019年10月

Futakuchi, M; Lami, K; Tachibana, Y; Yamamoto, Y; Furukawa, M; Fukuoka, J

単著

Cancer-Associated Fibroblasts Enhance Survival and Progression of the Aggressive Pancreatic Tumor Via FGF-2 and CXCL8，CANCER MICROENVIRONMENT，12(1) 37-46，2019年04月

Awaji, M; Futakuchi, M; Heavican, T; Iqbal, J; Singh, RK

単著

Evaluation of a biomarker for the diagnosis of pancreas cancer using an animal model，JOURNAL OF TOXICOLOGIC PATHOLOGY，32(3) 135-141，2019年

Fukamachi, K; Hagiwara, Y; Futakuchi, M; Alexander, DB; Tsuda, H; Suzui, M

単著

Mechanisms of induction of cancer stem cells in the bone microenvironment; involvement of drug resistance，CANCER SCIENCE，109 183，2018年12月

Futakuchi, M

単著

Persistent Pleural Lesions and Inflammation by Pulmonary Exposure of Multiwalled Carbon Nanotubes，CHEMICAL RESEARCH IN TOXICOLOGY，31(10) 1025-1031，2018年10月

Liao, DP; Wang, QQ; He, JL; Alexander, DB; Abdelgied, M; El-Gazzar, AM; Futakuchi, M; Suzui, M; Kanno, J; Hirose, A; Xu, JG; Tsuda, H

単著

Therapeutic and Preventive Effects of Osteoclastogenesis Inhibitory Factor on Osteolysis, Proliferation of Mammary Tumor Cell and Induction of Cancer Stem Cells in the Bone Microenvironment，INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES，19(3) ，2018年03月

Futakuchi, M; Nitanda, T; Ando, S; Matsumoto, H; Yoshimoto, E; Fukamachi, K; Suzui, M

単著

Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A，PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA，115(9) 2204-2209，2018年02月

Hashimoto, K; Ochi, H; Sunamura, S; Kosaka, N; Mabuchi, Y; Fukuda, T; Yao, K; Kanda, H; Ae, K; Okawa, A; Akazawa, C; Ochiya, T; Futakuchi, M; Takeda, S; Sato, S

単著

Growth inhibition of the crude extracts of the leaves of Musa basjoo in human colon cancer cells，CANCER SCIENCE，109 775，2018年01月

Matsumoto, H; Ando, S; Fukamachi, K; Futakuchi, M; Suzui, M

単著

In vitro and vivo anticancer activity of a novel agent palmitoyl piperidinopiperidine，CANCER SCIENCE，109 377，2018年01月

Ando, S; Matsumoto, H; Fukamachi, K; Futakuchi, M; Suzui, M

単著

Analysis of molecular mechanisms for tumor development and metastasis through a novel tumor suppressor gene NDRG2，CANCER SCIENCE，109 67，2018年01月

Ichikawa, T; Tamura, T; Nakahata, S; Futakuchi, M; Morishita, K

単著

Ferric nitrilotriacetate induced renal tumorigenesis in MUTYH deficient mice，CANCER SCIENCE，109 167，2018年01月

Akatsuka, S; Li, GH; Sakumi, K; Nakabeppu, Y; Futakuchi, M; Suzuki, H; Toyokuni, S

単著

Identification and Functional analysis of HNF1B as a multi-organ metastasis inducing gene，CANCER SCIENCE，109 874，2018年01月

Nakayama, J; Matsui, A; Fujimoto, J; Futakuchi, M; Ito, E; Watanabe, S; Semba, K

単著

Cancer cell-derived microRNA induces osteoblastic phenotype in bone metastasis microenvironment.，JOURNAL OF BONE AND MINERAL RESEARCH，32 S64-S65，2017年12月

Hashimoto, K; Sunamura, S; Ochi, H; Fukuda, T; Okawa, A; Futakuchi, M; Takeda, S; Sato, S

単著

Fenton reaction-induced renal carcinogenesis in <i>Mutyh</i>-deficient mice exhibits less chromosomal aberrations than the rat model，PATHOLOGY INTERNATIONAL，67(11) 564-574，2017年11月

Li, GH; Akatsuka, S; Chew, SH; Jiang, L; Nishiyama, T; Sakamoto, A; Takahashi, T; Futakuchi, M; Suzuki, H; Sakumi, K; Nakabeppu, Y; Toyokuni, S

単著

Growth inhibition of the crude extracts of <i>Musa basjoo</i> in human colon carcinoma cells，CANCER RESEARCH，77 ，2017年07月

Matsumoto, H; Ando, S; Fukamachi, K; Futakuchi, M; Kimura, K; Yoshimi, N; Suzui, M

単著

A new anticancer agent derived from decenoic acid for the treatment of colon cancer，CANCER RESEARCH，77 ，2017年07月

Suzui, M; Ando, S; Matsumoto, H; Fukamachi, K; Futakuchi, M; Yoshimi, N

単著

Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential，CANCER RESEARCH，77(9) 2363-2374，2017年05月

Tamura, T; Ichikawa, T; Nakahata, S; Kondo, Y; Tagawa, Y; Yamamoto, K; Nagai, K; Baba, T; Yamaguchi, R; Futakuchi, M; Yamashita, Y; Morishita, K

単著

A novel monoclonal antibody targeting coxsackie virus and adenovirus receptor inhibits tumor growth <i>in vivo</i>，SCIENTIFIC REPORTS，7 ，2017年01月

Kawada, M; Inoue, H; Kajikawa, M; Sugiura, M; Sakamoto, S; Urano, S; Karasawa, C; Usami, I; Futakuchi, M; Masuda, T

単著

Mechanism of action of a novel anti-tumor antibody, anti-CXADR 6G10A，EUROPEAN JOURNAL OF CANCER，69 S38，2016年12月

Kawada, M; Inoue, H; Kajikawa, M; Sugiura, M; Sakamoto, S; Urano, S; Karasawa, C; Usami, I; Futakuchi, M

単著

Development of a mechanism based short-term assay protocol to test carcinogenicity of multiple wall carbon nanotubes (MWNCTs) in the rat，TOXICOLOGY LETTERS，259 S22，2016年10月

Tsuda, H; Alexander, DB; Alexander, WT; Abd Elgied, M; Elgazzar, A; Xu, J; Numano, T; Suzui, M; Futakuchi, M; Fukamachi, K; Hirose, A; Kanno, J

単著

Suppression of C5a decreases ischemia/reperfusion injury and increases proliferation of epithelial cells in the rat small intestine，IMMUNOBIOLOGY，221(10) 1146，2016年10月

Tuboly, E; Futakuchi, M; Varga, G; Érces, D; Mészáros, A; Kisvári, G; Boros, M; Okada, H; Okada, N

単著

Multiwalled carbon nanotubes intratracheally instilled into the rat lung induce development of pleural malignant mesothelioma and lung tumors，CANCER SCIENCE，107(7) 924-935，2016年07月

Suzui, M; Futakuchi, M; Fukamachi, K; Numano, T; Abdelgied, M; Takahashi, S; Ohnishi, M; Omori, T; Tsuruoka, S; Hirose, A; Kanno, J; Sakamoto, Y; Alexander, DB; Alexander, WT; Xu, JG; Tsuda, H

単著

Heterogeneity of tumor cells in the bone microenvironment: Mechanisms and therapeutic targets for bone metastasis of prostate or breast cancer，ADVANCED DRUG DELIVERY REVIEWS，99 206-211，2016年04月

Futakuchi, M; Fukamachi, K; Suzui, M

単著

C5a inhibitor protects against ischemia/reperfusion injury in rat small intestine，MICROBIOLOGY AND IMMUNOLOGY，60(1) 35-46，2016年01月

Tuboly, E; Futakuchi, M; Varga, G; Erces, D; Tokés, T; Mészáros, A; Kaszaki, J; Suzui, M; Imai, M; Okada, A; Okada, N; Boros, M; Okada, H

単著

Chemokine (C-C motif) ligand 3 detection in the serum of persons exposed to asbestos: A patient-based study，CANCER SCIENCE，106(7) 825-832，2015年07月

Xu, JG; Alexander, DB; Iigo, M; Hamano, H; Takahashi, S; Yokoyama, T; Kato, M; Usami, I; Tokuyama, T; Tsutsumi, M; Tamura, M; Oguri, T; Niimi, A; Hayashi, Y; Yokoyama, Y; Tonegawa, K; Fukamachi, K; Fu...

単著

Murine Herc6 Plays a Critical Role in Protein ISGylation <i>In Vivo</i> and Has an ISGylation-Independent Function in Seminal Vesicles，JOURNAL OF INTERFERON AND CYTOKINE RESEARCH，35(5) 351-358，2015年05月

Arimoto, K; Hishiki, T; Kiyonari, H; Abe, T; Cheng, CY; Yan, M; Fan, JB; Futakuchi, M; Tsuda, H; Murakami, Y; Suzuki, H; Zhang, DE; Shimotohno, K

単著

<i>In vivo</i> <SUP>18</SUP>F-fluorodeoxyglucose-positron emission tomography/computed tomography imaging of pancreatic tumors in a transgenic rat model carrying the human <i>KRAS<SUP>G12V</SUP></i> oncogene，ONCOLOGY LETTERS，9(5) 2112-2118，2015年05月

Shibata, K; Fukamachi, K; Tsuji, A; Saga, T; Futakuchi, M; Nagino, M; Tsuda, H; Suzui, M

単著

Rat N-ERC/Mesothelin as a Marker for <i>In Vivo</i> Screening of Drugs against Pancreas Cancer，PLOS ONE，9(10) ，2014年10月

Fukamachi, K; Iigo, M; Hagiwara, Y; Shibata, K; Futakuchi, M; Alexander, DB; Hino, O; Suzui, M; Tsuda, H

単著

Inhibition of intestinal polyp growth by oral ingestion of bovine lactoferrin and immune cells in the large intestine，BIOMETALS，27(5) 1017-1029，2014年10月

Iigo, M; Alexander, DB; Xu, JG; Futakuchi, M; Suzui, M; Kozu, T; Akasu, T; Saito, D; Kakizoe, T; Yamauchi, K; Abe, F; Takase, M; Sekine, K; Tsuda, H

単著

Size- and shape-dependent pleural translocation, deposition, fibrogenesis, and mesothelial proliferation by multiwalled carbon nanotubes，CANCER SCIENCE，105(7) 763-769，2014年07月

Xu, JG; Alexander, DB; Futakuchi, M; Numano, T; Fukamachi, K; Suzui, M; Omori, T; Kanno, J; Hirose, A; Tsuda, H

単著

A Novel Transgenic Mouse Model Carrying Human Tribbles Related Protein 3 (TRB3) Gene and Its Site Specific Phenotype，BIOLOGICAL & PHARMACEUTICAL BULLETIN，37(6) 1068-1074，2014年06月

Sakai, Y; Fukamachi, K; Futakuchi, M; Miyoshi, I; Tsuda, H; Suzui, M; Hayashi, H

単著

Nanosized zinc oxide particles do not promote DHPN-induced lung carcinogenesis but cause reversible epithelial hyperplasia of terminal bronchioles，ARCHIVES OF TOXICOLOGY，88(1) 65-75，2014年01月

Xu, JG; Futakuchi, M; Alexander, DB; Fukamachi, K; Numano, T; Suzui, M; Shimizu, H; Omori, T; Kanno, J; Hirose, A; Tsuda, H

単著

Comparative Study of Toxic Effects of Anatase and Rutile Type Nanosized Titanium Dioxide Particles <i>in vivo</i> and <i>in vitro</i>，ASIAN PACIFIC JOURNAL OF CANCER PREVENTION，15(2) 929-935，2014年

Numano, T; Xu, JG; Futakuchi, M; Fukamachi, K; Alexander, DB; Furukawa, F; Kanno, J; Hirose, A; Tsuda, H; Suzui, M

単著

Promotive effects of cell proliferation and chromosomal instability induced by tribbles-related protein 3 in mouse mammary tumor cells，ONCOLOGY REPORTS，30(1) 64-70，2013年07月

Sakai, Y; Fukamachi, K; Futakuchi, M; Hayashi, H; Suzui, M

単著

Animal model for mammary tumor growth in the bone microenvironment，BREAST CANCER，20(3) 195-203，2013年07月

Futakuchi, M; Singh, RK

単著

Evaluation of carcinogenic effect of multiwall carbon nanotubes on the rat lung at 2 and 52 weeks after pulmonary instillation，CANCER RESEARCH，73(8) ，2013年04月

Suzui, M; Numano, T; Futakuchi, M; Fukamachi, K

単著

Effect of anatase type nanosized titanium dioxide particles on the rat lung and cultured macrophage，CANCER RESEARCH，73(8) ，2013年04月

Numano, T; Xu, JG; Futakuchi, M; Fukamachi, K; Furukawa, F; Suzui, M; Tsuda, H

単著

A novel reporter rat strain that expresses LacZ upon Cre-mediated recombination，GENESIS，51(4) 268-274，2013年04月

Fukamachi, K; Tanaka, H; Sakai, Y; Alexander, DB; Futakuchi, M; Tsuda, H; Suzui, M

単著

Inflammatory Activation after Experimental Cardiac Tamponade，EUROPEAN SURGICAL RESEARCH，51(1-2) 1-13，2013年

Vass, A; Süveges, G; Érces, D; Nógrády, M; Varga, G; Földesi, I; Futakuchi, M; Imai, M; Okada, N; Okada, H; Boros, M; Kaszaki, J

単著

Multi-walled carbon nanotubes translocate into the pleural cavity and induce visceral mesothelial proliferation in rats，CANCER SCIENCE，103(12) 2045-2050，2012年12月

Xu, JG; Futakuchi, M; Shimizu, H; Alexander, DB; Yanagihara, K; Fukamachi, K; Suzui, M; Kanno, J; Hirose, A; Ogata, A; Sakamoto, Y; Nakae, D; Omori, T; Tsuda, H

単著

Dose-dependent mesothelioma induction by intraperitoneal administration of multi-wall carbon nanotubes in p53 heterozygous mice，CANCER SCIENCE，103(8) 1440-1444，2012年08月

Takagi, A; Hirose, A; Futakuchi, M; Tsuda, H; Kanno, J

単著

Lack of promoting effect of titanium dioxide particles on chemically-induced skin carcinogenesis in rats and mice，JOURNAL OF TOXICOLOGICAL SCIENCES，37(2) 317-327，2012年04月

Sagawa, Y; Futakuchi, M; Xu, JG; Fukamachi, K; Sakai, Y; Ikarashi, Y; Nishimura, T; Suzui, M; Tsuda, H; Morita, A

単著

A Cross-Species Analysis of a Mouse Model of Breast Cancer-Specific Osteolysis and Human Bone Metastases Using Gene Expression Profiling，BMC CANCER，11 ，2011年07月

Sadanandam, A; Futakuchi, M; Lyssiotis, CA; Gibb, WJ; Singh, RK

単著

Lack of promoting effect of titanium dioxide particles on ultraviolet B-initiated skin carcinogenesis in rats，FOOD AND CHEMICAL TOXICOLOGY，49(6) 1298-1302，2011年06月

Xu, JG; Sagawa, Y; Futakuchi, M; Fukamachi, K; Alexander, DB; Furukawa, F; Ikarashi, Y; Uchino, T; Nishimura, T; Morita, A; Suzui, M; Tsuda, H

単著

Soluble receptor activator of nuclear factor-kB ligand and proteases: the involvement in osteolysis and its significance as therapeutics for bone metastasis of breast or prostate cancer，CLINICAL & EXPERIMENTAL METASTASIS，28(2) 207，2011年02月

Futakuchi, M; Nannuru, KC; Wilson, TJ; Fukamachi, K; Suzui, M; Singh, RK

単著

Cancer prevention by bovine lactoferrin: from animal studies to human trial，BIOMETALS，23(3) 399-409，2010年06月

Tsuda, H; Kozu, T; Iinuma, G; Ohashi, Y; Saito, Y; Saito, D; Akasu, T; Alexander, DB; Futakuchi, M; Fukamachi, K; Xu, JG; Kakizoe, T; Iigo, M

単著

Matrix Metalloproteinase (MMP)-13 Regulates Mammary Tumor-Induced Osteolysis by Activating MMP9 and Transforming Growth Factor-β Signaling at the Tumor-Bone Interface，CANCER RESEARCH，70(9) 3494-3504，2010年05月

Nannuru, KC; Futakuchi, M; Varney, ML; Vincent, TM; Marcusson, EG; Singh, RK

単著

Involvement of macrophage inflammatory protein 1α (MIP1α) in promotion of rat lung and mammary carcinogenic activity of nanoscale titanium dioxide particles administered by intra-pulmonary spraying，CARCINOGENESIS，31(5) 927-935，2010年05月

Xu, JG; Futakuchi, M; Iigo, M; Fukamachi, K; Alexander, DB; Shimizu, H; Sakai, Y; Tamano, S; Furukawa, F; Uchino, T; Tokunaga, H; Nishimura, T; Hirose, A; Kanno, J; Tsuda, H

単著

Cathepsin G-mediated enhanced TGF-β signaling promotes angiogenesis via upregulation of VEGF and MCP-1，CANCER LETTERS，288(2) 162-169，2010年02月

Wilson, TJ; Nannuru, KC; Futakuchi, M; Singh, RK

単著

Mature acinar cells are refractory to carcinoma development by targeted activation of Ras oncogene in adult rats，CANCER SCIENCE，101(2) 341-346，2010年02月

Tanaka, H; Fukamachi, K; Futakuchi, M; Alexander, DB; Long, N; Tamamushi, S; Minami, K; Seino, S; Ohara, H; Joh, T; Tsuda, H

単著

A Medium-Term, Rapid Rat Bioassay Model for the Detection of Carcinogenic Potential of Chemicals，TOXICOLOGIC PATHOLOGY，38(1) 182-187，2010年

Tsuda, H; Futakuchi, M; Fukamachi, K; Shirai, T; Imaida, K; Fukushima, S; Tatematsu, M; Furukawa, F; Tamano, S; Ito, N

単著

Enhanced expression and shedding of receptor activator of NF-κB ligand during tumor-bone interaction potentiates mammary tumor-induced osteolysis，CLINICAL & EXPERIMENTAL METASTASIS，26(7) 797-808，2009年10月

Nannuru, KC; Futakuchi, M; Sadanandam, A; Wilson, TJ; Varney, ML; Myers, KJ; Li, XD; Marcusson, EG; Singh, RK

単著

Anticarcinogenesis pathways activated by bovine lactoferrin in the murine small intestine，BIOCHIMIE，91(1) 86-101，2009年01月

Iigo, M; Alexander, DB; Long, N; Xu, JG; Fukamachi, K; Futakuchi, M; Takase, M; Tsuda, H

単著

Transforming growth factor-β signaling at the tumor-bone interface promotes mammary tumor growth and osteoclast activation，CANCER SCIENCE，100(1) 71-81，2009年01月

Futakuchi, M; Nannuru, KC; Varney, ML; Sadanandam, A; Nakao, K; Asai, K; Shirai, T; Sato, S; Singh, RK

単著

Construction of a Multi-Functional Helper-Dependent Adenovirus Based System for Cancer Gene Therapy，ASIAN PACIFIC JOURNAL OF CANCER PREVENTION，10(5) 939-960，2009年

Long, N; Hardiville, S; Pierce, A; Fukamachi, K; Futakuchi, M; Alexander, DB; Shirai, T; Tsuda, H

単著

Toxicology of Engineered Nanomaterials - A review of Carcinogenic Potential，ASIAN PACIFIC JOURNAL OF CANCER PREVENTION，10(6) 975-980，2009年

Tsuda, H; Xu, JG; Sakai, Y; Futakuchi, M; Fukamachi, K

単著

Modifying effects of chitin, chitosan and their related compounds on 2-amino-3,8-dimethylimidazo[4,5-<i>f</i>]quinoxaline (MeIQx) in a rat medium-term hepatocarcinogenesis model, and their post-initiation effects in a female rat 2-stage multi-organ carcinogenesis model，FOOD AND CHEMICAL TOXICOLOGY，46(8) 2758-2763，2008年08月

Kawabe, M; Futakuchi, M; Tamano, S; Shirai, T; Hirose, M

単著

Cathepsin g enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-κB ligand，CANCER RESEARCH，68(14) 5803-5811，2008年07月

Wilson, TJ; Nannuru, KC; Futakuchi, M; Sadanandam, A; Singh, RK

単著

Effect of heat therapy using magnetic nanoparticles conjugated with cationic liposomes on prostate tumor in bone，PROSTATE，68(7) 784-792，2008年05月

Kawai, N; Futakuchi, M; Yoshida, T; Ito, A; Sato, S; Naiki, T; Honda, H; Shirai, T; Kohri, K

単著

Heat therapy with cationic liposome might suppress the proliferation of prostate cancer in bone microenvironment via the reduction of TGF-β level in bone microenvironment，JOURNAL OF UROLOGY，179(4) 420-421，2008年04月

Kawai, N; Futakuchi, M; Naiki, T; Hashimoto, Y; Tozawa, K; Kohri, K

単著

Transforming growth factor β derived from bone matrix promotes cell proliferation of prostate cancer and osteoclast activation-associated osteolysis in the bone microenvironment，CANCER SCIENCE，99(2) 316-323，2008年02月

Sato, S; Futakuchi, M; Ogawa, K; Asamoto, M; Nakao, K; Asai, K; Shirai, T

単著

Differences in Expression Patterns of Cell Cycle Regulators after Cessation of Genotoxic and Non-genotoxic Carcinogen Treatment in the Rat Forestomach，JOURNAL OF TOXICOLOGIC PATHOLOGY，21(2) 77-87，2008年

Mizoguchi, Y; Ogawa, K; Futakuchi, M; Takahashi, S; Hirose, M; Shirai, T

単著

Both early and late stages of hepatocarcinogenesis are enhanced in cx32 dominant negative mutant transgenic rats with disrupted gap junctional intercellular communication，JOURNAL OF MEMBRANE BIOLOGY，218(1-3) 101-106，2007年08月

Hokaiwado, N; Asamoto, M; Futakuchi, M; Ogawa, K; Takahashi, S; Shirai, T

単著

Suppression of the prostate tumor growth and bone destruction in the bone microenvironment by heat therapy with magnetic nano-particle conjugated with cationic liposome，JOURNAL OF UROLOGY，177(4) 182，2007年04月

Kawai, N; Yoshida, T; Ito, A; Futakuchi, M; Honda, H; Tozawa, K; Kohri, K

単著

Spleen but not tumor infiltration by dendritic and T cells is increased by intravenous adenovirus-Flt3 ligand injection，CANCER GENE THERAPY，14(4) 364-371，2007年04月

Solheim, JC; Reber, AJ; Ashour, AE; Robinson, S; Futakuchi, M; Kurz, SG; Hood, K; Fields, RR; Shafer, LR; Cornell, D; Sutjipto, S; Zurawski, S; LaFace, DM; Singh, RK; Talmadge, JE

単著

MMP13 promotes prostate tumor growth in the bone microenvironment by activating TGF-β，CLINICAL & EXPERIMENTAL METASTASIS，24(4) 281，2007年

Futakuchi, M; Sato, SY; Shirai, T

単著

TGF-β promotes prostate tumor growth in the bone microenvironment，CLINICAL & EXPERIMENTAL METASTASIS，24(4) 282-283，2007年

Sato, SY; Futakuchi, M; Shirai, T

単著

Complete regression of experimental prostate cancer in nude mice by repeated hyperthermia using magnetite cationic liposomes and a newly developed solenoid containing a ferrite core，PROSTATE，66(7) 718-727，2006年05月

Kawai, N; Ito, A; Nakahara, Y; Honda, H; Kobayashi, T; Futakuchi, M; Shirai, T; Tozawa, K; Kohri, K

単著

TGF-β directly and indirectly promote mammary tumor growth in the bone microenvironment by increasing osteoclastgenesis，CANCER RESEARCH，66(8) ，2006年04月

Futakuchi, M; Varney, ML; Sadanandam, A; Nakao, K; Asai, K; Shirai, T; Singh, RK

単著

Gene expression profiling using a unique murine mammary tumor model reveal role of novel genes regulating tumor-stromal interaction in mammary tumor-induced osteolysis，FASEB JOURNAL，20(4) A222，2006年03月

Sadanandam, A; Futakuchi, M; Varney, M; Qiu, F; Singh, R

単著

Lack of prophylactic effect of incadronate an skeletal lesions associated with implants of prostate cancer，EUROPEAN UROLOGY，49(1) 176-182，2006年01月

Hikosaka, A; Futakuchi, M; Ogiso, T; Suzuki, S; Kohri, K; Shirai, T

単著

Anticancer effect of hyperthermia on prostate cancer mediated by magnetite cationic liposomes and immune-response induction in transplanted syngeneic rats，PROSTATE，64(4) 373-381，2005年09月

Kawai, N; Ito, A; Nakahara, Y; Futakuchi, M; Shirai, T; Honda, H; Kobayashi, T; Kohri, K

単著

Modification of an <i>in vivo</i> lung metastasis model of hepatocellular carcinoma by low dose n-nitrosomorpholine and diethylnitrosamine，CLINICAL & EXPERIMENTAL METASTASIS，22(5) 441-447，2005年09月

Yoshino, H; Futakuchi, M; Cho, YM; Ogawa, K; Takeshita, F; Imai, N; Tamano, S; Shirai, T

単著

MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL，CANCER CELL，7(5) 485-496，2005年05月

Lynch, CC; Hikosaka, A; Acuff, HB; Martin, MD; Kawai, N; Singh, RK; Vargo-Gogola, TC; Begtrup, JL; Peterson, TE; Fingleton, B; Shirai, T; Matrisian, LM; Futakuchi, M

単著

Kinetics of marked development of lung metastasis of rat prostatic carcinomas transplanted in syngeneic rats，CLINICAL & EXPERIMENTAL METASTASIS，22(4) 309-318，2005年

Zhao, LY; Futakuchi, M; Suzuki, S; Ohhara, Y; Hashimoto, T; Suzuki, T; Manabe, T; Shirai, T

単著

Suppression of metastasis by nuclear factor κB inhibitors in an <i>in vivo</i> lung metastasis model of chemically induced hepatocellular carcinoma，CANCER SCIENCE，95(1) 18-24，2004年01月

Futakuchi, M; Ogawa, K; Tamano, S; Takahashi, S; Shirai, T

単著

Dose response study of conjugated fatty acid derived from safflower oil on mammary and colon carcinogenesis pretreated with 7,12-dimethylbenz[<i>a</i>]anthracene (DMBA) and 1,2-dimethylhydrazine (DMH) in female Sprague-Dawley rats，CANCER LETTERS，196(2) 161-168，2003年07月

Cheng, JL; Futakuchi, M; Ogawa, K; Iwata, T; Kasai, M; Tokudome, S; Hirose, M; Shirai, T

単著

Lack of inhibitory effects of green tea catechins in 1,2-dimetylhydrazine-induced rat intestinal carcinogenesis model: comparison of the different formulations, administration routes and doses，CANCER LETTERS，188(1-2) 163-170，2002年12月

Hirose, M; Yamaguchi, T; Mizoguchi, Y; Akagi, K; Futakuchi, M; Shirai, T

単著

Effects of antioxidant 1-<i>O</i>-hexyl-2,3,5-trimethylhydroquinone or ascorbic acid on carcinogenesis induced by administration of aminopyrine and sodium nitrite in a rat multi-organ carcinogenesis model，JAPANESE JOURNAL OF CANCER RESEARCH，93(12) 1299-1307，2002年12月

Yada, H; Hirose, M; Tamano, S; Kawabe, M; Sano, M; Takahashi, S; Futakuchi, M; Miki, T; Shirai, T

単著

Suppression of lung metastasis by aspirin but not indomethacin in an <i>in vivo</i> model of chemically induced hepatocellular carcinoma，JAPANESE JOURNAL OF CANCER RESEARCH，93(10) 1175-1181，2002年10月

Futakuchi, M; Ogawa, K; Sano, M; Tamano, S; Takeshita, F; Shirai, T

単著

Organ differences in the enhancing potential of 2-amino-1-methyl-6-phenylimidazo[4,5-<i>b</i>]pyridine on carcinogenicity in the prostate, colon and pancreas，MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS，506 129-136，2002年09月

Shirai, T; Kato, K; Futakuchi, M; Takahashi, S; Suzuki, S; Imaida, K; Asamoto, M

単著

Distinctive gene expression of receptor-type tyrosine kinase families during rat hepatocarcinogenesis，INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE，9(5) 473-480，2002年05月

Kuroda, H; Ohtsuru, A; Futakuchi, M; Kawashita, Y; Nagayama, Y; Fukuda, E; Namba, H; Shirai, T; Kanematsu, T; Yamashita, S

単著

Inhibition of conjugated fatty acids derived from safflower or perilla oil of induction and development of mammary tumors in rats induced by 2-amino-1-methyl-6-phenylimidazo[4,5-<i>b</i>]pyridine (PhIP)，CANCER LETTERS，178(2) 131-139，2002年04月

Futakuchi, M; Cheng, JL; Hirose, M; Kimoto, N; Cho, YM; Iwata, T; Kasai, M; Tokudome, S; Shirai, T

単著

Chemoprevention of 2-amino-1-methyl-6-phenylimidazo[4,5-<i>b</i>]pyridine-induced colon carcinogenesis by 1-<i>O</i>-hexyl-2,3,5-trimethylhydroquinone after initiation with 1,2-dimethylhydrazine in F344 rats，CARCINOGENESIS，23(2) 283-287，2002年02月

Futakuchi, M; Hirose, M; Imaida, K; Takahashi, S; Ogawa, K; Asamoto, M; Miki, T; Shirai, T

単著

Organ dependent enhancement of rat 3,2′-dimethyl-4-aminobiphenyl (DMAB) carcinogenesis by 2-amino-1-methyl-6-phenylimidazo[4,5-<i>b</i>]pyridine (PhIP): positive effects on the intestine but not the prostate，CARCINOGENESIS，22(8) 1295-1299，2001年08月

Imaida, K; Sano, M; Tamano, S; Asamoto, M; Ogawa, K; Futakuchi, M; Shirai, T

単著

Site-dependent modulating effects of conjugated fatty acids from safflower oil in a rat two-stage carcinogenesis model in female Sprague-Dawley rats，CANCER LETTERS，168(1) 15-21，2001年07月

Kimoto, N; Hirose, M; Futakuchi, M; Iwata, T; Kasai, M; Shirai, T

単著

Establishment of rat hepatocellular carcinoma cell lines with differing metastatic potential in nude mice，INTERNATIONAL JOURNAL OF CANCER，91(6) 797-802，2001年03月

Ogawa, K; Nakanishi, H; Takeshita, F; Futakuchi, M; Asamoto, M; Imaida, K; Tatematsu, M; Shirai, T

単著

Strategy for ABO-incompatible living-related liver transplantation，TRANSPLANTATION PROCEEDINGS，32(7) 2104-2106，2000年11月

Hashimoto, T; Kondo, S; Suzuki, T; Nakamura, T; Shimizu, Y; Nakamura, Y; Hayashi, S; Zhao, L; Manabe, T; Futakuchi, M; Shirai, T

単著

Enhancing effects of Thai edible plants on 2-amino-3,8-dimethylimidazo(4,5-<i>f</i>)quinoxaline-hepatocarcinogenesis in a rat medium-term bioassay，CANCER LETTERS，158(2) 195-201，2000年10月

Tiwawech, D; Hirose, M; Futakuchi, M; Lin, C; Thamavit, W; Ito, N; Shirai, T

単著

Suppressive effects of dietary genistin and daidzin on rat prostate carcinogenesis，JAPANESE JOURNAL OF CANCER RESEARCH，91(8) 786-791，2000年08月

Kato, K; Takahashi, S; Cui, L; Toda, T; Suzuki, S; Futakuchi, M; Sugiura, S; Shirai, T

単著

Effects of arctiin on PhIP-induced mammary, colon and pancreatic carcinogenesis in female Sprague-Dawley rats and MeIQx-induced hepatocarcinogenesis in male F344 rats，CANCER LETTERS，155(1) 79-88，2000年07月

Hirose, M; Yamaguchi, T; Lin, C; Kimoto, N; Futakuchi, M; Kono, T; Nishibe, S; Shirai, T

単著

Inhibitory effects of low doses of melatonin on induction of preneoplastic liver lesions in a medium-term liver bioassay in F344 rats: relation to the influence of electromagnetic near field exposure，CANCER LETTERS，155(1) 105-114，2000年07月

Imaida, K; Hagiwara, A; Yoshino, H; Tamano, S; Sano, M; Futakuchi, M; Ogawa, K; Asamoto, M; Shirai, T

単著

Protective mechanisms against the intestinal nematode Strongyloides venezuelensis in Schistosoma japonicum-infected mice，PARASITE IMMUNOLOGY，22(6) 279-286，2000年06月

Maruyama, H; Osada, Y; Yoshida, A; Futakuchi, M; Kawaguchi, H; Zhang, RL; Fu, J; Shirai, T; Kojima, S; Ohta, N

単著

Experimental prostate carcinogenesis - rodent models，MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH，462(2-3) 219-226，2000年04月

Shirai, T; Takahashi, S; Cui, L; Futakuchi, M; Kato, K; Tamano, S; Imaida, K

単著

Establishment of an <i>in vivo</i> highly metastatic rat hepatocellular carcinoma model，JAPANESE JOURNAL OF CANCER RESEARCH，90(11) 1196-1202，1999年11月

Futakuchi, M; Hirose, M; Ogiso, T; Kato, K; Sano, M; Ogawa, K; Shirai, T

単著

Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo [4,5-<i>b</i>]pyridine (PhIP) in the rat prostate and induction of invasive carcinomas by subsequent treatment with testosterone propionate，CANCER LETTERS，143(2) 217-221，1999年09月

Shirai, T; Cui, L; Takahashi, S; Futakuchi, M; Asamoto, M; Kato, K; Ito, N

単著

Chemoprevention of heterocyclic amine-induced carcinogenesis by phenolic compounds in rats，CANCER LETTERS，143(2) 173-178，1999年09月

Hirose, M; Takahashi, S; Ogawa, K; Futakuchi, M; Shirai, T; Shibutani, M; Uneyama, C; Toyoda, K; Iwata, H

単著

Phenolics: Blocking agents for heterocyclic amine-induced carcinogenesis，FOOD AND CHEMICAL TOXICOLOGY，37(9-10) 985-992，1999年09月

Hirose, M; Takahashi, S; Ogawa, K; Futakuchi, M; Shirai, T

単著

Development of androgen-independent carcinomas from androgen-dependent preneoplastic lesions in the male accessory sex organs of rats treated with 3,2′-dimethyl-4-aminobiphenyl and testosterone propionate，JAPANESE JOURNAL OF CANCER RESEARCH，90(1) 23-30，1999年01月

Iwasaki, S; Kato, K; Mori, T; Takahashi, S; Futakuchi, M; Shirai, T

単著

ABO-incompatible living related liver transplantation for fulminant hepatitis: Report of a successful pediatric case with long-term follow-up，TRANSPLANTATION PROCEEDINGS，30(7) 3510-3512，1998年11月

Hashimoto, T; Suzuki, T; Shimizu, Y; Otobe, Y; Nakamura, T; Nakamura, Y; Tanaka, M; Ito, K; Ueda, N; Hayashi, S; Manabe, T; Futakuchi, M; Shirai, T

単著

Strong promoting activity of phenylethyl isothiocyanate and benzyl isothiocyanate on urinary bladder carcinogenesis in F344 male rats，INTERNATIONAL JOURNAL OF CANCER，77(5) 773-777，1998年08月

Hirose, M; Yamaguchi, T; Kimoto, N; Ogawa, K; Futakuchi, M; Sano, M; Shirai, T

単著

Stage and organ dependent effects of 1-<i>O</i>-hexyl-2,3,5-trimethylhydroquinone, ascorbic acid derivatives, n-heptadecane-8,10-dione and phenylethyl isothiocyanate in a rat multiorgan carcinogenesis model，INTERNATIONAL JOURNAL OF CANCER，76(6) 851-856，1998年06月

Ogawa, K; Futakuchi, M; Hirose, M; Boonyaphiphat, P; Mizoguchi, Y; Miki, T; Shirai, T

単著

Inhibition of DMBA-initiated rat mammary tumour development by 1-0-hexyl-2,3,5-trimethylhydroquinone, phenylethyl isothiocyanate, and novel synthetic ascorbic acid derivatives，EUROPEAN JOURNAL OF CANCER PREVENTION，7(2) 153-159，1998年04月

Futakuchi, M; Hirose, M; Miki, T; Tanaka, H; Ozaki, M; Shirai, T

単著

Studies of initiation and promotion of carcinogenesis by <i>N</i>-nitroso compounds，CANCER LETTERS，123(2) 185-191，1998年01月

Hasegawa, R; Futakuchi, M; Mizoguchi, Y; Yamaguchi, T; Shirai, T; Ito, N; Lijinsky, W

単著

Prevention by antioxidants of heterocyclic amine-induced carcinogenesis in a rat medium-term liver bioassay: results of extended and combination treatment experiments，EUROPEAN JOURNAL OF CANCER PREVENTION，7(1) 61-67，1998年

Hirose, M; Futakuchi, M; Tanaka, H; Orita, SI; Ito, T; Miki, T; Shirai, T

単著

Clinicopathological analysis on cancers of autopsy cases in a geriatric hospital，PATHOLOGY INTERNATIONAL，47(5) 293-300，1997年05月

Imaida, K; Hasegawa, R; Kato, T; Futakuchi, M; Takahashi, S; Ogawa, K; Asamoto, M; Yamamoto, T; Suzuki, K; Inagaki, T; Shinagawa, N; Shirai, T

単著

Effects of synthetic and naturally occurring compounds on heterocyclic (HCA) amine-induced hepatocarcinogenesis in the rat.，ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY，213 173-AGFD，1997年04月

Hirose, M; Futakuchi, M; Tanaka, H; Ito, T; Tiwawech, D; Shirai, T

単著

The prostate: A target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods，CANCER RESEARCH，57(2) 195-198，1997年01月

Shirai, T; Sano, M; Tamano, S; Takahashi, S; Hirose, M; Futakuchi, M; Hasegawa, R; Imaida, K; Matsumoto, K; Wakabayashi, K; Sugimura, T; Ito, N

単著

Highly metastatic hepatocellular carcinomas induced in male F344 rats treated with N-nitrosomorpholine in combination with other hepatocarcinogens show a high incidence of p53 gene mutations along with altered mRNA expression of tumor-related genes，CANCER LETTERS，112(1) 33-45，1997年01月

Masui, T; Nakanishi, H; Inada, K; Imai, T; Mizoguchi, Y; Yada, H; Futakuchi, M; Shirai, T; Tatematsu, M

単著

Modification of the carcinogenic potency of quinoline, a hepatocarcinogen, by fluorine atom substitution: Evaluation of carcinogenicity by a medium-term assay，BIOLOGICAL & PHARMACEUTICAL BULLETIN，20(1) 40-43，1997年01月

Saeki, K; Kadoi, M; Kawazoe, Y; Futakuchi, M; Tiwawech, D; Shirai, T

単著

Effects of low dose mixtures of four N-nitroso compounds on hepatic foci development in the rat，CANCER LETTERS，106(2) 263-269，1996年09月

Futakuchi, M; Lijinsky, W; Hasegawa, R; Hirose, M; Ito, N; Shirai, T

単著

Low susceptibility of the spontaneously hypertensive rat (SHR) to quinoline-induction of hepatic hemangioendothelial sarcomas，CANCER LETTERS，104(1) 37-41，1996年06月

Futakuchi, M; Hasegawa, R; Yamamoto, A; Cui, L; Ogiso, T; Ito, N; Shirai, T

単著

A study on the retrogradation of waxy corn starch，NIPPON KAGAKU KAISHI，(5) 477-482，1996年05月

Yamazaki, I; Futakuchi, M; Ono, S; Yoshimura, T; Morita, H; Tsukurimichi, E; Takai, J; Shimasaki, C

単著

VOID FRACTION DISTRIBUTION IN A BOILING WATER-REACTOR FUEL ASSEMBLY AND THE EVALUATION OF SUBCHANNEL ANALYSIS CODES，NUCLEAR TECHNOLOGY，112(3) 388-400，1995年12月

INOUE, A; FUTAKUCHI, M; YAGI, M; MITSUTAKE, T; MOROOKA, SI

単著

INCREASED RISK OF MAMMARY-CARCINOMA DEVELOPMENT FOLLOWING TRANSPLACENTAL AND TRANS-BREAST MILK EXPOSURE TO A FOOD-DERIVED CARCINOGEN, 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE (PHIP), IN SPRAGUE-DAWLEY RATS，CANCER RESEARCH，55(19) 4333-4338，1995年10月

HASEGAWA, R; KIMURA, J; YAONO, M; TAKAHASHI, S; KATO, T; FUTAKUCHI, M; FUKUTAKE, M; FUKUTOME, K; WAKABAYASHI, K; SUGIMURA, T; ITO, N; SHIRAI, T

単著

HEPATOCYTE GROWTH-FACTOR ENHANCEMENT OF PRENEOPLASTIC HEPATIC FOCI DEVELOPMENT IN RATS TREATED WITH DIETHYLNITROSAMINE AND N-ETHYL-N-HYDROXYETHYLNITROSAMINE，JAPANESE JOURNAL OF CANCER RESEARCH，86(8) 718-723，1995年08月

YAONO, M; HASEGAWA, R; MIZOGUCHI, Y; FUTAKUCHI, M; NAKAMURA, T; ITO, N; SHIRAI, T

単著

SITE-SPECIFIC EFFECTS OF TESTOSTERONE PROPIONATE ON THE PROSTATE OF RAT PRETREATED WITH 3,2'-DIMETHYL-4-AMINOBIPHENYL - DOSE-DEPENDENT INDUCTION OF INVASIVE CARCINOMAS，JAPANESE JOURNAL OF CANCER RESEARCH，86(7) 645-648，1995年07月

SHIRAI, T; TAMANO, S; SANO, M; IMAIDA, K; HAGIWARA, A; FUTAKUCHI, M; TAKAHASHI, S; HIROSE, M

単著

KI-RAS MUTATIONS WITH FREQUENT NORMAL ALLELE LOSS VERSUS ABSENCE OF P53 MUTATIONS IN RAT PROSTATE AND SEMINAL-VESICLE CARCINOMAS INDUCED WITH 3,2'-DIMETHYL-4-AMINOBIPHENYL，MOLECULAR CARCINOGENESIS，13(1) 21-26，1995年05月

MASUI, T; SHIRAI, T; IMAIDA, K; HIROSE, M; FUTAKUCHI, M; TATEMATSU, M; ITO, N

単著

MISORIENTATION DEPENDENCE OF NANOMETER GRAIN-BOUNDARY SLIDING OF [011]-TWIST BOUNDARIES IN COPPER，SCRIPTA METALLURGICA ET MATERIALIA，32(8) 1277-1282，1995年04月

MONZEN, R; FUTAKUCHI, M; SUZUKI, T

単著

VOID FRACTION CORRELATION FOR ROD BUNDLE VOID FRACTION CORRELATION-BASED ON VOID DATA OF BWR FUEL ASSEMBLY MEASURED BY X-RAY CT SCANNER，JOURNAL OF THE ATOMIC ENERGY SOCIETY OF JAPAN，37(2) 133-143，1995年02月

ISHIZUKA, T; INOUE, A; KUROSU, T; AOKI, T; FUTAKUCHI, M; YAGI, M; MOROOKA, S; HOSHIDE, A; YOSHIMURA, K

単著

PHENOTYPIC ALTERATION OF HEPATOCELLULAR FOCI IN RATS TREATED WITH CLOFIBRATE AND PHENOBARBITAL，CANCER LETTERS，83(1-2) 89-95，1994年08月

HASEGAWA, R; YOSHIDA, T; MIZOGUCHI, Y; FUTAKUCHI, M; KIM, DJ; CUI, L; ITO, N

単著

INHIBITION OF MAMMARY-GLAND CARCINOGENESIS BY GREEN TEA CATECHINS AND OTHER NATURALLY-OCCURRING ANTIOXIDANTS IN FEMALE SPRAGUE-DAWLEY RATS PRETREATED WITH 7,12-DIMETHYLBENZ[A]ANTHRACENE，CANCER LETTERS，83(1-2) 149-156，1994年08月

HIROSE, M; HOSHIYA, T; AKAGI, K; FUTAKUCHI, M; ITO, N

単著

13-WEEK ORAL TOXICITY STUDY OF MAGNESIUM-CHLORIDE IN B6C3F(1) MICE，TOXICOLOGY LETTERS，73(1) 25-32，1994年07月

TANAKA, H; HAGIWARA, A; KURATA, Y; OGISO, T; FUTAKUCHI, M; ITO, N

単著

SYNERGISTIC ENHANCEMENT OF HEPATIC FOCI DEVELOPMENT BY COMBINED TREATMENT OF RATS WITH 10 HETEROCYCLIC AMINES AT LOW-DOSES，CARCINOGENESIS，15(5) 1037-1041，1994年05月

HASEGAWA, R; MIYATA, E; FUTAKUCHI, M; HAGIWARA, A; NAGAO, M; SUGIMURA, T; ITO, N

単著

COMPARISON OF REVERSIBILITY OF RAT FORESTOMACH LESIONS INDUCED BY GENOTOXIC AND NONGENOTOXIC CARCINOGENS，JAPANESE JOURNAL OF CANCER RESEARCH，84(11) 1120-1129，1993年11月

KAGAWA, M; HAKOI, K; YAMAMOTO, A; FUTAKUCHI, M; HIROSE, M

単著

EFFECT OF AN ELEMENT ADDITION ON RELAXATION OF ELASTIC DISTORTION BASED ON PARTICLE-BLOCKED GRAIN-BOUNDARY SLIDING，SCRIPTA METALLURGICA ET MATERIALIA，29(4) 563-566，1993年08月

MONZEN, R; FUTAKUCHI, M; MIURA, H

単著

MEASUREMENT OF GRAIN-BOUNDARY SLIDING OF [011] TWIST BOUNDARIES IN COPPER BY ELECTRON-MICROSCOPY，ACTA METALLURGICA ET MATERIALIA，41(6) 1643-1646，1993年06月

MONZEN, R; FUTAKUCHI, M; KITAGAWA, K; MORI, T

単著

EFFECTS OF SODIUM-NITRITE AND CATECHOL, 3-METHOXYCATECHOL, OR BUTYLATED HYDROXYANISOLE IN COMBINATION IN A RAT MULTIORGAN CARCINOGENESIS MODEL，CANCER RESEARCH，53(1) 32-37，1993年01月

HIROSE, M; TANAKA, H; TAKAHASHI, S; FUTAKUCHI, M; FUKUSHIMA, S; ITO, N

単著

MODIFICATION OF HEPATOCARCINOGENESIS AND RENAL CARCINOGENESIS BY CATECHOL AND ITS ISOMERS IN RATS PRETREATED WITH N-ETHYL-N-HYDROXYETHYLNITROSAMINE，TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS，13(3) 127-137，1993年

OKAZAKI, S; HOSHIYA, T; TAKAHASHI, S; FUTAKUCHI, M; SAITO, K; HIROSE, M

単著

HIGH-RESOLUTION MEASUREMENTS OF ANALOG STATES IN MN-51，JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN，52(3) 802-810，1983年

ARAI, E; FUTAKUCHI, M; KOMAKI, J; OGAWA, M; OGURI, Y

単著

HIGH-RESOLUTION MEASUREMENTS OF ANALOG STATES IN CO-57，NUCLEAR PHYSICS A，378(2) 259-272，1982年

ARAI, E; FUTAKUCHI, M; KAMADA, H; KOMAKI, J; MATSUZAKI, T; OGAWA, M; OGURI, Y

単著

梁下野GBMの病理像および臨床像，日本脳腫瘍病理学会，Brain Tumor Pathology. Supplement，41(Suppl.) 133，2024年05月

水戸部祐太, 中村和貴, 石毛良美, 鈴木一司, 二口充, 金村米博, 園田順彦

後期高齢者膠芽腫における長期生存例についての検討，日本脳腫瘍病理学会，Brain Tumor Pathology. Supplement，41(Suppl.) 134，2024年05月

中村和貴, 水戸部祐太, 鈴木一司, 二口充, 金村米博, 園田順彦

tumor budding領域におけるマクロファージによる大腸癌細胞の表現型の変化，(一社)日本外科学会，日本外科学会定期学術集会(Web)，124th SF-5，2024年04月

川村一郎, 大江倫太郎, 河野通久, 岡崎慎史, 武井沙樹, 岸美菜子, 武者宏昭, 二口充, 元井冬彦

レジデントメモリーT細胞は炎症性白斑の表現型に寄与する(Resident memory T cell contributes to the phenotype of inflammatory vitiligo)，エルゼビア・ジャパン(株)，Journal of Dermatological Science，113(2) 74-76，2024年02月

Okamura Ken, Kabasawa Takanobu, Saito Toru, Arai Yosuke, Futakuchi Mitsuru, Suzuki Tamio

骨微小環境モデルを用いた腎癌の骨破壊メカニズムの解明(The mechanism of bone destruction in renal cancer using a bone microenvironment model)，日本病理学会会誌，113(1) 292，2024年02月

北岡 匠, 高原 大一郎, 大江 倫太郎, 樺澤 崇允, 二口 充

肺腺癌リンパ節転移巣ではマクロファージ由来のIL-6が癌細胞の増殖を促進する(IL-6 derived from Mφ may promote proliferation of lung adenocarcinoma cells in lymph node metastasis)，日本病理学会会誌，113(1) 313，2024年02月

樺澤 崇允, 大江 倫太郎, 鈴木 一司, 内山 尚哉, 北岡 匠, 二口 充

大腸癌浸潤先進部のMyxoidな線維性間質における腫瘍間質相互作用，(一社)日本病理学会，日本病理学会会誌，113(1) 473，2024年02月

菅原 健登, 大江 倫太郎, 樺澤 崇允, 北岡 匠, 二口 充

大腸がん肝転移巣を拡大させるマクロファージの同定と腫瘍細胞増殖シグナル解析(Identification of macrophages that expand liver metastases of colorectal cancer)，日本病理学会会誌，113(1) 311，2024年02月

大江 倫太郎, 内山 尚哉, 北岡 匠, 鈴木 一司, 樺澤 崇允, 二口 充

口腔扁平上皮癌の骨浸潤に関与する腫瘍間質相互作用(Tumor stromal interaction involved in bone invasion of oral squamous cell carcinoma)，日本病理学会会誌，113(1) 285，2024年02月

内山 尚哉, 笹原 庸由, 北岡 匠, 樺澤 崇允, 大江 倫太郎, 二口 充

Luminal乳がん骨転移におけるc-jun機能解析と治療戦略，日本がん転移学会学術集会・総会プログラム抄録集，33rd ，2024年

中山淳, 中山淳, 韓宇軒, 二口充, 仙波憲太郎

幽門側胃切除後局所進行切除不能膵癌に対し重粒子線併用化学療法後根治切除を得た1例，(株)癌と化学療法社，癌と化学療法，50(13) 1959-1961，2023年12月

渡邊 大史, 菅原 秀一郎, 高橋 良輔, 安次富 裕哉, 川城 壮平, 佐藤 啓, 根本 健二, 河野 通久, 二口 充, 元井 冬彦

トリプルネガティブ乳癌におけるCD8陽性T細胞によるPD-L1陽性MΦの誘導の組織学的空間解析(Histological spatial analysis on the induction of PD-L1+macrophages by CD8+ T cells of triple-negative breast cancer)，日本癌学会総会記事，82回 1589，2023年09月

北岡 匠, 鈴木 一司, 樺澤 崇允, 大江 倫太郎, 二口 充

腫瘍関連マクロファージの浸潤は肺腺癌のリンパ節における増殖に関与するが原発巣での増殖には関与しない(Involvement of TAMs on tumor growth in the lymph node microenvironment but not in primary site)，日本癌学会総会記事，82回 846，2023年09月

樺澤 崇允, 大江 倫太郎, 鈴木 一司, 北岡 匠, 二口 充

肺腺癌リンパ節転移巣における癌関連線維芽細胞の役割，(一社)日本病理学会，日本病理学会会誌，112(1) 329，2023年03月

樺澤 崇允, 鈴木 一司, 笹原 庸由, 福田 瑞貴, 内山 尚哉, 北岡 匠, 大江 倫太郎, 二口 充

脊髄神経膠腫の臨床像についての検討，日本脳腫瘍学会学術集会プログラム・抄録集，41st ，2023年

中村和貴, 松田憲一朗, 大江倫太郎, 二口充, 金村米博, 園田順彦

学術変革領域研究(学術研究支援基盤形成)，2023年04月 ～ 2024年03月，先端モデル動物支援プラットフォーム

基盤研究(C)，2022年04月 ～ 2025年03月，骨微小環境で腎がん細胞が増殖能を獲得するメカニズムの解析

基盤研究(C)，2022年04月 ～ 2025年03月，肺腺癌細胞が骨微小環境に適応する因子とこれを制御するmicroRNAの同定

肺腺癌細胞が骨微小環境に適応する因子とこれを制御するmicroRNAの同定，2022年04月 ～ 2025年03月，肺腺癌細胞が骨微小環境に適応する因子とこれを制御するmicroRNAの同定

肺癌は進行例に骨転移を認める例も多く、がん関連死亡の最も重要な病態のひとつである。肺癌の最も主要な組織型である腺がんのうち、充実性腺がんでは低分化型に分類され、高率に溶骨性の骨転移巣を形成することが知られている。我々は、これまでに溶骨性変化を示す乳がんの骨転移巣において、RANKL-RANKシグナルを介して誘導された破骨細胞により骨が破壊されることを明らかにした(Futakuchi M, Cancer Sci, 2009)。さらに造骨性変化を示す前立腺がんの骨転移巣においても、RANKL-RANKシグナルで破骨細胞が活性化される分子メカニズム
を明らかにした(Lynch C and Futakuchi M, Cancer cell, 2005)。 これらの結果からRANKL-RANKシグナルは、がんの種類に関わらず破骨細胞の活性化に重要な役割を示すことが示唆された。原発巣において肺腺癌細胞がRANKLを既に発現しているなら、骨転移巣での肺腺癌細胞の増殖を予測できるが、臨床的に予測するのは困難である。従って我々は、充実性腺癌の成分を含む肺腺癌症例において骨転移巣が形成されるには、骨微小環境に到達した肺腺癌細胞がRANKLを発現する形質を獲得すること、および骨微小環境に適応して増殖した結果、骨転移巣が形成されると考え、骨転移巣で増殖する肺腺癌細胞はRANKLを発現する形質を獲得し骨微小環境に適応し増殖していること、その形質獲得にはエピジェネティックな変化が関与すると仮説を立てた。本研究では、1) 骨微小環境におけるmicroRNAによるRANKLの発現制御、2) 骨微小環境において肺腺癌細胞が獲得したRANKL以外の因子の同定および、3) 同定された因子およびmicroRNAの骨転移形成における機能解析を動物実験で検証する。

日本学術振興会

骨微小環境で腎がん細胞が増殖能を獲得するメカニズムの解析，2022年04月 ～ 2025年03月，骨微小環境で腎がん細胞が増殖能を獲得するメカニズムの解析

腎がんは溶骨型骨転移を起こし、骨関連事象が発生すると重篤なADLの低下を招く。多発骨転移や手術による骨転移巣切除が不能な場合は予後不良となる。腎がんの骨転移巣をターゲットとした分子標的薬の開発が望まれる。我々は予備実験で、同一患者で発生した原発巣と骨転移巣の腫瘍組織をDNAシークエンスを用いて比較し、骨転移巣のみに高発現するCTNNB1 の変異を同定した。本研究は腎がん細胞が骨微小環境での増殖能を獲得する分子メカニズムについて解明を目指すものである。 骨微小環境で発現が上昇している遺伝子を検索・確認するために動物実験を行った。ヒト腎がん細胞株を6匹のヌードマウスの皮下と頭蓋骨直上に移植して皮下微小環境で腫瘍細胞が増殖する領域と骨微小環境で腫瘍細胞が増殖する領域を作成した。腫瘍は6匹中5匹で皮下に生着し、6匹全てで頭部に生着した。皮下微小環境と比較して骨微小環境では腫瘍サイズが大きい傾向にあった。ヘマトキシリンエオジン染色では頭部の腫瘍では頭蓋骨への骨浸潤、骨破壊が確認された。骨浸潤がみられる領域では、cathepsin-K陽性の破骨細胞が確認された。それぞれの領域で新鮮凍結検体からRNAを抽出し、RNAシークエンスで骨微小環境のモデルで高発現する遺伝子の検索を行った。皮下と骨の腫瘍で発現に差がある候補遺伝子を絞り込んだ。
絞り込んだ遺伝子発現について、PCR法で発現の確認を行い、動物実験によって経時的な発現量の変化を追加調査していく。

日本学術振興会

乳がん骨転移の潜在期において骨微小環境でがん細胞が生存するメカニズムの解析，2020年04月 ～ 2023年03月，乳がん骨転移の潜在期において骨微小環境でがん細胞が生存するメカニズムの解析

本研究の目的は、潜在期の骨微小環境において、乳がん細胞が生存できるメカニズムを明らかにすることである。我々は、骨および皮下微小環境におけるがん細胞の増殖を解析できる動物モデルを独自に開発した。本研究では、骨微小環境に潜むがん細胞がどのように顕在化するか、そのメカニズムを明らかにすることが可能となり、また顕在化する前に骨微小環境に潜むがん細胞（微小骨転移）を標的とした治療法が確立でき、原発巣治療後の骨転移巣の形成を防ぐ治療法を創造することができる。
潜在期の骨微小環境においてがん細胞の生存に関与する因子は、骨微小環境由来の潜在期のサンプルでのみ発現すると考えられる。前年度の動物実験で得られたサンプルを用いて東レmicroarrayにより遺伝子発現を検索した。その結果、微小環境において、潜在期のがん細胞の生存に関与する遺伝子群として同定できた。
次に我々は微小環境におけるがん幹細胞を単離する方法を用いて、がん細胞に発現を示す遺伝子を検索することで、候補遺伝子を絞り込んだ。動物実験でそれぞれの微小環境から組織片を作成する。これらの組織片をコラゲナーゼ処理してsingle cellを作成し、培養プレート上に30分培養した後非接着細胞を回収した。3D culture (96 well) で72時間培養しspheroidを形成したがん細胞をがん幹細胞として回収した（潜／骨／3D, 顕／骨／3D）。同様に通常の方法で96well plateで72時間培養したがん細胞を対照として回収する（潜／骨／2D, 顕／骨／2D）。それぞれの細胞からRNAを抽出し、東レmicroarrayにより遺伝子発現を検索した。

日本学術振興会

2022年度，病理学総論

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2022年度，臨床実習

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2022年度，看護病理学

2021年度，看護病理学