Title
Associate Professor
NOMURA Toshihisa
Research Areas
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Life Science / Molecular biology
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Life Science / Applied molecular and cellular biology
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Life Science / Cell biology
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Life Science / Plant molecular biology and physiology
External Career
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, Researcher, 2018.04 - 2023.12
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Yamagata University, Associate Professor, 2023.12 -
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RIKEN, 2023.12 -
Academic Society Affiliations
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THE BRYOLOGICAL SOCIETY OF JAPAN
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THE JAPANESE SOCIETY OF PLANT PHYSIOLOGISTS
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THE BOTANICAL SOCIETY OF JAPAN
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The Japanese Society for Genome Editing
Papers
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High-efficiency genome editing by Cas12a ribonucleoprotein complex in Euglena gracilis , Microbial Biotechnology, 17(2) , 2024.02
Toshihisa Nomura, June-Silk Kim, Marumi Ishikawa, Kengo Suzuki, Keiichi Mochida
Multiple Authorship (Only Japanese)
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Zeaxanthin is required for eyespot formation and phototaxis in Euglena gracilis., Plant physiology, 2023.01
Shun Tamaki, Kazunari Ozasa, Toshihisa Nomura, Marumi Ishikawa, Koji Yamada, Kengo Suzuki, Keiichi Mochida
Multiple Authorship (Only Japanese)
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CRISPR/Cas9-mediated generation of non-motile mutants to improve the harvesting efficiency of mass-cultivated Euglena gracilis., Plant biotechnology journal, 20(11) 2042-2044, 2022.08
Marumi Ishikawa, Toshihisa Nomura, Shun Tamaki, Kazunari Ozasa, Tomoko Suzuki, Kiminori Toyooka, Kikue Hirota, Koji Yamada, Kengo Suzuki, Keiichi Mochida
Multiple Authorship (Only Japanese)
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Expression of peat moss VASCULAR RELATED NAC-DOMAIN homologs in Nicotiana benthamiana leaf cells induces ectopic secondary wall formation., Plant molecular biology, 106(3) 309-317, 2021.06
Shiori Terada, Minoru Kubo, Nobuhiro Akiyoshi, Ryosuke Sano, Toshihisa Nomura, Shinichiro Sawa, Misato Ohtani, Taku Demura
Multiple Authorship (Only Japanese)
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Parental legacy and regulatory novelty in Brachypodium diurnal transcriptomes accompanying their polyploidy, NAR Genomics and Bioinformatics, 2(3) , 2020.09
Komaki Inoue, Kotaro Takahagi, Yusuke Kouzai, Satoru Koda, Minami Shimizu, Yukiko Uehara-Yamaguchi, Risa Nakayama, Toshie Kita, Yoshihiko Onda, Toshihisa Nomura, Hidetoshi Matsui, Kiyotaka Nagaki, Ryu...
Multiple Authorship (Only Japanese)
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Genetic Engineering Strategies for Euglena gracilis and Its Industrial Contribution to Sustainable Development Goals: A Review, Frontiers in Bioengineering and Biotechnology, 10.3389/fbioe.2020.00790(8) 790, 2020.05
Ryo Harada, Toshihisa Nomura, Koji Yamada, Keiichi Mochida, Kengo Suzuki
Single Author
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Highly Efficient CRISPR-Associated Protein 9 Ribonucleoprotein-Based Genome Editing in Euglena gracilis, STAR Protocols, 2020.03
Toshihisa Nomura, Mizuki Yoshikawa,Kengo Suzuki,Keiichi Mochida
Single Author
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Highly efficient transgene-free targeted mutagenesis and single-stranded oligodeoxynucleotide-mediated precise knock-in in the industrial microalga Euglena gracilis using Cas9 ribonucleoproteins., Plant biotechnology journal, 17(11) 2032-2034, 2019.11
Toshihisa Nomura, Komaki Inoue, Yukiko Uehara-Yamaguchi, Koji Yamada, Osamu Iwata, Kengo Suzuki, Keiichi Mochida
Single Author
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Targeted Mutagenesis using RNA-guided endonucleases in mosses, Bio-protocol , 7(12)(e2359) , 2017.06
Nomura T, Sakakibara H
Multiple Authorship (Only Japanese)
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The accumulation of iron at the basal portion of the shoot of an acidophilic liverwort, Jungermannia vulcanicola (Schiffn.) Steph , Hikobia , 17(1) , 2015.10
touga M, Kato Y, Ares A, Nomura T, Sakakibara H
Multiple Authorship (Only Japanese)
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Copper mediates auxin signalling to control cell differentiation in the copper moss Scopelophila cataractae , JOURNAL OF EXPERIMENTAL BOTANY , 2015.03
Toshihisa Nomura, Misao Itouga, Mikiko Kojima, Yukari Kato, Hitoshi Sakakibara, Seiichiro Hasezawa
Multiple Authorship (Only Japanese)
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Simplification of vacuole structure during plant cell death triggered by culture filtrates of Erwinia carotovora , JOURNAL OF INTEGRATIVE PLANT BIOLOGY , 2015.01
Yumi Hirakawa, Toshihisa Nomura, Seiichiro Hasezawa, Takumi Higaki
Single Author
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Regulation of gemma formation in the copper moss Scopelophila cataractae by environmental copper concentrations, JOURNAL OF PLANT RESEARCH , 2011.09
Toshihisa Nomura, Seiichiro Hasezawa
Multiple Authorship (Only Japanese)
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Fat accumulation in Caenorhabditis elegans is mediated by SREBP homolog SBP-1 , GENES AND NUTRITION , 2010.03
Toshihisa Nomura, Makoto Horikawa, Satoru Shimamura, Teppei Hashimoto, Kazuichi Sakamoto
Multiple Authorship (Only Japanese)
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Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16 , BIOGERONTOLOGY , 2010.02
Teppei Hashimoto, Makoto Horikawa, Toshihisa Nomura, Kazuichi Sakamoto
Multiple Authorship (Only Japanese)
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Elongation and desaturation of fatty acids are critical in growth, lipid metabolism and ontogeny of Caenorhabditis elegans , JOURNAL OF BIOCHEMISTRY , 2008
Makoto Horikawa, Toshihisa Nomura, Teppei Hashimoto, Kazuichi Sakamoto
Multiple Authorship (Only Japanese)
Books
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藻類培養技術 ～屋内外大量生産・各種処理評価／トラブル対応・商業化に向けた取り組み、第３章 大量培養生産・効率化・安定化・低コスト化の実務、第９節 微細藻類におけるゲノム編集技術・評価手法, 情報機構, 2021.10
野村俊尚
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ゲノム編集技術を応用した 製品開発とその実用化 ～研究開発動向・課題解決策・技術予測と市場展望～第４章 ゲノム編集によるスマートセルインダストリーの技術開発とその課題解決６節 ミドリムシの高効率ゲノム編集技術とバイオ燃料生産への応用展開, 技術情報協会, 2021.02
野村俊尚, 原田稜, 山田康嗣, 鈴木健吾, 持田恵一
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最新のゲノム編集技術と用途展開 第 3 編微生物 への応用と用途展開 14章 CRISPR RNP を用いたユーグレナでのゲノム編集, シーエムシー出版, 2021.02
野村俊尚
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脱石油に向けたCO2資源化技術―化学・生物プロセスを中心に 第3編生物プロセス 第3章ユーグレナの高効率ゲノム編集技術, シーエムシー出版, 2020.07
野村俊尚, 持田恵一
Other external funds procured
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Elucidation of the molecular mechanisms of paramylon granule formation in Euglena，2021.04 - 2024.03，Elucidation of the molecular mechanisms of paramylon granule formation in Euglena
Japan Society for the Promotion of Science
Academic Activity
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日本蘚苔類学会, 2014.01 - 2021.03
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日本蘚苔類学会, 2024.04 -
Media Coverage
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ゲノム編集で遊泳不全ミドリムシの作出に成功 －産業利用における回収効率の向上に期待－，2022.09
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理研と(株)ユーグレナ、ミドリムシ産業利用種のゲノム編集に成功，2019.06
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ミドリムシでの高効率ゲノム編集に成功 －バイオ燃料生産などに向けた有用ミドリムシ育種へ期待－，2019.06
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理研とユーグレナ、ミドリムシでの高効率ゲノム編集に成功，2019.06
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A highly efficient genome-editing method for Euglena，2019.06