Updated on 2023/11/30

写真a

 
ASAO Hironobu
 
Title
Professor
Date of Birth
1960
Contact information
メールアドレス
Laboratory Phone number
+81-23-628-5265
 
Laboratory Fax number
+81-23-628-5267
 

Research Areas

  • Life Science / Immunology

Graduating School

  • Tohoku University, Faculty of Medicine

    1985.03, Graduated

Graduate School

  • Tohoku University, Graduate School, Division of Medical Sciences

    Doctor's Course, 1991.03, Completed

 

Research Career

  • Analysis of interleukin-2 signal transduction, 1987.04 - 1996.09

  • Functional analysis of STAT1, 1996.10 - 1998.09

    STAT cytokine interferon

  • Analysis of interleukin-21 signal transduction, 2001.01 -

Papers

  • Interleukin-21 reduces Listeria monocytogenes secondary infection via CD8+ effector memory T cells(和訳中), 山形医学, 39(1) 45-51, 2021.02

    Gazi Md.Yeashin, Takeda Yuji, Nara Hidetoshi, Araki Akemi, Nemoto Nobuhito, Asao Hironobu

    Single Author

  • Interleukin-12p40 variant form reduces Interleukin-12p80 secretion., Cytokine, 2019

    Oshikiri Y, Nara H, Takeda Y, Araki A, Nemoto N, Gazi Md Yeashin, Saito S, Saitoh S, Nakajima O, Asao H.

    Multiple Authorship (Only Japanese)

  • Hyper-IgE syndrome, Journal of Japan Society of Immunology & Allergology in Otolaryngology, 36(4) 267-269, 2018

    Furukawa Takatoshi, Takada Yuji, Asao Hironobu, Ohta Nobuo, Kakehata Seiji

    Single Author

  • Effect of Temperature on Granulocyte and Monocyte Adsorption to Cellulose Acetate Beads., Ther Apher Dial, 2017

    Nishise S,Takeda Y,Abe Y, Sasaki Y, Nara H, Asao H, Ueno Y.

    Multiple Authorship (Including Foreigners)

  • Relationship between Immunological Abnormalities in Rat Models of Diabetes Mellitus and the Amplification Circuits for Diabetes., J Diabetes Res, 2017

    Takeda Y, Shimomura T, Asao H, Wakabayashi I.

    Multiple Authorship (Including Foreigners)

  • Analysis of signal transducers using flow cytometry is useful for detection of contractive and fluctuating signal., Yamagata Med J, 2017

    Takeda Y, Nara H, Asao H

    Multiple Authorship (Including Foreigners)

  • Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 (Ape1/Ref-1) Modulates Antigen Presenting Cell-Mediated T Helper Cell Type 1 Responses., J Biol Chem, 2016

    Akhter N, Takeda Y, Nara H. Araki A, Ishii N, Asao N, Asao H.

    Multiple Authorship (Including Foreigners)

  • The pattern of GPI-80 expression is a useful marker for unusual myeloid maturation in peripheral blood., Clin Exp Immunol., 2016

    Takeda Y, Kato T, Ito H, Kurota Y, Yamagishi A, Sakurai T, Araki A, Nara H, Tsuchiya N, Asao H.

    Multiple Authorship (Including Foreigners)

  • Circulating miR-223 in Oral Cancer: Its Potential as a Novel Diagnostic Biomarker and Therapeutic Target., PLoS One, 2016

    Tachibana H, Sho R, Takeda Y, Zhang X, Yoshida Y, Narimatsu H, Otani K, Ishikawa S, Fukao A, Asao H, Iino M.

    Multiple Authorship (Including Foreigners)

  • Selective induction of anti-inflammatory monocyte-platelet aggregates in a model of pulsatile blood flow at low shear rates., Platelets, 2016

    Takeda Y, Marumo M, Nara H, Feng Z-G, Asao H, Wakabayashi I.

    Multiple Authorship (Including Foreigners)

  • Identification of Novel ALK Rearrangement A2M–ALK in a Neonate with Fetal Lung Interstitial Tumor., Genes Chromosomes Cancer, 2014

    Onoda T, Kanno M, Sato H, Takahashi N, Izumino H, Ohta H, Emura T, Katoh H, Ohizumi H, Ohtake H, Asao H, Dehner LP, Hill AD, Hayasaka K, and Mitsui T

    Multiple Authorship (Including Foreigners)

  • Human peripheral neutrophils express functional IL-21 receptors., Inflammation, 2014

    Takeda Y, Nara H, Araki A and Asao H

    Multiple Authorship (Including Foreigners)

  • Role of Interleukin-21 isoform in dextran sulfate sodium (DSS)-induced colitis., Cytokine, 2013

    Araki A, Nara H, Rahman M, Onoda T, Li J, Juliana FM, Jin L, Murata K, Takeda Y and Asao H

    Multiple Authorship (Including Foreigners)

  • Apurinic/apyrimidinic endonuclease1/redox factor-1 (Ape1/Ref-1) is essential for IL-21-induced signal transduction through ERK1/2 pathway., Biochem. Biophys. Res. Commun., 420 628-634, 2012.04

    Juliana FM, Nara H, Onoda T, Rahman M, Araki A, Jin L, Fujii H, Tanaka N, Hoshino T and Asao H

    Multiple Authorship (Including Foreigners)

  • IL-21 isoform is a membrane-bound ligand and activates directly interacted cells., Cytokine, 2012

    Nara H, Rahman M, Araki A, Jin L, Takeda Y and Asao H

    Multiple Authorship (Including Foreigners)

  • Intrinsic Temperature Sensitivity of Influenza C Virus Hemagglutinin-Esterase-Fusion Protein., J. Virol., 2012

    Takashita E, Muraki Y, Sugawara K, Asao H, Nishimura H, Suzuki K, Tsuji T, Hongo S, Ohara Y, Kawaoka Y, Ozawa M, Matsuzaki Y

    Multiple Authorship (Only Japanese)

  • Impaired IL-7 signaling may explain a case of atypical JAK3-SCID., Cytokine, 49 221-228, 2010.02

    Li J, Nara H, Rahman M, Juliana FM, Araki A and Asao H

    Multiple Authorship (Including Foreigners)

  • Regulation of interleukin-21 receptor expression and its signal transduction by WSB-2., Biochem. Biophys. Res. Commun., 392 171-177, 2010.02

    Nara H, Onoda T, Rahman M, Araki A, Juliana FM, Tanaka N, Asao H

    Multiple Authorship (Including Foreigners)

  • Interactions between vitreous-derived cells and vascular endothelial cells in vitreoretinal diseases., Acta Ophthalmol., 2010

    Tojo N, Kashiwagi Y, Nishitsuka K, Yamamoto S, Asao H, Sugawara N, Yamashita T, Yamamoto T, Yamashita H

    Multiple Authorship (Only Japanese)

  • Transcriptional Activation of the Interleukin-21 Gene and Its Receptor Gene by Human T-cell Leukemia Virus Type 1 Tax in Human T-cells.(共著), J. Biol. Chem., 284 25501-25511, 2009.09

    Mizuguchi M, Asao H, Hara T, Higuchi M, Fijii M and Nakamura M

    Multiple Authorship (Including Foreigners)

  • Cloning and Characterization of an Isoform of Interleukin-21.(共著), FEBS Letters, 581 4001-4009, 2007.07

    56. Rahman M, Nara H, Onoda T, Araki A, Li J. Hoshino T. and Asao H

    Multiple Authorship (Including Foreigners)

  • Human CD4+ central and effector memory T cells produce IL-21; Effect on cytokine-driven proliferation of CD4+ T cell subsets.(共著), Int. Immunol., 19 1191-1199, 2007.07

    57. Onoda T, Rahman M, Nara H, Araki A, Makabe K, Tsumoto K, Kumagai I, Kudo T, Ishii N, Tanaka N, Sugamura K, Hayasaka K and Asao H

    Multiple Authorship (Including Foreigners)

  • Elevated oxidative stress in erythrocytes due to a SOD1 deficiency causes anaemia and triggers autoantibody production. , Biochemical Journal, 402 219-227, 2007.03

    Iuchi Y, Okada F, Onuma K, Onoda T, Asao H, Kobayashi M, Fujii J

    Multiple Authorship (Including Foreigners)

  • The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson's disease., J Neurosci., 2006

    Arawaka S, Wada M, Goto S, Karube H, Sakamoto M, Ren CH, Koyama S, Nagasawa H, Kimura H, Kawanami T, Kurita K, Tajima K, Daimon M, Baba M, Kido T, Saino S, Goto K, Asao H, Kitanaka C, Takashita E, Hon...

    Multiple Authorship (Including Foreigners)

  • Hrs, a mammalian master molecule in vesicular transport and protein-sorting, suppresses the degradation of ESCRT proteins STAM1 and STAM2., J. Biol. Chem., 2005

    Kobayashi H, Tanaka N, Asao H, Miura S, Kyuuma M, Semura K, Ishii N, Sugamura K

    Multiple Authorship (Only Japanese)

  • Enhanced expression of IL-18 and its receptor in idiopathic pulmonary fibrosis. , Am J Respir Cell Mol Biol., 2004

    Kitasato Y, Hoshino T, Okamoto M, Kato S, Koda Y, Nagata N, Kinoshita M, Koga H, Yoon DY, Asao H, Ohmoto H, Koga T, Rikimaru T, Aizawa H

    Multiple Authorship (Including Foreigners)

  • SARA and Hgs attenuate susceptibility to TGF-β1-mediated T-cell suppression., FASEB J., 2003

    Kunzmann S, Wohlfahrt JG, Itoh S, Asao H, Komada M, Akdis CA, Blaser K, Schmidt-Weber CB

    Multiple Authorship (Including Foreigners)

  • Effects of deficiencies of STAMs and Hrs, mammalian class E Vps proteins, on receptor downregulation., Biochem. Biophys. Res. Commun., 2003

    Kanazawa C, Morita E, Yamada M, Ishii N, Miura S, Asao H, Yoshimori T, Sugamura K

    Multiple Authorship (Only Japanese)

  • Identification of AMSH-LP containing a Jab1/MPN domain metalloenzyme motif., Biochem. Biophys. Res. Commun., 2003

    Kikuchi K, Ishii N, Asao H, Sugamura K

    Multiple Authorship (Only Japanese)

  • Human parvovirus B19 non-structural protein (NS1) induces cell cycle arrest at G1 phase., J. Virol., 2003

    Morita E, Nakashima A, Asao H, Sato H, Sugamura K

    Multiple Authorship (Only Japanese)

  • Ligand-Independent Degradation of Epidermal Growth Factor Receptor Involves Receptor Ubiquitylation and Hgs, an Adaptor Whose Ubiquitin-Interacting Motif Targets Ubiquitylation by Nedd4., Traffic, 2002

    Katz M, Shtiegman K, Tal-Or P, Yakir L, Mosesson Y, Harari D, Machluf Y, Asao H, Jovin T, Sugamura K, Yarden Y

    Multiple Authorship (Including Foreigners)

  • Signal transducing adaptor molecule STAM1 and STAM2 are required for T-cell development and survival., Mol. Cell. Biol., 2002

    Yamada M, Ishii N, Asao H, Murata K, Kanazawa C, Sasaki H, Sugamura K

    Multiple Authorship (Only Japanese)

  • The common g-chain is an indispensable subunit of the IL-21 receptor complex., Journal of Immunology, 167 1-5, 2001.04

    Asao H, Okuyama C, Kumaki K, Ishii N, Tsuchiya S, Foster D, Sugamura K

    Multiple Authorship (Including Foreigners)

  • Suppression of Thymic Development by the Dominant-negative Form of Gads., Int. Immunol., 2001

    Kikuchi K, Kawasaki Y, Ishii N, Sasaki Y, Asao H, Takeshita T. Miyoshi I, Kasai N, Sugamura K

    Multiple Authorship (Only Japanese)

  • Loss of Neurons in the Hippocampus and Cerebral Cortex of AMSH-Deficient Mice., Mol. Cell. Biol., 2001

    Ishii N, Owada Y, Yamada M, Miura S, Murata K, Asao H, Kondo H, Sugamura K

    Multiple Authorship (Only Japanese)

  • Promoting bone morphogenetic protein signaling through nagative regulation of inhibitory smads., EMBO J., 2001

    Itoh F, Asao H, Sugamura K, Heldin CH, ten Dijke P, Itoh S

    Multiple Authorship (Including Foreigners)

  • Human parvovirus B19 induces cell cycle arrest at G2 phase with accumulation of mitotic cyclines., J. Virol., 2001

    Morita E, Tada K, Chisaka H, Asao H, Sato H, Yaegashi N, Sugamura K

    Multiple Authorship (Only Japanese)

  • Interferon-gamma has dual potentials in inhibiting or promoting cell proliferation., Journal of Biological Chemistry, 275 867-874, 2000.01

    Asao H, Fu X-Y

    Multiple Authorship (Including Foreigners)

  • STAM2, a new member of the STAM family, binding to the Janus kinases., FEBS Letters, 2000

    Endo K, Takeshita T, Kasai H, Sasaki Y, Tanaka N, Asao H, Kikuchi K, Yamada M, Chenb M, O'Shea JJ, Sugamura K

    Multiple Authorship (Including Foreigners)

  • Hgs/Hrs, A FYVE domain protein is involved in Smad Signaling through cooperation with SARA., Mol. Cell. Biol., 2000

    Miura S, Takeshita T, Asao H, Kimura Y, Murata K, Sasaki Y, Hanai J, Beppu H, Tsukazaki T, Wrana JL, Miyazono K, Sugamura K

    Multiple Authorship (Including Foreigners)

  • Possible involvement of a novel STAM-associated molecule “AMSH” in intracellular signal transduction mediated by cytokines., J. Biol. Chem., 1999

    Tanaka N, Kanako K, Asao H, Kasai H, Endo Y, Fujita T, Takeshita T, Sugamura K

    Multiple Authorship (Only Japanese)

  • Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth., Journal of Biological Chemistry, 272 32785-32791, 1997.12

    Asao, H., Sasaki, Y., Arita, T., Tanaka, N., Endo, K., Kasai, H., Takeshita, T., Endo, Y., Fujita, T., Sugamura, K

    Multiple Authorship (Including Foreigners)

  • STAM, Signal transducing adaptor molecule, is associated with Janus Kinases and involved in signaling for cell growth and c-myc induction. , Immunity, 1997

    Takeshita T, Arita T, Higuchi M, Asao H, Endo K, Kuroda H, Tanaka N, Murata K, Ishii N, Sugamura K

    Multiple Authorship (Only Japanese)

  • Induction of IL-1β-converting enzyme-independent apoptosis by IL-2 in human T cell lines., Int. Immunol., 1997

    Oda K, Asao H, Higuchi M, Tanaka N, Moffatt S, Nakamura M, Tabayashi K, Sugamura K

    Multiple Authorship (Only Japanese)

  • Regulation of IL-2 signaling., Leukemia, 1997

    Higuchi M, Asao H, Tanaka N, Oda K, Takeshita T, Sugamura K

    Multiple Authorship (Only Japanese)

  • Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM., Biochem. Biophys. Res. Commun., 1996

    Takeshita T, Arita T, Asao H, Tanaka N, Higuchi M, Kuroda H, Kaneko K, Munakata H, Endo Y, Fujita T, Sugamura K

    Multiple Authorship (Including Foreigners)

  • Dispensability of Jak1 tyrosine kinase for interleukin-2-induced cell growth signaling in a human T cell line., Eur. J. Immunol., 1996

    Higuchi M, Asao H, Tanaka N, Oda K, Takeshita T, Nakamura M, Van Snick J, Sugamura K

    Multiple Authorship (Including Foreigners)

  • Demonstration of a cross-talk between IL-2 and IL-5 in phosphorylation of IL-2 and IL-5 receptor β chains. , Int. Immunol., 1996

    Ohbo K, Asao H, Kouro T, Nakamura M, Takaki S, Kikuchi Y, Hirokawa K, Tominaga A, Takatsu K, Sugamura K

    Multiple Authorship (Only Japanese)

  • The interleukin 2 receptor γ chain: Its role in the multiple cytokine receptor complexes and T cell development in XSCID., Annu. Rev. Immunol., 1996

    Sugamura K, Asao H, Kondo M, Tanaka N, Ishii N, Ohbo K, Nakamura M, Takeshita T

    Multiple Authorship (Only Japanese)

  • The common γ-chain for multiple cytokine receptors., Advances in Immunology, 1995

    Sugamura K, Asao H, Kondo M, Tanaka N, Ishii N, Nakamura M and Takeshita T

    Multiple Authorship (Only Japanese)

  • Impairment of ligand binding and growth signaling of mutant IL-2 receptor γ-chains in patients with X-linked severe combined immunodeficiency., J. Immunol., 1994

    Ishii N, Asao H, Kimura Y, Takeshita T, Nakamura M, Tsuchiya S, Konno T, Maeda M, Uchiyama T, Sugamura K

    Multiple Authorship (Only Japanese)

  • Interleukin 2-induced activation of JAK3: possible involvement in signal transduction for c-myc induction and cell proliferation. , FEBS Letters, 1994

    Asao H, Tanaka N, Ishii N, Higuchi M, Takeshita T, Nakamura M, Shirasawa T and Sugamura K

    Multiple Authorship (Only Japanese)

  • Physical association of JAK1 and JAK2 tyrosine kinases with the interleukin 2 receptor β and γ chains., Proc. Natl. Acad. Sci. USA, 1994

    Tanaka N, Asao H, Ohbo K, Ishii N, Takeshita T, Nakamura M, Sasaki H, Sugamura K

    Multiple Authorship (Only Japanese)

  • Reconstitution of the functional IL-2 receptor complexes on fibroblastoid cells: Involvement of the cytoplasmic domain of the γ chain in two distinct signaling pathways., Proc. Natl. Acad. Sci. USA, 1993

    Asao H, Takeshita T, Ishii N, Kumaki S, Nakamura M, Sugamura K

    Multiple Authorship (Only Japanese)

  • A novel human tyrosine kinase gene inducible in T cells by interleukin 2., FEBS Letters, 1993

    Tanaka N, Asao H, Ohtani K, Nakamura M, Sugamura K

    Multiple Authorship (Only Japanese)

  • Cloning of the mouse interleukin 2 receptor γ chain: Demonstration of functional differences between the mouse and human receptors., Biochem. Biophys. Res. Commun., 1993

    Kumaki S, Kondo M, Takeshita T, Asao H, Nakamura M, Sugamura K

    Multiple Authorship (Only Japanese)

  • IL-2-dependent in vivo and in vitro tyrosine phosphorylation of IL-2 receptor g chain., FEBS Letters, 304 141-145, 1992.04

    Asao H, Kumaki S, Takeshita T, Nakamura M, Sugamura K

    Multiple Authorship (Including Foreigners)

  • An associated molecule, p64, with IL-2 receptor b chain: its possible involvement in formation of the functional IL-2 receptor complex, Journal of Immunololy, 148 2154-2158, 1992.04

    Takeshita T, Ohtani K, Asao H, Kumaki S, Nakamura M, Sugamura K

    Multiple Authorship (Including Foreigners)

  • An associated molecule, p64, with IL-2 receptor b chain: its possible involvement in formation of the functional IL-2 receptor complex, Journal of Immunololy, 148 2154-2158, 1992.04

    Takeshita T, Ohtani K, Asao H, Kumaki S, Nakamura M, Sugamura K

    Multiple Authorship (Only Japanese)

  • Cloning of the g chain of the human IL-2 receptor, Science, 257 379-382, 1992.04

    Takeshita T, Asao H, Ohtani K, Ishii N, Kumaki S, Tanaka N, Munakata H, Nakamura M, Sugamura K

    Multiple Authorship (Only Japanese)

  • IL-2-dependent in vivo and in vitro tyrosine phosphorylation of IL-2 receptor g chain., FEBS Letters, 304 141-145, 1992.04

    Asao H, Kumaki S, Takeshita T, Nakamura M, Sugamura K

    Multiple Authorship (Only Japanese)

  • Cell type-specific activation of a tyrosine kinase associated with IL-2 receptor β chain in response to IL-2., FEBS Letters, 1992

    Kumaki S, Asao H, Takeshita T, Kurahayashi Y, Nakamura M, Beckers T, Engels JW, Sugamura K

    Multiple Authorship (Including Foreigners)

  • Interleukin 2 (IL-2)-induced tyrosine phosphorylation of IL-2 receptor p75., Journal of Experimental Medicine, 171 637-644, 1990.04

    Asao H, Takeshita T, Nagata K, Nakamura M, Sugamura K

    Multiple Authorship (Including Foreigners)

  • The evidence for the IL-2 receptor b chain processing from p70 to p75, International Immunology, 2 470-472, 1990.04

    Asao H, Takeshita T, Nakamura M, Nagata K, Sugamura K

    Multiple Authorship (Only Japanese)

  • An associated molecule, p64, with high-affinity interleukin 2 receptor, International Immunology, 2 477-480, 1990.04

    Takeshita T, Asao H, Suzuki J, Sugamura K

    Multiple Authorship (Only Japanese)

  • Monoclonal antibody defining a molecule possibly identical to the p75 subunit of interleukin 2 receptor., Journal of Experimental Medicine, 169 1323-1332, 1989.04

    Takeshita T, Goto Y, Tada K, Nagata K, Asao H, Sugamura K

    Multiple Authorship (Including Foreigners)

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Books

  • Interleukin-2., Reference Module in Biomedical Sciences , 2014.04

    Hironobu Asao

Grant-in-Aid for Scientific Research

  • Grant-in-Aid for Scientific Research(C),2023.04 - 2026.03

  • Grant-in-Aid for Scientific Research(C),2023.04 - 2024.03

  • Grant-in-Aid for Scientific Research(C),2020.04 - 2023.03

  • Grant-in-Aid for Scientific Research(C),2019.04 - 2022.03

  • Grant-in-Aid for Scientific Research(C),2019.04 - 2020.03

  • Grant-in-Aid for Scientific Research(C),2018.04 - 2021.03

  • Grant-in-Aid for Scientific Research(C),2018.04 - 2020.03

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