

Research Areas
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Life Science / Medical biochemistry
Graduating School
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Shinshu University, Faculty of Science, Biology
1991.03, Graduated
Graduate School
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Shinshu University, Graduate School, Division of Natural Science, Biology
Master's Course, 1993.03, Completed
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Shinshu University, Graduate School, Division of Medicine, Biochemistry
Doctor's Course, 1997.03, Completed
External Career
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Shinshu University, Special researcher of the Japan Society for the Promotion of Science, 1996.04 - 1997.03
Papers
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A case of autoimmune factor XIII deficiency due to clearance-accelerating and inhibitory anti-FXIII autoantibodies, INTERNATIONAL JOURNAL OF HEMATOLOGY, 121(2) 257-264, 2025.02
Tsunemine, H; Souri, M; Kumode, W; Arima, N; Ichinose, A
Single Author
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Detection of factor XIII inhibitors in 33 patients with autoimmune factor XIII deficiency in Japan, INTERNATIONAL JOURNAL OF HEMATOLOGY, 120(4) 472-481, 2024.10
Souri, M; Osaki, T; Ichinose, A
Single Author
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Detection of factor XIII inhibitors in 33 patients with autoimmune factor XIII deficiency in Japan(タイトル和訳中), International Journal of Hematology, 120(4) 472-481, 2024.10
Souri Masayoshi, Osaki Tsukasa, Ichinose Akitada
Single Author
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Development and Epitope Mapping of Seven Mouse Anti-Human Coagulation Factor XIII-B Subunit Monoclonal Antibodies., Monoclonal antibodies in immunodiagnosis and immunotherapy, 43(5) 135-143, 2024.10
Osaki T, Magari Y, Souri M, Ichinose A
Single Author
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Retrospectively diagnosed autoimmune VWF deficiency in a patient with repeated hemorrhagic events after two common colds, INTERNATIONAL JOURNAL OF HEMATOLOGY, 120(3) 375-381, 2024.09
Ogawa, Y; Ichinose, A; Yanagisawa, K; Souri, M; Osaki, T; Kanaya, S; Handa, H
Single Author
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Retrospectively diagnosed autoimmune VWF deficiency in a patient with repeated hemorrhagic events after two common colds(タイトル和訳中), International Journal of Hematology, 120(3) 375-381, 2024.09
Ogawa Yoshiyuki, Ichinose Akitada, Yanagisawa Kunio, Souri Masayoshi, Osaki Tsukasa, Kanaya Shuhei, Handa Hiroshi
Single Author
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Association between intake of health foods/supplements, background factors, and life expectancy in the general population: the Yamagata study(タイトル和訳中), 山形医学, 42(2) 102-108, 2024.08
Miharu Maya, Suzuki Natsuko, Sho Ri, Souri Masayoshi, Watanabe Masafumi, Ueno Yoshiyuki, Konta Tsuneo
Single Author
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Diagnosis and Treatment of Autoimmune Acquired Coagulation Factor Deficiencies: An Evidence-Based Review of Japanese Practice, SEMINARS IN THROMBOSIS AND HEMOSTASIS, 2024.06
Ichinose, A; Osaki, T; Souri, M
Single Author
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Autoimmune-acquired coagulation factor V deficiency with hyperfibrinolytic disseminated intravascular coagulation, INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 46(2) 395-399, 2024.04
Kaneda, Y; Fukuno, K; Minami, H; Nonaka, Y; Horinoue, A; Kuroki, Y; Osaki, T; Souri, M; Asakura, H; Ichinose, A
Single Author
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Establishment of a Novel RNA Therapeutic Approach for Oral Cancer Using miR-223, CANCER SCIENCE, 115 1076, 2024.03
Sho, R; Zhang, XH; Chida, K; Ito, T; Tachibana, H; Souri, M; Konta, T
Single Author
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Rehabilitation and outcomes in acquired hemophilia A: a single-center clinical study, Rinsho Ketsueki, 65(10) 1270-1275, 2024
MATSUMOTO Akira, OGAWA Yoshiyuki, KAJITA Mikiya, KOBAYASHI Nobuhiko, MIYAZAWA Yuri, YANAGISAWA Kunio, ISHIZAKI Takuma, TAZAWA Masayuki, WADA Naoki, SOURI Masayoshi, ICHINOSE Akitada, HANDA Hiroshi
Single Author
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Management of autoimmune factor XIII deficiency in a frail, elderly patient, BLOOD COAGULATION & FIBRINOLYSIS, 34(6) 408-413, 2023.09
Kaneko, M; Ishimaru, N; Nakajima, T; Kanzawa, Y; Seto, H; Kinami, S; Osaki, T; Souri, M; Ichinose, A
Single Author
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Antibodies against Noncatalytic B Subunit of Factor XIII Inhibit Activation of Factor XIII and Fibrin Crosslinking, THROMBOSIS AND HAEMOSTASIS, 123(09) 841-854, 2023.09
Souri, M; Yokoyama, C; Osaki, T; Ichinose, A
Single Author
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先制的コルチコステロイド療法によるin vitro非中和抗第X因子自己抗体により引き起こされた後天性第X因子欠乏症の管理(Management of Acquired Factor X Deficiency Caused by In Vitro Non-neutralizing Anti-factor X Autoantibodies with Pre-emptive Corticosteroid Therapy), Internal Medicine, 62(16) 2401-2406, 2023.08
Onishi Akio, Shimura Yuji, Nakamura Takahisa, Souri Masayoshi, Osaki Tsukasa, Mizutani Shinsuke, Tsukamoto Taku, Kobayashi Tsutomu, Ichinose Akitada, Kuroda Junya
Single Author
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Novel Immunochromatographic Test for Anti-factor XIII B Subunit Autoantibodies to Diagnose Autoimmune Acquired Factor XIII Deficiency, THROMBOSIS AND HAEMOSTASIS, 123(08) 793-803, 2023.08
Osaki, T; Yokoyama, C; Magari, Y; Souri, M; Ichinose, A
Single Author
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Clinical features and laboratory diagnostic issues of non-immune, non-amyloid related acquired factor X deficiency, HAEMOPHILIA, 29(4) 1150-1154, 2023.07
Ichinose, A; Osaki, T; Souri, M
Single Author
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Epitope analysis of human monoclonal antibodies from a patient with autoimmune factor XIII deficiency reveals their inhibitory mechanisms, FEBS LETTERS, 597(9) 1275-1289, 2023.05
Osaki, T; Souri, M; Ozawa, T; Muraguchi, A; Ichinose, A
Single Author
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Unmet Need for Reliable Immunological Detection Method for Anti-von Willebrand Factor Autoantibodies, THROMBOSIS AND HAEMOSTASIS, 123(04) 478-481, 2023.04
Osaki, T; Souri, M; Yokoyama, C; Magari, Y; Ichinose, A
Single Author
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Identification of non-neutralizing anti-factor X autoantibodies in three Japanese cases of autoimmune acquired factor X deficiency, HAEMOPHILIA, 29(2) 555-563, 2023.03
Souri, M; Osaki, T; Shimura, Y; Ichikawa, S; Mori, M; Ogawa, Y; Ichinose, A
Single Author
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Fatal acquired coagulation factor V deficiency after hepatectomy for advanced hepatocellular carcinoma as a possible immune checkpoint inhibitor-related adverse event: a case report, SURGICAL CASE REPORTS, 9(1) 16-7, 2023.02
Arakaki, S; Ono, S; Kawamata, F; Ishino, S; Uesato, Y; Nakajima, T; Nishi, Y; Morishima, S; Arakaki, S; Maeshiro, T; Souri, M; Ichinose, A; Masuzaki, H; Takatsuki, M
Single Author
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末期腎不全患者における紅斑および好酸球増加を伴う後天性第V因子インヒビター(Acquired factor V inhibitor with erythema and eosinophilia in a patient with end-stage renal disease), CEN Case Reports, 12(1) 91-97, 2023.02
Katsuren Eisuke, Kohagura Kentaro, Kinjyo Takanori, Zamami Ryo, Nakamura Takuto, Oshiro Nanako, Sunagawa Yoshitsugu, Omine Kumiko, Kudo Yuki, Shinzato Yuki, Osaki Tsukasa, Souri Masayoshi, Ichinose Ak...
Single Author
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Acquired factor V inhibitor with erythema and eosinophilia in a patient with end-stage renal disease, CEN CASE REPORTS, 12(1) 91-97, 2023.02
Katsuren, E; Kohagura, K; Kinjyo, T; Zamami, R; Nakamura, T; Oshiro, N; Sunagawa, Y; Omine, K; Kudo, Y; Shinzato, Y; Osaki, T; Souri, M; Ichinose, A; Yamazato, M; Ishida, A; Ohya, Y
Single Author
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Cloning of human anti-factor XIII monoclonal antibody dissects mechanisms of polyclonal antibodies in a single patient, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 21(2) 255-268, 2023.02
Souri, M; Ozawa, T; Osaki, T; Koyama, T; Muraguchi, A; Ichinose, A
Single Author
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IgA monoclonal gammopathyを伴うMALTリンパ腫と過粘稠度症候群を含む多疾患併存患者に生じた後天性von Willebrand症候群(Acquired von Willebrand Syndrome in a Patient with Multiple Comorbidities, Including MALT Lymphoma with IgA Monoclonal Gammopathy and Hyperviscosity Syndrome), Internal Medicine, 62(4) 605-611, 2023.02
Owari Mai, Harada-Shirado Kayo, Togawa Ryuichi, Fukatsu Masahiko, Sato Yuki, Fukuchi Koichiro, Endo Mamiko, Takahashi Hiroshi, Kimura Satoshi, Osaki Tsukasa, Souri Masayoshi, Ichinose Akitada, Shibata...
Single Author
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免疫チェックポイント阻害剤関連有害事象が疑われた進行性肝細胞癌に対する肝切除後の致死性後天性血液凝固第V因子欠乏症 1症例報告(Fatal acquired coagulation factor V deficiency after hepatectomy for advanced hepatocellular carcinoma as a possible immune checkpoint inhibitor-related adverse event: a case report), Surgical Case Reports, 9 1 of 7-7 of 7, 2023.02
Arakaki Shintaro, Ono Shinichiro, Kawamata Futoshi, Ishino Shinichiro, Uesato Yasunori, Nakajima Tomo, Nishi Yukiko, Morishima Satoko, Arakaki Shingo, Maeshiro Tatsuji, Souri Masayoshi, Ichinose Akita...
Single Author
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Management of Acquired Factor X Deficiency Caused by <i>In Vitro</i> Non-neutralizing Anti-factor X Autoantibodies with Pre-emptive Corticosteroid Therapy, INTERNAL MEDICINE, 62(16) 2401-2406, 2023
Onishi, A; Shimura, Y; Nakamura, T; Souri, M; Osaki, T; Mizutani, S; Tsukamoto, T; Kobayashi, T; Ichinose, A; Kuroda, J
Single Author
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Acquired von Willebrand Syndrome in a Patient with Multiple Comorbidities, Including MALT Lymphoma with IgA Monoclonal Gammopathy and Hyperviscosity Syndrome, INTERNAL MEDICINE, 62(4) 605-611, 2023
Owari, M; Harada-Shirado, K; Togawa, R; Fukatsu, M; Sato, Y; Fukuchi, K; Endo, M; Takahashi, H; Kimura, S; Osaki, T; Souri, M; Ichinose, A; Shibata, Y; Hashimoto, Y; Ikezoe, T
Single Author
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Coagulative complete remission following early gastric cancer resection in a patient with steroid-resistant acquired hemophilia A and nephrotic syndrome, Rinsho Ketsueki, 64(3) 203-208, 2023
MATSUMOTO Akira, OGAWA Yoshiyuki, OSAKI Tsukasa, SOURI Masayoshi, TAKEI Hisashi, ISHIKAWA Tetsuya, KOBAYASHI Nobuhiko, MIYAZAWA Yuri, ISHIZAKI Takuma, INOUE Madoka, ICHINOSE Akitada, HANDA Hiroshi
Single Author
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Autoimmune coagulation factor V/5 deficiency during chronic disseminated intravascular coagulation, Rinsho Ketsueki, 64(2) 113-118, 2023
ISHIMORI Noriko, WAKABAYASHI Mutsumi, SAKURAI Kenji, SUDA Akira, SOURI Masayoshi, OSAKI Tsukasa, ICHINOSE Akitada
Single Author
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Autoimmune acquired coagulation factor XIII/13 deficiency caused by type Ab anti-FXIII-A autoantibody, Rinsho Ketsueki, 64(12) 1508-1513, 2023
KADONO Moe, SOURI Masayoshi, SHIMOMURA Takeshi, KURODA Yoshiaki, MUNEMASA Shoso, OZAKI Tsukasa, ICHINOSE Akitada
Single Author
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Acquired hemophilia A that developed after BNT162b2 mRNA COVID-19 vaccination and worsened following re-vaccination, Rinsho Ketsueki, 64(1) 60-65, 2023
SORIMACHI Momoka, OGAWA Yoshiyuki, MATSUMOTO Akira, SOURI Masayoshi, KOITABASHI Rumiko, KAJITA Mikiya, AKASHI Naoki, NAITO Chiaki, ISHIKAWA Tetsuya, KOBAYASHI Nobuhiko, MIYAZAWA Yuri, ICHINOSE Akitada...
Single Author
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Complete remission in a bleeding patient with idiopathic autoimmune factor X deficiency caused by non-neutralizing anti-factor X autoantibody, HAEMOPHILIA, 25(2) E106-E109, 2019.03
Mori Makiko, Mochizuki Kanako, Souri Masayoshi, Nakamura Yuka, Tokuman Naoko, Kanouchi Kazunori, Morikane Keita, Ichinose Akitada
Multiple Authorship (Only Japanese)
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A high titer of acquired factor V inhibitor in a hemodialysis patient who developed arterial thrombosis, INTERNATIONAL JOURNAL OF HEMATOLOGY, 109(2) 214-220, 2019.02
Ogawa Hina, Souri Masayoshi, Kanouchi Kazunori, Osaki Tsukasa, Ohkubo Rie, Kawanishi Tomoko, Wakai Sachiko, Morikane Keita, Ichinose Akitada
Multiple Authorship (Only Japanese)
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Recurrence of acquired factor V inhibitor after four years of remission, Rinsho Ketsueki, 60(1) 46-50, 2019
AKASHI Naoki, ICHINOSE Akitada, HANDA Hiroshi, OGAWA Yoshiyuki, YANAGISAWA Kunio, OSAKI Yohei, SHIMIZU Hiroaki, ISHIZAKI Takuma, INOUE Madoka, MURAKAMI Masami, SOURI Masayoshi
Multiple Authorship (Only Japanese)
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The non-catalytic B subunit of coagulation factor XIII accelerates fibrin cross-linking., Journal of Biological Chemistry, 290(19) 12027-12039, 2015.05
Souri M, Osaki T, Ichinose A
Multiple Authorship (Including Foreigners)
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Anti-factor XIII A subunit (FXIII-A) autoantibodies block FXIII-A2B2 assembly and steal FXIII-A from native FXIII-A2B2., Journal of Thrombosis and Haemostasis, 13(5) 802-814, 2015.05
Souri M, Osaki T, Ichinose A
Multiple Authorship (Including Foreigners)
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Severe congenital factor XIII deficiency caused by novel W187X and G273V mutations in the F13A gene: diagnosis and classification according to the ISTH/SSC guidelines., Haemophilia, 20(2) 255-262, 2014.03
Souri M, Biswas A, Misawa M, Omura H, Ichinose A
Multiple Authorship (Including Foreigners)
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Alloantibodies against the B subunit of plasma factor XIII developed in its congenital deficiency., Thrombosis and Haemostasis, 109(4) 661-668, 2013.04
Wada H, Souri M, Matsumoto R, Sugihara T, Ichinose A
Multiple Authorship (Including Foreigners)
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Molecular modeling predicts structural changes in the A subunit of factor XIII caused by two novel mutations identified in a neonate with severe congenital factor XIII deficiency., Thrombosis Research, 130(3) 506-510, 2012.09
Souri M, Yee VC, Fujii N, Ichinose A
Multiple Authorship (Including Foreigners)
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Increase in the plasma levels of protein Z-dependent protease inhibitor in normal pregnancies but not in non-pregnant patients with unexplained recurrent miscarriage., Thrombosis and Haemostasis, 107(3) 507-512, 2012.05
Souri M, Sugiura-Ogasawara M, Saito S, Kemkes-Matthes B, Meijers JC, Ichinose A
Multiple Authorship (Including Foreigners)
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Reduced difference of alpha2-plasmin inhibitor levels between plasma and serum in patients with severe factor XIII deficiency, including autoimmune hemorrhaphilia due to anti-factor XIII antibodies., International Journal of Hematology, 95(1) 47-50, 2012.01
Ichinose A, Souri M
Multiple Authorship (Including Foreigners)
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As many as 12 cases with haemorrhagic acquired factor XIII deficiency due to its inhibitors were recently found in Japan., Thrombosis and Haemostasis, 105(5) 925-927, 2011.05
Ichinose A, Souri M; Japanese collaborative research group on "Acquired haemorrha-phillia due to factor XIII deficiency"
Multiple Authorship (Including Foreigners)
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Impaired clot retraction in factor XIII A subunit-deficient mice., Blood, 115(6) 1277-1279, 2010.02
Kasahara K, Souri M, Kaneda M, Miki T, Yamamoto N, Ichinose A
Multiple Authorship (Including Foreigners)
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Unique secretion mode of human protein Z: its Gla domain is responsible for inefficient, vitamin K-dependent and warfarin-sensitive secretion., Blood, 113(16) 3857-3864, 2009.04
Souri M, Iwata H, Zhang WG, Ichinose A
Multiple Authorship (Including Foreigners)
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Sushi domains in the B subunit of factor XIII responsible for oligomer assembly., Biochemistry, 47(33) 8656-8664, 2008.08
Souri M, Kaetsu H, Ichinose A
Multiple Authorship (Including Foreigners)
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Male-specific cardiac pathologies in mice lacking either the A or B subunit of factor XIII., Thrombosis and Haemostasis, 99(2) 401-408, 2008.02
Souri M, Koseki-Kuno S, Takeda N, Yamakawa M, Takeishi Y, Degen JL, Ichinose A
Multiple Authorship (Including Foreigners)
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Administration of factor XIII B subunit increased plasma factor XIII A subunit levels in factor XIII B subunit knock-out mice., International Journal of Hematology, 87(1) 60-68, 2008.01
Souri M, Koseki-Kuno S, Takeda N, Degen JL, Ichinose A
Multiple Authorship (Including Foreigners)
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Regulation of human protein Z gene expression by liver-enriched transcription factor HNF-4alpha and ubiquitous factor Sp1., Journal of Thrombosis and Haemostasis, 5(11) 2250-2258, 2007.11
Sugawara H, Iwata H, Souri M, Ichinose A
Multiple Authorship (Including Foreigners)
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An additional Glu30Lys substitution in the Gla domain of the protein Z gene is not a common polymorphism but a rare mutation, which would cause its deficiency., Journal of Thrombosis and Haemostasis, 3(10) 2360-2361, 2005.10
Iwata H, Souri M, Kemkes-Matthes B, Ichinose A
Multiple Authorship (Including Foreigners)
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A naturally occurring E30Q mutation in the Gla domain of protein Z causes its impaired secretion and subsequent deficiency., Blood, 105(8) 3149-3154, 2005.04
Souri M, Koseki-Kuno S, Iwata H, Kemkes-Matthes B, Ichinose A
Multiple Authorship (Including Foreigners)
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R255h amino acid substitution of protein Z identified in patients with factor V Leiden mutation., British Journal of Haematology, 128(2) 248-252, 2005.01
Kemkes-Matthes B, Matthes KJ, Souri M, Koseki-Kuno S, Ichinose A
Multiple Authorship (Including Foreigners)
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Impaired protein folding, dimer formation, and heterotetramer assembly cause intra- and extracellular instability of a Y283C mutant of the A subunit for coagulation factor XIII., Biochemistry, 40(45) 13413-13420, 2001.11
Souri M, Ichinose A
Multiple Authorship (Including Foreigners)
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Truncated Mutant B Subunit for Factor XIII Causes its Deficiency due to Impaired Intracellular Transportation., Blood, 97(9) 2667-2672, 2001.05
Koseki S, Souri M, Koga S, Yamakawa M, Shichishima T, Maruyama Y, Yanai F, Ichinose A
Multiple Authorship (Including Foreigners)
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Transcriptional regulation of cell type-specific expression of the TATA-less A subunit gene for human coagulation factor XIII., Journal of Biological Chemistry, 274(10) 6138-6147, 1999.05
Kida M, Souri M, Yamamoto M, Saito H, Ichinose A
Multiple Authorship (Including Foreigners)
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Relationship between structure and substrate-chain-length specificity of mitochondrial very-long-chain acyl-coenzyme A dehydrogenase., European Journal of Biochemistry, 257(3) 592-598, 1998.11
Masayoshi Souri, Toshifumi Aoyama, Seiji Yamaguchi, and Takashi Hashimoto
Multiple Authorship (Including Foreigners)
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A founder effect is proposed for factor XIII B subunit deficiency caused by the insertion of triplet AAC in exon III encoding the second sushi domain., Thrombosis and Haemostasis, 80(2) 211-213, 1998.08
Masayoshi Souri, Tomonori Izumi, Yoichiro Higashi, Antonio Girolami, and Akitada Ichinose
Multiple Authorship (Including Foreigners)
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Very-long-chain acyl-CoA dehydrogenase subunit assembles to the dimer form on mitochondrial inner membrane, FEBS Letters, 426(2): 187-190, FEBS Letters, 426(2) 187-190, 1998.04
Masayoshi Souri, Toshifumi Aoyama, George Hoganson, and Takashi Hashimoto
Multiple Authorship (Including Foreigners)
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Catalytic and FAD-binding residues of mitochondrial very long chain acyl-coenzyme A dehydrogenase., Journal of Biological Chemistry, 273(7) 4227-4231, 1998.02
Masayoshi Souri, Toshifumi Aoyama, Gerald F. Cox, and Takashi Hashimoto
Multiple Authorship (Including Foreigners)
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Mutation analysis of very-long-chain acyl-coenzyme A dehydrogenase(VLCAD)deficiency:identification and characterization of mutant VLCAD cDNAs from four patients., American Journal of Human Genetics, 58(1) 97-106, 1996.01
Masayoshi Souri, Toshifumi Aoyama, Kohji Orii, Seiji Yamaguchi, and Takashi Hashimoto
Multiple Authorship (Including Foreigners)
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Purification of human very-long-chain acyl-coenzyme A dehydrogenase and characterization of its deficiency in seven patients., Journal of Clinical Investigation, 95(6) 2465-2473, 1995.01
Toshifumi Aoyama, Masayoshi Souri, Seiichi Ushikubo, Takehiko Kamijo, Seiji Yamaguchi, Richard I. Kelley, William J. Rhead, Kimiaki Uetake, Kay Tanaka, and Takashi Hashimoto Toshifumi Aoyama, Masayosh...
Multiple Authorship (Including Foreigners)
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A sensitive assay of acyl-coenzyme A oxidase by coupling with β-oxidation multienzyme complex., Analytical Biochemistry, 221(2) 362-367, 1994.09
Masayoshi Souri, Toshifumi Aoyama and Takashi Hashimoto
Multiple Authorship (Including Foreigners)
Review Papers
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Molecular and genetic mechanisms of factor XIII A subunit deficiency., Seminars in Thrombosis and Hemostasis, 26(1) 5-10, 2000
Ichinose A, Souri M, Izumi T, Takahashi N