Updated on 2023/11/30

写真a

 
NAKAJIMA Osamu
 
Title
Professor
Date of Birth
1968
Contact information
メールアドレス
Laboratory Phone number
81-23-628-5901
 
Laboratory Fax number
81-23-628-5900
 

Research Areas

  • Life Science / Medical biochemistry

  • Life Science / Pathological biochemistry

Degree

  • Doctor (Pharmaceutical Science), The University of Tokyo, 1997.03

 

Papers

  • Heterozygous disruption of ALAS1 in mice causes an accelerated age-dependent reduction in free heme, but not total heme, in skeletal muscle and liver., Archives of biochemistry and biophysics, 697 108721, 2021.01

    van Wijk K, Akabane T, Kimura T, Saitoh S, Okano S, Kelly VP, Takagi M, Kodama K, Takahashi K, Tanaka T, Nakajima M, Nakajima O

    Single Author

  • Genetic ablation of aldehyde reductase (Akr1a) augments exercise endurance in mice via activation of the PGC-1α-involved pathway., Life sciences, 249 117501, 2020.05

    Takahashi M, Homma T, Yamada KI, Miyata S, Nakajima O, Fujii J

    Single Author

  • Knock-Ins of Type-2 Calr Mutants Cause Myeloproliferative Neoplasm (MPN)-like Hematopoiesis in Mice, BLOOD, 134 , 2019.11

    Minakawa Keiji, Ueda Koki, Nakajima Osamu, Yokokawa Tetsuro, Kinishima Yusuke, Misaka Tomofumi, Ogawa Kazuei, Ikezoe Takayuki, Takeishi Yasuchika, Ikeda Kazuhiko

    Single Author

  • Interleukin-12p40 variant form reduces Interleukin-12p80 secretion., Cytokine, 120 251-257, 2019.08

    Oshikiri Y, Nara H, Takeda Y, Araki A, Nemoto N, Gazi MY, Saito S, Saitoh S, Nakajima O, Asao H

    Single Author

  • Over expression of 5-aminolevulinic acid synthase 2 increased protoporphyrin IX in nonerythroid cells., Photodiagnosis and photodynamic therapy, 17 22-28, 2017.03

    Huang H, Wang W, Zou J, Nakajima O, Zhang L, He Q, Diao Y, Liang H, Zhou L, Peng Y

    Single Author

  • Heightened aggressive behavior in mice deficient in aldo-keto reductase 1a (Akr1a)., Behavioural brain research, 319 219-224, 2017.02

    Homma T, Akihara R, Okano S, Shichiri M, Yoshida Y, Yamada KI, Miyata S, Nakajima O, Fujii J

    Single Author

  • Poor embryo development in post-ovulatory in vivo-aged mouse oocytes is associated with mitochondrial dysfunction, but mitochondrial transfer from somatic cells is not sufficient for rejuvenation., Human reproduction (Oxford, England), 31(10) 2331-8, 2016.10

    Igarashi H, Takahashi T, Abe H, Nakano H, Nakajima O, Nagase S

    Single Author

  • HECT-Type Ubiquitin E3 Ligase ITCH Interacts With Thioredoxin-Interacting Protein and Ameliorates Reactive Oxygen Species-Induced Cardiotoxicity., Journal of the American Heart Association, 5(1) , 2016.01

    Otaki Y, Takahashi H, Watanabe T, Funayama A, Netsu S, Honda Y, Narumi T, Kadowaki S, Hasegawa H, Honda S, Arimoto T, Shishido T, Miyamoto T, Kamata H, Nakajima O, Kubota I

    Single Author

  • Unique food-entrained circadian rhythm in cysteine414-alanine mutant mCRY1 transgenic mice., Sleep and biological rhythms, 14 261-269, 2016

    Okano S, Yasui A, Hayasaka K, Nakajima O

    Single Author

  • Role of chemokine C-C motif ligand-1 in acute and chronic pulmonary inflammations., SpringerPlus, 5(1) 1241, 2016

    Kishi H, Sato M, Shibata Y, Sato K, Inoue S, Abe S, Kimura T, Nishiwaki M, Yamauchi K, Nemoto T, Igarashi A, Tokairin Y, Nakajima O, Kubota I

    Single Author

  • Over-expression 5-aminolevulinic acid synthase 2 in nonerythroid cell may causes protoporphyrin IX accumulation., Photodiagnosis and photodynamic therapy, 2015.10

    Huang H, Wang W, Zou J, Liu Z, Zhou Z, Nakajima O, Zhang L, Luo J, Li M, He Q, Diao Y, Liang H, Zhou L, Gao X

    Single Author

  • SOD1 deficiency induces the systemic hyperoxidation of peroxiredoxin in the mouse., Biochemical and biophysical research communications, 463(4) 1040-6, 2015.08

    Homma T, Okano S, Lee J, Ito J, Otsuki N, Kurahashi T, Kang ES, Nakajima O, Fujii J

    Single Author

  • Heme-mediated inhibition of Bach1 regulates the liver specificity and transience of the Nrf2-dependent induction of zebrafish heme oxygenase 1., Genes to cells : devoted to molecular & cellular mechanisms, 20(7) 590-600, 2015.07

    Fuse Y, Nakajima H, Nakajima-Takagi Y, Nakajima O, Kobayashi M

    Single Author

  • Characterization of age-associated alterations of islet function and structure in diabetic mutant cryptochrome 1 transgenic mice., Journal of diabetes investigation, 4(5) 428-35, 2013.09

    Okano S, Hayasaka K, Igarashi M, Togashi Y, Nakajima O

    Single Author

  • Reduced number and morphofunctional change of alveolar macrophages in MafB gene-targeted mice., PloS one, 8(9) e73963, 2013

    Sato-Nishiwaki M, Aida Y, Abe S, Shibata Y, Kimura T, Yamauchi K, Kishi H, Igarashi A, Inoue S, Sato M, Nakajima O, Kubota I

    Single Author

  • Heme oxygenase-1 transgenic overexpression did not prevent artery injury induced by electric stimulation and pressure overload in mice., European journal of pharmacology, 659(2-3) 199-205, 2011.06

    Gao X, Liu HB, Wu JC, Liang J, Zhou LY, Zhao LL, Chen C, Tong Y, Gong DM, Nakajima O, Yang BF, Dong DL

    Single Author

  • Heme regulates B-cell differentiation, antibody class switch, and heme oxygenase-1 expression in B cells as a ligand of Bach2., Blood, 117(20) 5438-48, 2011.05

    Watanabe-Matsui M, Muto A, Matsui T, Itoh-Nakadai A, Nakajima O, Murayama K, Yamamoto M, Ikeda-Saito M, Igarashi K

    Single Author

  • Systemic heme oxygenase-1 transgenic overexpression aggravates pressure overload-induced cardiac hypertrophy in mice., Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 28(1) 25-32, 2011

    Chen C, Huo R, Tong Y, Sheng Y, Liu HB, Gao X, Nakajima O, Yang BF, Dong DL

    Single Author

  • Long-term overexpression of heme oxygenase 1 promotes tau aggregation in mouse brain by inducing tau phosphorylation., Journal of Alzheimer's disease : JAD, 26(2) 299-313, 2011

    Hui Y, Wang D, Li W, Zhang L, Jin J, Ma N, Zhou L, Nakajima O, Zhao W, Gao X

    Single Author

  • Non-obese early onset diabetes mellitus in mutant cryptochrome1 transgenic mice., European journal of clinical investigation, 40(11) 1011-7, 2010.11

    Okano S, Hayasaka K, Igarashi M, Iwai H, Togashi Y, Nakajima O

    Single Author

  • Indispensable function for embryogenesis, expression and regulation of the nonspecific form of the 5-aminolevulinate synthase gene in mouse., Genes to cells : devoted to molecular & cellular mechanisms, 15(1) 77-89, 2010.01

    Okano S, Zhou L, Kusaka T, Shibata K, Shimizu K, Gao X, Kikuchi Y, Togashi Y, Hosoya T, Takahashi S, Nakajima O, Yamamoto M

    Single Author

  • Keratinocyte-/fibroblast-targeted rescue of Col7a1-disrupted mice and generation of an exact dystrophic epidermolysis bullosa model using a human COL7A1 mutation., The American journal of pathology, 175(6) 2508-17, 2009.12

    Ito K, Sawamura D, Goto M, Nakamura H, Nishie W, Sakai K, Natsuga K, Shinkuma S, Shibaki A, Uitto J, Denton CP, Nakajima O, Akiyama M, Shimizu H

    Single Author

  • Rescue of anaemia and autoimmune responses in SOD1-deficient mice by transgenic expression of human SOD1 in erythrocytes., The Biochemical journal, 422(2) 313-20, 2009.08

    Iuchi Y, Okada F, Takamiya R, Kibe N, Tsunoda S, Nakajima O, Toyoda K, Nagae R, Suematsu M, Soga T, Uchida K, Fujii J

    Single Author

  • Unusual circadian locomotor activity and pathophysiology in mutant CRY1 transgenic mice., Neuroscience letters, 451(3) 246-51, 2009.02

    Okano S, Akashi M, Hayasaka K, Nakajima O

    Single Author

  • Hepatocyte-specific deletion of heme oxygenase-1 disrupts redox homeostasis in basal and oxidative environments., The Tohoku journal of experimental medicine, 216(4) 331-9, 2008.12

    Mamiya T, Katsuoka F, Hirayama A, Nakajima O, Kobayashi A, Maher JM, Matsui H, Hyodo I, Yamamoto M, Hosoya T

    Single Author

  • High-mobility group box 1 restores cardiac function after myocardial infarction in transgenic mice., Cardiovascular research, 80(1) 40-6, 2008.10

    Kitahara T, Takeishi Y, Harada M, Niizeki T, Suzuki S, Sasaki T, Ishino M, Bilim O, Nakajima O, Kubota I

    Single Author

  • Deletion of the selenocysteine tRNA gene in macrophages and liver results in compensatory gene induction of cytoprotective enzymes by Nrf2., The Journal of biological chemistry, 283(4) 2021-30, 2008.01

    Suzuki T, Kelly VP, Motohashi H, Nakajima O, Takahashi S, Nishimura S, Yamamoto M

    Single Author

  • Inducibility of cytochrome P450 1A1 and chemical carcinogenesis by benzo[a]pyrene in AhR repressor-deficient mice., Biochemical and biophysical research communications, 365(3) 562-7, 2008.01

    Hosoya T, Harada N, Mimura J, Motohashi H, Takahashi S, Nakajima O, Morita M, Kawauchi S, Yamamoto M, Fujii-Kuriyama Y

    Single Author

  • In vivo function of the 5' flanking region of mouse estrogen receptor beta gene., The Journal of steroid biochemistry and molecular biology, 105(1-5) 57-62, 2007.06

    Fujimoto N, Nakajima O, Kitamura S, Ohta S

    Single Author

  • In vivo oxygen imaging using green fluorescent protein., American journal of physiology. Cell physiology, 291(4) C781-7, 2006.10

    Takahashi E, Takano T, Nomura Y, Okano S, Nakajima O, Sato M

    Single Author

  • Transgenic rescue of erythroid 5-aminolevulinate synthase-deficient mice results in the formation of ring sideroblasts and siderocytes., Genes to cells : devoted to molecular & cellular mechanisms, 11(6) 685-700, 2006.06

    Nakajima O, Okano S, Harada H, Kusaka T, Gao X, Hosoya T, Suzuki N, Takahashi S, Yamamoto M

    Single Author

  • Differential gene expression profiling between wild-type and ALAS2-null erythroblasts: identification of novel heme-regulated genes., Biochemical and biophysical research communications, 340(1) 105-10, 2006.02

    Fujiwara T, Harigae H, Takahashi S, Furuyama K, Nakajima O, Sun J, Igarashi K, Yamamoto M, Sassa S, Kaku M, Sasaki T

    Single Author

  • Cardiac-specific overexpression of diacylglycerol kinase zeta prevents Gq protein-coupled receptor agonist-induced cardiac hypertrophy in transgenic mice., Circulation, 113(1) 60-6, 2006.01

    Arimoto T, Takeishi Y, Takahashi H, Shishido T, Niizeki T, Koyama Y, Shiga R, Nozaki N, Nakajima O, Nishimaru K, Abe J, Endoh M, Walsh RA, Goto K, Kubota I

    Single Author

  • The distal sequence element of the selenocysteine tRNA gene is a tissue-dependent enhancer essential for mouse embryogenesis., Molecular and cellular biology, 25(9) 3658-69, 2005.05

    Kelly VP, Suzuki T, Nakajima O, Arai T, Tamai Y, Takahashi S, Nishimura S, Yamamoto M

    Single Author

  • Genetic oxygen sensor: GFP as an indicator of intracellular oxygenation., Advances in experimental medicine and biology, 566 39-44, 2005

    Takahashi E, Takano T, Numata A, Hayashi N, Okano S, Nakajima O, Nomura Y, Sato M

    Single Author

  • The transcriptional programme of antibody class switching involves the repressor Bach2., Nature, 429(6991) 566-71, 2004.06

    Muto A, Tashiro S, Nakajima O, Hoshino H, Takahashi S, Sakoda E, Ikebe D, Yamamoto M, Igarashi K

    Single Author

  • Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse., Proceedings of the National Academy of Sciences of the United States of America, 100(10) 5652-7, 2003.05

    Moriguchi T, Motohashi H, Hosoya T, Nakajima O, Takahashi S, Ohsako S, Aoki Y, Nishimura N, Tohyama C, Fujii-Kuriyama Y, Yamamoto M

    Single Author

  • Functional analysis of basic transcription element binding protein by gene targeting technology., Molecular and cellular biology, 23(7) 2489-500, 2003.04

    Morita M, Kobayashi A, Yamashita T, Shimanuki T, Nakajima O, Takahashi S, Ikegami S, Inokuchi K, Yamashita K, Yamamoto M, Fujii-Kuriyama Y

    Single Author

  • HLF/HIF-2alpha is a key factor in retinopathy of prematurity in association with erythropoietin., The EMBO journal, 22(5) 1134-46, 2003.03

    Morita M, Ohneda O, Yamashita T, Takahashi S, Suzuki N, Nakajima O, Kawauchi S, Ema M, Shibahara S, Udono T, Tomita K, Tamai M, Sogawa K, Yamamoto M, Fujii-Kuriyama Y

    Single Author

  • Aberrant iron accumulation and oxidized status of erythroid-specific delta-aminolevulinate synthase (ALAS2)-deficient definitive erythroblasts., Blood, 101(3) 1188-93, 2003.02

    Harigae H, Nakajima O, Suwabe N, Yokoyama H, Furuyama K, Sasaki T, Kaku M, Yamamoto M, Sassa S

    Single Author

  • Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene., The EMBO journal, 21(19) 5216-24, 2002.10

    Sun J, Hoshino H, Takaku K, Nakajima O, Muto A, Suzuki H, Tashiro S, Takahashi S, Shibahara S, Alam J, Taketo MM, Yamamoto M, Igarashi K

    Single Author

  • Heme mediates depression of Maf recognition element through direct binding to transcription repressor Bach1, EMBO J, 2001.04

    中島 修,Ogawa K, Sun J, Taketani S, Nakajima O, et al.

    Multiple Authorship (Including Foreigners)

  • Heme deficiency in erythroif lineage causes differentiation arrest and cytoplasmic iron overload, EMBO J., Vol.18, 6282-6289, 1999.11

    中島 修,O. Nakajima, S. Takahashi, H. Harigae, K. Kazumichi, M. Yamamoto et al.

    Multiple Authorship (Including Foreigners)

  • Regulation of Lens Fiber Cell Differentiation by Transcription Factor c-Maf, J. Biol. Chem., Vol. 274, 19254-19260, 1999.07

    中島 修,S. Kawauchi, S. Takahashi, O. Nakajima, et al.

    Multiple Authorship (Including Foreigners)

  • Role of GATA-1 in Proliferation and Differentiation of Definitive Erythroid and Megakaryocytic Cells In Vivo, Blood, Vol. 92, 434-442, 1998.07

    中島 修,S. Takahashi, T. Komeno, N. Suwabe, K. Yoh, O. Nakajima, et al.

    Multiple Authorship (Including Foreigners)

  • Non-Ionic Water-Soluble Dextran-Coupled Tetraphenylporhyrin Derivaives., J. Am. Chem. Soc., Vol. 114, 9203-9205, 1992.12

    中島 修,O. Nakajima, H. Mizoguchi, Y. Hashimoto, S. Iwasaki

    Multiple Authorship (Including Foreigners)

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Review Papers

  • 生体内のヘム欠乏は,ATP代謝障害によるグリコーゲン合成異常のため,耐糖能異常・インスリン抵抗性を発症させる, (一社)日本糖尿病学会, 糖尿病, 62(Suppl.1) S-316, 2019.04

    中島 修, 斉藤 真一, 尾崎 司, van Wijk Koen, 木村 朋寛, 浅尾 裕信, 山本 雅之, 高橋 究, 田中 徹, 中島 元夫

  • 生体内でのヘム欠乏は,グリコーゲン合成異常を伴うインスリン抵抗性を惹起する, (一社)日本糖尿病学会, 糖尿病, 62(3) 203, 2019.03

    中島 修, 斉藤 真一, 尾崎 司, 木村 朋寛, 岡野 聡, 山本 雅之, 高橋 究, 田中 徹, 中島 元夫

  • ALA欠乏マウスにおける糖代謝異常の発症メカニズムの解析, (公社)日本生化学会, 日本生化学会大会(Web), 91st ROMBUNNO.3T14a‐06(3P‐295) (WEB ONLY)-06(3P, 2018.09

    斉藤真一, 岡野聡, 木村朋寛, 尾崎司, 山本雅之, ケリー ビンセントP, 高橋究, 田中徹, 中島元夫, 中島修

  • Heme Deficiency Causes Impaired Glycogen Synthesis in Skeletal Muscle Leading to Insulin Resistance, DIABETES, 67 , 2018.07

    Nakajima Osamu, Saitoh Shinichi, Kimura Tomohiro, Osaki Tsukasa, Vincent Kelly P, Takahashi Kiwamu, Tanaka Tohru, Nakajima Motowo

  • ALA生合成不全マウスでの糖代謝異常の分子機構解析, 日本分子生物学会年会プログラム・要旨集(Web), 41st ROMBUNNO.3P‐0609 (WEB ONLY), 2018

    斉藤真一, 斉藤真一, 尾崎司, 木村朋寛, 岡野聡, 山本雅之, 浅尾裕信, 高橋究, 田中徹, 中島元夫, 中島修

Grant-in-Aid for Scientific Research

  • Grant-in-Aid for Scientific Research(B),2021.04 - 2022.03

  • Grant-in-Aid for Scientific Research(C),2020.04 - 2023.03

  • Grant-in-Aid for Scientific Research(C),2019.04 - 2022.03

  • Grant-in-Aid for Scientific Research(C),2019.04 - 2022.03

  • Grant-in-Aid for Scientific Research(C),2018.04 - 2021.03

  • Grant-in-Aid for Scientific Research(C),2018.04 - 2019.03

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