Updated on 2023/11/30

写真a

 
ZHANG Xuhong
 
Title
Assistant Professor

Research Areas

  • Life Science / Medical biochemistry

Graduating School

  • Shanghai medical university, Faculty of Medicine

    1990.07, Graduated

Degree

  • MD, Shanghai Medical University (China), 1990.07

  • PhD, Yamagata University, 1998.03

External Career

  • , Assistant Professor, 1990.07 - 1995.03

  • Yamagata University, Assistant Professor, 1997.07 -

 

Papers

  • Establishment of Patient-Derived Oral Cancer Organoid Cultures, CANCER SCIENCE, 112 775, 2021.02

    Tachibana Hirohiko, Sho Ri, Zhang Xuhong, Ozaki Hisashi, Koike Shuji, Kurakami Kazuya, Konta Tsuneo

    Multiple Authorship (Including Foreigners)

  • Crystal structure of higher plant heme oxygenase-1 and its mechanism of interaction with ferredoxin, The Journal of Biological Chemistry, 296 100217, 2020.12

    Rei Tohda, Hideaki Tanaka, Risa Mutoh, Xuhong Zhang, Young-Ho Lee, Tsuyoshi Konuma, Takahisa Ikegami, Catharina T. Migita, Genji Kurisu

    Multiple Authorship (Including Foreigners)

  • Protective role of testis-specific peroxiredoxin 4 against cellular oxidative stress., J Clin Biochem Nutr., 60(3) 156-161, 2017.05

    Eisuke Tasaka, Shotaro Matsumoto, Hisashi Tada, Toshihiro Kurahashi, Xuhong Zhang, Junichi Fujii, Toshihiko Utsumi, Yoshihito Iuchi.

    Multiple Authorship (Including Foreigners)

  • Circulating miR-223 in Oral Cancer: Its Potential as a Novel Diagnostic Biomarker and Therapeutic Target., PLoS One., 11(7) e0159693, 2016.07

    Tachibana H, Sho R, Takeda Y, Zhang X, Yoshida Y, Narimatsu H, Otani K, Ishikawa S, Fukao A, Asao H, Iino M

    Multiple Authorship (Including Foreigners)

  • Ascorbic acid reverses the prolonged anesthetic action of pentobarbital in Akr1a-knockout mice., Life Sciences, 95 1-8, 2014.01

    Ito J, Otsuki N, Zhang X, Konno K, Kurahashi T, Takahashi M, Yamato M, Matsuoka Y, Yamada K, Miyata S, and Fujii J.

    Multiple Authorship (Including Foreigners)

  • Role of propionates in substrate binding to heme oxygenase from Neisseria meningitidis: a nuclear magnetic resonance study., Biochemistry., 51(36) 7054-7063, 2012.09

    Peng D, Ma LH, Smith KM, Zhang X, Sato M, La Mar GN.

    Multiple Authorship (Including Foreigners)

  • Influence of substrate modification and C-terminal truncation on the active site structure of substrate-bound heme oxygenase from Neisseriae meningitidis. A 1H NMR study., Biochemistry., 50(41) 8823-8833, 2011.10

    Peng D, Satterlee JD, Ma LH, Dallas JL, Smith KM, Zhang X, Sato M, La Mar GN.

    Multiple Authorship (Including Foreigners)

  • 1H NMR study of the influence of mutation on the interaction of the C-terminus with the active site in heme oxygenase from Neisseria meningitidis: implications for product release., Biochemistry, 49(28) 5832-5840, 2010.07

    Peng D, Ma LH, Ogura H, Yang EC, Zhang X, Yoshida T, La Mar GN.

    Multiple Authorship (Including Foreigners)

  • 1H NMR study of the effect of variable ligand on heme oxygenase electronic and molecular structure. , J Inorg Biochem., 103(1) 10-19, 2009.01

    Ma LH, Liu Y, Zhang X, Yoshida T, La Mar GN.

    Multiple Authorship (Including Foreigners)

  • Relevant expression of Drosophila heme oxygenase is necessary for the normal development of insect tissues. , Biochem Biophys Res Commun. , 377 1156-1161, 2008.12

    Cui L, Yoshioka Y, Suyari O, Kohno Y, Zhang X, Adachi Y, Ikehara S, Yoshida T, Yamaguchi M, Taketani S.

    Multiple Authorship (Including Foreigners)

  • Variation of the oxidation state of verdoheme in the heme oxygenase reaction., Biochem Biophys Res Commun., 376 293-298, 2008.11

    Gohya T, Sato M, Zhang X, Migita CT.

    Multiple Authorship (Including Foreigners)

  • Spectroscopic characterization of a higher plant heme oxygenase isoform-1 from Glycine max (soybean)--coordination structure of the heme complex and catabolism of heme., FEBS J., 273(23) 5384-5399, 2006.12

    Gohya T, Zhang X, Yoshida T, Migita CT.

    Multiple Authorship (Including Foreigners)

  • 1H NMR Study of the influence of hemin vinyl-->methyl substitution on the interaction between the C-terminus and substrate and the "aging" of the heme oxygenase from Neisseria meningitidis: induction of active site structural heterogeneity by a two-fold symmetric hemin., Biochemistry, 45(46) 13875-13888, 2006.11

    Liu Y, Ma LH, Zhang X, Yoshida T, Satterlee JD, La Mar GN.

    Multiple Authorship (Including Foreigners)

  • (1)H NMR Study of the Magnetic Properties and Electronic Structure of the Hydroxide Complex of Substrate-bound Heme Oxygenase from Neisseria Meningitidis: Influence of the Axial Water Deprotonation on the Distal H-bond Network, J Am Chem Soc, 128(20) 6657-6668, 2006.05

    Ma, L. H. Liu, Y. Zhang, X. Yoshida, T. La Mar, G. N.

    Multiple Authorship (Including Foreigners)

  • Modulation of the Axial Water Hydrogen-Bonding Properties by Chemical Modification of the Substrate in Resting State, Substrate-Bound Heme Oxygenase from Neisseria meningitidis; Coupling to the Distal H-Bond Network via Ordered Water Molecules, J Am Chem Soc, 128(19) 6391-6399, 2006.05

    Ma, L. H. Liu, Y. Zhang, X. Yoshida, T. Langry, K. C. Smith, K. M. La Mar, G. N.

    Multiple Authorship (Including Foreigners)

  • Characterization of the Spontaneous "Aging" of the Heme Oxygenase from the Pathological Bacterium Neisseria meningitidis via Cleavage of the C-Terminus in Contact with the Substrate. Implications for Functional Studies and the Crystal Structure, Biochemistry, 45(12) 3875-3886, 2006.03

    Liu, Y. Ma, L. H. Zhang, X. Yoshida, T. Satterlee, J. D. La Mar, G. N.

    Multiple Authorship (Including Foreigners)

  • Evidence for the hydrophobic cavity of heme oxygenase-1 to be a CO-trapping site, Biochem Biophys Res Commun , 338 584-589, 2005.12

    Migita CT. Togashi S. Minakawa M. Zhang X. Yoshida T

    Multiple Authorship (Including Foreigners)

  • Solution (1) H NMR Characterization of the Distal H-Bond Network and the Effective Axial Field in the Resting-State, High-Spin Ferric, Substrate-Bound Complex of Heme Oxygenase from N meningitides, Journal of the American Chemical Society , 127(17) 6409-6422, 2005.05

    Liu Y, Zhang X, Yoshida T & La Mar GN

    Multiple Authorship (Including Foreigners)

  • Crystal Structure of Dimeric Heme Oxygenase-2 from Synechocystis sp.PCC 6803 in Complex with Heme, Biochemistry, 44(11) 4257-4266, 2005.02

    2 Sugishima M, Hagiwara Y, Zhang X, Yoshida T, Migita CT, Fukuyama K

    Multiple Authorship (Including Foreigners)

  • Protein expressed by the ho2 gene of the cyanobacterium Synechocystis sp. PCC 6803 is a true heme oxygenase, FEBS Journal, 272(4) 1012-1022, 2005.02

    Zhang X, Migita CT, Sato M, Sasahara M, Yoshida T

    Multiple Authorship (Including Foreigners)

  • Crystal structure of heme oxygenase-1 from cyanobacterium Synechocystis sp PCC 6803 in complex with heme, European Journal of Biochemistry, 271 4517-4525, 2004.11

    Sugishima M, Migita CT, Zhang X, Yoshida T, Fukuyama K

    Multiple Authorship (Including Foreigners)

  • 1H NMR Characterization of the Solution Active Site Structure of Substrate-Bound, Cyanide-Inhibited Heme Oxygenase from Neisseria meningitidis: Comparison to Crystal Structures, Biochemistry, 43(31) 10112-10126, 2004.08

    Liu Y, Zhang X, Yoshida T, La Mar GN

    Multiple Authorship (Including Foreigners)

  • Unique features of recombinant heme oxygenase of Drosophila melanogaster compared with those of other heme oxygenases studied, European Journal of Biochemistry , 271(9) 1713-1724, 2004.05

    Zhang X, Sato M, Sasahara M, Migita CT, Yoshida T

    Multiple Authorship (Including Foreigners)

  • Essential Amino Acid Residues Controlling the Unique Regioselectivity of Heme Oxygenase in Pseudomonas aeruginosa, Journal of the American Chemical Society , 126(14) 4466-4467, 2004.03

    Fujii H, Zhang X, Yoshida T

    Multiple Authorship (Including Foreigners)

  • Stereo selectivity of each of the three steps of the heme oxygenase reaction: Hemin to meso-hydroxyhemin, meso-hydroxyhemin to verdoheme, and verdoheme to biliverdin, Biochemistry, 42(24) 7418-7426, 2003.06

    Zhang X, Fujii H, Matera KM, Migita CT, Sun DY, Sato M, Ikeda-Saito M, Yoshida T

    Multiple Authorship (Including Foreigners)

  • Expression and characterization of cyanobacterium heme oxygenase, a key enzyme in the phycobilin synthesis - Properties of the heme complex of recombinant active enzyme, European Journal of Biochemistry , 270 687-698, 2003.02

    Migita CT, Zhang X, Yoshida T

    Multiple Authorship (Including Foreigners)

  • A role for highly conserved carboxylate, aspartate-140, in oxygen activation and heme degradation by heme oxygenase-1., J Am Chem Soc. 2001 Jul 11;123(27):6475-84., 2001.06

    張 旭紅

    Multiple Authorship (Including Foreigners)

  • Diversity of hepatitis G virus within a single infected individual., Virus Genes. 21(3), 2000.10

    張 旭紅

    Multiple Authorship (Including Foreigners)

  • Participation of Carboxylate Amino Acid Side Chain in Regiospecific Oxidation of Heme by Heme Oxygenase., J Am Chem Soc. 122(34), 2000.08

    張 旭紅

    Multiple Authorship (Including Foreigners)

  • Histidine 20, the crucial proximal axial heme ligand of bacterial heme oxygenase Hmu O from Corynebacterium diphtheriae. , J Biol Chem. 275(23), 2000.06

    張 旭紅

    Multiple Authorship (Including Foreigners)

  • Heme degradation as catalyzed by a recombinant bacterial heme oxygenase(Hum O) from Corynebacterium diphtheriae., J Biol Chem. 274(30), 1999.07

    張 旭紅

    Multiple Authorship (Including Foreigners)

  • Epidemiological study and genetic analysis of GB Virus C infection in general population from an area endemic for hepatitis C, J. Med. Virol.,54(4), 1998.04

    張 旭紅

    Multiple Authorship (Including Foreigners)

  • Detection of Hepatitis G Virus RNA in patients with Hepatitis B, Hepatitis C, and non-A-E Hepatitis by RT-PCR using multiple primer sets, J. Med. Virol.,52(4), 1997.08

    張 旭紅

    Multiple Authorship (Including Foreigners)

  • Sequence of Hepatitis G Virus genome isolated from a Japanese patient with non-A-E-Hepatitis:Amplification and cloning by long reverse transcription-PCR, Biochem. Biophys. Res. Commun., 228(3) 785-791, 1996.01

    張 旭紅

    Multiple Authorship (Including Foreigners)

  • Study on antibody response versus Hepatitis C Virus by synthetic peptides, Shanghai Medicine, 15(6), 1992.06

    張 旭紅

    Multiple Authorship (Including Foreigners)

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Grant-in-Aid for Scientific Research

  • Grant-in-Aid for Scientific Research(C),2022.04 - 2025.03

  • Grant-in-Aid for Scientific Research(C),2020.04 - 2023.03