Research Areas
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Life Science / Developmental biology
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Life Science / Evolutionary biology
Graduating School
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Tohoku University, Faculty of Science
1988.03, Graduated
Graduate School
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Tohoku University, Graduate School, Division of Natural Science
Doctor's Course, 1993.03, Completed
Degree
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Doctor(Science), Tohoku University, 1993.03
Papers
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Identification and characterization of sperm motility-initiating substance-2 gene in internally fertilizing Cynops species, DEVELOPMENT GROWTH & DIFFERENTIATION, 65(3) 144-152, 2023.04
Furukawa Haruka, Mito Shinya, Nishio Jun, Sato Nozomi, Ando Yoshihiro, Tominaga Atsushi, Toyama Fubito, Nakauchi Yuni, Takayama-Watanabe Eriko, Watanabe Akihiko
Multiple Authorship (Only Japanese)
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Differences of extracellular cues and Ca2+ permeable channels in the signaling pathways for inducing amphibian sperm motility. , Zoological science, 38 343-351, 2021.04
T. Sato, T. Arimura, K. Murata, M. Kawamura, W. Obama, M. Suzuki, Y. Nakauchi, A.Tominaga, M. Morita, K. Hiraoka, E. Takayama-Watanabe, A.Watanabe
Multiple Authorship (Only Japanese)
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Localization of sperm intracellular Ca2+ keeps fertilizability in the newt vas deferens. , Reproduction, 159 339-349, 2020.02
N. Makino, N. Sato, E. Takayama-Watanabe, A. Watanabe
Multiple Authorship (Only Japanese)
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Acrosome reaction inducing substance triggers two different pathways of sperm intracellular signaling in newt fertilization., Int. J. Dev. Biol., 63 589-595, 2019.12
S. Kon, A. Takaku, F. Toyama, E. Takayama-Watanabe, A. Watanabe
Multiple Authorship (Only Japanese)
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NMDA-type glutamate receptors mediate the acrosome reaction and motility initiation in newt sperm. , Molecular Reproduction and Development, 2019
Daisuke Endo, Shinnosuke Kon, Tae Sato, Fubito Toyama, Yohei Katsura, Yuni Nakauchi, Eriko Takayama-Watanabe, Akihiko Watanabe
Multiple Authorship (Only Japanese)
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Novel erythrocyte clumps revealed by an orphan gene Newtic1 in circulating blood and regenerating limbs of the adult newt, SCIENTIFIC REPORTS, 8 7455, 2018.07
R.M. Casco-Robles, A. Watanabe, K. Eto, K. Takeshima, S. Obata, T. Kinoshita, T. Ariizumi, K. Nakatani, T. Nakada, P.A. Tsonis, M.M. Casco-Robles, K. Sakurai, K. Yahata, F. Maruo, F. Toyama, C. Chiba
Multiple Authorship (Including Foreigners)
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Sperm storage influences the potential for spontaneous acrosome reaction of the sperm in the newt Cynops pyrrhogaster, Mol. Reprod. Dev., 84 1314-1322, 2017.12
S. Kon, T. Sato, D. Endo, T. Takahashi, A. Takaku, Y. Nakauchi, F. Toyama, V. B. Meyer-Rochow, E. Takayama-Watanabe, A.Watanab
Multiple Authorship (Including Foreigners)
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Sperm motility initiating substance may be insufficient to induce forward motility of Cynops ensicauda sperm. , Mol. Reprod. Dev., 84 686-692, 2017.08
T. Sato, M. Yokoe, D. Endo, M. Morita, F. Toyama, Y. Kawamura, Y. Nakauchi, E. Takayama-Watanabe, A. Watanabe
Multiple Authorship (Including Foreigners)
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A novel cysteine knot protein for enhancing sperm motility that might facilitate the evolution of internal fertilization in amphibians. , PLOS ONE, 11 e0160445, 2016.08
M. Yokoe, E. Takayama-Watanabe, Y. Saito, M. Kutsuzawa, K. Fujita, H. Ochi, Y. Nakauchi, A. Watanabe
Multiple Authorship (Including Foreigners)
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Contribution of different Ca2+ channels to the acrosome reaction-mediated initiation of sperm motility in the newt Cynops pyrrhogaster. , Zygote, 23 342-351, 2015.06
E. Takayama-Watanabe, H. Ochiai, S. Tanino, A. Watanabe
Multiple Authorship (Including Foreigners)
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In silico identification of the genes for sperm-egg interaction in the internal fertilization of the newt Cynops pyrrhogaster., Int. J. Dev. Biol., 58 873-879, 2014.12
A. Watanabe,, E. Takayama-Watanabe
Multiple Authorship (Including Foreigners)
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Sperm proteases that may be involved in the initiation of sperm motility in the newt, Cynops pyrrhogaster., Int. J. Mol. Sci., 15 15210-15224, 2014.08
M. Yokoe, M. Sano, H. Shibata, D. Shibata, E. Takayama-Watanabe, K. Inaba, A. Watanabe
Multiple Authorship (Including Foreigners)
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Distinct Ca2+ channels maintain a high motility state of the sperm that may be needed for penetration of egg jelly of the newt, Cynops pyrrhogaster. , Develop. Growth Differ., 55 657-667, 2013.08
T. Takahashi, M. Kutsuzawa, K. Shiba, E. Takayama-Watanabe, K. Inaba, A. Watanabe
Multiple Authorship (Including Foreigners)
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Sperm motility initiation by egg jelly of the anuran, Discoglossus pictus may be mediated by sperm motility-initiating substance of the internally-fertilizing newt, Cynops pyrrhogaster., Zygote, 20 417-422, 2012.11
E. Takayama-Watanabe, C. Campanella, H. Kubo A. Watanabe
Multiple Authorship (Including Foreigners)
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Characterization of an alternative chromatin remodeling to parasperm in a cottid fish, Hemilepidotus gilberti., Zoological Science, 28 438-443, 2011.06
Y. Nakauchi, Y. Hayakawa, M. Fujinoki, O.Yamamura, M. Kobayashi, A. Watanabe
Multiple Authorship (Including Foreigners)
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Sperm motility-initiating substance in newt egg-jelly induces differential initiation of sperm motility based on sperm intracellular calcium levels., Develop. Growth Differ., 53 9-17, 2011.01
A. Watanabe, E. Takayama-Watanabe, C. A. Vines, G. N. Cherr
Multiple Authorship (Including Foreigners)
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Sperm motility-initiating activity in the egg jelly of the externally-fertilizing urodele amphibian, Hynobius lichenatus. , Zoological Science, 27 875-879, 2010.11
M. Ohta, H. Kubo, Y. Nakauchi A. Watanabe
Multiple Authorship (Including Foreigners)
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Identification of the sperm motility-initiating substance in the newt, Cynops pyrrhogaster, and its possible relation with the acrosome reaction during internal fertilization., Int. J. Dev. Biol., 54 591-597, 2010.10
T. Watanabe, H. Kubo, S. Takeshima, M. Nakagawa, M. Ohta, S. Kamimura, E. Takayama-Watanabe, A. Watanabe and K. Onitake
Multiple Authorship (Including Foreigners)
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Two states of active spermatogenesis switch between reproductive and non-reproductive seasons in the testes of the medaka, Oryzias latipes. , Develop. Growth Differ. , 51 521-532, 2009.05
. Y. Iwasaki, K. Ohkawa, H. Sadakata, A. Kashiwadate, E. Takayama-Watanabe, K. Onitake and A. Watanabe.
Multiple Authorship (Including Foreigners)
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Identification of egg-jelly substances triggering sperm acrosome reaction in the newt, Cynops pyrrhogaster., Mol Reprod Dev., 79 399-406, 2009.02
. A. Watanabe, K. Fukutomi, H. Kubo, M. Ohta, E. Takayama-Watanabe, and K. Onitake.
Multiple Authorship (Including Foreigners)
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Partial formation of sperm dimorphism from spermatocytes of the cottoid fish, Hemilepidotus gilberti in cell culture. (共著), Zygote, 15 285-293, 2007.11
. Y. Hayakawa, E. Takayama-Watanabe, A. Watanabe, M. Kobayashi, H. Munehara, K. Onitake
Multiple Authorship (Including Foreigners)
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Spermatogenesis involving parasperm production in the marine cottoid fish, Hemilepidotus gilberti. , The Raffles bulletin of zoology, Sup 14 29-352, 2007.01
Hayakawa, Y., Kobayashi, M., Munehara, H., Watanabe, A., and Onitake K.
Multiple Authorship (Including Foreigners)
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Egg-jelly of the newt, Cynops pyrrhogaster contains a factor essential for sperm binding to the vitelline envelope., Journal of Experimental Zoology, 307A 301-311, 2007.01
W. Hiyoshi, T. Sasaki, E. Takayama-Watanabe, H. Takai, A. Watanabe, and K. Onitake
Multiple Authorship (Including Foreigners)
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The outermost layer of egg-jelly is crucial to successful fertilization in the newt, Cynops pyrrhogaster., Journal of Experimental Zoology, 305A 1010-1017, 2006.12
. Takahashi, S., Nakazawa, H., Watanabe, A., and Onitake, K.
Multiple Authorship (Including Foreigners)
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Ordered progress of spermiogenesis to the fertilizable sperm of the medaka fish, Oryzias latipes, in cell culture. , Development Growth Differentiation, 47 87-97, 2005.02
. Sasaki, T., Watanabe, A., Takayama-Watanabe, E., Suzuki, M., Abe H., and Onitake, K.
Multiple Authorship (Including Foreigners)
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Characteristics of sperm motility induced on the egg-jelly in the internal fertilization of the newt, Cynops pyrrhogaster., Zoological science, 20 345-352, 2003.03
T. Watanabe, T. Itoh, A. Watanabe and K. Onitake
Multiple Authorship (Including Foreigners)
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Newt ZPC molecule, cpZPC, localizes in the inner surface of the egg envelope. , International Journal of Developmental Biology, 47 51-58, 2003.02
Y. Makabe-Kobayashi, E. Kudaira, A. Watanabe and K. Onitake
Multiple Authorship (Including Foreigners)
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The activity for the induction of sperm acrosome reaction localises in the outer layers and exists in the high molecular weight components of egg-jelly of the newt, Cynops pyrrhogaster. , Zygote, 10 1-9, 2002.02
T. Sasaki, S. Kamimura, H. Takai, A. Watanabe and K. Onitake
Multiple Authorship (Including Foreigners)
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Egg-jelly structure promotes efficiency of internal fertilization in the newt, Cynops pyrrhogaster. , Journal of Experimental Zoology, 291 314-322, 2002.01
T. Itoh, S. Kamimura, A. Watanabe and K. Onitake
Multiple Authorship (Including Foreigners)
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Organization of carbohydrate components in the egg-jelly layers of the newt, Cynops pyrrhogaster., Zoologocal Science, 18 909-918, 2001.01
M. Okimura, A. Watanabe and K. Onitake
Multiple Authorship (Including Foreigners)
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Significance of egg-jelly substances in the internal fertilization of the newt, Cynops pyrrhogaster. , Comparative Biochemistry and Physiology , 126 121-128, 2000.01
K. Onitake, H. Takai, M. Ukita, J. Mizuno, T. Sasaki and A. Watanabe
Multiple Authorship (Including Foreigners)
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Sperm surface heparin/heparan sulfate is responsible for sperm binding to the uterine envelope in the newt, Cynops pyrrhogaster. , Development Growth & differentiation, 41 101-107, 1999.01
S. Nakai, A. Watanabe and K. Onitake
Multiple Authorship (Including Foreigners)
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Initiation of sperm motility in the newt, Cynops pyrrhogaster, is induced by a heat-stable component of egg-jelly. , Zygote, 7 329-334, 1999.01
J. Mizuno, A. Watanabe and K. Onitake
Multiple Authorship (Including Foreigners)
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Substances for the initiation of sperm motility in egg-jelly of the Japanese newt, Cynops pyrrhogaster. , Zoological Science, 16 763-802, 1999.01
M. Ukita, T. Itoh, A. Watanabe and K. Onitake
Multiple Authorship (Including Foreigners)
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Fibroblast growth factor may regulate the initiation of oocyte growth in the developing ovary of the medaka, Oryzias latipes. , Zoological Science, 15 531-536, 1998.01
渡邉 明彦
Multiple Authorship (Including Foreigners)
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Establishment of in vitro spermatogenesis from spermatocytes in the medaka, Oryzias latipes., Development Growth Differentiation, 39 337-344, 1997.10
A. Saiki, M. Tamura, M. Matsumoto, J. Katowgi, A. Watanabe and K. Onitake
Multiple Authorship (Including Foreigners)
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Distributions of fibroblast growth factor and the mRNA for its receptor, MFR1, in the developing testis of the medaka, Oryzias latipes. , Journal of Experimental Zoology, 279 177-184, 1997.05
A. Watanabe, N. Hatakeyama, A. Yasuoka and K. Onitake
Multiple Authorship (Including Foreigners)
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Changes in the distribution of fibroblast growth factor in the teleostean testis during spermatogenesis. , Journal of Experimental Zoology, 272 475-483, 1995.09
A. Watanabe and K. Onitake
Multiple Authorship (Including Foreigners)
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Basic FGF maintains some characteristics of the progress zone of chick limb bud in cell culture. , Developmental Biology, 159 223-231, 1993.10
Akihiko Watanabe and Hiroyuki Ide
Multiple Authorship (Including Foreigners)
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Formation of distal structures from stumps of chick wing buds at stage 24-25 following the grafting of quail tissue from X-irradiated distal limb buds. , Journal of Experimental Zoology, 267 447-453, 1993.10
A. Watanabe, K. Ohsugi and H. Ide
Multiple Authorship (Including Foreigners)
Books
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Fish Spermatology "jointly worked", Alpha Science Ltd.Publications , 2007.05
Akihiko Watanabe and Kazuo Onitake
Review Papers
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Adaptive Modifications of the Regulation of Sperm Motility in the Diversification of Reproductive Modes of Amphibians, XIIIth International Symposium on Spermatology, 12-122, 2021.07
A. Watanabe、 E. Takayama-Watanabe
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Molecular basis of adaptive evolution of sperm motility involved in in vivo fertilization of terrestrial animals, Impact, 2020(6) 73-75, 2020.11
Akihiko Watanabe
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Acrosome reaction-mediated motility initiation that is critical for the internal fertilization of urodele amphibians. , Sexual reproduction in animals and plants, 97-103, 2014.02
E. Takayama-Watanabe, T. Takahashi, M. Yokoe, A. Watanabe
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In vitro spermatogenesis from primary spermatocytes, Medaka–Biology, Management, and Experimental Protocols, 350-353, 2009.06
A. Watanabe
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Genetic Variation in Wild Population of the Medaka, Oryzias latipes, in Yamagata Prefecture, Yamagata University, Bulletin of the Yamagata University, 16(2) 55-69, 2006.02
E. Takayama-Watanabe, T. Tsuji, M. Sato, T. Doi , T. Yakuwa, T. Sasaki, A. Watanabe and K. Onitake
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Sperm activation, Science Publishers Incorporation, Reproductive Biology and Phylogeny of Urodela (Amphibia), 2003.03
A. Watanabe and K. Onitake
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Urodela egg-coat as the apparatus for the internal fertilization., The zoological sosiety of Japan, Zoological Science, 19 1341-1347, 2002.12
A. Watanabe and K. Onitake
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Mechanism for vertebrate limb development and regeneration, Shokabo publisher, BIology and genetics, (別冊6) 109-116, 1994.09
A. Watanabe and H. Ide
Grant-in-Aid for Scientific Research
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Grant-in-Aid for Scientific Research(C),2020.04 - 2023.03
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Grant-in-Aid for Scientific Research(C),2016.04 -
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Grant-in-Aid for Scientific Research(C),2016.04 - 2019.03
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Grant-in-Aid for Scientific Research(C),2015.10 -
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Grant-in-Aid for Scientific Research(A),2012.04 - 2016.03
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Grant-in-Aid for Scientific Research(C),2012.04 - 2015.03
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Grant-in-Aid for Scientific Research(C),2009.04 - 2012.03